Title and Position

Associate Professor (PMCH and Anesthesiology)

Address

Division of Nutrition, Preventive Medicine & Community Health

University of Texas Medical Branch

700 Harborside Drive

Galveston, TX 77555

Significant Professional Appointments and Activities

• 1980-1982 Postdoctoral Fellow, The University of Chicago, Chicago, IL

• 1982-1986 Research Associate, Unversitaet des Saarlandes, Saarbruecken, Germany

• 1996-1998 Lecturer and Adjunct Assistant Professor, Bouvé College of Pharmacy and Health Sciences, Northeastern University, Boston, MA

• 1986-2002 Assistant Professor, Harvard Medical School, Boston, MA

Active Research

• Nutritional Biochemistry, Role of Micronutrients in Degenerative Diseases, Redox Metabolism

Editorial Boards

• BioMetals

• Journal of Trace Elements in Medicine and Biology

• The Journal of Trace Elements in Experimental Medicine

Selected Peer-Reviewed Publications (in chronological order)

1. Maret, W. and Makinen, M.W. The pH Variation of Steady-State Kinetic Parameters of Site-specific Co2+-reconstituted Liver Alcohol Dehydrogenase. A Mechanistic Probe for the Assignment of Metal-Linked Ionizations. J. Biol. Chem. 266:20636-20644; 1991.

2. Edman, K. and Maret, W. Alcohol Dehydrogenase Genes: Restriction Fragment Length Polymorphisms for ADH4 and ADH5 and Construction of Haplotypes Among Different ADH Classes. Hum. Genet. 90:395-401; 1992.

3. Maret, W. Oxidative Metal Release from Metallothionein via Zinc-Thiol/Disulfide Interchange. Proc. Natl. Acad. Sci. USA 91:237-241; 1994.

4. Maret, W. Human Sorbitol Dehydrogenase - A Secondary Alcohol Dehydrogenase with Distinct Pathophysiological Roles, in: Weiner, H., Lindahl, R., Crabb, D. W., and Flynn, G. F., eds., Enzymology and Molecular Biology of Carbonyl Metabolism 6:383-393 Plenum, New York; 1996.

5. Maret, W. and Vallee, B.L. Thiolate Ligands in Metallothionein Confer Redox Activity on Zinc Clusters. Proc. Natl. Acad. Sci. USA 95:3478-3482; 1998.

6. Maret, W., Jacob, C., Vallee, B.L., and Fischer, E.H. Inhibitory Sites in Enzymes: Zinc Removal and Reactivation by Thionein. Proc. Natl. Acad. Sci. USA 96:1936-1940; 1999.

7. Maret, W. The Function of Zinc Metallothionein: A Link between Cellular Zinc and Redox State. J. Nutr. 130:1455S-1458S; 2000.

8. Maret, W., Heffron, G., Hill, H.A.O., Djuricic, D., Jiang, L-J., and Vallee, B.L. The ATP/Metallothionein Interaction: NMR and STM. Biochemistry 41:1689-1694; 2002.

9. Maret, W. Optical Methods for Measuring Zinc Binding and Release, Zinc Coordination Environments in Zinc Finger Proteins, and the Redox Sensitivity and Activity of Zinc-Bound Thiols. Methods Enzymol. 348:230-237; 2002.

10. Maret, W. Zinc and Sulfur: A Critical Biological Partnership. Biochemistry 43:3301-3309; 2004.

11. Maret, W. Protein Interface Zinc Sites: A Role of Zinc in the Supramolecular Assembly of Proteins and in Transient Protein-Protein Interactions, in: Messerschmidt, A., Bode, W., and Cygler, M., eds., Handbook of Metalloproteins, Vol. 3, pp. 432-441, John Wiley, Chichester; 2004.

12. Hong, S-H., Hao, Q., and Maret, W. Domain-specific fluorescence resonance energy transfer (FRET) sensors of metallothionein/thionein, Protein Engineering, Design, and Selection 18:255-263; 2005.