Anthony Okorodudu

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Anthony Okorodudu
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Academic Appointments
Appointment Organization
Director, Clinical Chemistry
Professor
Professional Education
Degree Institution Field of Study Graduation Year
M.S. Houston Baptist University Management, Computing and Systems 1997
Post-Doctoral Fellowship Hartford Hospital Clinical Chemistry 1988
Ph.D. University of Medicine & Dentistry of New Jersey Pathology 1982
B.A. Rutger's - The State University of New Jersey Biological Sciences 1977
Appalachian State University 1975
Honors
Title Organization Year(s)
Distinguished Alumni Award, Graduate School of Biomedical Science, University of Medicine & Dentistry of New Jersey 2001
Outstanding Clinical Chemist Award for 1999, Texas Section of the American Association for Clinical Chemistry 1999
Past Chairman's Award, Texas Section, American Association for Clinical Chemistry 1996
Chairman's Award, Texas Section, American Association for Clinical Chemistry 1994
Recipient of the 1991-92 Faculty Teaching Award, Department of Pathology, University of Texas Medical Branch 1992
Nominee for the award of Outstanding Scientific Achievement by a Young Investigator, Connecticut Valley Section, American Association for Clinical Chemistry 1990
Nominee for the award of Outstanding Scientific Achievement by a Young Investigator, Connecticut Valley Section, American Association for Clinical Chemistry 1988
Nominated in 1985 to represent Nigeria in Geneva, Switzerland at an International Meeting for Biotechnology and Biosafety Federal Ministry of Science and Technology. Lagos, Nigeria 1985
Doctoral Fellowship, University of Medicine and Dentistry of New Jersey. Newark, NJ 1979 - 1982
Cornwall Scholarship, University of Medicine and Dentistry of New Jersey. Newark, NJ 1977 - 1978
Chemistry Academic Award, Appalachian State University. Boone, NC 1975 - 1976
Tuition Scholarship, Appalachian State University. Boone, NC 1974 - 1975
Professional Affiliations
Society Year(s)
Association of Clinical Scientists 1990 - 1999
American Society of Clinical Pathologists 1990 - 1996
Clinical Laboratory Management Association 1989 - 1996
American Association for Clinical Chemistry 1982
Research Interests

Clinical Chemistry

Intracellular ions are intricately involved in numerous metabolic processes, especially as cofactors in the enzymatic reactions and pathways within the cell. To ensure proper functioning of the cells, the intracellular ions must be maintained within relatively narrow concentration ranges. Understanding the regulation of the pathways and effect of drugs (i.e., cocaine, ethanol, cocaethylene) on the homeostasis of these ions are the focus in my laboratory. For example, the concentration of intracellular ionized magnesium [Mg2+]I has been reported to be between 200 to 800 mol/l, which represents 1-2% of the total cellular magnesium. However, the exact mechanisms involved in the homeostatic control of the [Mg2+]I relative to extracellular ionized magnesium concentration ([Mg2+]o) remain unclear. These studies will enhance our understanding of the diverse biological functions of intracellular ions, and aid in therapeutic interventions and/or prevention of drug toxicities. My research activity related to clinical services is focused on the metabolism and post-mortem drug distribution.

Methods used in my laboratory include immunoassays, electrophoresis, chromatography (TLC, GC, HPLC and GCMS), electrochemistry, tissue culture and spectroscopy (UV, fluorescence and visible).

Selected Publications
  1. Tacker DPH, Okorodudu AO. Evidence for Injurious Effect of Cocaethylene in Human Microvascular Endothelial Cells Clinica Chimica Acta 345(1-2): 69-77, 2004
  2. Ajayi AA, Ogungbade GO, Okorodudu AO. Sex Hormone Regulation of Systemic Endothelial and Renal Microvascular Reactivity in Type-2 Diabetes: Studies in Gonadectomized and Sham-Operated Zucker Diabetic Rats. European Journal of Clinical Investigation 34:349-357, 2004
  3. Mohammad AA, Elefano EC, Leigh D, Stredler D, Okorodudu AO, Petersen JR. Using Computer Simulation to Study the Impact of Increasing Routine Test Volume On Turn Around Times of Stat Samples on ci8200 Integrated Chemistry and Immunoassay Analyzer. Clin Chem 50(10):1952-1955, 2004.
