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Education:
B.S.
Pharmacy, National Taiwan University, Taiwan
Ph.D. Medicinal Chemistry, University of Michigan, Ann Arbor, Mich.
Research Interests:
Translational
preventative medical research in humans; breast cancer prevention with
particular emphasis on the role of soy diet, phytoestrogens, environmental
estrogens, phytochemicals, and nutrients on reproductive endocrine
functions and immune responses; development of biological markers in sera
and nipple aspirate fluids for detection, risk assessment and prevention
of breast cancer using state-of-the-art proteomic approaches;
investigation of factors influencing bone and breast density; metabolism
and disposition of xenobiotics, phytochemicals, and environmental
chemicals; and use of 32P-postlabeling methods to detect DNA
adducts.
Active Research:
Lu, L.J. W. Ph.D. (P.I.),
“Soybean Diets and Breast Density”, Department of Defense Breast Cancer
Research Program, DAMD17-01-1-0417 (BC004028),
$2,002,123 (direct only) or
$2,983,163 (including indirect)
(August 1, 2001 to July 31, 2005).
Lu, L‑J. W. (P.I.),
“Comparative Hormonal Effects of Animal Protein and Soy Protein.” January
31, 2002 to January 30, 2004, and AICR #01B110, $164,912
Lu, L‑J. W. (P.I.), “Mammographic Density and Soy Isoflavones.” (US
PHS 1 RO1 CA 95545-01A1), $1,418,535
(direct only), Sept. 15, 2003 to
August 31, 2007.
Yafei Huang (PI), Lu (Mentor),
“Early Markers for Breast Cancer Risk in Nipple Aspirate Fluid”,
DAMD17-BC030018-PREDOC, $29,966 per year, total for 3 years $89,898
(direct only).
Lu, L‑J. W. (P.I.),
Detection of Precarcinogenic DNA Adducts
in Tissues by 32P-Postlabeling Method (Program Resources Inc.)
$118,000.
Lu, L‑J. W. (P.I.),
“Mammographic Density and Soy Isoflavones.” (US PHS 1 RO1 CA
95545-01A1), $1,418,535 (direct only),
or $2,070,416 (including indirect), Sept. 15, 2003 to August 31, 2007.
Selected Publications:
Fortune Kohen,
Shoshana Lichter,
Batya Gayer,
Yehudith
Amir-Zaltsman, Herzl
Ben-Hur, Emily Thomas and Lee-Jane W. Lu. A non-isotopic enzyme-based
immunoassay for assessing human exposure to genistein, acceptance pending
revision, Nutrition and Cancer, 35: 96-103, 1999.
Lu, Lee-Jane W., Cree, Melanie,
Josyula Shylaja, Nagamani, Manubai, Grady, James J., and
Anderson, Karl E. Increased
Urinary Excretion of 2-Hydroxyestrone but not 16a-Hydroxyestrone
in Premenopausal Women During a Soya Diet Containing Isoflavones. Cancer
Research, 60: 1209-1305, 2000.
X. Steven Wan, Lee-Jane W. Lu, Karl, E.
Anderson, Jeffrey H. Ware and Ann R. Kennedy. Urinary Excretion of Bowman-Birk
Inhibitor in Humans after Soya Consumption as Determined by a Monoclonal
Antibody-Based Immunoassay. Cancer Epidemiology, Biomarkers & Prevention,
9: 741 – 747, 2000.
Lu, L-J. W. Lu, Anderson, K.E., Grady,
J.J., Kohen, F., and Nagamani, M. Decreased ovarian hormones but not
gonadotropins during a soya diet: implications for breast cancer
prevention. Cancer Research, 60: 4112 – 4121, 2000.
Cao, S., Hudnall, S.D., Kohen, F., and Lu, L-J.W.
Measurement of estrogen receptors in intact cells by flow cytometry.
Cytometry, 41: 109-114, 2000.
Shylaja Josyula, Lee-Jane W. Lu, James J.
Salazar, Pratibha V. Nerurkar, Ann Butler Jones, Elizabeth Snyderwine, and
Lucy M. Anderson. DNA Adducts of
2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in Fetal Tissues of Patas
Monkeys after Transplacental Exposure. Toxicol. Applied Pharmacology, 166:
151 – 160, 2000.
Lu, L-J.W., Tice,
J. and Bellino, F. Phytoestrogens and Healthy Aging: Gaps in knowledge (A
Workshop Report), Menopause, The Journal of the North American Menopause
Society. 8: 157-170, 2001.
Lu, L-J. W., Anderson, K.E., Grady, J.J.,
and Nagamani, M. Effects of an isoflavone-free soy diet on ovarian hormone
levels in premenopausal women. J Clin Endocrinol Metab. 2001;
86(7):3045-3052.
Somjen, D., Zaltsman, Y., Gayer, B.,
Kulik, T., Knoll, E., Stern, N., Lu, L.-J.W., L Toldo, L., and Kohen, F.
6-Carboxymethyl genistein: a novel selective oestrogen receptor modulator
(serum) with unique, differential effects on the vasculature, bone and
uterus J. Endocrinol., 173: 415-428, 2002.
Biography:
Dr. Lu has been
actively researching the health effects of soy in women for over 10 years.
Her current focuses are on breast cancer prevention and bone health. She
and her UTMB colleagues found that a diet with about ~15% of daily energy
replaced by soy was effective in lowering ovarian hormones in women. This
result will have a significant public health implication. Dr. Lu and her
research team is investigating the mechanisms by which soy affect breast
cancer risk markers, the effects of soy on the immune system, and the
active components in soy that may play a role in lowering breast cancer
risk markers. Dr. Lu’s is also developing protein markers in serum and
nipple aspirate fluids that may be useful for early breast cancer
detection and prevention. She also has expertise in the use of DNA adducts
as biomarkers for assessing carcinogen exposure, and she has a substantial
interest in biotransformation. Dr. Lu is a member of the Graduate School
of Biomedical Sciences and she is involved in training students in
Environmental Toxicology and Human Nutrition.
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PMCH