| |
Education:
B.A.
Ohio Wesleyan University ('54)
M.D.
Vanderbilt University School of Medicine ('58)
Intern
Ward Medicine, Barnes Hospital, Washington University ('59)
Asst Resident Ward
Medicine, Barnes Hospital, Washington University ('60)
Asst Resident
Pathology, Vanderbilt University Hospital ('61)
Research Resident Medicine, Thayer Veterans Administration Hospital
('64)
Chief Resident Medicine,
Vanderbilt University Hospital ('65)
Honors:
AFA,
Vanderbilt University School of Medicine ('58)
SC,
Vanderbilt University ('65)
Fellow, American College of Physicians
('67)
Future Leader Award, Nutrition Foundation
('68-71)
Special
Recognition, Vanderbilt University School of Medicine for research and
teaching in nutrition ('71)
Mead Johnson
Award, American Institute of Nutrition ('72)
Cosmos Club ('72)
Secretary, President Elect, & President,
American Society for Clinical Nutrition ('72-5, 81-2, 82-3)
WO Atwater Award
Medal & Lecture, U.S. Department of Agriculture ('84)
Ellen Swallow
Richards Memorial Lecture, University of North Carolina Institute of
Nutrition ('85)
Raymond Ewell
Memorial Lecture, University of Buffalo, SUNNY, School of Medicine ('85)
FASEB Wellcome
Visiting Professor in Basic Medical Science, Pennsylvania State University
('88)
Fellow, American
Society for Nutrition Sciences ('98)
President,
International Society for Trace Element Research in Humans ('02-4)
Special Recognition by USDA Agricultural Research Service for service as
Director, USDA ARS Grand Forks Human Nutrition Research Center, Grand
Forks, ND. ('03)
ISI Citation Classic ('89)
Sandstead HH, Prasad AS, Schulert AR,
Farid Z, Miale A Jr, Bassilly S, Darby
WJ. Human zinc deficiency,
endocrine manifestations, response to treatment. Am J Clin Nutr
1967;20:422-42.
ISI Citation Classic ('89).
Prasad AS, Miale A Jr, Farid Z, Sandstead
HH, and Schulert AR. Zinc metabolism in patients with syndrome of iron
deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism. J Lab
Clin Med 1963;61:537-49.
ISI Citation Classic ('92).
Sandstead HH, Zinc nutrition in the
United States. Am J Clin Nutr 1973;26:1251-60.
ISI Citation Classic ('92).
Prasad AS, Miale A Jr, Farid Z, Sandstead
HH, Schulert AR, Darby WJ. Biochemical studies on dwarfism, hypogonadism,
and anemia. Arch Int Med 1963;111:407-28.
Research Interests:
Support (past 5 years):
95-01 Principal Investigator; Repletion of iron and zinc deficiencies
improves cognition of premenopausal women. Agency: US Army Medical
Research & Development Command
97-01 Principal Investigator; Zinc Repletion on Cognition and Growth of
Mexican American Children. Agency: United States Department of Agriculture
97-01
Principal
Investigator;
Zinc or Iron Repletion on Cognition and Growth of Mexican American
Children Agency:
The Gerber
Foundation.
Publications in Peer Reviewed Journals (from 169):
Yokoi K, Alcock N, Sandstead H. Iron and zinc nutriture of
premenopausal women: associations of diet with serum ferritin and plasma
zinc disappearance, and of serum ferritin with plasma zinc and plasma zinc
disappearance. J Lab Clin Med 1994;124:852-61
Sandstead HH. Requirements and toxicity of essential trace
elements, illustrated by zinc and copper. Am
J Clin Nutr 1995;61:621S-4S.
Sandstead HH, Smith JC, Jr. Deliberations and evaluations of
approaches, endpoints and paradigms for determining zinc dietary
recommendations. J Nutr 1996;126:2410S-8S.
Sandstead HH, Penland JG, Alcock NW, Dayal HH, Chen XC, Li
JS, Zhao FJ, Yang JJ. Effects of Zinc and Other Micronutrient Repletion on
Growth and Brain Function of Chinese Children. Am J Clin Nutr
1998;68:470S-5S.
Yokoi K, Egger NG, Ramanujam VM, Alcock NW, Dayal HH,
Penland JG, Sandstead, HH. Association between plasma zinc concentration
and zinc kinetic parameters in premenopausal women. Am J Physiol
Endocrinol Metab 2003; 285: E1010-1020.
Biography:
Harold H Sandstead,
M.D., was assistant professor of biochemistry and instructor in medicine
('65-70),
and associate professor of nutrition (tenure) and instructor in
medicine ('70-1) at Vanderbilt University
School of Medicine. In '71 he
became Director, USDA Agricultural Research Service Laboratory
(later,
Human Nutrition Research Center), and adjunct professor, biochemistry and
medicine, University
of North Dakota School of Medicine, Grand Forks, ND.
He organized the research program, and
increased space to 85,000 ft2.
Facilities include basic science laboratories, a 14 bed clinical research
unit
for long-term studies, a neuropsychology laboratory, an exercise and
body composition laboratory, and
a vivarium for trace element research in
a variety of species. In '84 he became Director of the USDA
ARS Human
Nutrition Research Center for Study of Aging at Tufts University and
Professor in the School
of Nutrition. In 1985 he became Professor and
Chairman of Preventive Medicine and Community Health
at UTMB. He resigned
Chairman in 1990.
His work on zinc
began in 1961 as a member of the team that
described zinc deficiency in
Egyptian adolescents. Later in rats he described effects of zinc
deficiency on
thymidine incorporation into liver and brain DNA;
incorporation of uridine into liver RNA; polymerization
of liver RNA; and
liver and brain polysome profiles, and effects of pre and/or postnatal
zinc deficiency on
brain composition, microscopic anatomy of the
cerebellum, and later life behavior and microscopic
anatomy of
hippocampus. He studies humans at various stages of the life cycle.
Current major focus is
on neuropsychological function, the co-occurrence
of zinc and iron deficiencies, and zinc kinetics.
He works in
collaboration with scientists at UTMB, other
Universities, and at the
Grand Forks Human
Nutrition Research Center. He teaches in the Medical School and is a
member of the Graduate School.
He has served on committees of the World
Health Organization, the International Atomic Energy Agency,
the US
National Academy of Sciences, the NIH, the USDA, and various NGOs
including professional societies, The American Council on Science and
Health, and the US Pharmacopoeia.
|
PMCH