  4. Petersen JR, Okorodudu AO, Mohammad AA, Payne DA. Capillary Electrophoresis and its Application in the Clinical Laboratory. Clin Chim Acta. Clin Chi Acta 330 (1-2):1-30, 2003
  5. Wu J, Petersen JR, Mohammad AA, Okorodudu AO. Evaluation of Stat-Site MHgb Reflectance Meter Using Hemosite for POC Hemoglobin Measurement. Point of Care 2(1):8-11, 2003
  6. Glew RH, Kassam HA, Bhanji RA, Okorodudu AO, VanderJagt DJ. Serum lipid profiles and risk of cardiovascular disease in three different male populations in northern Nigeria. J Health, Population and Nutrition. J Health Popul Nutr. 20(2):166-74, 2002
  7. VanderJagt DJ, Shores J, Okorodudu AO, Okolo SN, Glew RH. Hypocholesterolemia in Nigerian children with sickle cell disease. J Trop Pediatr 48(3): 156-161, 2002
  8. DeHoyos DR, Mann P, Okorodudu AO, Mohammad AA, Petersen JR. Development of a website for a decentralized point of care testing program. Journal of Point of Care Testing 1(2): 63-70, 2002
  9. Okorodudu AO, Elghetany MT, Yang H. Role of Ionized Magnesium in the Homeostasis of Cell: Intracellular Threshold for Mg2+ Mobilization in Human Platelets. Clin Chim Acta 303:147-154, 2001
  10. Okorodudu AO, Jacobs E, Fogh-Andersen N. Critical care testing in the new millennium: the integration of point of care testing. Clin Chim Acta 307: 1-2, 2001
  11. Yuoh CM, Eghetany MT, Petersen JR, Mohammad A, Okorodudu AO. Accuracy and precision of point of care testing for glucose and prothrombin time at the critical care units. Clin Chim Acta 307:119-123, 2001
  12. Mohammad AA Fujinari E, Okorodudu AO, Petersen JR. Apparatus and Method for Interfacing Capillary Electrophoresis and Chemiluminescence Nitrogen Detection for the Analysis of Nitrogen-Containing Compounds. J. Chromatog A 868(1):121-122, 2000.
  13. Liu X, Turner B, Peyton CE, Reisner BS, Okorodudu AO, Mohammad AA, Hankins GDV, Weissfeld AS, Petersen JR. Prospective Study of IgM to Toxoplasma gondii on Beckman Coulter’s AccessTM Immunoassay System and Comparison with Zeus ELISA and Gull IFA Assays. Diagn Microbiol Infect Dis 36:237-239, 2000
  14. Okorodudu AO, Yuoh C, Elghetany MT, Petersen JR, Mohammad A. Accuracy and Precision of Point of Care Testing at the Critical Care Units. Adv Adm Lab 9:8-10, 2000
  15. Rao, LV, Okorodudu AO, Petersen JR, Elghetany MT. Stability of Prothrombin Time and Activated Partial Thromboplastin Time Tests under Different Storage Conditions. Clin Chim Acta 300(1-2):13-21, 2000
  16. Chance JJ, Li DJ, Sokoll lJ, Silberman MA, Engelstad ME, Nichols JH, Liu X, Mohammad AA, Petersen JR, Okorodudu AO. Multi-Site Analytical Evaluation of the SenDx 100TM Blood Gas/Electrolyte Analyzer for Point-of-Care Testing. Crit Care Med 28(8):2081-2085, 2000.
