UTMB Department of Pathology

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Cardiovascular and Respiratory Physiology; Microcirculation, Bioengineering and Pathobiology

My research interest is microcirculatory transport of fluid and macromolecules, in particular, edema formation and resolution. Our Resuscitation Research Lab group is actively involved with the development of novel resuscitation fluids for the treatment of traumatic hypovolemia and shock. One focus has been hypertonic saline solutions and blood substitutes. Most recently we have been developing drug and fluid delivery systems and oxygen monitoring technology for medical emergencies.

Ongoing Studies include the use of novel solutions and infusion regimens to treat circulatory shock.

Resuscitation of Burn Shock: In year 2005-08, we will test efficacy of enteral resuscitation (oral or intestinal infusion) as an emergency treatment and perform a retrospective analysis of clinical resuscitation.

Closed-Loop Infusion Therapy: In year 2005-08, we will continue studies using microprocessor-automated control of infusion using both invasive and noninvasive monitoring of resuscitation endpoints (blood pressure, hepatic oxygenation, cardiac output and urinary output). Our work on this project consists of whole animal studies and patient trials.

Efficacy and Side Effects of Hemoglobin Based Oxygen Carriers (HBOC): In year 2005-06, we will continue evaluating second-generation blood substitutes in studies of intraoperative hemorrhage and anemia.

Vascular Volume Dynamics Fluid Therapy: We use animal experiments and clinical trials and endogenous tracers and mathematical models to evaluate fluid therapy.

Intraosseous Vascular Access Technologies: We continue to refine new vascular access and fluid infusion technologies that use the bone marrow as an emergency alternative to vascular cannulations for treatment of cardiac arrest and circulatory shock.