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Dr. McBride

Jere W. McBride, Ph.D.

Associate Professor, Department of Pathology
Center for Biodefense and Emerging Infectious Diseases
Sealy Center for Vaccine Development

University of Texas Medical Branch
301 University Blvd,
Keiller 1.136
Galveston, Texas 77555-0609

Office: (409) 747-2498
Fax: (409) 747-2455
jemcbrid@utmb.edu

Professional Education

Degree Institution Field of Study Graduation Year
B.S. Louisiana State University, Baton Rouge Microbiology 1987
M.S. Louisiana State University, Baton Rouge Microbiology/Immunology 1993
Ph.D. University of California, Davis Comparative Pathology 1997
Fellowship University of Texas Medical Branch Molecular Microbiology 1999

Honors

1999 James W. McLaughlin Award for Research Excellence in Infection and Immunity, University of Texas Medical Branch
1999 Postdoctoral Award for Molecular/ Cell Biology Research, Department of Pathology, Pathology    Trainee Research Session University of Texas Medical Branch
2004 Experimental Pathology Graduate Student Award for Teaching and Mentoring, University of Texas Medical Branch
2004 Department of Pathology nominee for the W.M. Keck Foundation Distinguished Young Scholars in Medical Research Award
2009 Department of Pathology, Researcher of the Year

Professional Affiliations

  • American Society for Microbiology
  • American Society for Investigative Pathology
  • American Society for Rickettsiology

Research Interests

Obligately intracellular bacteria, Molecular Pathobiology, Host Defense and Immunity, Diagnostics and Vaccines

