UTMB Department of Pathology

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Acute Inflammation in the Reactions of Injured Tissues

My laboratory is investigating the role of acute inflammation in the reactions of injured tissues. Most of my work is morphologic, and involves collaborations with experts in other aspects of biological research. The work is carried out in the core electron microscopy laboratory at the Shriners Burns Hospital. In this well-equipped laboratory we also provide research support for multiple investigators interested in problems related to burn injury. The methods regularly in use include quantitative light microscopy, immunohistochemistry, and scanning and transmission electron microscopy. Most of my current research involves investigation of the pathogenesis of respiratory failure following smoke inhalation injury. I participate in an NIH-funded program project grant headed by Dr. Traber that is focused on this problem. We utilize an animal model designed to mimic the problems experienced by patients who develop severe respiratory distress after burn injury and inhalation of toxic smoke, some of whom die of this injury. I also perform autopsies on children who die in the Shriners Burns Hospital. The other collaborators in this research are Dr. Frank Schmalstieg, head of the pediatric immunology service, and Dr. Jay Zwischenberger, an innovative thoracic surgeon. We are especially interested in the roles of neuropeptides in stimulating and sustaining the inflammatory response to smoke, and also in the roles of nitric oxide synthases and poly(ADP)-ribose polymerase in acute lung injury. The roles of cellular adhesion molecules are also subjects of investigation. Recent work has stimulated our interest in the role of mucus secretion in this problem, and in the pro-inflammatory effects of cytokine secretion by mucus glands. I also have an active interest in mechanisms of wound healing and the effects of peptide growth factors on this process.

1. Barrow RE, Mlcak R, Barrow LN, Hawkins HK. Increased liver weights in severely burned children: Comparison of ultrasound and autopsy measurements. Burns 30:565-8, 2004
2. Murakami K, Enkhbaatar P, Shimoda K, Cox RA, Burke AS, Hawkins HK, Traber LD, Schmalstieg FC, Salzman AL, Mabley JG, Komjati K, Pacher P, Zsengeller Z, Szabo C, Traber DL. Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21:126-33, 2004
3. Dasu MR, Barrow RE, Hawkins HK, McCauley RL. Gene expression profiles of giant hairy naevi. J Clin Pathol 57:849-55, 2004
4. Dasu MRK, Hawkins HK, Barrow RE, Xue H, Herndon DN. Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. J Pathol 202:476-85, 2004
5. de Oliveira GV, Sanford AP, Murphy KD, de Oliveira HM, Wilkins JP, Wu X, Hawkins HK, Kitten G, Chinkes DL, Barrow RE, Herndon DN. Growth hormone effects on hypertrophic scar formation: A randomized controlled trial of 62 burned children. Wound Repair Regen 12:404-11, 2004
6. Enkhbaatar P, Murakami K, Cox R, Westphal M, Morita N, Brantley K, Burke A, Hawkins H, Schmalstieg F, Traber L, Herndon D, Traber D. Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation. Shock 22:70-5, 2004
7. Enkhbaatar P, Murakami K, Cox R, Westphal M, Morita N, Brantley K, Burke A, Hawkins H, Schmalstieg F, Traber L, Herndon D, Traber D. Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation. Shock 22:70-5, 2004
8. Oliveira GV, Shimoda K, Enkhbaatar P, Jodoin J, Burke AS, Chinkes DL, Hawkins HK, Herndon DN, Traber L, Traber D, Murakami K. Skin nitric oxide and its metabolites are increased in nonburned skin after thermal injuries. Shock 22:278-82, 2004
