Alarcon-Chaidez Francisco

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Alarcon-Chaidez Francisco
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Academic Appointments
Appointment Organization
Assistant Professor Pathology
Professional Education
Degree Institution Field of Study Graduation Year
Ph.D. Oklahoma State University Microbiology, Cell, and Molecular Biology 1997
M.Sc. Texas A&M University Food Science and Technology 1984
B.S. Technological Institute of Culiacan Biochemical Engineering 1982
Professional Affiliations
Society Year(s)
Member of the American Society for Microbiology -
Research Interests

My current research interests focus on the study of the pharmacology of blood feeding arthropod saliva, the immunology of the blood feeding arthropod-host interface, and factors in the saliva of hematophagous arthropods that facilitate transmission of infectious diseases. Knowledge obtained through the use of biochemistry, molecular biology, proteomics, genomics, and immunological analysis can then be applied to the development of vaccines for more effective control of vector and vector-borne diseases.

Selected Publications
  1. Krause PJ, Grant-Kels JM, Tahan SR, Dardick KR, Alarcon-Chaidez F.J., Bouchard K, Visini C, Deriso C, Foppa IM, Wikel S. (2009). Dermatologic Changes Induced by Repeated Ixodes scapularis Bites and Implications for Prevention of Tick-Borne Infection. Vector Borne Zoonotic Dis. Feb 5. [Epub ahead of print].
  2. Alarcon-Chaidez, F.J., Boppana, V.D., Hagymasi, A.T., Adler, A.J., Wikel, S.K. A novel sphingomyelinase-like enzyme in Ixodes scapularis tick saliva drives host CD4 T cells to express IL-4. Parasite Immunol. 31(4):210-9
  3. Alarcon-Chaidez, F.J., Sun, J., and Wikel, S.K. Transcriptome analysis of the salivary glands of the tick Dermacentor andersoni Stiles (Acari: Ixodidae). Insect Biochem. Mol. Biol. 37(1):48-71.
  4. Ribeiro, J.M.C., Alarcon-Chaidez, F.J., Francischetti, I.M., Mans, B.J., Mather, T.N., Valenzuela, J.G., Wikel, S.K. An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochemistry and Molecular Biology 36 (2), 111-129.
  5. Alarcon-Chaidez, F.J., Ryan, R., Wikel, S.K., Dardick, K., Lawler, C., Foppa, I., Tomas, P., Cushman, A., Hsieh, A., Spielman, A., Bouchard, K., Dias, F., Aslanzadeh, J., and Krause, P.J. Confirmation of tick bite by detecting antibody to Ixodes calreticulin salivary protein. Clin. Vaccine Immunol. 13(11):1217-22.
  6. Sun JX, Alarcon-Chaidez F.J., Schenkman, J.B., and Wikel, S.K. 2006. Dathoxin-1, a dual functional and blood feeding regulated salivary gland protein of the tick, Dermacentor andersoni. Am. J. Trop. Med. Hyg. 75 (5): 115-116 394 Suppl. S, Nov.
  7. Brooks, D.M., Hernández-Guzmán, G. Kloek, A.P., Alarcón-Chaidez, F.J. Sreedharan, A., Rangaswamy, V., Peñaloza-Vázquez, A., Bender, C.L., and Kunkel, B.N. Identification and characterization of a well-defined series of coronatine biosynthetic mutants of Pseudomonas syringae pathovar tomato strain DC3000. Molecular Plant-Microbe Interactions, 17(2):162-74.
  8. Alarcon-Chaidez, F.J. and Wikel, S.K. Comparative Aspects of the Tick-Host Relationship: Immunobiology, Genomics and Proteomics. In, Host-Parasite Relationships in Animals: A Comparative Approach; Chapter 9; G. Flik, G. Wiegertjes, and S.E. Wendelaar Bonga Eds. BIOS Scientific Publishers LTD, Oxford, UK, pp. 185-210.
  9. Alarcon-Chaidez F.J., Wikel S.K. Comparative aspects of the tick-host relationship: immunobiology, genomics and proteomics. Symp Soc Exp Biol. (55):185-209; discussion 243-5.
  10. Wikel, S.K., Alarcon-Chaidez, F.J., and Mueller-Dobblies, U. Immunological control of vectors. In, Biology of Disease Vectors; Chapter 45, 2nd Edition; J. Hemingway, Ed. Elsevier, pp 671-682.
  11. Alarcón-Chaidez F.J., Keith L, Zhao Y, and Bender CL. RpoN (σ54) is required for plasmid-encoded coronatine biosynthesis in Pseudomonas syringae. Plasmid, 49:106-117.
  12. Alarcón-Chaidez, F.J., Mueller-Dobblies, U., and S. K. Wikel. Characterization of a recombinant immunomodulatory protein from the salivary glands of Dermacentor andersoni. Parasite Immunology, 25:69-77.
  13. Wang X., Alarcón-Chaidez F.J., Peñaloza-Vázquez A., and C.L. Bender. Differential Regulation of Coronatine Biosynthesis in Pseudomonas syringae pv. tomato DC3000 and P. syringae pv. glycinea PG4180. Physiological and Molecular Plant Pathology, 60:111-120.
  14. Alarcón-Chaidez F.J., C. L. Bender. Analysis of the rpoN locus in the plant pathogenic bacterium, Pseudomonas syringae pv. glycinea. DNA Seq. Jul; 12(1):77-84.
  15. Wikel SK, Alarcón-Chaidez F.J. Progress toward molecular characterization of ectoparasite modulation of host immunity. Vet Parasitol. Nov 22; 101(3-4):275-87.
  16. Bender, C. L., F. Alarcón-Chaidez, and C. G. Dennis. Pseudomonas syringae phytotoxins: Mode of action, regulation, and biosynthesis by peptide and polyketide synthetases. Microbiol. Mol. Biol. Rev. 63(2):266-292.
  17. Alarcón-Chaidez, F. J., A. Peñaloza-Vázquez, M. Ullrich, and C. L. Bender. Characterization of plasmids encoding the phytotoxin coronatine in Pseudomonas syringae. Plasmid. 42(3):210-220.
  18. Alarcón-Chaidez, F., Sampath, J., Srinivas, P., and Vijayakumar, M. N. Tn5252: A model for complex streptococcal conjugative transposons. In T. Horaud, A. Bouvet, R. Leclercq, H. de Montclos, and M. Sicard, (Eds.) Streptococci and the Host. Advances in Experimental Medicine and Biology, Vol. 418. Plenum Publishing Corporation, pp.1029-32.

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