John Sealy Distinguished Chair for MD/PhD Combined Degree Studies in Honor of Dr. Truman G. Blocker
Chair, Department of Pharmacology and Toxicology
Professor of Pharmacology and Medicine
Director, MD-PhD Combined Degree Program
Kang, J., Burdzy, A., Liu, P., Sowers L.C.,: Synthesis and Characterization of Oligonucleotides containing 5-chlorocytosine. (2004) Chemical Research in Toxicology 17, 1236- 1244.
Valinluck, V. Liu, P. Kang, JI Jr., Burdzy, A., Sowers, L.C.:5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methlcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2). (2005) Nucleic Acids Res. 33, 3057-64.
Valinluck, V., Wu, W., Lui, P., Neidigh, J., Sowers, L.C.: The impact of cytosine 5-halogens on the interaction of DNA with restriction endonucleases and methyltransferases. (2006) Chem Res Tox. 19, 556-62.
Valinluck, V., Sowers, L.C.: Endogenous cytosine damage products alter the site-selectivity of human DNA maintenance methyltransferase DNMT1. (2007) Cancer Research 67, 946-50.
Valinluck, V.V. and Sowers, L.C. Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers. (2007) Cancer Res. 67, 5583-6.
Kang, J., Sowers, L.C.: Examination of hypochlorous acid-induced damage to cytosine residues in a CpG dinucleotide in DNA. (2008) Chem Res Tox. 21, 1211-8.
Cui, Z., Theruvathu, J., Farrel, A., Sowers, L.C.: Characterization of synthetic oligonucleotides containing biologically important modified bases by MALDI-TOF mass spectrometry. (2008) Analytical Biochemistry 379, 196-207
Darwanto, A., Theruvathu, J., Sowers, J.L., Pascal, T., Goddard, W.A. III, and Sowers, L.C.: Mechanism of base selection by hSMUG1. (2009) J. Biol. Chem. 284, 885-93.
Lao, V.V., Herring, J.L., Kim, C.H., Darwanto, A., Soto, U., Sowers, L.C.: Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns. (2009) Carcinogenesis 30, 886-93.
Herring, J.L., Rogstad, D.K., Sowers, L.C.: Enzymatic methylation of DNA incultured human cells studied by stable isotope incorporation and mass spectrometry. (2009) Chem Res Toxicol 22, 1060-8.
Rogstad, D.K., Herring, J.L., Theruvathu, J.A., Burdzy A., Perry, C.C., Sowers, L.C.: Chemical decomposition of 5-asa-2'-deoxycytidine (Decitabine): kinetic analyses and identification of products by NMR, HPLC, and mass spectrometry. 2009) Chem Res Tox. 22, 1194-204.
Darwanto, A., Farrel, A., Rogstad, D.K., Sowers, L.C.: Characterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. (2009) Analytical Biochem. 394, 13-23.
Theruvathu, J.A., Kim, C.H., Rogstad, D. K., Neidigh, J., Sowers, L.C.: Base pairing configuration and stability of an oligonucleotide duplex containing a 5-chlorouracil-adenine base pair. (2009) Biochemistry 48, 7539-46.
Theruvathu, J.A., Kim, C.H., Darwanto, A., Neidigh, J., Sowers, L.C.: pH-Dependent configurations of a 5-chlorouracil-guanine base pair. (2009) Biochemistry 48, 11312-8.
Williams, A.A., Darwanto, A., Theruvathu, J.A., Burdzy, A., Neidigh, J., Sowers, L.C.: Impact of sugar pucker on base pair and mispair stability. (2009) Biochemistry 48, 11994-2004.
Kim, C.H., Darwanto, A., Theruvathu, J.A., Herring, J.L., Sowers, L.C.: Polymerase Incorporation and Miscoding Properties of 5-Chlorouracil. (2010) Chem Res Tox. 23, 740-8.
Ito, S., D”Alessio, A.C., Taranova, O.V Hing, K., Sowers, L.C. and Zhang, Y. (2010) Role of Tet proteins in 5mc to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129-33.