9. Murakami K, Enkhbaatar P, Shimoda K, Mizutani A, Cox RA, Schmalstieg FC, Jodoin JM, Hawkins HK, Traber LD, Traber DL. High-dose heparin fails to improve acute lung injury following smoke inhalation in sheep. Clin Sci 104:349-56, 2003
10. Shimoda K, Murakami K, Enkhbaatar P, Traber LD, Cox RA, Hawkins HK, Schmalstieg FC, Komjati K, Mabley JG, Szabo C, Salzman AL, Traber DL. Effect of poly (ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 285:L240-9, 2003
11. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips GB, Parkinson JF, Cox R, Hawkins H, Herndon D, Traber D. The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 167:1021-1026, 2003
12. Enkhbaatar P, Murakami K, Shimoda K, Salsbury J, Cox R, Hawkins H, Traber L, Herndon D, Traber D. Ketorolac attenuates cardiopulmonary derangements in sheep with combined burn and smoke inhalation injury. Clin Sci 105:621-8, 2003
13. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips G, Parkinson J, Salsbury JR, Biondo N, Schmalstieg F, Burke A, Cox R, Hawkins H, Herndon D, Traber D. Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury. Am J Physiol Heart Circ Physiol 285:H2430-6, 2003
14. Cox RA, Burke AS, Soejima K, Murakami, K, Katahira J, Traber LD, Herndon DN, Schmalstieg FC Jr., Traber DL, Hawkins HK. Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Resp Cell Mol Biol 29:295-302, 2003
15. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, McGuire R, Schmalstieg F, Cox R, Hawkins H, Jodoin J, Lee S, Traber L, Herndon D, Traber DL. Inhibition of neuronal nitric oxide synthase (nNOS) by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Comp Physiol 285:R366-72, 2003
16. Murakami K, Cox RA, Hawkins HK, Schmalstieg FC, McGuire RW, Jodoin JM, Traber LD, Traber DL. Cepharanthin, an alkaloid from Stephania cepharantha, inhibits increased pulmonary vascular permeability in an ovine model of sepsis. Shock 20:46-51, 2003
17. Chandra A, Katahira J, Schmalstieg FC, Murakami K, Enkhbaatar P, Cox RA, Hawkins HK, Traber LD, Herndon DN, Traber DL. P-selectin blockade fails to improve acute lung injury in sheep. Clin Sci 104:313-21, 2003
18. Murakami K, McGuire R, Cox RA, Jodoin JM, Schmalstieg FC, Traber LD, Hawkins HK, Herndon DN, Traber DL. Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep. Crit Care Med 31:577-83, 2003
19. Syed S, Haque AK, Hawkins HK, Sorensen PH, Cowan DF. Desmoplastic small round cell tumor of the lung. Arch Pathol Lab Med 126:1226-8, 2002
20. Wolfe RR, Martini WZ, Irtun O, Hawkins HK, Barrow RE. Dietary fat composition alters pulmonary function in pigs. Nutrition 18:647-53, 2002
21. Sakurai H, Nozaki M, Traber LD, Hawkins HK, Traber DL. Microvascular changes in large flame burn wound in sheep. Burns 28:3-9, 2002
22. Katahira J, Murakami K, Schmalstieg FC, Cox R, Hawkins H, Traber LD, Traber DL. Role of anti-L-selectin antibody in burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 283:L1043-50, 2002
23. Murakami K, McGuire R, Cox RA, Jodoin JM, Bjertnaes LJ, Katahira J, Traber LD, Schmalstieg FC, Hawkins HK, Herndon DN, Traber Dl. Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock 18:236-41, 2002
24. Murakami K, Bjertnaes LJ, Schmalstieg FC, McGuire R, Cox RA, Hawkins HK, Herndon DN, Traber LD, Traber DL. A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med 30:2083-90, 2002
25. Jeschke MG, Low JF, Spies M, Vita R, Hawkins HK, Herndon DN, Barrow RE. Cell proliferation, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats. Am J Physiol Gastrointest Liver Physiol 280:G1314-20, 2001
26. Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabo C, Szabo E, Varig L, Salzman A, Traber DL. Role of nitric oxide in vascular permeability after combined burn and smoke inhalation injury. Am J Respir Crit Care Med 163:745-752, 2001
27. Ventura KC, Hawkins H, Smith MB, Walker DH. Fatal neonatal echovirus 6 infection: autopsy case report and review of the literature. Mod Pathol 14:85-90, 2001
28. Cox RA, Soejima K, Burke AS, Traber LD, Herndon DN, Schmalstieg FC, Traber DL, Hawkins HK. Enhanced pulmonary expression of endothelin-1 in an ovine model of smoke inhalation injury. J Burn Care Rehab 22:375-83, 2001
29. Sporri S, Chopra V, Egger N, Hawkins HK, Motamedi M, Dreher E, Schneider H. Effects of 5-aminolaevulinic acid on human ovarian cancer cells and human vascular endothelial cells in vitro. J Photochem Photobiol B 64:8-20, 2001
30. Banerji TK, Maitra SK, Dey M, Hawkins HK. Gametogenic responses of the testis in spotted munia (Lonchura punctulata, Aves) to oral administration of lithium chloride. Endocr Res 27:345-56, 2001
31. Chiles LR, Christian MM, McCoy DK, Hawkins HK, Yen AH, RaimeR SS. Langerhans cell histiocytosis in a child while in remission for acute lymphocytic leukemia. J Am Acad Dermatol 45:S233-4, 2001
32. Popnikolov NK, Payne Da, Hudnall SD, Hawkins HK, Kumar M, Norris BA, Elghetany MT. CD13-positive anaplastic large cell lymphoma of T-cell origin - A diagnostic and histogenetic problem. Arch Pathol Lab Med 124: 1804-1808, 2000
33. Bi LX, Simmons DJ, Hawkins H, Cox R, Mainous E. Comparative morphology of the marrow sac. Anat Rec 260:410-415, 2000
34. Jeschke MG, Barrow RE, Hawkins HK, Tao Z, Perez-Polo JR, Herndon DN. Biodistribution and feasibility of non-viral IGF-1 gene transfers in thermally injured skin. Lab Invest 80:151-158, 2000
35. Elgio GI, Traber DL, Hawkins HK, Kramer GC. Burn resuscitation with two doses 4 ml/kg hypertonic saline dextran provides sustained fluid sparing. A 48-h prospective study in conscious sheep. J Trauma 49:251-263, 2000
36. Friedman NR, Pachigolla R, Deskin RW, Hawkins HK. Optimal technique to diagnose primary ciliary dyskinesia. Laryngoscope 110:1548-1551, 2000
37. Walden JL, Garcia H, Hawkins H, Crouchet JR, Traber L, Gore DC. Both dermal matrix and epidermis contribute to an inhibition of wound contraction. Ann Plast Surg 45:162-166, 2000
38. Murphey ED, Chattopadhyay N, Bai M, Kifor O, Harper D, Traber D, Hawkins HK, Brown EM, Klein GL. Up-regulation of the parathyroid calcium-sensing receptor following burn injury in sheep: a potential contributory factor to post-burn hypocalcemia. Crit Care Med 28:3885-90, 2000
39. Tao Z, Herndon D, Hawkins H, Wood T, Perez-Polo R. Insulin-like growth factor-I cDNA gene transfer in vitro and in vivo. Biochem Genet 38:41-55, 2000
40. Schenarts PJ, Schmalstieg FC, Hawkins H, Bone HG, Traber LD, Traber DL. Effects of an L-selectin antibody on the pulmonary and systemic manifestations of severe smoke inhalation injuries in sheep. J Burn Care Rehabil 21:229-240, 2000
41. Bidani A, Hawkins HK, Wang CZ, Heming TA. Dose dependence and time course of smoke inhalation injury in a rabbit model. Lung 177:111-122, 1999
42. Jeschke MG, Barrow RE, Hawkins HK, Yang K, Hayes RL, Lichtenbelt BJ, Perez-Polo JR, Herndon DN. IGF-1 gene transfer in thermally injured rats. Gene Therapy 6:1015-1020, 1999
43. Molina CP, Hawkins H, Campbell G, Rowe T, Grafe M. Case of the month: January 1999 – Fetus with echogenic mass in third ventricle. Brain Path 9:605-606, 1999
44. Sakurai H, Schmalstieg F, Traber L, Hawkins H, Traber D. Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. J Appl Physiol, 86:1151-1159, 1999
45. Jeschke MG, Barrow RE, Hawkins HK, Chrysopoulo MT, Perez-Polo JR, Herndon DN. Effect of multiple gene transfers of insulinlike growth factor I complementary DNA gene constructs in rats after thermal injury. Archives Surg 134:1137-1141, 1999
