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Course Descriptions
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PATH
6012
- Research
Rotation
The purpose of this course is to provide
introductory laboratory experiences that will help students choose
their areas of specialization and assist in the selection of a
supervisory professor for their subsequent dissertation research.
A student works on an individual basis with a member of the
faculty for a term, either independently performing a short project
designed by the faculty member, or jointly working on some facet of
ongoing research. Students
do rotations in the laboratories of at least three program faculty
members.
Prerequisites: PATH
6210 and consent of instructor
Year offered:
Annually
Terms offered: I,
II, III
Hours per week:
Conference 1; Lab, up to 20
Course coordinator:
Ansari, Staff
1-6 Credits
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PATH
6097
- Research
in Pathology
This course will vary in credit according
to the work performed. The
student will concentrate on a problem of his or her own choosing with
faculty advice.
Prerequisite:
None
Year offered: Annually
Terms offered: I, II, III
Course Coordinator: Herzog, Staff
1-9 Credits
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PATH
6115
- Conferences
in Pathology
This
course requires attendance at, and participation in, weekly grand
rounds and pathology research work in progress or clinical conferences
where staff, guests from other departments, residents, postdoctoral
fellows and graduate students present current research and other
topics of interest. Bi-weekly attendance at the Classics Journal Club
(Term I only) and graduate student research presentations is also
required.
Prerequisites:
Consent of program director;
Year
offered: Annually
Terms
offered: I, II, III
Hours
per week: Conference 1
Course
Coordinator: Herzog, Staff
1
Credit
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PATH
6195
- SEMINARS
IN PATHOLOGY
This course requires attendance at, and participation in, weekly
Pathology Grand Rounds, where the staff and guests from other
departments and from other educational institutions present current
research or relevant topics of interest.
Prerequisites:
None
Year
offered: Annually
Terms
offered: I, II, III
Hours
per week: Seminar 1
Course
Coordinator: Herzog, Staff
1 Credit
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PATH
6210 - INTRODUCTION
TO RESEARCH
The
goal of this course is to introduce newly admitted students to the research
activities of individual faculty members through faculty presentations,
discussions, brief reviews of the pertinent literature, and observations of
ongoing laboratory activities. Each week students meet with faculty members and
then type a two-page report on the primary research objective and techniques
used in the faculty member’s laboratory.
These activities will help students select mentors for research rotations
and to develop the writing skills needed in the more advanced graduate courses
and throughout a career in biomedical research.
Participation in experiments will be encouraged.
Prerequisite: Consent of
instructor
Year offered:
Annually
Term offered:
1
Hours per week: Lecture
2
Course coordinators:
Ansari/Kanz
2
Credits
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PATH
6237 -
TEACHING
IN PATHOLOGY
The
goals of this course are to allow students to gain experience in teaching both
graduate and medical courses, to learn teaching skills and methods, and to
reinforce their knowledge of pathology. Students will be required to present a
seminar and to participate in teaching the Fundamentals of Pathology course
(PATH 6503) for graduate students, specifically to conduct a one-hour discussion
on a selected topic during the term. Students will also be required to assist in
at least six of the two-hour laboratories of the General Pathology Course for
second-year medical students, which are held twice weekly at the beginning of
the medical school term. In these laboratories, the student will conduct
discussions, answer questions and demonstrate specimens. The students will also
attend a one-hour session each week with the course coordinator to plan the
laboratory exercises, review material covered in the teaching exercises and
discuss teaching techniques. Grading (A,B,C,F) will be based on knowledge of
materials (20%), organization and content of seminar (20%), ability to lead
class discussions (40%), ability to interact effectively with small groups in
the lab, participation in orientation and review sessions (20%), and ability to
lead discussions, answer questions and demonstrate specimens in the laboratory.
Experimental Pathology graduate students are required to take this course once.
Prerequisites: PATH 6503, PATH 6435, consent of instructor
Year offered: Annually
Term offered:
III
Hours per week: conference or discussion: 2; Laboratory:
3
Course coordinator:
Kanz
2 Credits
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PATH
6245 -
COLLOQUIUM
OF FRONTIERS OF INFECTIOUS DISEASE AND TROPICAL MEDICINE
The
purpose of this weekly seminar course is to present to students the frontiers of
infectious diseases and tropical medicine.
Local and visiting scientists will be invited to present their most
recent work in the infectious disease and tropical medicine field. Students will
be taught at two different stages: 1) students will attend the one hour seminar;
2) after the seminar, students will write a 2 page report summarizing what they
have learned and with comments on the presentation and future research direction.
