Landon Stout

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Landon Stout
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Academic Appointments
Appointment Organization
Professor Pathology
Professional Education
Degree Institution Field of Study Graduation Year
Fellow University of Oklahoma Medical Center Pathology 1968
Resident University of Oklahoma Medical Center Pathology 1967
Resident University of Oklahoma Medical Center Internal Medicine 1961
University of Oklahoma Medical Center Internship 1958
M.D. University of Maryland 1957
B.S. University of Maryland Premedical 1954
Honors
Title Organization Year(s)
Selected by the residents as 1999-2000 outstanding Faculty Member – Anatomic Pathology 1999 - 2000
Senior Faculty Marshall, 1994 Medical School Graduation Ceremony 1994
Selected as one of several UTMB faculty as outstanding teachers by the 1991 " Centennial Graduating Class". 1991
Aesculapian Award nominee for excellence in pre-clinical instructionUniversity of Oklahoma Medical Center 1972
Professional Affiliations
Society Year(s)
Texas Medical Association -
American Heart Association, Council on Epidemiology -
American Gastroenterological Association -
Galveston County Medical Society -
American Diabetes Association -
U.S. and Canadian Academy of Pathology -
American Association of Pathologists -
American College of Physicians -
Research Interests

Pathogenesis of Diabetic Glomerulopathy

Diabetic glomerulopathy is the leading cause of renal insufficiency in the United States. Our work focuses on the pathogenesis of lesions that are characteristic of the advanced stages of diabetic glomerulopathy. An understanding of how these lesions develop is a prerequisite to their prevention and treatment.

Our initial studies suggest that focal mesangiolyses (FM) are the precursors of Kimmelstiel-Wilson (KW) nodules. KW nodules are large lesions capable of impairing glomerular function. FM's appear to result from hemodynamic disturbances and to develop into KW nodules within a relatively short period of time, possibly a few months. This rapid evolution of structural lesions is contrary to prevailing opinion, but does fit with recent observations that diabetic nephropathy can be relatively rapidly improved by various antihypertensive regimens. Our current studies suggest that insudative lesions (deposits of plasma lipids and proteins in glomerular arteriolar and capillary walls) can impair glomerular function and also appear to develop rapidly.

