Alter originally trained for a
career as a clinical nurse, but “fell in love with
epidemiology,” she said, after taking a CDC training course
in applied epidemiology as preparation for building a
hospital infection control program. That passion led her to
graduate school at Johns Hopkins University and drove her to
ignore the advice of professors who told her that at the
time—the mid-1970s—infectious-disease research was a dead
end because funding had dried up. On her own, she obtained
an FDA grant to study what was then known as “non-A, non-B
hepatitis,” and is today called hepatitis C — a
liver–destroying disease that currently affects 3.2 million
Americans and back then was spreading quietly through blood
transfusions and intravenous drug use, as well as accidental
needlesticks in health-care settings and high-risk sexual
behavior.
Alter continued her
viral hepatitis research after joining the CDC, where she
designed and carried out the first community-based study to
follow the progression of illness among people newly
infected with the hepatitis C virus. The study revealed for
the first time the chronic nature of most hepatitis C virus
infections. The author of a definitive series of
epidemiological studies on the natural history and
mechanisms of transmission of hepatitis B and C, Alter also
served as the CDC’s main liaison to national and
international groups created to deal with the problems posed
by the viruses: finding ways to screen blood supplies,
develop better diagnostic techniques, anti-viral agents and
vaccines, and both manage disease in infected people and
prevent the spread of the virus to uninfected populations.
In 2005, the American
Public Health Association recognized Alter’s achievements at
the CDC when it presented her with its John P. Snow Award
for “distinguished service to the health of the public
through contributions to epidemiology.” Alter received the
Distinguished Service Award from the American Association of
Blood Banks in 1999 and an appointment to the Senior
Biomedical Research Service at the CDC in 1997 for her
outstanding contributions to public health. Alter has also
received four James H. Nakano Citations from the CDC for
outstanding scientific papers published in 1996, 1997, 2002
and 2005, as well as the Health and Human Services
Secretary’s Award for Distinguished Service in 1998 for her
team’s investigation of a multi-state outbreak of hepatitis
A.