46. Banerji TK, Maitra JR, Basu A, Hawkins HK. Lithium-induced alterations in the testis of the Roseringed parakeet (Psittacula krameri): evidence for significant changes and disruption in the spermatogenic activity. Endocr Res 25(1):35-49, 1999
47. Jiang Z, Nagata N, Molina E, Bakaletz LO, Hawkins HK, Patel JA. Fimbria-mediated enhanced attachment of nontypeable Haemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells. Inf Immun 67(1):187-192, 1999
48. Klein GL, Dallas JS, Hawkins HK, Swischuk LE, McCauley RL. Congenital linear sebaceous nevus syndrome. J Bone Min 13(6):1056-1057, 1998
49. Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai MH, Wolfe RR, Herndon DN. Effects of insulin on wound healing. J Trauma: Injury, Infection, and Critical Care 44(2):342-345, 1998
50. Alagappan A, Shattuck KE, Rowe T, Hawkins H. Massive intracranial immature teratoma with extracranial extension into oral cavity, nose, and neck. Fetal Diagn Ther 13:321-324, 1998
51. Shin CS, Han JU, Kim JL, Schenarts PJ, Traber LD, Hawkins H, Traber DL. Heparin attenuated neutrophil infiltration but did not affect renal injury induced by ischemia reperfusion. Yonsei Med J 38:133-141, 1997
52. Birdsall HH, Green D, Trial J, Youker KA, Burns AR, MacKay CR, LaRosa GJ, Hawkins HK, Smith CW, Michael LH, Entman ML, Rossen RD: Complement C5a, TFG-1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. Circulation 95:684-692, 1997
53. Kumar AG, Ballantyne CM, Michael LH, Kukielka GL, Youker KA, Lindsay ML, Hawkins HK, Birdsall HH, MacKay CR, LaRosa GJ, Rossen RD, Smith CW, Entman ML. Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation 95:693-700, 1997
54. Kumar N, Sapire DW, Lockhart LH, McCombs JL, Hawkins HK, Van Mierop LHS. Letter to the Editor: Atrioventricular septal defect with pulmonary atresia in DiGeorge anomaly: Expansion of the cardiac Phenotype. Am J Med Genetics 61:89-91, 1996
55. Ballantyne CM, Masri BM, Clubb FJ, Radovancevic B, Smith CW, Hawkins HK, Frazier OH, Willerson JT. Increased expression of ICAM-1 in a case of accelerated coronary artery disease after heart transplantation. Tex Heart Inst J 23:293-295, 1996
56. Hawkins HK, Entman ML, Zhu JY, Youker KA, Berens K, Dore M, Smith CW. Acute inflammatory reaction after myocardial ischemic injury and reperfusion. Development and use of a neutrophil-specific antibody. Am J Pathol 148(6):1957-1969, 1996
57. Kukielka GL, Smith CW, LaRosa GL, Manning AM, Mendoza LH, Daly TJ, Hughes BJ, Youker KA, Hawkins HK, Michael LH, Rot A Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo. J Clin Invest 95:89-103, 1995
58. Hartley CJ, Youker KA, Zhu J, Hall SR, Hawkins HK. Myocardial ischemia and reperfusion: A murine model. Am J Physiol 269:H2147-2154, 1995
59. Mickelson JK, Kukielka G, Bravenec JS, Mainolfi E, Rothlein R, Hawkins HK, Kelly JH, Smith CW. Differential expression and release of CD54 induced by cytokines. Hepatol 22:866-875, 1995
60. Herndon DN, Hawkins HK, Nguyen TT, Pierre E, Cox R, Barrow RE. Characterization of growth hormone enhanced donor site healing in patients with large cutaneous burns. Ann Surg 221(6):649-659, 1995
61. Jones D, Kay M, Craigen W, McCabe E, Hawkins HK, Dominey A. Coal-black hyperpigmentation at birth in a child with congenital adrenal hypoplasia. J Am Acad Dermatol 33:323-326, 1995
62. Cheirif J, Narkiewicz-Jodko JB, Hawkins HK, Bravenec JS, Quinones MA, Mickelson JK. Myocardial contrast echocardiography: Relation of collateral perfusion to extent of injury and severity of contractile dysfunction in a canine model of coronary thrombosis and reperfusion. J Am Coll Cardiol 26:537-546, 1995
