C. Wild, K.A. Cunningham, and J. Zhou. Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery, Austin J. Pharmacol. Ther. 2014, 2(2), 3. (Editorial)
H. Chen, C. Wild, X. Zhou, N. Ye, X. Cheng, J. Zhou. Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC). J. Med. Chem. 2014, In press. DOI:10.1021/jm401425e. PMID:24256330; PMC Journal-in process.
N. Ye, J. Zhou. KRAS - An Evolving Cancer Target. Austin J. Cancer Clin. Res. 2014, 1(1), 3. (Editorial)
C. Ding, Y. Zhang, H. Chen, Z. Yang, C. Wild, C.D. Ester, A. Xiong, M.A. White, Q. Shen, J. Zhou. Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis. J. Med. Chem. 2013, 56(21), 8814-8825.
H. Chen, T. Tsalkova, O.G. Chepurney, F.C. Mei, G.G. Holz, X. Cheng, J. Zhou. Identification and Characterization of Small Molecules as Potent and Specific Epac2 Antagonists, J. Med. Chem. 2013, 56(3), 952-962.
C. Ding, Y. Zhang, H. Chen, C. Wild, T. Wang, M. White, Q. Shen, J. Zhou. Overcoming Synthetic Challenges of Oridonin A-Ring Structural Diversification: Regio- and Stereoselective Installation of Azides and 1,2,3-Triazoles at the C-1, C-2, or C-3 Position. Org. Lett. 2013, 15(14), 3718-3721.
C. Ding, Y. Zhang, H. Chen, L. Chu, Z. Yang, C. Wild, H. Liu, Q. Shen, J. Zhou. Novel Nitrogen-Enriched Oridonin Analogs with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility. J. Med. Chem. 2013, 56(12), 5048-5058.
G.G. Gurkoff, J.F. Feng, K.C. Van, A. Izadi, R. Ghiasvand, K. Shahlaie, M. Song, D.A. Lowe, J. Zhou, B.G. Lyeth. NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia. Brain Res. 2013, 1515, 98-107.
H. Chen, Z. Yang, C. Ding, L. Chu, H. Liu, Y. Zhang, K. Terry, Q. Shen, J. Zhou. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med. Chem. Lett. 2013, 4, 180-185.
H. Chen, Z. Yang, C. Ding, Y. Zhang, L. Chu, H. Liu, Q. Shen J. Zhou. Fragment-Based Drug Design and Identification of HJC0123, A Novel Orally Bioavailable STAT3 Inhibitor for Cancer Therapy. Eur. J. Med. Chem. 2013, 62, 498-507.
H. Chen, C. Ding, C. Wild, H. Liu, T.Wang, M. White, X. Cheng, J. Zhou. Efficient Synthesis of ESI-09, A Novel Non-Cyclic Nucleotide EPAC Antagonist. Tetrahedron Lett. 2013, 54, 1546-1549.
M. Almahariq, T. Tsalkova, F.C. Mei, H. Chen, J. Zhou, S.K. Sastry, F. Schwede, X. Cheng, A Novel EPAC Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion. Mol. Pharmacol. 2013, 83, 122-128.
H. Chen, C.Z. Wang, C. Ding, C. Wild, B. Copits, G.T. Swanson, K.M. Johnson, J. Zhou. A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents, ChemMedChem. 2013, 8 (2), 226-230. [Cover paper of the journal].
C. Ding, N. M. Bremer, T. D. Smith, P. K. Seitz, N. C. Anastasio, K. A. Cunningham, J. Zhou. Exploration of Synthetic Approaches and Pharmacological Evaluation of PNU-69176E and Its Stereoisomer as 5-HT2C Receptor Allosteric Modulators. ACS Chem. Neurosci., 2012, 3 (7), 538-545.
J. Feng, G.G. Gurkoff, K.C.Van , M. Song, D.A. Lowe, J. Zhou, B.G. Lyeth. NAAG Peptidase Inhibitor Reduces Cellular Damage in a Model of TBI with Secondary Hypoxia. Brain Res. 2012, 1469, 144-152.
