Core Facilities

The department of Pharmacology and Toxicology in association with the Center for Molecular Design, through the Office of the Dean of the Medical School, have initiated the formation of the Parallel Synthesis & Medicinal Chemistry Facility (PSMCF) in September 2004.

The PSMCF serves a two-fold purpose: 1) to provide a parallel synthesis facility with expertise in the synthesis of a variety of defined small/large molecule libraries that are commercially unavailable and/or unaffordable; 2) to provide a high-throughput and reliable source of biologically active compounds to be tested thus hopefully leading to an increased output of important scientific results; use in-house medicinal chemistry expertise to make the necessary compound modifications thus improving their drug-like properties.

In order to achieve the above-defined purposes the PSMCF core utilizes state-of-the-art instrumentation as well a plethora of differently available synthetic protocols amenable to compound library generation. In some cases, however, it is anticipated the need for the development of novel protocols.

This will be done through the use of broadly existent in-house organic chemistry expertise.

Researchers interested in acquiring specific compound libraries or initiating collaborative projects please contact: