UTMB Department of Pathology

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Cellular Mechanisms of Rickettsial Diseases

A major goal of my research is to study the cellular mechanisms of rickettsial diseases at the ultrastructural level. The interrelationships of Rickettsia conorii and R. typhi with different host cells were studied in the recently developed mouse models of these rickettsioses, and also of an ehrlichia (IOE), closely related to Ehrlichia chafeensis, in a mouse model of fatal human monocytotropic ehrlichiosis. Ultrastructural characteristics of 15 strains and isolates of ehrlichiae belonging to three genogroups of genetically related organisms united in genera Ehrlichia, Anaplasma, Neorickettsia and a strain of Wolbachia pipientis which represents a fourth genogroup in this cluster of species in the family Rickettsiaceae, were studied in continuous cell cultures or in vivo. Differences in the structure of intracytoplasmic micro-colonies (morulae) of ehrlichiae and their interrelations with the host cells allowed differentiation of the genogroups. In immunoelectron microscopy which allows to visualize the intracellular localization of the protein molecules it was revealed that gp120 protein of E. chaffeensis is expressed only at the surface of dense-cored cells (DC), not reticulate cells (RC), and is abundantly shed into the morula cavity. This protein serves as an adhesin of DC. Iron-binding Fbp of E. chaffeensis and E. canis was found primarily in the periplasmic space of their RC and also on the intramorular fibrils and on the morula membrane but only in the morulae containing DC.

I am also interested in studying the cellular mechanisms of infection with other intracellular pathogens-bacteria, viruses and protozoans and collaborate with other researchers on campus, nationwide, and internationally on the projects involving different techniques of electron microscopy. We characterized the ultrastructure of a novel alphavirus, an arenavirus, and two rhabdoviruses, a monkeypox virus in experimentally infected ground squirrels, described the morphology of a novel chlamydia pathogenic for fish, Piscichlamydia salmonis, gen.nov., sp.nov., diagnosed cases of cutaneous leishmaniasis and amebic encephalitis caused by Sappinia diploidea.

1. Feng H-M, Whitworth T, Olano JP, Popov VL, Walker DH. Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. Infect Immun, 72,4: 2222-2228, 2004
2. Wang C, Anastasio N, Popov V, Leday A, Johnson KM. Blockade of N-Methyl-daspartate receptors by phencyclidine causes the loss of corticostrial neurons. Neuroscience, 125:473-483, 2004
3. Campbell K, Popov V, Soong L. Identification and molecular characterization of a gene encoding a protective Leishmania amazonensis Trp-ASP (WD) protein. Infect Immun, 72,4: 2194-2202, 2004
4. Feng H-M, Whitworth T, Popov V, Walker DH. Effect of antibody on the rickettsia-host cell interaction. Infect Immun, 72:6:3524-3530, 2004.