63. Jevon GP, Dunne WM Jr, Hawkins HK, Armstrong DL, Musser JM. Fatal group A streptococcal meningitis and toxic-shock-like syndrome: Case report. Clin Infect Dis 18:91-93, 1994
64. Youker KA, Hawkins HK, Kukielka GL, Perrard JL, Michael LH, Ballantyne CM, Smith CW, Entman ML. Molecular evidence for a border zone vulnerable to inflammatory reperfusion injury. Trans Assoc Am Physicians 106:145-154, 1994
65. Rossen RD, Michael LH, Hawkins HK, Youker K, Dreyer WJ, Baughn RE, Entman ML. Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion. Circ Res 75:546-555, 1994
66. Youker KA, Hawkins HK, Kukielka GL, Perrard JL, Michael LH, Ballantyne CM, Smith CW, Entman ML. Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart. Circulation 89:2736-2746, 1994
67. Murray JC, Gmoser DJ, Barnes DA, Oshman D, Hawkins HK, Gresik MV, Dreyer ZE. Isolated bone relapse during hematologic remission in childhood acute lymphoblastic leukemia: Report of a metatarsal relapse and review of the literature. Med Pediatr Oncol 23:153-157, 1994
68. Kukielka GL, Youker KA, Hawkins HK, Perrard JL, Michael LH, Ballantyne CM, Smith CW, Entman ML. Regulation of ICAM-1 and IL-6 in myocardial ischemia: Effect of reperfusion. Ann NY Acad Sci 723:258-270, 1994
69. Dore M, Hawkins HK, Entman ML, Smith CW. Production of a monoclonal antibody against canine GMP-140 (P-selection) and studies of its vascular distribution in canine tissues. Vet Pathol 30:213-222, 1993
70. Kukielka GL, Hawkins HK, Michael L, Manning AM, Youker K, Lane C, Entman ML, Smith CW, Anderson DC. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. J Clin Invest 92:1504-1516, 1993
71. Ackermann MR, Kehrli ME Jr, Hawkins HK, Amenson JL, Galagher JE. Identification of β2 integrins in bovine neutrophils by scanning electron microscopy in the backscatter mode and transmission electron microscopy. Vet Pathol 30:296-298, 1993
72. Margraf LR, Finegold MJ, Stanley LA, Major A, Hawkins HK, DeMayo FJ. Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: Comparison of endogenous expresson to rabbit uteroglobin promoter-driven transgene expression. Am J Resp Cell Mol Biol 9:231-238, 1993
73. Sligh JE, Ballantyne CM, Rich SS, Hawkins HK, Smith CW, Bradley A, Beaudet AL. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Nat Acad Sci 90:8529-8533, 1993
74. Hawkins HK, Rehm LS, Zhu JY. Colloidal gold labeling of sections and cell surfaces. Utltrastruct Pathol 16:61-70, 1992
75. Hawkins KH, Heffelfinger SC, Anderson DC. Leukocyte adhesion deficiency: Clinical and postmortem observations. Pediatr Pathol 12:119-130, 1992
76. Rowen JL, Correa AG, Sokol DM, Hawkins HK, Levy ML, Edwards MS. Invasive aspergillosis in neonates: Report of five cases and literature review. Pediatr Infect Dis J 11:576-582, 1992
77. Hayani A, Mahoney DH Jr, Hawkins HK, Steuber CP, Hurwitz R, Fernbach DJ. Soft-tissue sarcomas other than rhabdomyosarcoma in children. Med Pediatr Oncol 20:114-118, 1992
78. Dominey AM, Hawkins HK, Levy ML. Congenital cutaneous and subcutaneous nodules. Pediatr Dermatol 9:304-306, 1992
79. Smith CW, Entman ML, Lane CL, Beaudet AL, Ty TI, Youker K, Hawkins HK, Anderson DC. Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1. J Clin Invest 88:1216-1223, 1991
80. Lewis LL, Hawkins HK, Edwards MS. Disseminated mucormycosis in an infant with methylmalonic aciduria. Pediatr Infect Dis J 9:851-854, 1990
81. Truong LD, Rangdaeng S, Cagle P, Ro JY, Hawkins H, Font RL. The diagnostic utility of desmin: A study of 584 cases. Am J Clin Pathol 93:305-314, 1990
82. Rabinovitz RS, Hartley CJ, Michael LH, Hawkins KH, Sekela ME, Noon GP. Implantable sensor for intraoperative and postoperative monitoring of blood flow: A preliminary report. J Vasc Surg 12:148-157, 1990
