Graduate Education – Space Life Sciences
Faculty
 Harold Sandstead, M.D.
   

Title and Position

Professor (PMCH and Internal Medicine)

Address

Division of Nutrition, Preventive Medicine & Community Health

University of Texas Medical Branch

700 Harborside Drive

Galveston, TX 77555

Significant Professional Appointments and Activities

  • 1965-70        Asst Prof, Biochemistry (Nutrition); Instr Medicine, Vanderbilt U School of Medicine, Nashville, TN

  • 1970-1          Assoc Prof, Biochemistry (Nutrition) & Asst Prof, Medicine, Vanderbilt U School of Medicine, Nashville, TN

  • 1970-1          Research Assoc., John F. Kennedy Center for Research, Education & Human Development, Vanderbilt University, Nashville, TN

  • 1971-84         Director, US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND

  • 1972-84        Adjunct Prof, Biochemistry & Medicine, University of North Dakota School of     
                       Medicine, Grand Forks, ND

  • 1984-5          Director & Senior Scientist, US Department of Agriculture, Agricultural Research Service Human Nutrition Research Center on Aging, Tufts University, Boston, MA

  • 1984-5          Prof, Nutrition, Tufts U School of Nutrition, Medford, MA

  • 1985-90        Prof & Chair, Preventive Medicine Community Health, U TX Med Branch, Galveston, TX

    •

  • 1986-now      Prof, Internal Medicine, & Biochemistry & Molecular Biology, UTMB, Galveston, TX

  • 1990-now      Prof Preventive Medicine and Community Health, UTMB, Galveston, TX

Active Research

  • Current interests: Zinc requirements & bioavailability;  relationships between zinc & copper, zinc & iron, zinc & toxic metals; zinc deficiency: effects on brain, immunity, body composition, reproduction, fetal origins of adult disease

Editorial Boards

  • 1972-6; 1981-5    Journal of Nutrition

  • 1975-8                American Journal of Clinical Nutrition

  • 1978-83              Journal of Laboratory and Clinical Medicine

  • 1979-now            Biological Trace Element Research 

  • 1981-5                Nutrition Research

  • 1981-8                Nutrition Reports International

  • 1983-98              Trace Elements in Medicine and Biology

  • 1998-now            Trace Elements in Medicine and Biology (Advisory Board)

  • 1987-now            Journal of Trace Elements in Experimental Medicine

  • 1987-8                Journal of American College of Nutrition

  • 1990-4                Cancer Prevention

  • 1991-5                Nutrition, Classics Editor 

Selected Peer-Reviewed Publications (in chronological order)

  1. Prasad AS, Miale Jr A, Farid Z, Sandstead HH, Schulert AR. Zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism. J. Lab. Clin. Med. 1963; 61:537-49.

  2. Sandstead HH, Prasad AS, Schulert AR, Miale Jr. A, Bassily S, Darby W. Human zinc  deficiency, endocrine manifestations, and response to treatment. Am J Clin Nutr 1967; 20: 422-42.

  3. Sandstead HH, Shepard GH. The effect of zinc deficiency on the tensile strength of healing surgical incisions in the integument of the rat. Proc Soc Exp Biol Med 1968; 128: 687-9.

  4. Sandstead H, Rinaldi R. Impairment of deoxyribonucleic acid synthesis by dietary zinc deficiency in the rat. J Cell Physiol 1969; 73: 81-3.

  5. Sandstead HH, Stant EG, Brill AB, Arias L, Terry RT. Lead intoxication and the thyroid. AMA Arch Int Med 1969; 123: 632-5.

  6. Sandstead HH, Michelakis AM, Temple TE. Lead intoxication: its effect on the renin-aldosterone response to sodium deprivation. AMA Arch Environ Health 1970; 20: 356-63.

  7. Sandstead HH, Lanier VC, Jr., Shephard GH, Gillespie DD. Zinc and wound healing. Effects of zinc deficiency and zinc supplementation. Am J Clin Nutr 1970; 23: 514-9.

  8. Sandstead HH, Carter JP, House FR, McConnell F, Horton KB, VanderZwaag R. Nutritional deficiencies in disadvantaged preschool children and their relationship to mental development. Am J Diseases of Children 1971; 121: 455-63.

  9. Sandstead HH, Gillespie DD, Brady RN. Zinc deficiency: effect on brain of the suckling rat. Pediatr Res 1972; 6: 119-25.

  10. Brill AB, Sandstead HH, Price R, Johnson RE, Law DH, Scott HW. Changes in body composition after jejuno-ileal bypass in morbidly obese patients. Am J Surg 1972;123: 49-54.

  11. Terhune MW, Sandstead HH. Decreased RNA polymerase activity in mammalian zinc deficiency. Science 1972; 177: 68-9.

  12. VanWay CW, Meng HC, Sandstead HH. An assessment of the role of parenteral alimentation in the management of surgical patients. Ann Surg 1973;117:103-11.

