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Education:
B.S. Kyungpook
National Univ., Taegu, Korea
M.S. Kansas State Univ., Manhattan,
Kansas
Ph.D. Kansas State
Univ., Manhattan, Kansas
Research Interests:
Study the effects
of heme (heme arginate or heme albumin) and tin mesoporphyrin (SnMP) drugs
on heme precursors in porphyria.
Analysis of heme
precursors, porphyrin compounds, and enzymes involved in heme pathway.
CYP2C9 phenotype based on Warfarin enantiomers.
Nutritional influences and management
in porphyria.
Active Research:
Tin mesoporphyrin and heme therapy in acute
porphyria. FDA Office of Orphan Product Development, 9/1/97 - 8/31/05
(Karl E. Anderson, PI)
Impact of CYP2C9 genotype on long-term warfarin
dose requirements. The Doris Duke Charitable Foundation, 7/1/02 - 8/31/05
(Sherif Abdel-Rahman, PI)
Selected Publications:
Lee C, Fryer BA, Fryer HC. Effect of dietary carnitine on lysine and
methionine sparing action in rats. Nutr Rept Interntl
1977;16(6):761‑768.
Ranhotra GS, Lee C, Gelroth, JA. Bioavailability of zinc in soy
forified wheat breat. Nutr Rept Interntl 1978; 18(4): 487-494
Ranhotra GS, Lee C, Gelroth, JA. Bioavailability of iron in high cellulose
bread. Cereal Chem 1979;56(3):156-158.
Ranhotra GS, Lee C, Gelroth, JA. Bioavailability of zinc in cookies
fortified with soy and zinc. Cereal Chem 1979; 56(6):552-554
Ranhotra GS, Lee C, Gelroth JA. Expanded cereal fortification:
Bioavailibility and functionality (breadmaking) of various calcium
sources. Nutr Rept Interntl 1980;22:469‑475.
Lee C. Clinical significance of dietary carnitine. J Med Tech
1985;2(8):528‑531.
Lee C. Turbidimetric assay of serum apolipoprotein B.
Clin Lab Sci
1988;1(1):48‑50.
Lee C. A competitive enzyme immunoassay for urinary albumin at low
concentration. Lab Med 1989;20(8): 564‑566.
Lee, C. A statistical estimation of sensitivity in immunochemical
assays. Clin Lab
Sci 1989;2(5):307‑309.
Lee C, Richmond SA.
Prealbumin(transthyretin) as a
biochemical marker for nutritional assessment.
TSAHP Newsletter June:4‑5, 1991.
Lee C. Data reduction of enzyme immunoassay by log‑logit curve. Lab Med
1991;22(12):877‑879.
Lee C, Richmond SA. Immunoturbidimetric assay of serum prealbumin (transthyretin)
with a centrifugal analyzer.
Clin Lab Sci
1992;5(1):44-47.
Lee C, Richmond SA, Berrett PG. Determination of serum prealbumin (transthyretin)
by competitive enzyme immunoassay. Lab Med 1992;23(7):473-476.
Lee C. Kornberg on chemistry. Clin Chem 1992;38(5):787.
Lee, C. Determination of interference using multiple regression. Lab
Med 1993;24(3):170-172.
Lee C. Enzymatic determination of L-phenylalanine in serum. Lab Med
1993;24(5):301-304.
Lee C. Urinary 6ß-hydroxycortisol in humans: analysis, biological
variations, and reference ranges. Clin Biochem 1995;28(1):49-54.
Lee C. 6b-Hydroxycortisol
interferes with immunoassay of urinary free cortisol. Clin Chem
1996;42(8):1290-1291.
Lee C,
Goeger DE. Interference of 6b-hydroxycortisol
in the quantitation of urinary free cortisol by immunoassay and its
elimination by solid phase extraction. Clin Biochem 1998;31(4):229-233.
Lee C. Antioxidant ability of caffeine and its metabolites based on the
study of oxygen-radical absorbing capacity and inhibition of LDL
peroxidation. Clin Chim Acta 2000;295:141-154.
Biography:
Dr. Lee is an Associate Professor in the Department of Preventive
Medicine and Community Health, Division of Nutrition. He teaches
GI/Nutrition as a course facilitator in the medical school and often
interacts with students about the analytical aspects of porphyrin
compounds. He oversees the operation of the Porphyria Laboratory,
which serves not only UTMB patients but also serves as an international
reference laboratory. He is a clinical chemist and works on heme
precursors, porphyrin compounds, and enzymes involved in heme pathway.
He serves currently as an Editorial Board Member of Clinica Chimica
Acta (2001 - 2004).
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PMCH