83. Hawkins EP, Krischer JP, Smith BE, Hawkins HK, Finegold MJ. Nasopharyngeal carcinoma in children—a retrospective review and demonstration of Epstein-Barr viral genomes in tumor cell cytoplasm: A report of the Pediatric Oncology Group. Hum Pathol 21:801-810, 1990
84. Sharif DS, Huhta JC, Marantz P, Hawkins HK, Yoon GY. Two-dimensional echocardiographic determination of ventricular septal defect size: Correlation with autopsy. Am Heart J 117:1333-1336, 1989
85. Diaz DM, Smith RJH, Adams JM, Hawkins KH. Tracheal agenesis: A case report and literature review. Arth Otolaryngol 115:741-745, 1989
86. Benke TA, Clark JW, Wisoff PJ, Schneider S, Balasubramaniam C, Hawkins HK, Laurent J, Perling L, Shehab A. Comparative study of suture and laser-assisted anastomoses in rat sciatic nerves. Lasers Surg Med 9:602-615, 1989
87. Sifers RN, Rogers BB, Hawkins HK, Finegold MJ, Woo SLC. Elevated synthesis of human alpha-1-antitrypsin hinders the secretion of murine alpha-1-antitrypsin from hepatocytes of transgenic mice. J Biol Chem 264(15):696-700, 1989
88. Kessler BH, Cochran WS, Wagner ML, Hawkins HK, Klish WJ. Graft-versus-host disease: Gastrointestinal involvement with a rectovaginal fistula. J Pediatr Gastroenterol Nutr 7:288-292, 1988.
89. Lifschitz CH, Hawkins HK, Guerra C, Byrd N. Anaphylactic shock due to cow’s milk protein hypersensitivity in a breast-fed infant. J Pediatr Gastroenterol Nutr 7:141-144, 1988
90. Carlson JA, Rogers BB, Sifers RN, Hawkins HK, Finegold MJ, Woo LS. Multiple tissues express alpha-1-antitrypsin in transgenic mice and man. J Clin Invest 82:26-36, 1988
91. Fine JD, Eady RA J, Levy ML, Hejtmancik JF, Courtney KG, Carpenter RJ, Holbrook KA, Hawkins HK. Prenatal diagnosis of dominant and recessive dystrophic epidermolysis bullosa: Application and limitations in the use of KF-1 and LH 7:2 monoclonal antibodies and immunofluorescence mapping technique. J Invest Dermatol 91:465-471, 1988
92. Katz JA, Mahoney DH, Shukla LW, Smith CW, Gresik MV, Hawkins HK. Endovascular papillary angioendothelioma in the spleen. Pediatr Pathol 8:185-193, 1988
93. Hawkins HK, Rehm LS. Immunogold labeling in pathology. TSEM Journal 19:15-20, 1988
94. Donnelly WH, Hawkins HK. Optimal examination of the normally formed perinatal heart. Hum Pathol 18:55-60, 1987
95. Hawkins HK, Camacho-Velasquez JV. Rhabdomyosarcoma in children: Correlation of form and prognosis in one institution’s experience. Am J Surg Pathol 11(7):531-542, 1987
96. Gospe SM, Armstrong DL, Gresik MV, Hawkins HK. Life-threatening congestive heart failure as the presentation of centronuclear myopathy. Pediatr Neurol 3:117-120, 1987
97. Hawkins EP, Hawkins HK, Armstrong D. Lymphocyte autofluorescense: A screening procedure for neurodegenerative diseases. Pediatr Neurol 2:160-166, 1986
98. Hashimoto K, Bale GF, Hawkins HK, Langston C, Pritzker MS. Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker type). Int J Dermatol 25:516-523, 1986
99. Hawkins EP, Finegold MJ, Hawkins HK, Krischer JK, Starling KA, Weinberg A. Nongerminomatous malignant germ cell tumors in children. A review of 89 cases from the Pediatric Oncology Group, 1971-1984. Cancer 58:2579-2584, 1986
100. Trulock TS, Ricketts RR, Verras A, Kim TH, Hawkins HK, Woodard JR. Wilms’ tumor arising in horseshoe kidney. Urology 25:306-309, 1985
101. Guyton RA, Dorsey LM, Silberman MS, Hawkins HK, Williams WW, Hatcher CR. The broadly based pericardial flap: A tissue for atrial wall replacement that grows. J Thor Cardio Surg 87:619-625, 1984
102. Walker DH, Hawkins HK, Hudson P. Fulminant rocky mountain spotted fever: Its pathologic characteristics associated with glucose-6-phosphate dehydrogenase deficiency. Arch Pathol Lab Med 107:121-125, 1983.
