UTMB Department of Pathology

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Pathologic and epidemiologic studies involving the changes in the distribution of the histologic types of lung cancer

Lung cancer is the leading cause of cancer death in men and women accounting for 157,200 deaths in 2003 and corresponding to 28% of all cancer deaths. Specifically lung cancer causes 88,400 (31%) deaths in men and 68,800 (25%) deaths in women.

Death rates for lung cancer have been rising from 40 per 100,000 in the male population in 1962 to 81 per 100,000 in 2003 and among women from 7 per 100,000 to 51.4 per 100,000 during the same period of time. In women, lung cancer has become the major cause of death followed by breast cancer which for the previous 40 years has been the major cause of cancer death in women. All histologic types of lung cancer have contributed to the increase of incidence of lung cancer, but the distribution of each type has varied over the past years. Our local experience and published data showed that in men the most common type of lung cancer is still squamous cell carcinoma, followed by adenocarcinoma and small cell carcinoma. In women the most common lung cancer is adenocarcinoma, followed by small cell carcinoma and squamous cell carcinoma. Over the last years there has been a steady rise in the incidence of adenocarcinoma in men and a rise of small cell carcinoma in women. If this trend continues the death rates among women for lung cancer may rapidly increase because the survival of small cell carcinoma is poor. These changes in the distribution of lung cancer are important to plan strategies for early detection of lung cancer particularly for small cell carcinoma.

My research on lung cancer involves collaborations from 3 large university centers in Texas to determine the distribution of lung cancer according to histologic type, sex, smoking and patient age for the past 23 years and to find out any changes in the trends of lung cancer type and its relation to patient survival. In addition, I am interested in studying the clinicopathologic process in different disciplines in surgical pathology including non-neoplastic lung disease, intraoperative histo-cytologic correlation and breast cancer.

1. Chauddhary H, Pucci R, Eltorky M. Intraoperative cytology in diagnosis of testicular seminomn. Cytopathology 32(3), 2004
2. Bing Z, Levine L, Lucci j, Hatch S, Eltorky M. Primary small cell neuroendocrine carcinoma of the vagina: a clinicopathologic study. Arch. Path. Lab. Med, 128:857-882, 2004
3. Sanati S, Pucci R, Eltorky M. Intraoperative Cytology in diagnosis of Pheochromocytoma. Cytopathology 31(11), 2003
4. Chahuan R, Gingrich J and Eltorky M. The natural progression of adenocarcinoma of the epididymis. J Uorlogy 166:608-610; 2001
5. Eltorky M and Cutlan R. Pulmonary granular cell tumor coexisting with primary lung carcinoma. Report of three cases and review of the literature. Ann Diag Pathol 5(2): ; 2001
6. Munir A and Eltorky M. Toxoplasma pneumonia, an uncommon complication of immunosuppression therapy in transplant patients. South Med J 93(6):614-617; 2000
7. Greer J, Eltorky M and Robbins KT. A feasibility study of salivary gland autograft transplantation for xerostoma. Head Neck J 22(3):241-246; 2000
8. Cutlan R, Greer J, Wong F and Eltorky M. Immunohistochemical characterization of thyroid gland angiomatoid tumors. Exp Mol Pathol J 69:159-164; 2000
9. Lipscomb G, Gildner K, Shulman K, Eltorky M and Ling F. Comparison of karman cannula and diagnosis of ectopic pregnancy. Int J Gyn, Ob Surg 63(2)153-158; 1998.
10. Lamngan M and Eltorky M. Sarciodosis mimicking disseminated histoplasmosis. South Med J, 21(8), 1998
11. Winer-Muran H, Steiner R, Gurney J, Shah R, Jennings G, Arheart K, Eltorky M and Meduri U. Ventilator-associated pneumonia in patients with adult respiratory distress syndrome: CT evaluation. Radiology 208(12):193-199; 1998
12. Tenholder M, Muram H and Eltorky M. Hemopytosis and multiple myeloma. J Bronchol 4:26-28; 1997
13. Pate T, Tenholder M, Eltorky M and Meduri U. Endobronchial mesenchymoma. J Bronchol 3:36-39; 1996
14. Meduri GU, Blenchia JM, Massie JD, Eltorky M and Tolley EA. The role of gallium-67 scintigraphy in diagnosing sources of fever in ventilated patients. Intensive Care Med 22:395-403; 1996
15. Eltorky M, Khare V and Shanklin D. Placental metastasis from maternal carcinoma: report of three cases and review of literature. J Reprod Med 40:399-403; 1995
16. Muram HW, Headley S, Menke P and Eltorky M. Manifestations of thoracic vascular behcetis disease in African-American men. J Thorac Imag 9:176-179; 1994
17. Eltorky M, Headley S, Winer-Muram H, Garrett E and Griffin J. Pulmonary capillary hemangiomatosis. Ann Thorac Surg 57:772-6; 1994
18. Eltorky M, Chesney T and Sebes J. Spindle cell hamangioendothelioma: report of three cases and review of literature. J Dermatol Surg and Oncol 20:196-202; 1994
19. Meduri A, Chinn A, Leeper K and Eltorky M. Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Chest 105:1516-1527; 1994
20. Eltorky M, Osborne P and Hall C. Clinicopathological evaluation of steroid hormone receptors status and DNA ploidy in signet ring carcinoma of breast. Arch Pathol and Lab Med 118(3):245-248; 1994
21. Eltorky M, O’Brien T and Walter Y. Primary testicular of malignant fibrous histiocytoma. J Urolo Pathol 1:425-429; 1993
22. Rumbak R, Eason A, Muram H and Eltorky M. Inflammatory bronchial flap “check valve” bronchial obstruction. Am J Med Sci 303:121-123; 1992
23. Baselski V, Eltorky M, Coalson J and Griffin J. International consensus conference: clinical investigations of ventilator associated pneumonia. Chest (102)571S-579S; 1992
24. Baselski V, Eltorky M, Coalson J and Griffin J. The standardization of criteria for processing and interpreting laboratory specimens in patients with suspected ventilator-associated pneumonia. Infect Control and Hsop Edpiermiol 13(11):667; 1992
25. Meduri GU, Belenchia JM, Estes RJ, Leeper K, Wunderink RG and Eltorky MA. Fibroproliferative phase of ARDS. Clinical and pathological findings and the effect of corticosteroids. Chest 100:943-952; 1991
26. Miller B, Docktor M, Eltorky M and Photopulos G. Small cell carcinoma of the cervix: a clinical and flow cytometric study. Gyn Oncol 42:27-33; 1991
27. Miller B, Eltorky M and Photopolus G. Simultaneous small cell carcinoma of the cervix and adenocarcinoma of the ovary. Gynecol Oncol 39:99-102; 1990
28. Eltorky M, Elzeky F and Hall C. Significant changes in the distribution of histologic types of lung cancer. Cancer 65:2361-2367; 1990
29. Eltorky M, Giltman L and Maijub A. Uterine arteriovenous fistula. J Rep Med 31(4):283-286; 1986
30. Eltorky M, Giltman L and Dabbous M. Collagens in scar carcinoma of the lung. Am J Pathol 121:; 1985
31. Dabbous M, Eltorky M, Haney L and Brinkley B. Sr. Collagenase activity in rabbit carcinoma: cell source and cell interactions. Int J Cancer, 31:357-367; 1983
32. Dabbous M, Eltorky M, Haney L, Sobhy N. and Brinkley B Sr. Separation of VX rabbit carcinoma-derived cells capable of releasing collagenase. Exp Mol Pathol, 38:1-21; 1983

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