5. Labruna MB, Whitworth T, Horta MC, Bouyer DH, McBride JW, Pinter A, Popov V, Gennari SM, Walker DH. Rickettsia species infecting Amblyomma cooperi ticks from an area in the state of Sao Paulo, Brazil where Brazilian spotted fever is endemic. J Clin Microbiol, 42,1:90-98, 2004
6. Sha J, Fadl AA, Klimpel GR, Niesel DW, Popov VL, Chopra AK. The two murein lipoproteins of Samonella enterica serovar typhimurium contribute to the virulence of the organism. Infect Immun, 72:7: 3987-4003, 2004
7. Torres AG, Kanack KJ, Tutt CB, Popov V, Kaper JB. Characterization of the second long polar (LP) fimbriae of Escherichia coli O157:H7 and distribution of LP fimbriae in other pathogenic E. coli strains. FEMS Microbiol Lett, 238:333-344, 2004
8. Li F, Templeton TJ, Popov V, Comer JE, Tsuboi T, Torii M, Vinetz JM. Plasmodium ookinete-secreted proteins secreted through a common micronemal pathway are targets of blocking malaria transmission. J Biol Chem, 279(25):26636-26644, 2004
9. Copland JA, Eghtedari M, Popov VL, Kotov N, Mamedova N, Motamedi M, Oraevsky AA. Bioconjugated gold nanoparticles as a molecular based contrast agent: Implications for imaging of deep tumors using optoacoustic tomography. Molecular Imaging & Biology. 6(5):341-349, 2004
10. Tesh RB, Watts DM, Sbrana E, Siirin M, Popov VL, Xiao S-Y. Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus. Emerg Infect Dis. 10(9):1563-1567, 2004
11. Galindo CL, Fadl AA, Sha J, Gutierrez, Jr C, Popov VL, Aggarwal BB, Chopra AK. Aeromonas hydrophila cytotoxic enterotixin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelia cells. J. Biol Chem. 279(36):37597-37612, 2004
12. Sharma R, Yang Y, Sharma A, Dwivedi S, Popov V, Boor P, Signbal S, Awasthi S, Awasthi Y. Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonental in human lens epithelial cell. Invest Ophtl & Visual Sci, 44(8):3438-3449, 2003
13. Sha J, Galindo CL, Pancholi V, Popov VL, Zhao Y, Houston CW, Chopra AK. Differential expression of the encolase gene under in vivo versus in vitro growth conditions of Aeromonas hydrophila. Microbial Pathogensis 34:195-204, 2003
14. Gessell-Lee DL, Popov VL, Boldogh I, Olano JP, Peterson JW. Role of cyclooxygenase enzymes in a murine model of experimental cholera. Infect Immun, 71, 11:6234-6242, 2003
15. Gelman BB, Popov V, Chaljub G, Nader R, Rauf SJ, Nauta HW, Visvesvara GS. Neuropathological and ultrastructural features of amebic encephalitis caused by Sappinia dipolidea. J Neuropathol Exp Neurol. 62(10):990-998, 2003
16. Stenos J, Graves S, Popov VL, Walker DH. Aponomma hydrosauri, the reptile-associated tick reservoir of Rickettsia honei on Flinders Island, Australia. Amer J Trop Med Hyg, 63(3):314-317, 2003
17. Martin A, Bodola F, Sangar D, Goettge K, Popov V, Rijnbrand R, Lanford R, Lemon S. Chronic hepatitis associated with GB virus B persistence in a tamarin after intrahepatic inoculation of synthetic viral RNA. PNAS, 100(17):9962-9967, 2003
18. Garg N, Popov VL, Papaconstantinou J. Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development. Biochim Biophys Acta. 1638(2):106-20,2003
19. Maloney DM, Maloney JE, Dotson D, Popov VL, Sanchez RL. Cutaneous leishmaniasis: Texas case diagnosed by electron microscopy. J Am Acad Dermatol. 47(4):614-616, 2002
20. Langer RC, Li F, Popov V, Kurosky A, Vinetz JM. Monoclonal antibody against the Plasmodium falciparum chitinase, PfCHT1, recognizes a malaria transmission-blocking epitope in Plasmodium gallinaceum ookinetes unrelated to the chitinase PgCHT1. Infec Immun. 70(3):1581-1590, 2002.
21. Qiao J, Mei FC, Popov VL, Vergara LA, Cheng X. Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J Biol Chem 277(29):26581-26586, 2002.