Selected Publications

  1. Zhu B, Nethery KA, Kuriakose JA, Zhang, XF, and McBride JW.  Nuclear translocated Ehrlichia chaffeensis ankyrin repeat protein interacts with the mid-A stretch of host promoter and intronic Alu elements. 2009; 77:4243-4255. (Selected by the editors as an article of significant interest-“Spotlight” p.4181) PMID: 19651857
  2. Luo T, Zhang XF and McBride JW.  Major species-specific antibody epitopes of the E. chaffeensis p120 and E. canis p140 orthologs in surface-exposed tandem repeat regions. Clin. Vaccine Immunol. 2009; 16:982-990.  PMID:  19420187
  3. Wakeel A, Kuriakose J, and McBride JW.  An Ehrlichia chaffeensis tandem repeat protein interacts with multiple host targets involved in cell signaling, transcriptional regulation and vesicle trafficking. Infect Immun.  2009; 76:1572-1580.  (Selected by the editors as an article of significant interest-“Spotlight” p.1721) PMID: 19273555
  4. Zhang XF, Lou T, Keysary A, Baneth G, Strenger C, Waner T and McBride JW.  Genetic and antigenic diversities of major immunoreactive proteins in globally distributed Ehrlichia canis strains.   Clin.Vaccine Immunol. 2008;15:1080-1088. PMID: 18480237
  5. Luo T, Zhang XF, Wakeel A, Popov VL, and McBride JW.  Variable-length PCR target protein of Ehrlichia chaffeensis contains major species-specific antibody epitopes in highly acidic serine-rich tandem repeats. Infect. Immun.  2008; 76:1572-1580. PMID: 18212082
  6. Nethery KA, Doyle CK, Zhang XF, McBride JW.  Ehrlichia canis gp200 contains dominant species-specific antibody epitopes in terminal acidic domains. Infect. Immun. 2007; 75:4900-4908. PMID: 17682040
  7. Ndip LM, Ndip RN, Ndive VE, Awuh JA, Walker DH, and McBride JW. Ehrlichia species in Rhipicephalus sanguineus ticks in Cameroon. Vect. Borne Zoo. Dis. 2007; 7:221-228. PMID: 17627442
  8. Cardenas AM, Doyle CK, XF Zhang, Nethery KA, Corstvet RE, Walker DH, McBride JW.   Enzyme-linked immunosorbent assay with conserved immunoreactive glycoproteins gp36 and gp19 has enhanced sensitivity and provides species-specific immunodiagnosis of Ehrlichia canis infection.  Clin Vaccine Immunol. 2007; 14:123-128. PMID: 17151186
  9. McBride JW, Doyle CK, Zhang XF, Cardenas AM, Popov VL, Nethery KA, Woods ME. Identification of a glycosylated Ehrlichia canis 19-kDa major immunoreactive protein with a species-specific serine-rich glycopeptide epitope.  Infect Immun. 2007; 75:74-82. PMID: 17088359
  10. Labruna MB, McBride JW, Carmargo  LMA, Aguiar DM, Yabsley MJ, Davidson WR, Stromdahl EY, Williamson PC, Stich RW, Long SW, Camargo EP, Walker DH.  A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil. Vet Parasitol. 2007; 143:189-195. PMID: 16962245
  11. Mavromatis K, Doyle CK, Lykidis A, Ivanova N, Chain P, Larimer F, Copeland A, Detter JC, Land M, Richardson PM, Yu XJ, Walker DH, McBride JW, Kyrpides NC.  The genome of Ehrlichia canis reveals themes of complex membrane structure and immune evasion strategies.  J Bact. 2006; 188:4015-4023. PMID: 16707693
  12. Doyle CK, Nethery KA, Popov VL, McBride JW.  Differentially expressed and secreted major immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis elicit early antibody responses to epitopes on glycosylated tandem repeats.  Infect Immun. 2006; 74:711-720. PMID: 16369028
  13. Yager E, Bitsaktsis C, Nandi B, McBride JW, Winslow G.  An essential role for humoral immunity during Ehrlichia infection in immunocompetent mice. Infect Immun. 2005; 73:8009-8016. PMID: 16299294
  14. Ndip LM, Ndip RN, Esemu SN, Dickmu VL, Fokan EB, Walker DH, McBride JW.  Ehrlichial infection in Cameroonian canines with Ehrlichia canis and E. ewingii. Vet Microbiol. 2005; 111:59-66. PMID: 16181750
  15. Doyle CK, Labruna MB, Breitschwerdt EB, Tang Y, Corstvet RE, Hegarty B, Bloch KC, Li P, Walker DH, McBride JW.  Detection of medically important Ehrlichia by quantitative multicolor Taqman real-time PCR of the dsb gene.  J Mol Diagn. 2005; 10:504-510. PMID: 16237220
  16. Doyle CK, Zhang X, Popov VL, McBride JW.  An immunoreactive 38-kilodalton protein of Ehrlichia canis shares structural homology and iron-binding capacity with the ferric-ion binding protein family. Infect Immun. 2005; 73:62-69. PMID: 15618141
  17. Labruna MB, Whitworth T, Bouyer DH, McBride JW, Camargo LM, Camargo EP, Popov VL, Walker DH.  Rickettsia bellii and Rickettsia amblyommii in Amblyomma ticks from the state of Rondonia, Western Amazon, Brazil. J Med Entomol.2004; 41:1073-1081. PMID: 15605647
  18. Ismail N, Soong L, McBride JW, Valbuena G, Olano JP, Feng HM, Walker DH.  Overproduction of TNF-a by CD8+ type-1 cells and downregulation of INF-g by CD4+ Th-1 cells contribute to toxic shock-like syndrome in an animal model of fatal monocytotropic ehrlichiosis.  J Immuol. 2004; 172:1786-1800. PMID: 14734762
  19. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov VL, Gennari  SM, Walker DH.  Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil, where Brazilian spotted fever is endemic.  J Clin Microbiol.2003; 42:90-98. PMID: 14715737
  20. McBride JW, Corstvet RE, Gaunt SD, Boudreaux C, Guedry T, Walker DH.  Kinetics of antibody response to Ehrlichia canis immunoreactive proteins.  Infect Immun.2003; 71:2516-24. PMID: 12704123

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