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Dr. Motin

Vladimir L. Motin, Ph.D.

Associate Professor, Department of Pathology

University of Texas Medical Branch
3.148 Keiller Building, Route 0609
301 University Boulevard
Galveston, TX 77555-0609

Office: (409) 772-3155
Lab: (409) 772-3158
Fax: (409) 747-2437
vlmotin@utmb.edu

Professional Education

Degree Institution Field of Study Graduation Year
B.S. Institute for Engineering and Physics, Moscow, Russia Biophysics 1983
Ph.D. Gamaleya Research Institute for Epidemiology and Microbiology, Academy of Medical Sciences, Moscow, Russia Microbiology and Genetics 1988

Appointments

Department of Pathology
Department of Microbiology & Immunology
Centers for Biodefense and Emerging Infectious Diseases
Sealy Center for Vaccine Development
Institute for Human Infections and Immunity

Honors

1987 Best Young Scientist Research Award, Gamaleya Research Institute for Epidemiology and  Microbiology, Moscow, Russia
1997 Faculty Career Development Award, University of California, Irvine

Professional Affiliations

1993–Present Member, American Society for Microbiology
2006–Present Member, Chlamydia Basic Research Society
2008–Present Member, International Society for Vaccines
2008–Present Editorial Board, Infectious Diseases: Research and Treatment
2011 Editorial Board, World Journal Vaccine

Research Interests

Currently, my major research interest is pathogenesis of Yersinia pestis, the etiological agent of plague. Although plague is not a public heath problem in most parts of the world, its potential for contagion, the lack of an effective vaccine, and the recent emergence of multiple antibiotic resistance strains place this organism squarely at the top of the United States’ select agent list as a potential candidate for bioterrorism use.  The long-term goal of my research is to elucidate the molecular mechanisms that underlie the nature of the acute bacterial infectious process caused by Y. pestis. The identification of the environmental signals that the bacteria encounter in the host cells and the potential virulence genes regulated by those signals will lead to better understanding of the process of cross-talk between pathogen and its host during the infection.  The unraveling of Y. pestis virulence network will allow us to determine novel targets for therapeutics beyond antibiotics, generation of new vaccines and for development of robust diagnostic assays.