22. Travassos da Rosa APA, Mather TN, Takeda T, Whitehouse CA, Shope RE, Popov VL, Guzman H, Coffey L, Araujo TP, Tesh RB. Two new rhabdoviruses (Rhabdoviridae) isolated from birds during surveillance for arboviral encephalitis, northeastern United States. Emerg Infect Dis. 8(6):608-612, 2002
23. McBride JW, Ndip LM, Popov VL, Walker DH. Identification and functional analysis of an immunoreactive DsbA-Like thio-disulfide oxidoreductase of Ehrlichia ssp. Infec Immun. 70(5):2700-2703, 2002
24. Gelman BB, Rauf SJ, Nader R, Popov V, Borkowski J, Chaljub G, Nauta HW, Visvesvara GS. Amoebic encephalitis due to Sappinia diploidea. JAMA, 285(19): 2450-2451, 2001
25. Moron CG, Popov VL, Feng HM, Wear D, Walker DH. Identification of the target cells of Orientia tsutsugamushi in human cases of scrub typhus. Mod Pathol 14:752-759, 2001
26. Sotomayor EA, Popov VL, Feng HM, Walker DH, Olano JP. Animal model of fatal human monocytotropic ehrlichiosis. Am J Pathol. 158:757-769, 2001.
27. Qi H, Popov V, Soong L. Leishmania amazonensis-dendritic cell interactions in vitro and the priming of parasite-specific CD4+ T cells in vivo. J Immunol, 167:4534-4542, 2001
28. Walker DH, Feng HM, Popov VL.Rickettsial Phospholipase A² as a pathogenic mechanism in a model of cell injury by typus and spotted fever group rickettsiae. Am J Trop Med Hyg. 65(6):936-942, 2001
29. Moncayo AC, Hice CL, Watts DM, Travassos da Rosa AP, Guzman H, Russell KL, Calampa C, Gozalo A, Popov VL, Weaver SC, Tesh RB. Allpahuayo virus: a newly recognized arenavirus (Arenaviridae) from arboreal rice rats (Oecomys bicolor and Oecomys paricola) in Northeastern Peru. Virology. 284:277-286, 2001
30. Travassos da Rosa AP, Turell MJ, Watts DM, Powers AM, Vasconcelos PF, Jones JW, Klein TA, Dohm DJ, Shope RE, Degallier N, Popov VL, Russell KL, Weaver SC, Guzman H, Calampa C, Brault AC, Lemon AP, Tesh RB. Trocara virus: a newly recognized Alphavirus (Togaviridae) isolated from mosquitoes in the Amazon Basin. Am J Trop Med Hyg. 64:93-97, 2001.
31. Bouyer DH, Stenos J, Crocquet-Valdes P, Moron CG, Popov VL, Zavala-Velazquez JE, Foil LD, Stothard DR, Azad AF, Walker DH. Rickettsia felis: molecular characterization of a new member of the spotted fever group. Intl J Syst Evol Microbiol 51:339-347, 2001
32. Stuart CA, Wen G, Peng B-H, Popov VL, Hudnall SD, Campbell GA. GLUT-3 expression in human skeletal muscle. Am J Physiol Endocrinol Metab. 279:855-861, 2000
33. Kain KH, Popov VL, Herzog NK. Alterations in mitochondria and mtTFA in response to LPS-induced differentiation of B-cells. BBA. 1494 (1-2):91-103, 2000
34. Selvarangan R, Goluszko P, Popov V, Singhal J, Pham T, Lublin DM, Nowicki S, Nowicki B. Role of decay-accelerating factor domains and anchorage in internalization of Dr-fimbriated Escherichia coli. Infect Immun. 68:1391-1399, 2000
35. Zhang Y, Gao F, Popov VL, Wen JW, Hamill OP. Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes. J Physiol. 523:117-130, 2000
36. Caturegli P, Asanovich KM, Walls JJ, Bakken JS, Madigan JE, Popov VL, Dumler JS. ankA: an Ehrlichia phagocytophila group gene encoding a cytoplasmic protein antigen with ankyrin repeats. Infect Immun. 68:5277-5283, 2000
37. Walker DH, Popov VL, Feng HM. Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T Lymphocytes. Lab Invest. 80:1361-1372, 2000
38. Boehme KW, Popov VL, Heidner HW. The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells. J Virol. 74(12):11398-11406, 2000
39. Goluszko P, Selvarangan R, Popov V, Pham T, Wen JW, Singhal J: Decay-accelerating factor and cytoskeleton redistribution pattern in HeLa cells infected with recombinant Escherichia coli strains expressing Dr family of adhesins. Infect Immun. 67:3989-3997, 1999
40. Yu X-J, Crocquet-Valdes PA, Cullman LC, Popov VL, Walker DH: Comparison of Ehrlichia chaffeensis recombinant proteins for serologic diagnosis of human monocytotropic ehrlichiosis. J Clin Microbiol. 37:2568-2575, 1999
41. Popov VL, Yu X-J, Walker DH: The 120 kDa outer membrane protein of Ehrlichia chaffeensis: Preferential expression on dense-core cells and gene expression in Escherichia coli associated with attachment and entry. Microbial Pathogenesis. 28:71-80, 1999
42. Chopra AK, Huang JH, Xu X-J, Burden K, Niesel DW, Rosenbaum MW, Popov VL, Peterson JW: Role of Salmonella enterotoxin in overall virulence of the organism. Microbial Pathogenesis 27:155-171, 1999.
43. Powers AM, Mercer DR, Watts DM, Guzman H, Fulhorst CF, Popov VL, Tesh RB: Isolation and genetic characterization of a hantavirus (Bunyaviridae: Hantavirus) from a rodent, Oligoryzomys microtis (Muridae), collected in northeastern Peru. Am J Trop Med Hyg. 61:92-98, 1999
44. Popov VL, Han VC, Chen S-M, Dumler JS, Feng-H-M, Andreadis TG, Tesh RB, Walker DH: Ultrastructural differentiation of the genogroups in the genus Ehrlichia. J Med Microbiol. 47:235-251, 1998.
45. Peterson JW, Boldogh I, Popov VL, Saini SS, Chopra AK: Anti-inflammatory and antisecretory potential of histidine in Salmonella-challenged mouse small intestine. Lab Invest. 78(5):523-534, 1998
46. Xu X-J, Ferguson MR, Popov VL, Houston CW, Peterson JW, Chopra AK: Role of a cytotoic enterotoxin in Aeromonas-mediated infections: Development of transposon and isogenic mutants. Infect Immun. 66(8):3501-3509, 1998
47. Chen S-M, Yu X-J, Popov VL, Westerman EL, Hamilton FG, Walker DH: Genetic and antigenic diversity of Ehrlichia chaffeensis: Comparative analysis of a novel human strain from Oklahoma and previously isolated strains. J Infect Dis. 175:856-863, 1997
48. Walker DH, Popov VL, Crocquet-Valdes PA, Walsh CJR, Feng H-M: Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells. Lab Invest. 76 (1):129-138, 1997
49. Feng H-M, Popov VL, Yuoh G, Walker DH: Role of T lymphocyte subsets in immunity to spotted fever group rickettsiae. J Immunol. 158:5314-5320, 1997
50. Valentich JD, Popov V, Saada JI, Powell DW: Phenotypic characterization of an intestinal subepithelial myofibroblast cell line. Am J Physiol. 272:C1513-C1524, 1997
51. Pham TQ, Goluszko P, Popov V, Nowicki S, Nowicki BJ: Molecular cloning and characterization of Dr-II, a nonfimbrial adhesin-I-like adhesin isolated from gestational pyelonephritis-associated Escherichia coli that binds to decay-accelerating factor. Infect Immun. 65(10):4309-4318, 1997
52. Ferguson MR, Xu X-J, Houston CW, Peterson JW, Coppenhaver DH, Popov VL, Chopra AK: Hyperproduction, purification, and mechanism of action of the cytotoxic enterotoxin produced by Aeromonas hydrophila. Infect Immun. 65(10):4299-4308, 1997
53. Reisner BS, Woods GL, Popov VL: Electron microscopic analysis of Mycobacterium avium complex isolates exposed to ciprofloxacin, rifabutin, ethambutol and clarithromycin. Int J Tuberc Lung Dis. 1(3):270-275, 1997
54. Goluszko P, Popov V, Selvarangan R, Nowicki S, Pham T, Mowicki BJ: Dr fimbriae operon of uropathogenic Esherichia coli mediate microtubule-dependent invasion to the HeLa epithelial cell line. J Infect Dis. 176:158-167, 1997
55. Chen S-M, Popov V, Feng H-M, Walker DH: Analysis and ultrastructural localization of Ehrlichia chaffeensis proteins with monoclonal antibodies. Am J Trop Med Hyg. 54:405-412, 1996
56. Radulovic S, Feng H-M, Morovic M, Djelalija B, Popov V, Crocquet-Valdes P, Walker DH: Isolation of Rickettsia akari from a patient in a region where Mediterranean spotted fever is endemic. Clin Infect Dis 22:216-220, 1996
57. Popov VL, Chen S-M, Feng H-M, Walker DH. Ultrastructural variation of cultured Ehrlichia chaffeensis. J Med Microbiol 43(6): 411-421, 1995
58. Dumler JS, Chen S-M, Asanovich K, Trigiani E, Popov VL, Walker DH. Isolation and characterization of a new strain of Ehrlichia chaffeensis from a patient with nearly fatal monocytic ehrlichiosis. J Clin Microbiol, 33(7): 1704-1711, 1995
59. Chen S-M, Popov VL, Feng H-M, Wen J, Walker DH. Cultivation of Ehrlichia chaffensis in mouse embryo, Vero, BGM, and L929 cells and study of Ehrlichia-induced cytopathic effect and plaque formation. Infect Immun, 63(2): 647-655, 1995
60. Walker DH, Feng H-M, Saada JI, Crocquet-Valdes P, Radulovic S, Popov VL, Manor E. Comparative antigenic analysis of spotted fever group Rickettsiae from Israel and other closely related organisms. Am J Trop Med Hyg, 52(6): 569-576, 1995
61. Walker DH, Popov VL, Wen J, Feng H-M. Rickettsia conorii infection of C3H/HeN mice: a model of endothelial target rickettsiosis. Lab Investigation, 70(3): 358-368, 1994
62. Feng H-M, Popov VL, Walker DH. Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect Immun, 62(5): 1952-1960, 1994
63. Popov VL, Daiter AB, Tokarevich NK, Kartseva NA. Ultrastructure of viable and inactivated Coxiella burnetii after inoculation to mice. Acta Virol, 36(1): 32-38, 1992
64. Popov VL, Pankratova VN, Prozorovsky SV, Saikku P, Smirnova NS, Shatkin AA. Ultrastructure of Chlamydia pneumoniae, a new Chlamydia species. J Microbiol Epidemiol Immunobiol, 7-8: 2-8, 1992
65. Kekcheeva NG, Kokorin IN, Popov VL, Chereshkova EA, Smirnova NS, Vovk OA, Shirokova, E.M. Persistence of Rickettsia prowazekii in cotton rat macrophage cultures. Acta Virol, 36(1): 103-110, 1992
66. Pushkareva VI, Konstantinova ND, Litwin VY, Popov VL. Pseudomonads as parasites of Protozoa. J Microbiol, 2: 4 10, 1992
67. Gosteva VV, Klitsunova NV, Rehacek J, Kocianova E, Popov VL, Tarasevich IV. Mixed rickettsia virus infection in Dermacentor reticulatus imago. Acta Virol, 35: 174 186, 1991
68. Eremeeva ME, Klitsunova NV, Gosteva VV, Konstantinova ND, Smirnova NS, Popov VL, Balaeva NM. Localization of the major protein I in Rickettsia prowazekii cell. J. Microbiol, 1: 8 12, 1991
69. Popov VL, Sutakova G, Rehacek J, Smirnova NS, Daiter AB. Coxiella and Rickettsiella: comparison of ultrastructure with special reference to their envelope. Acta Virol, 35: 573 579, 1991
70. Popov VL, Shatkin AA, Pankratova VN, Smirnova NS, von Bosdorff CH, Ekman MR, et al. Ultrastructure of Chlamydia pneumoniae in cell culture. FEMS Microbiol Lett, 84(4): 129 134, 1991
71. Popov VL, Konstantinova ND, Merkurov AE, Tartakovsky IS. Ultrastructure of the interaction of Legionella pneumophila with the infusoria Tetrahymena pyriformis. J Microbiol, 3: 5 10, 1991
72. Gosteva VV, Rehacek J, Kocianova E, Klitsunova NV, Smirnova NS, Popov VL, Makarova VA, Tarasevich IV. Ultrastructure of the interaction of Rickettsia sibirica and R. slovaca with ixodid tick cells. J Microbiol Epidermiol Immunobiol, 2: 68 72, 1991
73. Pushkareva VI, Konstantinova ND, Litwin VY, Popov VL, Korn M. Analysis of the mechanisms of Yersinia interaction with infusoria Tetrahymena pyriformis on cellular and subcellular level. J Microbiol Epidermiol Immunobiol, 1: 3 9, 1990
74. Pereverzev NA, Kulikov VI, Popov VL, Grigorian GY. Morphology of liposomes in ultrathin sections. J Microbiol, 6: 107 109, 1989.
75. Eremeeva ME, Ignatovich VF, Popov VL, Balaeva NM. Inactivation of concentrated biomass of Rickettsia prowazekii. J Microbiol, 7: 12 17, 1989
76. Kaminsky GD, Konstantinova ND, Popov VL, Chakhava OI. Dissociation and ultrastructure of Shigella sonnei cells isolated from gnotobionts and obtained in vitro. J Microbiol, 7: 20 24, 1989
77. Zlishtcheva LI, Konstantivova ND, Popov VL. Dehydrogenase activity in Staphylococcus after antibacterial drug Balis 2 action; Biochemical and electron microscope study. J Microbiol, 3: 15 18, 1988
78. Tseneva GY, Bondarenko VM, Polotsky YE, Smirnov IV, Popov VL, Smirnova NS. Invasiveness and cytotoxicity as criteria for the evaluation of Yersinia attenuation. J Microbiol 9: 10 16, 1988
79. Kirillova FM, Kudriavtseva LY, Popov VL, Belaya YA. Electron microscopic study of the interaction of virulent and avirulent Shigella flexneri strains with peritoneal exudate macrophages. J Microbiol Epidemiol Immunobiol, 10: 8 11, 1988
80. Popov VL, Prozorovsky SV, Vovk OA, Kekcheeva NK, Smirnova NS. Electron microscopic analysis of in vitro interaction of Rickettsia prowazekii with guinea pig microphages; I. Macrophages from nonimmune animals. Acta Virol, 31(1): 53 58, 1987
81. Popov VL, Prozorovsky SV, Vovk OA, Kekcheeva NK, Smirnova NS. Electron microscopic analysis of in vitro interaction of Rickettsia prowazekii with guinea pig microphages; II. Macrophages from immune animals. Acta Virol, 31: 59 64, 1987
82. Popov VL, Dyuisalieva RG, Smirnova NS, Tarasevch IV. Ultrastructure of Rickettsia sibirica during interaction with the host cell. Acta Virol, 30: 494 498, 1986
83. Smirnova NS, Popov VL, Kokorin IN. Peculiarities of Rickettsia prowazekii in the cell culture as revealed by cryoultramicrotomy. Acta Virol, 30: 436 439, 1986
84. Zaloguev SN, Moroz AF, Glatman LI, Terekhov AA, Antiferova NG, Popov VL, et al. Possible use of plasmids for investigation of space flight action on biological objects. Antibiotics Med Biotechnol, 5: 357 362, 1986
85. Popov VL. Pathology of Rickettsia cells. J Microbiol, 11: 27, 1985
86. Shatkin AA, Orlova OE, Popov VL, Beskina SR. Persistent chlamydial infection in cell culture. Vestnik Acad Med Sci, 3: 51 55, 1985
87. Zaloguev SN, Moroz AF, Antsiferova NG, Glatman LI, Popov VL, et al. Some biological characteristics of bacteria in the Soviet French space experiment Cytos 2. J Microbiol, 8: 3 7, 1985
88. Popov VL, Beskina SR, Gulevskaya SA, Mikhailov AB. Study of Chlamydia release from the infected cells in scanning electron microscope. J Microbiol, 3: 29 32, 1984