H. Chen, T. Tsalkova, F. C. Mei, Y. Hu, X. Cheng, J. Zhou. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as Potent Antagonists Targeting Exchange Proteins Directly Activated by cAMP, Bioorg. Med. Chem. Lett., 2012, 22, 4038-4043.
J. Feng, K. C. Vana, G. Gurkoff, C. Kopriva, R. T. Olszewski, M. Song, S. Sun, M. Xu, J. H. Neale, P. Yuen, D. A. Lowe, J. Zhou, B. G. Lyeth, Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI. Brain Res. 2011, 1395, 62-73.
Caldarone B.J., Paterson N.E., Zhou J., Brunner D., Kozikowski A.P., Westphal K., Korte-Bouws G., Prins J., Korte S.M., Olivier B., Ghavami A., The novel triple reuptake inhibitor, JZAD-IV-22, exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties. J. Pharmacol. Exp. Ther. 2010, 335, 762-770.
Zhang B., West E. J., Van K. C., Gurkoff G. G., Zhou J., Zhang X. M., Kozikowski A. P., Lyeth B. G., HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain Res. 2008, 1226, 181-191.
R. T. Olszewski, M. M. Wegorzewska, A. C. Monteiro, K. Krolikowski, J. Zhou, A. P. Kozikowski, K. Long, J. Mastropaolo, S. Deutsch, J. H. Neale, PCP and MK-801 Induced Positive and Negative Symptoms Reduced by NAAG Peptidase Inhibition via Group II Metabotropic Glutamate Receptors. Biol. Psychiatry, 2008, 63, 86-91.
T. Yamamoto, O. Saito, T. Aoe, A. Bartolozzi, J. Sarva, J. Zhou, A. Kozikowski, B. Wroblewska, T. Bzdega, J. H. Neale, Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. European J. Neurosci., 2007, 25 (1), 147-158.
B. Wang, J. Zhou, M. Lodder, R. D. Anderson, III and S. M. Hecht, Tandemly Activated tRNAs as Participants in Protein Synthesis. J. Biol. Chem., 2006, 281, 13865-13868.
J. Zhou, J. H. Neale, M. G. Pomper, A. P. Kozikowski, NAAG Peptidase Inhibitors and Their Potential for Diagnosis and Therapy. Nature Reviews Drug Discovery, 2005, 4, 1015-1026.
J. Zhou, T. Klass, K. M. Johnson, K. M. Giberson, A. P. Kozikowski, Discovery of Novel Conformationally Constrained Tropane-Based Biaryl and Arylacetylene Ligands as Potent and Selective Norepinephrine Transporter Inhibitors and Potential Antidepressants. Bioorg. Med. Chem. Lett., 2005, 15, 2461-2465.
J. Zhou, Norepinephrine Transporter Inhibitors and Their Therapeutic Potential. Drugs of the Future, 2004, 29 (12), 1235-1244.
J. Zhou, R. He, K. M. Johnson, Y. Ye, A. P. Kozikowski, Piperidine-Based Nocaine/Modafinil Hybrid Ligands as Highly Potent Monoamine Transporter Inhibitors: Efficient Drug Discovery by Rational Lead Hybridization. J. Med. Chem., 2004, 47 (24), 5821-5824.
J. Zhou, A. Zhang, T. Klass, K. M. Johnson, C. Z. Wang, Y. Ye and A. P. Kozikowski, Biaryl Analogues of Conformationally Constrained Tricyclic Tropanes as Potent and Selective Norepinephrine Reuptake Inhibitors: Synthesis and Evaluation of Their Uptake Inhibition at Monoamine Transporter Sites, J. Med. Chem., 2003, 46, 1997-2007.
R. D. Anderson, III, J. Zhou, S. M. Hecht, Fluorescence Resonance Energy Transfer between Unnatural Amino Acids in a Structurally Modified Dihydrofolate Reductase, J. Am. Chem. Soc., 2002, 124, 9674-9675.
B. Wang, M. Lodder, J. Zhou, T. T. Baird, Jr., K. C. Brown, C. S. Craik, S. M. Hecht, Chemically Mediated Site-Specific Cleavage of Proteins, J. Am. Chem. Soc., 2000, 122, 7402-7403.