  13. Lokken PM, Halas ES, Sandstead HH. Influence of zinc deficiency on behavior. Proc Soc Exp Biol Med 1973; 144: 680-2.

  14. Halas ES, Sandstead HH. Some effects of prenatal zinc deficiency on behavior of the adult rat. Ped Res 1975; 9: 94-7.

  15. Fosmire GJ, al-Ubaidi YY, Sandstead HH. Some effects of postnatal zinc deficiency on developing rat brain. Pediatr Res 1975; 9: 89-93.

  16. Halas ES, Hanlon MJ, Sandstead HH. Intra-uterine nutrition and aggression. Nature 1975; 257: 221-2.

  17. Arakawa T, Tamura T, Igarashi Y, Suzuki H, Sandstead HH. Zinc deficiency in two infants during total parenteral alimentation for diarrhea. Am J Clin Nutr 1976; 29: 197-204.

  18. Solomons NW, Layden TJ, Rosenberg IH, Vo-Khactu K, Sandstead HH. Plasma trace metals during total parenteral alimentation. Gastroenterology 1976; 70: 1022-5.

  19. Solomons NW, Rosenberg IH, Sandstead HH. Zinc nutrition in celiac sprue. Am J Clin Nutr 1976; 29: 371-5.

  20. Fosmire GJ, Fosmire MA, Sandstead HH. Zinc deficiency in the weanling rat: Effects of liver composition and polysomal profile. J Nutr 1976; 106: 1152-8.

  21. Buell SJ, Fosmire GJ, Ollerich DA, Sandstead HH. Effects of postnatal zinc deficiency on cerebellar and hippocampal development in the rat. Exp Neurol 1977; 55: 199-210.

  22. Duerre J, Ford K, Sandstead HH. Effect of zinc deficiency on protein synthesis in brain and liver of suckling rats. J Nutr 1977; 107: 1082-93.

  23. Solomons NW, Rosenberg IH, Sandstead HH, Vo-Khactu KP. Zinc deficiency in Crohn's Disease. Digestion 1977; 16: 87-95.

  24. Munoz JM, Sandstead HH, Jacob RA, Logan GM, Jr., Reck SJ, Klevay LM, Dintzis FR, Inglett GE, Shuey WC. Effects of some cereal brans and textured vegetable protein on plasma lipids. Am J Clin Nutr 1979; 32: 580-92.

  25. Munoz JM, Sandstead HH, Jacob RA. Effects of dietary fiber on glucose tolerance of normal men. Diabetes 1979; 28: 496-502.

  26. Pekarek R, Sandstead HH, Jacob R, Barcome D. Abnormal cellular immune responses during acquired zinc deficiency. Am J Clin Nutr 1979; 32: 1466-71.

  27. Klevay LM, Reck SJ, Jacob RA, Logan GM, Jr., Munoz JM, Sandstead HH. The human requirement for copper. I. Healthy men fed conventional, American diets. Am J Clin Nutr 1980; 33: 45-50.

  28. Jacob RA, Sandstead HH, Klevay LM, Johnson LK. Utility of serum ferritin as a measure of iron deficiency in normal males undergoing repetitive phlebotomy. Blood 1980; 56: 786-91.

  29. Wallwork JC, Fosmire GJ, Sandstead HH. Effect of zinc deficiency on appetite and plasma amino acid concentrations in the rat. Br J Nutr 1981; 45: 127-36.

  30. Tucker D, Sandstead HH. Spectral electroencephalographic correlates of iron status: tired blood revisited. Physiol Behavior 1981; 26: 439-49.

  31. Jacob RA, Sandstead HH, Munoz JM, Klevay LM, Milne DB. Whole body surface loss of trace metals in normal males. Am J Clin Nutr 1981; 34: 1379-83.

  32. Metcoff J, Costiloe P, Crosby W, Bentle L, Seshachalam D, Sandstead HH, Bodwell CE, Weaver F, McClain P. Maternal nutrition and fetal outcome. Am J Clin Nutr 1981; 34:708-21.

  33. Sandstead HH. Methods for determining nutrient requirements in pregnancy. Am J Clin Nutr 1981; 34:697-704.

  34. Sandstead HH, Henriksen LK, Greger JL, Prasad AS, Good RA. Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing. Am J Clin Nutr 1982;36:1046-59.

  35. Sandstead HH. Copper bioavailability, requirements. Am J Clin Nutr 1982;35:809-14.

  36. Sandstead HH, Howard L. Zinc deficiency in Crohn's disease (case presentation). Nutr Rev 1982; 40: 109-12.

  37. Lykken GI, Lukaski HC, Bolonchuk WW, Sandstead HH. Potential errors in body composition determination by whole body scintillation counting. J Lab Clin Med 1983; 101: 651-8.

  38. Milne DB, Canfield WK, Mahalko JR, Sandstead HH. Effect of dietary zinc on whole body surface loss of zinc: impact on estimation of zinc retention by balance method. Am J Clin Nutr 1983; 38: 181-6.

  39. Halas ES, Eberhardt MJ, Diers MA, Sandstead HH. Learning and memory impairment in adult rats due to severe zinc deficiency during lactation. Physiol Behav 1983; 30: 371-81.

  40. Milne DB, Johnson LK, Mahalko JR, Sandstead HH. Folate status of adult males living in a metabolic unit: possible relationships with iron nutriture. Am J Clin Nutr 1983; 37:  768-73.

  41. Greeley S, Sandstead HH. Oxidation of alanine and B-hydroxybutyrate in late gestation. J Nutr 1983; 113: 1803-10.

  42. Tucker DM, Sandstead HH, Penland JG, Dawson SL, Milne DB. Iron status and brain function: serum ferritin levels associated with asymmetries of cortical electrophysiology and cognitive performance. Am J Clin Nutr 1984; 39: 105-13.

  43. Milne DB, Canfield WK, Mahalko JR, Sandstead HH. Effect of oral folic acid supplements on zinc, copper, and iron absorption and excretion. Am J Clin Nutr 1984; 39: 535-9.

  44. Mukherjee MD, Sandstead HH, Ratnaparkhi MV, Johnson LK, Milne DB, Stelling HP. Maternal zinc, iron, folic acid, and protein nutriture and outcome of human pregnancy. Am J Clin Nutr 1984; 40: 496-507.

    45.

  45.  Lukaski HC, Bolonchuk WW, Klevay LM, Milne DB, Sandstead HH. Changes in plasma zinc content after exercise in men fed a low-zinc diet. Am J Physiol 1984; 247: E88-93.

  46. Dvergsten CL, Fosmire GJ, Ollerich DA, Sandstead HH. Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. II. Impaired maturation of Purkinje cells. Brain Res 1984; 318: 11-20.

  47. Klevay LM, Inman L, Johnson LK, Lawler M, Mahalko JR, Milne DB, Lukaski HC, Bolonchuk W, Sandstead HH. Increased cholesterol in plasma in a young man during experimental copper depletion. Metabolism 1984; 33: 1112-8.

  48. Lykken GI, Johnson PE, Mahalko J, Milne D, Sandstead H, Garcia WJ, Dintzis FR, Inglett GE. Effect of browned and unbrowned corn products intrinsically labeled with Zn on absorption of Zn in humans. J Nutr 1986; 116: 795-801.

  49. Cherry FF, Sandstead HH, Rojas P, Johnson LK, Batson HK, Wang XB. Adolescent pregnancy: associations among body weight, zinc nutriture, pregnancy outcome. Am J Clin Nutr 1989; 50: 945-54.

  50. Tucker DM, Penland JG, Sandstead HH, Milne DB, Heck DG, Klevay LM. Nutritional status and brain function in aging. Am J Clin Nutr 1990; 52: 93-102.

  51. Milne DB, Johnson P, Klevay L, Sandstead H. Effect of copper intake on balance, absorption, and status indices of copper in men. Nutr Res 1990; 10: 975-86.

  52. Sandstead HH. Zinc Deficiency: A Public Health Problem? Am J Dis Child 1991; 145:853-9.

  53. Yokoi K, Alcock N, Sandstead H. Iron and zinc nutriture of premenopausal women: associations of diet with serum ferritin and plasma zinc disappearance, and of serum ferritin with plasma zinc and plasma zinc disappearance. J Lab Clin Med 1994; 124: 852-61 (published erratum appears in J Lab Clin Med 1995;125:681).

  54. Sandstead HH. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am J Clin Nutr 1995;61:621S-4S

  55. Sandstead HH, Smith JC, Jr. Deliberations and evaluations of approaches, endpoints and paradigms for determining zinc dietary recommendations. J Nutr 1996;126:2410S-8S.

  56. Sandstead HH, Penland JG, Alcock NW, Dayal HH, Chen XC, Li JS, Zhao FJ, Yang JJ. Effects of Zinc and Other Micronutrient Repletion on Growth and Brain Function of Chinese Children. Am J Clin Nutr 1998;68:470S-5S.

    57.

  57.  Lukaski HC, Bolonchuk WW, Klevay LM, Milne, DB, Sandstead, HH. Interactions among dietary fat, mineral status, and performance of endurance athletes: a case study. Internat J Sport Nutr & Exercise Metab 2001; 11: 186-98.

  58. Yokoi K, Egger NG, Ramanujam VM, Alcock NW, Dayal HH, Penland JG, Sandstead, HH. Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women. Am J Physiol Endocrinol Metab 2003; 285: E1010-20.