Selected Publications
  1. Stout LC, Lyon RE, Murray NGB, Barth MH. Pseudointimal biliary epithelial proliferation and Zahn's infarct associated with a 6 month old transjugular intrahepatic portosystemic shunt. Am J Gastro 90:126-130, 1995
  2. Stout LC, Kumar S, Whorton EB. Insudative lesions - their pathogenesis and association with glomerular obsolescence in diabetes: A dynamic hypothesis based on single views of advancing human diabetic nephropathy. Hum Pathol 25:1213-1227, 1994
  3. Stout LC, Kumar S and Whorton EB. Focal mesangiolyisis and the pathogenesis of the Kimmelstiel-Wilson nodule. Hum Pathol 24:77-89, 1993. Selected for Yearbook of Nephrology, 1994
  4. Stout LC, Boor PJ and Whorton EB. Myofibroblastic proliferation on mitral valve chordae tendineae. A distinctive lesion associated with alcoholic liver disease. Hum Pathol 19:720-725, 1988. Selected for Yearbook of Pathology & Clinical Pathology, 1990
  5. Stout LC, Folse DS, Meier J, Crosby WM, Kling R, Williams GR, Price WE, Geyer JR, Padula R, Whorton E and Kimmelstiel P. Quantitative glomerular morphology of the normal and diabetic baboon kidney. Diabetologia 29:734-740, 1986
  6. Stout LC. Water clear cell hyperplasia mimicking parathyroid adenoma. Hum Pathol 16:1075-1076, 1985
  7. Stout LC, Whorton EB and Vaghela M. Pathogenesis of diffuse intimal thickening (DIT) in non-human primate thoracic aortas. Atherosclerosis 47:1-6, 1983
  8. Stout LC. Pathogenesis of diffuse intimal thickening (DIT) in aortas and coronary arteries of 2 1/2 year old miniature pigs. Exp Molec Pathol 37:427-432, 1982
  9. Williams EH, Conti VR, Nishimura A, Stout LC and Ferrans V. Early calcific stenosis of aortic and mitral Ionescu-Shiley valves in a patient with bioprosthetic infection. J Thor and Cardiovas Surg 82:391-397, 1981
  10. Stout LC and Thorpe LW. Histology of normal aortas in non-human primates with emphasis on diffuse intimal thickening (DIT). Atherosclerosis 35:165-180, 1980
  11. Tyers GFO, Larrrieu AJ, Stout LC, Tonnesen AS and Williams EH. Delayed recurrent massive thromboembolism through a vena caval clip after pulmonary embolectomy. Chest 77:114-115, 1980
  12. Stout LC and Thorpe LW. Histology of normal aortas in birds with emphasis on intimal thickening. Atherosclerosis 36:545-558, 1980
  13. Alperin JB, Dow PA and Stout LC. A comparison of hemoglobin A1c in human and baboon blood. Acta Haemat 61:334-338, 1979
  14. Bojanovski D, Alaupovic P, Kelley JL and Stout C. Isolation and characterization of the major lipoprotein density classes of normal and diabetic baboon (Papio Anubis) plasma. Atherosclerosis 31:481-487, 1978
  15. Folse DS and Stout C. Endometriosis in a baboon (Papio doguera). Lab Anim Sci 28:217-218, 1978
  16. Stout C. Studies on the distribution of lipids within fibrous plaques. Atherosclerosis 23:443-450, 1976
  17. Thompson WM and Stout C. Tachypnea, tachycardia, cyanosis, and mediastinal mass in a neonate. J Pediat 84:769-772, 1974
  18. Ordway N and Stout C. Thromboembolus to abdominal aorta in a neonate. J Pediat 82:143-148, 1973
  19. Stout C, Hampton JW, Anderson JD and Oruc N. Fatal non-traumatic splenic rupture in hemophilia and the Kasabach-Merritt syndrome. South Med J 66:791-795, 1973
  20. Ordway N and Stout C. Intrauterine growth retardation, jaundice and hypoglycemia in a neonate. J Pediat 83:867-874, 1973
  21. Reynolds DW, Riley HD, LaFont DS, Vorse H, Stout C and Carpenter RL. An outbreak of Reye's syndrome associated with influenza B. J Pediat 80:429-432, 1972
  22. Massion WH, McNeill JR, Rosenbluth B, Stout C and Brecher G. Effect of biventricular massage on barbiturate-induced circulatory arrest. J Thoracic Cardiovas Surg 63:230-234, 1972
  23. Bohorquez F and Stout C. Arteriosclerosis in exotic mammals. Atherosclerosis 16:225-231, 1972
  24. Crosby WM, King AI and Stout C. Fetal survival following impact: Improvement with shoulder harness restraint. Am J Obstet Gynecol 11:1101-1106, 1972
  25. Stout C, Hartsuck JM, Howe J and Richardson JL. Atheromatous embolism after subdiaphragmatic aortofemoral bypass and infrarenal aortic ligation. Arch Path 93:271-275, 1972
  26. Bohorquez F and Stout C. Aortic atherosclerosis in exotic avians. Exp Molec Path 17:261-273, 1972
  27. Stout C and Lemmon WB. Hypertensive-like vascular lesions in a chimpanzee. Exp Molec Path 14:151-157, 1971
  28. Aljeboori T, Stout C and Ivey M. Toxocara canis infection in baboons. II. Distribution of larvae and histopathologic response. Amer J Trop Med Hyg 19:815-820, 1970
  29. Stout C and Koehl G. Aortic embolism in a newborn infant. Amer J Dis Child 120:74-76, 1970
  30. Stout C. Coronary thrombosis without coronary atherosclerosis. Amer J Cardiol 24:564-569, 1969
  31. Stout C and Lemmon WB. Glomerular capillary endothelial swelling in a pregnant chimpanzee. Amer J Obstet Gynecol 105:212-215, 1969
  32. Stout C and Bohorguez F. Aortic atherosclerosis in hoofed mammals. J Atheroscler Res 9:73-80, 1969
  33. Stout C and Lemmon WB. Predominant coronary and cerebral atherosclerosis in captive nonhuman primates. Exp Molec Pathol 10:312-322, 1969
  34. Stout C. Atherosclerosis in exotic Carnivora and Pinnipedia. Amer J Path 57:673-688, 1969
  35. Stout C, Wight M and Bruhn J. The Cornell Medical Index in disability evaluations. Brit J Prev Soc Med 23:4:251-254, 1969
  36. Stout C and Snyder RL. Ulcerative colitis-like lesion in Siamang gibbons. Gastroenterol 57:256-261, 1969
  37. Stout C. Clostridial septicemia. J Okla State Med Assn 61:447-449, 1968
  38. Stout C. Circulatory capacity of the coronary arteries. J Okla State Med Assn 60:94-96, 1967
  39. Groover ME Jr and Stout C. Physiochemical properties of blood in postmyocardial infarction patients and controls. Angiol 17:85-95, 1966
  40. Groover ME Jr and Stout C. Electrophoretic activity of arterial plasma and experimental thrombi. Angiol 16:651-663, 1965
  41. Groover ME Jr and Stout C. Neurogenic myocardial necrosis and protective effects of atropine. Angiol 16:180-186, 1965
  42. Stout C, Holland CK and Bird RM. Hemoglobin D in an Oklahoma family. Arch Int Med 114:296-300, 1964
  43. Stout C, Morrow J, Brandt E and Wolf S. Unusually low incidence of death from myocardial infection. Study of an Italian American Community in Pennsylvania. JAMA 188:845-849, 1964.

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