Karl E. Anderson, M.D., Professor and Director, Division of Human Nutrition

PMCH

Karl E. Anderson, M.D.

Professor and Director
Division of Human Nutrition, Department of Preventive Medicine and Community Health

Professor, Internal Medicine

Professor, Pharmacology and Toxicology

Education:

B. A.     The Johns Hopkins University, Baltimore, Maryland
M.D.     The Johns Hopkins University School of Medicine
             Internship and Residency, Internal Medicine,
             Vanderbilt University Hospital, Nashville, Tennessee
             Residency, Internal Medicine, The New York Hospital-Cornell Medical
             Center, New York, N. Y.
             Fellowship in Gastroenterology, The New York Hospital-Cornell
             Medical Center, New York, N. Y.

Research Interests:

His research interests include human porphyrias, especially the interaction of genetic and environmental factors and development of new treatments for these conditions. A related area of interest is effects of diet on human drug and hormone metabolism. Sources of research support have included NIH, FDA and the American Porphyria Foundation.

Active Research:

He directs the Clinical Science Program in the graduate school, which provides training and an advanced degree (PhD or MS) and to physicians and others interested in a career in clinical research. As director of the Clinical Research Education Office he oversees additional clinical research education activities on campus that are funded in part of a K30 grant (Clinical Research Curriculum Award) from NIH, for which he is PI. He is on student committees for students in this program as well as students in Human Nutrition.

As Associate Program Director of the NIH-funded General Clinical Research Center, he helps to facilitate patient-oriented research by faculty in PMCH and other departments. He maintains clinical teaching activities in the Department of Internal Medicine and its Division of Gastroenterology and Hepatology.

Selected Publications:

The following are selected from more than 160 articles, book chapter and reviews

1. Anderson KE, Goeger DE, Carson RW, Lee S-MK, Stead RB. Erythropoietin for treatment of porphyria cutanea tarda in a patient on long-term hemodialysis. New England Journal of Medicine 1990; 322:315-317.

2. Anderson KE, Spitz IM, Bardin CW, Kappas A. A GnRH analogue prevents cyclical attacks of porphyria. Archives of Internal Medicine 1990;150:1469-1474.

3. Winkler M, Anderson KE. Vampires, porphyria and the media. Perspectives in Biology and Medicine 1990; 33:598-611.

4. Anderson KE, McCleery RB, Vesell ES, Vickers FF, Kappas A. Diet and cimetidine induce comparable changes in theophylline metabolism in normal subjects. Hepatology 1991; 13:941-946.

5. Egger NG, Goeger DE, Anderson KE. Effects of chloroquine in hematoporphyrin-treated animals. Chemico-Biological Interactions 1996;102:69-78.

6. Egger NG, Schoenecker JA Jr, Gourley WK, Motamedi M, Anderson KE, Weinman SA. Photosensitization of experimental hepatocellular carcinoma after d-aminolevulinic acid. Journal of Hepatology 1997;26:913-920.

7. Sinclair PR, Gorman N, Shedlofsky SI, Honsinger C, Sinclair JF, Karagas MR, Anderson KE. Ascorbic acid deficiency in porphyria cutanea tarda. Journal of Laboratory and Clinical Medicine 1997;130:197-201.

8. Lu L-J, Cree M, Josyula S, Nagamani M, Grady JJ, Anderson KE. Increased urinary excretion of 2-hydroxyestrone but not 16a-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. Cancer Research 2000; 60:1299-1305.

9. Anderson KE, Sassa S, Bishop D, Desnick RJ. Disorders of heme biosynthesis: X-Linked sideroblastic anemia and the porphyrias. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B, Childs B, eds. The Metabolic and Molecular Basis of Inherited Disease, 8th edition. New York: McGraw-Hill Book Company, 2000: 2991-3062.

10. Egger NE, Goeger DE, Payne DA, Miskovsky EP, Weinman SA, Anderson KE. Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C and inherited uroporphyrinogen decarboxylase deficiency. Digestive Diseases and Sciences 2002; 47:419-426.

11. Anderson KE, Greenblatt D. Assessing and managing drug-nutrient interactions. Journal of the American Pharmaceutical Association 2002: 42, Suppl 1:2-3.

12. Anderson KE. The porphyrias (Chapter 11). In: Zakim D, Boyer T, eds. Hepatology, 4th edition. Philadelphia: W.B. Saunders Co., 2003:291-346.

13. Anderson, KE. The porphyrias (Chapter 223). In: L. Goldman and D. Ausiello., eds Cecil Textbook of Medicine. Philadelphia, W.B. Saunders Co., 2004: 1292-1300.

14. Akagi R, Hanafusa R, Muranaka S, Tahara T, Watanabe S, Taketani S, Anderson KE, Sassa S. Deficiencies of 5-aminolevulinate dehydratase and coproporphyrinogen oxidase in a patient with acute porphyria. Submitted.

Biography:

Dr. Anderson is a graduate of the Johns Hopkins University School of Medicine, completed his internal medicine residency at Vanderbilt University and the New York Hospital-Cornell Medical Center and postgraduate training in gastroenterology also at the New York Hospital-Cornell Medical Center. He was a member of the faculty at the Rockefeller University, Cornell University Medical College and New York Medical College before coming to UTMB in 1987.

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Last Modified: 3/17/08