Smita Vaidya

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Smita Vaidya
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Academic Appointments
Appointment Organization
Director of Tissue Antigen Pathology
Professor Pathology
Professional Education
Degree Institution Field of Study Graduation Year
Ph.D. Texas Women's University Molecular Biology 1978
M.S. University of North Carolina Physics 1971
B.Sc. Gujarat University Applied Mathematics 1969
Honors
Title Organization Year(s)
Recipient of NIH Post-Doctoral Fellowship 1997
Professional Affiliations
Society Year(s)
Member of the UNOS Minority Affairs Committee 1999 - 2001
Research Interests

HLA and Disease

Antiphospholipid antibodies and end-stage renal disease: End-stage renal disease (ESRD) patients with antiphospholipid antibody syndrome (APAS) are at high risk for the development of post transplant thrombosis. Our large multi-center study has shown for the first time, frequency, potential risk and therapeutic intervention in ESRD patients with APAS.

Selected Publications
  1. VAIDYA S, Guggliuzza K, Daller JA Efficacy of anticoagulation therapy in ESRD patients with anti-phospholipid antibody syndrome. Transplantation 77 (7):1046-49, 2004
  2. VAIDYA S, Guggliuzza K, Daller, JA. Role of anti-beta2 glycoprotein 1antibodies in ESRD Patients with antiphospholipid antibody syndrome. Clin Transpl 16: 362-367,2002
  3. VAIDYA S, Sellers R, Gugliuzza K, Daller J and Fish JC. Therapy in ESRD patients with antiphospholipid antibody syndrome. Transpl Proc 33:1257-1258, 2001
  4. VAIDYA S, Cooper T, Stewart D, Bray R. Pronase improves detection of HLA antibodies in flow crossmatches. Transpl Proc 33:473-474, 2001
  5. VAIDYA S, Cooper T, Stewart D, Bray R, Daller J, Fish J, Gugliuzza K. Improved flow cytometric detection of HLA antibodies using pronase: Potential implications in renal transplantation. Transplantation 71(3):422-428, 2001
  6. VAIDYA S, Sellers R, Kimball P, Shanahan T, Gugliuzza K and Fish JC. Frequency potential risk and theraputic intervention in ESRD patients with antiphospholipid antibody syndrome – A multi-center study. Transplantation 69(7):1348-1352, 2000
  7. VAIDYA S, Wang CC, Gugliuzza K, and Fish JC. Antiphospholipid antibody syndrome and post-transplant renal thrombosis. Transpl Proc 31:230-233, 1999
  8. Brayman AA, Coppage ML, VAIDYA S and Miller MW. Transient poration and cell surface receptor removal from human lymphocytes in vitro by 1MH ultrasound. Ultrasound Med Biol 25(6):999-1008, 1999
  9. VAIDYA S, Wang CC, Gugliuzza K and Fish JC. Relative risk of post-tranplant renal thrombosis in ESRD patients with antiphospholipid antibodies. Clin Transpl 12:439-444, 1998
  10. VAIDYA S, want CC, Roorda C, Billings A, Rajaraman S and Fish JC. Tolerance for fraft-versus-host disease by intrathymic injection of recipient-type splenocytes into donor. Transplant Proc 29:1073-1075, 1997
  11. VAIDYA S, Wang CC, Roorda C and Fish JC. Prevention of graft-vs-host disease by intrathymic injection of recipient-type splenocytes into donors. Transplantation 629) 1366-1368, 1996
  12. VAIDYA S, Orchard P, Haneke R and Fish JC. Primary non function and performed anti HLA antibodies. Trans Proc 27(1):1033-1035, 1995
  13. Ying G, Zigler HK, Nissel DW, VAIDYA S and Klimpel G. Human T cell recognition of lysteria monocytogenes; recognition of lysteria by / and T cells. Infect Immun 63:2288-2294, 1995
  14. Sharma A, Baethge BA, Lisse JR, VAIDYA S, Reveille JD. Human leucocyte antigen typing in rheumatoid arthritis/polymyositis overlap syndrome. Ann Rheuma Dis 54(9):780-781, 1995
  15. VAIDYA S, Orchard P, Schroeder N, Haneke R, Brooks K, Thomas A, Corba A, Asfour A, Fish JC. Clinical importance of pre-mortem blood lymphocytes in cadaver donor tissue typing. Clin Trans 9:165-170, 1995