  17. Sawh RV, Okorodudu AO. Secondary Hypertension: Clinical and Laboratory Findings in Primary Aldosteronism. Adv Med Lab Prof 11:22-25, 1999
  18. Rao LV, Petersen JR, Mohammad AA, Bissell MG, Okorodudu AO. Appropriateness in the use of CKMB mass and activity for myocardial infarction in a tertiary care institution. Lab Med 30:271-75, 1999
  19. Rao LV, Petersen JR, Bissell MG, Okorodudu AO, Mohammad AA. Development of a urinary free cortisol using solid-phase extraction capillary electrophoresis (SPE-CE). J Chromatog B Biomed Sci Appl 730(1):123-28, 1999
  20. Nix RJ, Elghetany MT, Petersen J, Mohammad AA, Okorodudu AO. Dehydration – Its Manifestations, Complications, Laboratory Findings and Treatment. Adv Med Lab Prof 7:7-10, 1998
  21. Heikkinen T, Ghaffar F, Okorodudu AO, Chonmaitree T. Serum Interleukin-6 in Bacterial and Nonbacterial Acute Otitis Media. Pediatrics 102(2):296-99, 1998
  22. Nix RJ, Mohammad AA, Petersen JR, Okorodudu AO. Interference with Glucose and Lactate Measurements in Blood Gas/Electrolyte/Metabolite and Routine Clinical Chemistry Analyzers. In: Proceedings of the 17th International Symposium on the Confluence of Critical Care Analysis and Near Patient Testing Pages 220-31, 1998
  23. Kost GJ, Vu H-T, Lee JH, Bourgeois P, Kiechle FL, Martin C, Miller SS, Okorodudu AO, Podczasy JJ, Webster R, Whitlow KJ. Multicenter Study of Oxygen-insensitive Handheld Glucose Point-of-Care Testing in Critical Care/Hospital/Ambulatory Patients in the United States and Canada. Crit Care Med 26(3):581-90, 1998
  24. Petersen JR, Smith ER, Okorodudu AO, Valbuena, G, Bissell MG. Utilization of LDH Isoenzymes in the Routine Diagnosis of Myocardial Infarction. J Clin Lab Manage Rev 11:103-7, 1997
  25. Rao LV, James OA, Mann L, Mohammad AA, Okorodudu AO, Bissell MG, Petersen JR. Evaluation of Technicon Immuno-1 Toxoplasma IgG Assay in Prenatal Diagnosis of Toxoplasmosis. Diag Microbiol Infect Dis 27:13-15, 1997
  26. Bissell MG, Okorodudu AO, Petersen JR, Mohammad AA. Laser Induced Resonance Energy Transfer – A Novel Approach for Avoiding Derivatization in LIF Detection in Capillary Electrophoresis: Part II Environmental Applications. J Chromatog A 767:217-21, 1997.
  27. Mohammad AA, Okorodudu AO, Bissell MG, Dow P, Reger G, Meier A, Guodagno P, Petersen JR. Clinical Application of Capillary Isoelectric Focusing on Fused Silica Capillary for Determination of Hemoglobin Variants. Clin Chem 43:1798-99, 1997
  28. Valbuena GA, Rao LV, Petersen JR, Okorodudu AO, Bissell MG, Mohammad AA. Anionic-Zwitterionic Mixed Micelles in the Micellar Electrokinetic Separation of Clinically Relevant Steroids on a Fused-Silica Capillary. J Chromatog A, 781:467-74, 1997
  29. Rao LV, Petersen JR, Bissell MG, Okorodudu AO, Mohammad AA. Specific Determination of Urinary Free Cortisol by Solid-Phase Microparticle Extraction Capillary Electrophoresis with Fused Silica Capillaries. Clin Chem 43:1801-03, 1997.
