M. Firoze Khan, Ph.D.
Professor and Vice Chair for Research, Department of Pathology;
Member, NIEHS Center;
Member, Sealy Center for Environmental Health & Medicine
University of Texas Medical Branch
301 University Boulevard
Galveston, TX 77555-0438
Office: (409) 772-6881
Fax: (409) 747-1763
mfkhan@utmb.edu
|
Professional Education
| Degree |
Institution |
Field of Study |
Graduation Year |
| B.S. |
Aligarh Muslim University, Aligarh, India |
Chemistry, Zoology, Botany |
1976 |
| M.S. |
Aligarh Muslim University, Aligarh, India |
Biochemistry |
1978 |
| M.Phil. |
Aligarh Muslim University, Aligarh, India |
Biochemistry |
1980 |
| Ph.D. |
Aligarh Muslim University, Aligarh, India |
Biochemistry |
1983 |
Honors
| 2007 |
“Researcher of the Year”, Department of Pathology, UTMB, Galveston, TX |
| 2006 |
Chairperson of a session on “Biomarkers”, 45th Annual Meeting of Society of Toxicology, San Diego, CA |
| 1998 |
Young Scientist Award, Association of Scientists of Indian Origin in America, San Francisco, CA |
| 1996 |
Chairperson of a session on “Hematopoietic System”, 35th Annual Meeting of Society of Toxicology, Anaheim, CA |
Professional Affiliations
| 2003–Present |
Society for Free Radical Biology and Medicine (SFRBM) |
| 1997-2009 |
American Chemical Society (ACS) |
| 1997–2007 |
Society for Experimental Biology and Medicine (SEBM |
| 1996–2006 |
American Association for the Advancement of Science |
| 1996–Present |
American Society for Pharmacology and Experimental Therapeutics (Elected) |
| 1994–Present |
Society of Toxicology (Elected) |
| 1993–Present |
International Society for the Study of Xenobiotics (ISSX) |
Research Interests
- Oxidative stress and autoimmune diseases
- Molecular mechanisms of splenic toxicity of aromatic amines
- Chemical-induced autoimmunity
- Biomarkers of chemical exposure
Selected Publications
- Khan MF, Gallagher JE, Brody AR. Effect of alveolar lining layer proteins and lipids on particle binding and phagocytosis. Toxicol In Vitro 4:93–101, 1990.
- Lemaire I, Jones S, Khan MF. Bombesin-like peptides in alveolar macrophage –increased release in pulmonary inflammation and fibrosis. Neuropeptides 20:63–72, 1991.
- Khan MF, Gupta GSD. Cellular and biochemical indices of bronchoalveolar lavage for the detection of lung injury following insult by airborne toxicants. Toxicol Lett 58:239–255, 1991.
- Khan MF, Boor PJ, Kaphalia BS, Alcock NW, Ansari GAS. Hematopoietic toxicity of linoleic acid anilide: Importance of aniline. Fundam Appl Toxicol 25:224-232, 1995.
- Khan MF, Srivastava SK, Singhal SS, Chaubey M, Awasthi S, Petersen DRR, Ansari GAS, Awasthi YC. Iron induced lipid peroxidation in rat liver is accompanied with preferential induction of glutathione S-transferase 8-8 isozyme. Toxicol Appl Pharmacol 131:63-72, 1995.
- Khan MF, Kaphalia BS, Prabhakar BS, Kanz MF, Ansari GAS. Trichloroethene-induced autoimmune response in female MRL+/+ mice. Toxicol Appl Pharmacol 134:155-160, 1995.
- Khan MF, Gu, Y, Alcock NW, Boor PJ, Ansari GAS. Oxidative stress in splenotoxicity of aniline. Fundam Appl Toxicol 35:22-30, 1997.
- Khan MF, Green, SM, Ansari GAS, Boor PJ. Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis in rats. Toxicol Sci 42:64-71, 1998.
- Khan MF, Wu X, Boor PJ, Ansari GAS. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol Sci 48:134-140, 1999.
- Khan MF, Wu X, Ansari GAS. Anti-malondialdehyde antibodies in MR +/+ mice treated with trichloroethene and dichloroacetyl chloride:Possible role of lipid peroxidation in autoimmunity. Toxicol Appl Pharmacol 170:88-92, 2001.
- Khan MF, Wu, X, Tipnis UR, Ansari GAS, Boor PJ. Protein adducts of malondialdehyde and 4-hydroxynonenal in the livers of iron-loaded rats: Quantitation and localization. Toxicology 173:193-201, 2002.
- Khan MF, Wu X, Wang J. Up-regulation of transforming growth factor-beta 1 in splenic toxicity of aniline. Toxicol Appl Pharmacol 187:22-28, 2003.
- Khan MF, Wu X, Boor PJ, Ansari GAS. Nitrotyrosine formation in splenic toxicity of aniline. Toxicology 194:95-102, 2003.
- Wang J, Kannan S, Li H, Khan MF. Cytokine gene expression and activation of NF-κB in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 203:36-44, 2005.
- Khan MF, Kannan S, Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 210:86-93, 2006.
- Wang G, Cai P, Ansari GAS, Khan MF. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology 229:186-193, 2007.
- Wang G, Konig R, Ansari GAS, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via CD4+Tcell activation. Free Radic Biol Med 44:1475-1482, 2008.
- Wang J, Wang G, Ansari GAS, Khan MF. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. Toxicol Appl Pharmacol 230:227-234, 2008.
- Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF. Oxidative DNA damage and its repair in rat spleen following subchronic aniline exposure. Toxicol Appl Pharmacol 233:247-253, 2008.
- Wang G, Ma H, Wang J, Khan MF. Nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: Possible role of protein oxidation in autoimmunity. Toxicol Appl Pharmacol 237:188-195, 2009.
NIH Biosketch
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