Selected Publications

  1. Motin, V.L., M.S. Pokrovskaya, M.V. Telepnev, V.V. Kutyrev, N.A. Vidyaeva, A.A. Filippov, and G.B. Smirnov. 1992. The difference in the lcrV sequences between Y. pestis and Y. pseudotuberculosis and its application for characterization  of Y. pseudotuberculosis strains. Microb. Pathogen. 12:165-175.
  2. Motin, V.L., R. Nakajima, G.B. Smirnov, and R.R. Brubaker. 1994. Passive immunity to Yersinia mediated by anti-recombinant V antigen and anti-protein A-V antigen fusion peptide. Infect. Immun. 62:4192-4201.
  3. Nakajima, R., V.L. Motin, and R.R. Brubaker 1995. Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization. Infect. Immun.  63:3021-3029.
  4. Motin, V.L., Yu.A. Nedialkov, and R.R. Brubaker. 1996. V antigen-polyhistidine fusion peptide: specific binding to LcrH and active immunity against plague. Infect. Immun. 64:4313-4318.
  5. Nedialkov, Yu.A., V.L. Motin, and R.R. Brubaker. 1997.  Resistance to lipopolysaccharide mediated by the Yersinia pestis  V antigen-polyhistidine fusion peptide: amplification of Interleukin-10.  Infect. Immun.  65:1196-1203.
  6. Motin, V.L., S.M. Kutas, and R.R. Brubaker. 1997. Suppression of mouse skin allograft rejection by protein A-yersinia V antigen fusion peptide. Transplantation 63:1040-1042.
  7. Motin, V.L., L.M. de la Maza, and E.M. Peterson. 1999. Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing variable domain 4 of the major outer membrane protein of Chlamydia trachomatis. Clin. Diagn. Lab. Immunol. 6:356-363.
  8. Motin, V.L., A.M. Georgescu, J.M. Elliott, P. Hu, P.L. Worsham, L.L. Ott, T.R. Slezak, B.A., Sokhansanj, W.M. Regala, R.R. Brubaker, and E. Garcia.  2002.  Genetic variability of Yersinia pestis isolates as predicted by PCR-based IS100 genotyping and analysis of structural genes encoding glycerol-3-phosphate dehydrogenase (glpD).  J. Bacteriol. 184:1019-1027.
  9. Slepenkin, A., V. Motin, L.M. de la Maza, and E.M. Peterson. 2003. Temporal expression of type III secretion genes of Chlamydia pneumoniae. Infect. Immun. 71:2555-2562.
  10. Chain,  P.S.G., E. Carniel, F. W. Larimer, J. Lamerdin, P. O. Stoutland, W. M. Regala, A. M. Georgescu, L. M. Vergez, M. L. Land, V. L. Motin, R. R. Brubaker, J. Fowler, J. Hinnebusch, M. Marceau, C. Medigue, M. Simonet, V. Chenal- Francisque, B. Souza, D. Dacheux, J. M. Elliott, A. Derbise, L. J. Hauser, and E.Garcia. 2004. Insights into the evolution of Yersinia pestis through whole genome comparison with Yersinia pseudotuberculosis. Proc. Natl. Acad. Sci. USA. 101:13826-13831.
  11. Motin, V.L., A. M. Georgescu, J. P. Fitch, P. P. Gu, D. O. Nelson, S. L. Mabery, J. B. Garnham, B. A. Sokhansanj, L. L. Ott, M. A. Coleman, J. M. Elliott, L. M. Kegelmeyer, A. J. Wyrobeck, T. R. Slezak, R. R. Brubaker, and E. Garcia.  2004. Temporal Global Changes in Gene Expression during Temperature Transition in Yersinia pestis. J. Bacteriol.186:6398-6305.
  12. Abramov, V.M., Khlebnikov, V.S., Vasiliev, A.M., Kosarev, I.V., Vasilenko, R.N., Kulikova, N.L., Khodyakova, A.V., Evstigneev, V.I., Uversky, V.N., Motin, V.L., Smirnov, G.B., Brubaker, R.R.  2007. Attachment of LcrV from Yersinia pestis at Dual Binding Sites to Human TLR-2 and Human IFN-gamma Receptor. J Proteome Res. 6:2222-2231.
  13. Feodorova, V.A., L.N. Pan’kina, E.P. Savostina, L.V. Sayapina, V.L. Motin, S.V. Dentovskaya, R.Z. Shaikhutdinova, S.A. Ivanov, B. Lindner, A.N. Kondakova, O.V. Bystrova, N.A. Kocharova, S.N. Senchenkova, O. Holst, G.B. Pier, Y.A. Knirel, A.P. Anisimov. 2007. Yersinia pestis EV NIIEG ΔlpxM live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 25:7620-7628.
  14. Kim, T.-J., S. Chauhan, V.L. Motin, E.-B. Goh, M.M. Igo and G.M. Young. 2007. Direct transcriptional regulation of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein.  J Bacteriol. 189:8890-900.
  15. Agarkov, A., S. Chauhan, P.J. Lory, S.R. Gilbertson and V. L. Motin. 2008. Substrate specificity and screening of the integral membrane protease Pla. Bioorg. Med. Chem. Lett. 18:427-431.
  16. Garcia, E., P. Chain, J.M. Elliott, A.G. Bobrov, V.L. Motin, O.A. Kirillina, V. Lao,  R. Calendar, and A.  Filippov. 2008. Molecular characterization of L-413C, a P2-related plague diagnostic bacteriophage. Virology. 372:85-96.
  17. Sha, J., Agar, S.L., Baze, W.B., Olano, J.P., Fadl, A.A., Erova, T.E., Wang, S., Foltz, S.M., Suafez, G., Motin, V.L., Chauhan, S., Klimpel, G.R., Peterson, J.W., and Chopra, A.K. 2008. Braun Lipoprotein (Lpp) contributes to the virulence of Yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague. Infect. Immun. 76:1390-1409
  18. Feodorova, V.A., L.N. Pan’kina, E.P. Savostina, O.V. Kuznetsov, N.P. Konnov, L.V. Sayapina, S.V. Dentovskaya,  R.Z. Shaikhutdinova, S.A. Ageev, B. Lindner, A.N. Kondakova, O.V. Bystrova, N.A. Kocharova, S.N. Senchenkova, O. Holst, G.B. Pier, Y.A. Knirel, A.P. Anisimov, and V.L. Motin. 2009. Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens. Vaccine 27:2240-2250.
  19. Endsley, J.J., Torres, A.G., Gonzales, C.M., Kosykh, V.G., Motin, V.L., Peterson, J.W., Estes, D.M., Klimpel, G.R.  2009. Comparative antimicrobial activity of granulysin against bacterial biothreat agents.  Open Microbiol. J. 3:92-96.
  20. Telepnev, M.V., G.R. Klimpel, J. Haithcoat, Y.A. Knirel, A.P. Anisimov and V.L. Motin. 2009. Tetra-acylated lipopolysaccharide of Yersinia pestis can inhibit multiple Toll-Like Receptor (TLR)-mediated signaling pathways in human dendritic cells. J Infect Dis 200:1694-1702
  21. Robinson, J.B., Telepnev, M.V., Zudina, I.V., Bouyer, D., Montenieri, J.A., Bearden, S.W., Gage, K.L., Agar, S.L., Foltz, S.M., Chauhan, S., Chopra, A.K., and Motin, V.L. 2009. Evaluation of a Yersinia pestis Mutant Impaired in Thermoregulated Type VI-Like Secretion System in Flea, Macrophage and Murine Models. Microb Pathogen 47:243-251.
  22. Anisimov, A.P., S.V. Dentovskaya, E.A. Panfertsev, T.E. Svetoch, P.Kh. Kopylov, B.W. Segelke, A. Zemla, M.V. Telepnev and V.L. Motin. 2010. Amino acid and structural variability of Yersinia pestis LcrV protein. Infection, Genetics and Evolution 10:137-145.
  23. Colborn,  J.M., M.Y. Kosoy, V.L. Motin, M.V. Telepnev, G. Valbuena, K.S. Myint, Y. Fofanov, C. Putonti, C. Feng and L. Peruski. 2010. Improved detection of Bartonella DNA in mammalian hosts and arthropod vectors using the NADH dehydrogenase gamma subunit (nuoG). J Clin Microbiol 48:4630-4633.

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