  30. James OA, Petersen JR, Bissell MG, Okorodudu AO, Harris PL, Clayton SS, Mohammad AA. Improved Sample Retrieval and Turn Around Time (TAT) in Clinical Laboratory Using a Spreadsheet Template for Sample Storage. Clin Chem 42(9):1571-73, 1996
  31. Smith ER, Petersen J, Okorodudu AO, Bissell MG. Does the Addition of Unconjugated Estriol in Maternal Serum Screening Improve the Detection of Trisomy 21?: A Meta-analysis. J Clin Lab Manage Rev 10:176-181, 1996
  32. James OA, Petersen JR, Bissell MG, Okorodudu AO. Evaluation of a Portable Blood Gas Analyzer for Point of Care Testing. Am Clin Lab, Jan-Feb:18-19, 1996
  33. Petersen JR, Smith E, Okorodudu AO, Bissell MG. Comparison of Four Methods (L/S Ratio, TDx FLM, Lamellar Bodies, PG) for Fetal Lung Maturity using Meta-Analysis. J Clin Lab Manage Rev 10:169-175, 1996.
  34. Petersen JR, Mohammad AA, Okorodudu AO, Bissell MG. Laser Induced Resonance Energy Transfer- A Novel Approach for Avoiding Derivatization in LIF Detection in Capillary Electrophoresis: Part I Clinical Applications. J Chromatog A 744:37-44, 1996
  35. Mohammad AA, Summers H, Burchfield JE, Petersen JR, Bissell MG, Okorodudu AO. Improved STAT Testing by Point-to-Point Testing and Satellite Laboratories. Lab Med 27(10):794-798, 1996
  36. Douzdjian V, Filos D, Okorodudu AO. Serum Ionized Magnesium Changes During and Immediately After Liver Transplantation. Ann Clin Lab Sci. 25(4):297-305, 1995
  37. Filos D, Okorodudu AO. A Method for the Measurement of Ionized Magnesium. Lab Med 26(1):62-65, 1995
  38. Okorodudu AO, Adegboyega PA, Scholz CI. Intracellular Calcium and Hydrogen Ions in Diabetes Mellitus. Ann Clin Lab Sci 25(5):394-401, 1995
  39. Adegboyega PA, Okorodudu AO. Intracellular Ionized Calcium and Increasing Doses of Lithium Chloride Therapy in Healthy Sprague-Dawley Rats. Pharmacol Biochem Behav 49(4):1087-1091, 1994
  40. Schwartz JG, Okorodudu AO. A Healthy Adult Male Had a Chemistry Panel Performed as Part of a Routine Physical. His Total Creatine Kinase was 800 IU/L, with a CK-MB of 25 Percent by the Monoclonal Antibody Method. His Total CK was Normal When Retested Two Weeks Later. Other Than an Undiagnosed Myocardial Infarction, What Might Have Caused These Results? CAP TODAY 7(8):57-58, 1993
  41. Gunaratna PC, Koch WF, Paule RC, Cormier AD, D'Orazio P, Greeburg N, O'Connell KM, Malenfant A, Okorodudu AO, Miller R, Kus DM, Bowers GN. Frozen Human Serum Reference Material for Standardization of Sodium and Potassium Measurements in Serum or Plasma by Ion-Selective Electrode Analyzers. Clin Chem 38(8):1459-1465, 1992
  42. Schwartz JG, Phillips WT, Shriver CA, Okorodudu AO. The Risk of Radiation Exposure to Laboratory Personnel. Lab Med 22(2):114-119, 1991
  43. Schwartz JG, Zollars PR, Okorodudu AO, Carnahan JJ, Wallace JE, Briggs JE. Accuracy of Common Drug Screen Tests. Am J Emerg Med 9:166-170, 1991
  44. Okorodudu AO, Burnett RW, McComb RB, Bowers GN. Evaluation of three First Generation Lithium ISE Analyzers. Analytical Specifications Based on Comparative Performance, Systematic Errors, and Frequency of Random Interferences. Clin Chem 36(1):104-110, 1990.