89. Avakian AA, Popov VL. Rickettsiaceae and Chlamydiaceae: comparative electron microscopic studies. Acta Virol, 28(2): 159 173, 1984
90. Popov VL, Barkhatova OI. Interaction of Rickettsia akari with the host cell: multiplication, formation of the spheroplast like cells, and destruction in phagolysosomes. J Microbiol, 2: 23 27, 1984
91. Popov VL, Kirillova FM, Orlova OE. Surface structure of chlamydial elementary bodies. J Microbiol, 5: 30 33, 1984
92. Tixador R, Popov VL, et al. Etude de la sénsibilité bactérienne aux antibiotiques et ultrastructure realisées á bord de station orbitale Saliout 7(expépience Cytos 2). Innovation et technol. en biologie et médécine, 5(3): 325 332, 1984
93. Blumkin VL, Skaletsky NN, Popov VL, Kauricheva NI, et al. Floating embryo pancreas cell cultures. Bull Exp Biol Med, 97(6): 764 766, 1984
94. Zaloguev SN, Prozorovsky SV, Katz LN, Popov VL, et al. Structure and function of bacterial cells during the space flight. Ann USSR Acad Sci (DAN), 78(5): 1236 1237, 1984
95. Barkhatova OI, Popov VL, Kekcheeva NK, Prozorovsky SV. Electron microscopic study of penicillin action on Rickettsia conorii and R. akari in vitro. Antibiotiki, 8: 580 585, 1984
96. Blumkin VN, Skaletsky NN, Popov VL, Shalnev VI. Intrasplenic xenotransplantation of human embryo pancreatic cell cultures into rats with experimental diabetes mellitus. Bull Exp Biol Med 95(5): 89 91, 1983
97. Tartakovsky IS, Prozorovsky SV, Popov VL. Isolation of the first strains of Legionella pneumophila in the USSR. J Microbiol Epidemiol Immunobiol, 11: 41 45, 1983
98. Avakian AA, Popov VL, Chebanov SM, Shatkin AA, Sidorov VE, Kudelina RI. Comparison of the ultrastructure of small dense forms of Chlamydia and Coxiella burnetii. Acta Virol, 27(2): 168 172, 1983
99. Vasilevskaya VY, Popov VL, Titova TS, Sukhareva Nemakova NN. The changes in Crithidia oncopelti ultrastructure after inhibition of intracellular lipid biosynthesis by olivomycine. Proc Acad Sci USSR Ser Biol, 4: 599 605, 1983
100. Kagan GY, Schmitt Slomska K, Gontcharova SA, Katz LN, Popov VL, Churilova NS. Some antigenic features of group B streptococcal L forms. J Microbiol Epidemiol Immunobiol, 4: 33 36, 1983
101. Popov VL, Shatkin AA, Prozorovsky SV. Urogenital chlamydiosis: atypic agent forms and their possible role in the infection etiopathogenesis. Vestnik Dermatol Venerol, 2: 26 28, 1982
102. Manjgaladse MV, Popov VL, Chernov VA. Prospidin action on tumor cell ultrastructure in experiment. Bull Exp Biol Med 93(3): 79 81, 1982
103. Popov VL, Prozorovsky SV, Tartakovsky IS. Ultrastructural localization of the type specific antigen in Legionella pneumophila. Bull Exp Biol Med, 93(3): 63-65, 1982
104. Bondarenko VM, Popov VL, Timofeeva IT. Interaction of Citrobacter freundii with epithelial cells and macrophages in vitro. J Microbiol Epidemiol Immunobiol, 6: 64 67, 1981