103. Kim TH, Hargreaves HK, Brynes RK, Hawkins HK, Lui VK, Woodard J. Ragab AH. Pretreatment testicular biopsy in childhood acute lymphocytic leukemia. Lancet ii: 657-658 Sept. 26, 1981
104. Sharov VG, Jennings RB, Lowe J, Reimer K, Hawkins HK. On the importance of changes in cardiomyocytes in the development of acute cardiac insufficiency in experimental myocardial infarction. Arkiv Patologiyeh (Moscow) 41:9-14, 1979
105. Lowe JE, Hawkins HK, Jennings RB. Relationship between depletion of high energy phosphate compounds and elthal ischemic myocardial cell injury. Surg Forum 29:247-250, 1979
106. Klintworth GK, Hawkins HK, Smith CF. Acridine orange particles in cultured fibroblasts – a comparative study of systemic mucopolysaccharidoses types IH and II and normal controls. Arch Pathol Lab Med 103:297-299, 1979.
107. Gosden RG, Hawkins HK, Gosden CA. Autofluorescent particles of human uterine muscle cells. Am J Pathol 91:155-74, 1978
108. Jennings RB, Hawkins HK, Lowe JE, Hill ML, Klotman S, Reimer KA. Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog. Am J Pathol 92:187-214, 1978
109. Klintworth GK, Reed JW, Hawkins KH, Ingram P. Calcification of soft contact lenses in patient with dry eye and elevated calcium concentration in tears. Invest Ophthalmol Visual Sci 16:158-61, 1977
110. Bradford WD, Hawkins HK. Rocky mountain spotted fever in childhood. Am J Dis Child 131:1228-232, 1977
111. Schwartz JN, Cashwell F, Hawkins HK, Klintworth GK: Necrotizing retinopathy with herpes zoster ophthalmicus. Arch Pathol Lab Med 100:386-91, 1976
112. Mitchener JS, Bradford WD, Shelburne JD, Hawkins HK. Cellular autophagocytosis induced by deprivation of serum and amino acids in HeLa cells. Am J Pathol 83:485-98, 1976
113. Shelburne JD, Ingram P, Hawkins HK, Waters MD. X-ray mapping of lysosomal inclusions. Scan Elect Microscopy 485-500, 1976
114. Kane RD, Hawkins HK, Miller JA, Noce PS. Microscopic pulmonary tumor emboli associated with dyspnea. Cancer 36:1473-82, 1975
115. Stone RA, Tisher CC, Hawkins KH, Robinson RR. Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure. Am J Med 56:119-23, 1974
116. Hawkins HK, Ericsson JLE, Biberfeld P, Trump BF. Lysosome and phagosome stability in lethal cell injury. Am J Pathol 68:255-88, 1972
117. Saladino AJ, Hawkins HK. Ion movements in cell injury: Effects of the cationic detergent cetyl pyridinium chloride on the ultrastructure and function of the toad bladder. Am J Pathol 64:271-94, 1971
118. Dudley AW, Hawkins HK. Mineralization of the central nervous system in pseudopseudohypopar-athyroidism (PPH). J Neurol Neurosurg Psych 33:147-52, 1970
119. Kelly JW, Clabaugh WA, Hawkins HK. Photographic cytophotometry with a dual microscope, II. J Histochem Cytochem 12:600-04, 1964

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