  45. Okorodudu AO, Wians FH, Schwartz JG, Seastrunk BK. Coordinated Evaluation of Four Li/ISE Analyzers and a Flame Photometer for the Effect of Protein, Triglyceride, Bilirubin, and Hemoglobin on Lithium Measurement. In: Proceedings of the International Symposium on Methodology and Clinical Applications of Ion-Selective Electrodes 11:271-277, 1990
  46. Okorodudu AO, Gillmor R, Onoroski M, Parker L, Moore RE. Dependence of Reliable Circulating Immune Complex Measurement on a Stable and Accurate Reference Material. Clin Chem 35(7):1555, 1989
  47. Okorodudu AO, Pelletier PR, Valcour AA, Bowers GN, McComb RB. Evaluation of the IFCC Reference Method for Alanine Aminotransferase: Spurious non-ALT Activity due to Contamination of D-Alanine with L-Alanine and Recommendation for a Correction. Clin Chem 35(1):153-156, 1989.
  48. Bowers GN, Okorodudu AO, Sena S, Lewis S. A New Standard Reference Material for Sodium and Potassium Measurement: A Three-Level Human Serum to Unifying Undiluted Direct ISE Results to the National Reference System for Sodium and Potassium. In: Proceedings of the International Symposium on Methodology and Clinical Applications of Ion-Selective Electrodes 10:45-46, 1989
  49. Okolo A, Okorodudu AO, Glew RH, Omene JA. Decreased Serum Alpha-Amylase Levels in Infected Nigerian Newborn Infants. Biol Neo 53:138-143, 1988
  50. Okpere E, Okorodudu AO, Gbinigie O. Observations on the Alkaline Phosphatase Isoenzyme Distribution in Maternal Amniotic Fluid Compactments in Nigerian parturients. Clin Exp Obstet Gynecol 15:53-55, 1988
  51. Bowers GN, Okorodudu AO, Burnett RW. A Reference System for Ionized Calcium Measurements in Serum: II. A Primary Calibration Solution. In: Proceedings of the International Symposium on Ion Selective Electrodes 9:218-227, 1987
  52. Okpere EE, Okorodudu AO, Lackmann C, Gbinigie O. Is Maternal Serum Heat Stable Alkaline Phosphatase an Index of Fetal Maturity? Med Hypoth 21(2): 225, 1986.
  53. Okpere EE, Gbinigie AO, Ihongbe JC, Okorodudu AO. Relationship between Amniotic Fluid Heat Stable Alkaline Phosphatase and B-glucuronidase. IRSC Med Sci 14(2): 168-169, 1986
  54. Lambert WC, Okorodudu AO, Schwartz RA. Cutaneous Nasocilliary Neuralgia. Acta Dermatol-Venerol (Stockh) 65(3):257-258, 1985
  55. Okpere EE, Okorodudu AO, Gbinigie AO. Heat Labile Alkaline Phosphatase Isoenzyme during Labor. IRSC Med Sci 13(12):1196, 1985
  56. Okpere EE, Okorodudu AO, Lackmann C, Gbinigie O. Fall in Heat-Labile Alkaline Phosphatase Isoenzyme Levels during Pregnancy in Healthy Nigerians. Br J Obst Gyn 92(11):1134-1136, 1985
  57. Lambert MW, Lambert WC, Okorodudu AO. Nuclear DNA Endonuclease Activities on Apurinic/Apyrimidinic DNA in Normal Human and Mouse Melanoma Cells. Chem-Biol Interact 446:109-120, 1983
  58. Lee DE, Okorodudu AO, Lambert WC, Lambert MW. Defective DNA Endonuclease Activity on Anthramycin Treated DNA in Xeroderma Pigmentosum and Mouse Melanoma Cells. Biochem Biophys Res Commun 107:305-402, 1982
  59. Okorodudu AO, Lambert WC, Lambert MW. Nuclear Deoxyribonuclease Activities in Normal and Xeroderma Pigmentosum Lymphoblastoid Cells. Biochem Biophys Res Commun 108:576-584, 1982
  60. Lambert MW, Lee DE, Okorodudu AO, Lambert WC. Nuclear Deoxyribonuclease Activities in Human Lymphoblastoid and Mouse Melanoma Cells: A Comparative Study. Biochem Biophys Acta 699:192-203, 1982

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