105. Shatkin AA, Popov VL, Beskina SR. Urogenital chlamydiosis: morphology and ultrastructure of the agent. Vestnik Dermatol Venerol, 1: 24 28, 1981
106. Popov VL, Beskina SR, Shatkin AA, Avakian AA. Ultrastructure of the early stages of Chlamydia interaction with the host cell. J Microbiol Epidemiol Immunobiol, 8: 28 33, 1980
107. Popov VL, Viron A, Eb F, Lefebvre JF, Orfila J. Use of cryoultramicrotomy technique in Chlamydia ultrastructure studies. J Microbiol Epidemiol Immunobiol 3: 75 79, 1979
108. Beskina SR, Barkhatova OI, Popov VL, Shatkin AA, Prozorovsky SV. Penicillin action on paratrachoma agent in infection dynamics in vitro. Antibiotiki, 24(8): 598 603, 1979
109. Ignatovich VF, Podboronov VM, Grokhovskaya IM, Popov VL, Vorontzova TA, Revina TA. Action of lysozyme, isolated from some ixodid ticks, on Rickettsia prowzekii, R. canada, R. sibirica. Med Parasitol Parasitic Dis, 6: 16 22, 1979
110. Popov VL, Eb F, Lefebvre JF, Orfila J, Viron A. Morphological and cytochemical study of Chlamydia with EDTA regressive technique and Gautier staining in ultrathin frozen sections and infected cell cultures: a comparison with embedded material. Ann Microbiol (Inst Pasteur), 129B(3): 313 337, 1978
111. Popov VL, Shatkin AA, Avakian AA, Prozorovsky SV. Unusual minute forms in Chlamydia developmental cycle and their possible relation to the L-transformation phenomena. J Microbiol, 3: 42 46, 1977
112. Shatkin AA, Popov VL, Shtcherbakova NI. Morphology of Chlamydia, isolated in Reiter's disease. J Microbiol, 4: 60 64, 1976
113. Shatkin AA, Beskina SR, Pankratova VN, Popov VL, and Zakharova N. Indication of Chlamydia antigens with direct immunoperoxidase test. J Microbiol Epidemiol Immunobiol (Zh Microbiol), 9: 74 78, 1976
114. Popov VL, Ignatovich VF. Electron microscopy of surface structure of Rickettsia prowazekii stained with ruthenium red. Acta Virol, 20(5): 424 428, 1976
115. Popov VL, Beskina SR, Shatkin AA. Electron microscopic detection of the Chlamydia group specific antigen localization with the direct immunoperoxidase technique. J Microbiol, 12: 70 73, 1976
116. Gulevskaya SA, Popov VL, Ignatovich VF. New data on the polymorphism of Rickettsia prowazekii and Coxiella burnetii during cultivation in cell culture. J Microbiol Epidemiol Immunobiol 7: 68 72, 1975
117. Kudelina RI, Popov VL. Cultivation of Francisella tularensis in developing chicken embryos. J Microbiol, 12: 66 71, 1975
118. Bondarev IM, Agipa YI, Gulevskaya SA, Popov VL, Larina IM. Study of isoniazid inclusion in Mycobacterium tuberculosis cells using electron microscopic autoradiography. Proc Acad Sci USSR, Ser Biol 5: 740 743, 1974
119. Popov VL, Martynova VR, Shatkin AA. Interaction of lymphogranuloma venereum agent with macrophages from immune animals in vitro. Probl Virol, 6: 678 683, 1974
120. Popov VL, Martynova VR, Shatkin AA. Interaction of lymphogranuloma venereum agent with macrophages in vitro. Probl Virol (Voprosy Virusol), 2: 175 182, 1973

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