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Education
B.S. Wildlife and Fisheries Sciences, Texas
A&M
University
M.S. Wildlife and Fisheries
Sciences-Environmental Toxicology,
Texas A&M University
Ph.D. Biology, Texas Tech
University
My primary interest is in understanding
the possible impacts that environmental toxicants have on exposed
individuals and populations. This involves estimating levels of exposure,
duration of exposure, and relating endpoints of adverse outcome to those
exposures. Specifically, I am working on the genotoxicity of
environmental and occupational exposures to mutagenic and/or carcinogenic
agents. Many of these agents are essential in the production of numerous
consumer items, however ensuring the safety and health of workers remains
paramount. In addition, many compounds are environmental pollutants, and
the role that these agents might play in reducing the quality of life is
important to understand. I am particularly interested in the mutagenicity
of occupational and environmental toxicants. Techniques that I use
measure genomic damage, increases in the frequency of mutations in
particular genes, and DNA sequence analysis to characterize the precise
nature of such mutations. I am also interested in the biological and
biochemical processes by which genotoxicants are biotransformed, alter the
transcriptional, translational, and protein dynamics from homeostasis, and
the repair processes responsible for maintaining genomic integrity and
proper cellular function.
Currently, I am fortunate enough to be
supported by an NIEHS Toxicology Training Fellowship and am interacting
with a diverse faculty investigating genotoxicity and carcinogenicity in
occupationally exposed humans and transgenic mice modeling genetic
sensistivity in toxicant biotransformation and DNA repair.
Publications
Wickliffe, J. K., A. M. Bickham, B. E.
Rodgers, R. K. Chesser, S. P. Gaschak, I. Chizhevsky, J. A. Goryana, C. J.
Phillips, and R. J. Baker. Exposure to chronic, low-dose rate radiation at
Chornobyl does not induce point mutations in Big Blue mice.
Environmental and Molecular Mutagenesis 42(1):11-18.
Wickliffe, J. K.,
V. H. Lee, E. Smith, B. Tandler, and C. J. Phillips. Gene expression, cell
localization, and evolution of rodent submandibular gland androgen-binding
protein. European Journal of Morphology 40(4):257-260.
Chesser, R. K., M. Bondarkov, R. J.
Baker, J. K. Wickliffe, and B. E. Rodgers. Reconstruction of radioactive
plume characteristics along Chernobyl’s Western trace. Journal of
Environmental Radioactivity 71(2):147-157.
Wickliffe, J. K., M. M. Ammenheuser,
J. J. Salazar, S. Z. Abdel-Rahman, D. A. Hastings-Smith, E. M.
Postlethwait, R. S. Lloyd, and J. B. Ward, Jr. A model of sensitivity:
1,3-butadiene increases mutant frequencies and genomic damage in mice
lacking microsomal epoxide hydrolase activity. Environmental and
Molecular Mutagenesis 42(2):106-110.
Wickliffe, J.
K., B. E. Rodgers, R. K. Chesser, C. J. Phillips, S. P. Gaschak, and R. J.
Baker. Letter to the editor: response to Dubrova. Radiation Research
160(5):611-612.
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PMCH