Benjamin Gelman

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Benjamin Gelman
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Academic Appointments
Appointment Organization
Professor Pathology and Anatomy & Neurosciences
Professional Education
Degree Institution Field of Study Graduation Year
M.D. University of Cincinnati College of Medicine, 1983
Ph.D. University of Cincinnati College of Medicine Department of Environmental Health 1978
A.B Ohio University Major: Renaissance Literature; Minor: Biochemistry 1971
Honors
Title Organization Year(s)
Southern Medical Association Research Award 1984 - 1985
University Research Council Award, University of North Carolina at Chapel Hill, Chapel Hill, NC 1984
American Society of Anesthesiologists Preceptorship in Anesthesiology 1983
Muscular Dystrophy Association of America Postdoctoral Fellowship Award 1979 - 1980
Chemical Industry Institute of Toxicology Predoctoral Fellowship 1976 - 1978
NIEHS Predoctoral Trainee 1975 - 1976
Professional Affiliations
Society Year(s)
International Brain Research Organization, Paris 2000
Pathology Residency Program Directors Section American Association of Pathology Chairmen 1990 - 1997
Society for Neuroscience 1990
Galveston County Medical Society 1990
Texas Medical Association 1990
American Association of Neuropathologists 1990
College of American Pathologists 1987 - 1990
Southern Medical Association 1984 - 1986
American Medical Association 1980
American Association for the Advancement of Science 1978
Research Interests

Mononuclear Phagocytes in the Nervous System

Research in the laboratory is focused on HIV-related neurodegeneration. One project is elucidating how reducing HIV loads with highly active antiretroviral therapy influences painful peripheral neuropathy. Another project is exploring how neuronal protein turnover through the ubiquitin-proteasome system is abnormal in people with HIV dementia. Our basic approach is to perform neurochemical analysis of banked human brain specimens that we collected from people with HIV infection. Dr. Gelman is the founder and Principal Investigator of the Texas NeuroAIDS Research Center with clinics in Galveston, Houston and Dallas. The Center is one of four HIV brain repositories of the National NeuroAIDS Tissue Consortium (NNTC). Subjects are followed prospectively and CNS and PNS specimens and data are banked at autopsy. Neurological, neurocognitive and drug use documentation information is stored in a database for use by researchers. Specimens and data are distributed to investigators around the world.

Selected Publications
  1. Woods, SP, Rippeth, JD, Frol, AB, Levy, JK, Ryan, E, Soukup, VM, Hinkin, CH, Lazzaretto, D, Cherner, M, Marcotte, TD, GELMAN BB, Morgello, S, Singer, EJ, Grant, I, and Heaton, RK. Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. Journal of Clinical and Experimental Neuropsychology, 26, 759-778, 2004
  2. Diaz-Arrastia R, Gong Y, Kelly CJ, GELMAN BB. Host Genetic Polymorphisms in HIV-Related Neurological Disease. J Neurovirol. 10,Supple 1:67-73, 2004
  3. deCastro R Jr, Hughes MG, Xu G-Y, Clifton C. Calingasan NY, GELMAN BB, McAdoo DJ. Evidence that infiltrating neutrophils do not release reactive oxygen species in the site of spinal cord injury. Experimental Neurology 189:440-450, November, 2004
  4. GELMAN BB, Schuenke KW. Brain aging in AIDS: Increased ubiquitin-protein conjugate and correlation with decreased synaptic protein but not A-stained diffuse plaque. J Neurovirol. 10:98-108, 2004
  5. Schuenke KI and GELMAN BB. Human microglial cell isolation from adult autopsy brain: Brain pH, regional variation, and infection with HIV-1. J Neurovirol 9:346-357, 2003
  6. GELMAN BB, Popov V, Chaljub G, Nader R, Rauf S, Nauta H, and Visvesvara GS. Neuropathology and ultrastructural features of encephalitis due to Sappinia diploidea. J Neuropathol Exp Neurol 62:990-998, 2003
  7. GELMAN BB, Nader R, Popov V, Borkowski J, Rauf S, Chaljub G,, Visvesvara, Nauta H. Encephalitis due to Sappinia diploidea. JAMA 285:2450-2451, 2001
  8. Morgello, S, GELMAN BB, Grant E, Singer E, Vinters H and Kozlowski P. The National NeuroAIDS Tissue Consortium. Neuropathology and Applied Neurobiology 27:326-335, 2001
  9. Painter TJ, Chaljub G, Asthi R, GELMAN BB. Meningeal melanocytoma of the basal meninges and upper cervical meninges. Amer J Neuroradiol 21:1349-1353, 2000
  10. GELMAN BB, Trier TT, Chaljub G, Borokowski J, Nauta HJW. Oncocytoma in melanocytoma of the spinal cord. Neurosurgery 47:756-759, 2000
  11. Wang L, GELMAN BB, Konig R, Cloyd MW. A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: Induction of lymph node homing and apoptosis upon secondary signaling through homing receptors. J Immunol 162:268-276, 1999
  12. Singh IP, Chopra AK, Coppenhaver DH, GELMAN BB, Poast J, Baron S. A broadly antiviral substance in the human nervous system. J Neuroimmunol 85:168-173, 1998
  13. Haque AK, Myers JL, Hudnall SD, GELMAN BB, Lloyd RV, Payne D, Borucki M. Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: Lesions with Epstein-Barr virus infection. Modern Pathology 11:347-356, 1998
  14. Wolf DA, Keherly MJ, Maggio WW, GELMAN BB. Chondromyxoid fibroma of the brain. Arch Pathol Lab Med 121:626-630, 1997
  15. DiPatre PL, GELMAN BB. Microglial cell activation in aging and Alzheimer's disease: partial correlation with neurofibrillary tangle burden. J Neuropathol Exp Neurol 56:137- 143, 1997
  16. Wolf DA, Dholakia S, Cloyd MW, GELMAN BB. Proteolysis in the myelopathy of acquired immunodeficiency syndrome: preferential loss of the C-8 component of myelin basic protein. Lab Invest 77(5):513-523, 1997
  17. GELMAN BB, Wolf DA, Rodriguez-Wolf M, West B, Haque A, Cloyd MW. Mononuclear phagocyte hydrolytic enzyme activity associated with cerebral HIV infection. Am J Pathol 151:1437-1446, 1997
  18. Nichols MM, GELMAN BB, Gilbert-Barness E. Autolyzed brain tissue beneath dermis of thigh and back. Arch Pediatr Adolesc Med 150:997-8, 1996
  19. GELMAN BB, Dholakia S, Casper K, Kent TA, Cloyd MW, Freeman DH Jr. Expansion of the cerebral ventricles and correlation with AIDS neuropathology in 232 patients. Arch Pathol Lab Med 120:866-871, 1996
  20. GELMAN BB, Wolf DA, Olano JP, Linthicum LC. Incarceration and the acquired immunodeficiency syndrome: autopsy results in Texas prison inmates. Human Pathology 27:1282-1287, 1996
  21. J Neuropathol Exp Neurol 55:1164-1172, 1996
  22. Jaffey PB, GELMAN BB. Increased vulnerability to demyelination in streptozotocin diabetic rats. J Comp Neurol 373:55-61, 1996
  23. GELMAN BB. Iron in CNS disease. J Neuropathol Exp Neurol 54:477-486, 1995
  24. Kent TA, GELMAN BB, Casper K, Langsjoen HS, Levin HS, Hillman GR. Neuroimaging in HIV infection: Neuropsychological and pathological correlation. In: Grant I and Martin A, eds. Neuropsychology of HIV Infection. New York, NY: Oxford University Press, pp. 260-275, 1994
  25. GELMAN BB. Diffuse microgliosis associated with cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 34:65-70, 1993
  26. GELMAN BB, Rodriguez MG, Wen J, Campbell GA, Herzog N. Siderotic cerebral macrophages in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 116:509-516, 1992
  27. Fan X and GELMAN BB. Schwann cell nerve growth factor receptor expression during initiation of remyelination. J Neuroscience Res 31:58-67, 1992
  28. GELMAN BB and Guinto FC Jr. Morphometry, histopathology, and tomography of cerebral atrophy in the acquired immunodeficiency syndrome. Ann Neurol 32:32-40, 1992
  29. GELMAN BB, Goodrum JF, and Bouldin TW. Macrophage apolipoprotein synthesis and endoneurial distribution as a response to segmental demyelination. J Neuropathol Exp Neurol 50:383-407, 1991
  30. Nolte KB, GELMAN BB. Intracerebral hemorrhage associated with cocaine abuse. Arch Pathol Lab Med 113:812-813, 1989
  31. GELMAN BB, Rifai N, Christenson RN, and Silverman LM. Cerebrospinal fluid and plasma apolipoprotein concentrations in patients with multiple sclerosis. Ann Clin Lab Sci 18:46-52, 1988
  32. GELMAN BB, Goodrum JF, Bouldin TW, and Krigman MR. Apolipoprotein E is released by rat sciatic nerve during segmental demyelination and remyelination. J Neuropathol Exp Neurol 46:644-652, 1987
  33. Rifai N, Christenson RH, GELMAN BB, and Silverman LM. Cerebrospinal fluid apolipoprotein E and IgG indexes during exacerbation and remission of multiple sclerosis. Clin Chem 33:1155-1157, 1987
  34. Rifai N, Christenson RN, GELMAN BB, and Silverman LM. Automated determination of apolipoprotein E in cerebrospinal fluid. Clin Chem 32:2207-8, 1986
  35. Davis MH, GELMAN BB, and Gruenstein E. Decreased structure-linked latency of dipeptidyl aminopeptidase-I activity in Duchenne's muscular dystrophy fibroblasts. Neurology 32:486-491, 1982
  36. GELMAN BB, Davis MH, Morris RE, and Gruenstein E. Structural changes in lysosomes from cultured human fibroblasts in Duchenne's muscular dystrophy. J Cell Biol 88:329-337, 1981
  37. GELMAN BB, Papa L, Davis MH, and Gruenstein E. Decreased lysosomal dipeptidyl aminopeptidase-I activity in cultured human skin fibroblasts in Duchenne's muscular dystrophy. J Clin Invest 65:1298-1406, 1980
  38. GELMAN BB, Michaelson, IA. Neonatal lead toxicity and in vitro lipid peroxidation of rat brain. J Toxicol Environ Health 5:671-682, 1979
  39. GELMAN BB, Michaelson IA, Bornschein RL. Brain lipofuscin concentration and oxidant defense enzymes in lead poisoned neonatal rats. J Toxicol Environ Health 5:683-698, 1979
  40. GELMAN BB, Michaelson IA, Bus JS. The effect of lead on oxidative hemolysis and erythrocyte defense mechanisms in the rat. Toxicol Appl Pharmacol 45:119-129, 1978
  41. Olano JP, Wolf DA, Keherly MJ, GELMAN BB. Quantifying apoptosis in banked human

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