  16. Brooks EG, Klimpel GR, VAIDYA S, Keeney SE, Raimer S, Glodman AS, Schmalsteig FC. Thymic hypoplasia and T-cell deficiency in ectodermal dysplasia: Case report and review of the literature: Clin Immunol Immunol Pathol 71(1):44-52, 1994
  17. Brooks EG, Wirt DP, Klimpel GR, VAIDYA S and Glodblum RM. In Vivo and In Vitro suppression of T cell receptor / CD4-CD8-T lymphocytes by cyclosporine A. Clin Immunol Immunol Pathol 67(3) 224-231, 1993
  18. Fleming RYD, Herndon DN, VAIDYA S, Nichols R, Desai M, Rutan RL and Waymack JP. The effect of erythropoietin in normal healthy volunteers and pediatric patients with burn injuries. Surgery 112(2):424-432, 1992
  19. VAIDYA S, Tyring SK, Johnson L, Fine JD. HLA and recessive dystrophic epidermolysis bullosa. Arch Dermatol 127, 1991
  20. VAIDYA S, Tyring SK, Johnson L, Feldkemp M, Fine JD. HLA and epidermolysis bullosa: Evidence for independent assortment of Weber-Cockayne Subtype of epidermolysis bullosa and HLA complex. J Dermatol Sci 2:155-60, 1991
  21. VAIDYA S, Mamlok R, Daeshner CW, Williams J, Ruth J, Goldblum RM. Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal fetal T cell engraftment. Am J Pediatric Hematol/Oncol 13:172-175, 1991
  22. Brooks EG, Wirt DP, Goldblum RM, VAIDYA S, Asuncion MT, Patterson JC, Ware CF, Klimpel GR. Double negative T cells with an / T cell receptor: Non-MHC restricted cytotoxic activity and lymphokine production. J Immunol 144:4507-12, 1990
  23. Wirt DP, Brooks EG, VAIDYA S, Klimpel GR, Waldmann TA, Goldblum RM. New human T cell phenotype in combined immunodeficiency with graft-versus-host disease like reactions. N Eng J Med 321:370-74, 1989
  24. VAIDYA S and Doran M. Successful transplantation without pre-operative crossmatches. Trans Proc 21(1):718, 1989
  25. VAIDYA S and Keesy J. A micromethod for absorption of HLA Class I antibodies. Trans Proc 21(1):726-727, 1989
  26. VAIDYA S and Ruth J. Contribution and clinical significance of IgM antibodies in sensitized renal allograft recipient. Transplantation 47(6):956-58, 1989
  27. McWatters A, Franco M, VAIDYA S and Fish JC. The effect of UV treated allogeneic cells upon host reactivity in MECLR. Trans Proc 21(1):273-75, 1989
  28. Doran M, Ruth J, Lowery B, Fish J, Winsett O and VAIDYA S. Renal allograft survival in highly sensitized patients treated with cyclosporin. Trans Proc 19(1):1988, 1987
  29. VAIDYA S, Sommer B and Ferguson R. Evaluation of the risk factors associated with donor specific blood transfusion. Trans Proc 19(1):2268, 1987
  30. Adams P, Ferguson R, VAIDYA S and Orosz C. Clinical utility of serologic HLA-DR antigen identification using activated T lymphocytes. J Hum Immunol 16(3):295-303, 1986
  31. VAIDYA S, Sommer B, Pagel E, Koegel M and Ferguson R. Assessment of factors associated with donor specific sensitization in patients given donor specific blood transfusion. Transplantation 46(6):695-97, 1986
  32. Oroscz C, VAIDYA S, Adams P, Sing D, Zinn N and Ferguson R. Evidence for a cyclosporin – induced immunosuppressive substance separable from native cyclosporin in the serum of renal transplant patients. Trans Proc 19(1):571-72, 1985
  33. VAIDYA S, Orosz C, Cerilli J, Sommer B and Ferguson R. Clinical significance of anti donor B cell activity in donor specific blood transfusion in kidney transplantation. Trans Proc 16(6):1447, 1984
  34. BALL E, VAIDYA S and Stastny P. The human T cell response to protein and synthetic polypeptide antigens. Trans Proc 13:1044-45, 1981
  35. VAIDYA S, Colbaugh P and Stastny P. Predictive value for HLA-DR matching for non-reactivity in mixed lymphocyte culture depends on matching for HLA-DR. Trans Proc 9(4):1779-80, 1979
  36. Miller MW, VAIDYA S, and Kaufman GE. Variable G2 duration in root meristem cells of Vicia faba. J Exp Bot 25:84-211-15, 1974

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