Prerequisites: Consent of
instructor
Year offered:
Annually
Term
offered: I, II
Hours per week: Seminar
2
Course coordinator: Lanzaro
2 Credits
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PATH
6311- MOLECULAR
CYTOMETRY
This
course provides an introduction to the theory and experimental methods of
molecular cytometry for single-cell molecular analysis approaches to problems in
biology and medicine. Methods
include: multicolor flow cytometry and cell sorting, image and confocal
microscopy, quantitative immunocytochemistry, molecular probes, fluorescence in-situ
hybridization and single-cell PCR techniques. Application areas include: multicolor immunophenotyping of
tumors, cell cycle, proliferation and apoptosis; chromosome structural
aberrations in disease and environmental toxicology; bone marrow transplantation
and stem cell processing. The
course is conducted as a weekly lecture and recitation/labs (with 2 exams, lab
write-ups, and a brief research topic paper on the student’s research
interests for evaluation).
Prerequisites:
Consent of instructor
Year offered:
Annually
Term
offered: I
Hours per week: Lecture
3
Course coordinator: Leary
3
Credits
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PATH
6318 - TROPICAL
DISEASES
This
course is designed to provide graduate students with an overview of tropical
diseases and related current research. The course is not designed to be
comprehensive, but will sample representatives of major infectious tropical
diseases. Emphasis will be placed
on the ecology, epidemiology and control of tropical diseases.
The class will meet twice per week for 90 minutes; each session will
include a 45 minute lecture by a faculty member, followed by the presentation of
a pertinent paper and discussion questions.
Students are expected to submit their selected reference and at least 5
discussion questions to the lecturer one week in advance.
Prerequisites: Consent of
instructor
Hours per week: Lecture
3
Year
offered: Annually
Term offered:
II
Course coordinators: Weaver,
Shope, Staff
3 Credits
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PATH
6360 - PATHOGENESIS
OF INFECTIOUS DISEASES
This
advanced course will provide an in-depth examination of representative
infectious diseases that present significant health hazard to human populations.
Subject matter will be mode of transmission, etiology of disease, including
acute and chronic manifestations; molecular mechanisms of cell injury; and
rationale behind treatment modalities. Emphasis will be given to diseases with
prototypic pathogenic mechanisms or to diseases where molecular biology or
animal models have provided major insights into the steps of pathogenesis,
including the mechanisms of cell injury. Topics will include infectious diseases
frequently found in AIDS patients (candidiasis, histoplasmosis, cytomegalovirus),
in varied populations (respiratory viral infections, aspergillosis) and
prevalent endemically in certain geographical regions (dengue fever, Lassa
fever, malaria, schistosomiasis, Rocky Mountain spotted fever). Teaching will be
accomplished through lectures, class discussions and readings in primary
literature. Grading will be based on class discussions (30%), one research paper
(30%) and student presentations of recent research papers (40%).
Prerequisites;
PATH 6503, PATH 6435;
Term offered:
II
Year offered:
Annually
Hours per week:
Lecture 1, Conference 2
Course coordinator: Barrett
3
Credits
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PATH
6398 -
THESIS
Formal
research and writing leading to the preparation and completion of the thesis for
the Master of Science degree under the direction of the student’s supervisory
committee. Grading will be based
upon the student’s level of performance as reported by the chairperson of the
student’s supervisory committee and will be assigned as satisfactory or
unsatisfactory.
Prerequisite: Admission to candidacy for the masters
degree
Term offered: I, II, III
Year offered:
Annually
Course coordinator: Herzog
3
Credits
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PATH
6399 -
Formal
research and writing leading to the preparation and completion of the
dissertation for the Doctor of Philosophy degree under the director of the
student’s supervisory committee. Grading
will be based upon the student’s level of performance as reported by the
chairperson of the student’s supervisory committee and will be assigned as
satisfactory or unsatisfactory.
Prerequisite:
Admission to candidacy for the Ph.D. degree;
Term offered: I,
II, III
Year
offered: Annually
Course Coordinator: Herzog
3
Credits
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PATH
6435 - PATHOBIOLOGY
OF HUMAN DISEASE
The
purpose of this advanced course is to analyze approximately eight representative
human diseases. Analysis of each
disease begins with a clinical presentation about the epidemiology, etiology and
pathogenesis, including gross and microscopic pathology, and major diagnostic
procedures. Recent clinical and experimental papers are critically evaluated for
information about molecular mechanisms, unknowns and potentially useful avenues
for further research. Diseases covered could include fetal alcohol syndrome,
chronic granulomatous disease, protein S deficiency, atherosclerosis,
Alzheimer’s disease, AIDS, lung cancer and hemochromatosis. Grading will be
based on contributions to class discussions (30%), assigned presentations (50%),
and a research proposal (20%). Graded A, B, C, F.
Prerequisites: PATH 6503 or
consent of instructor
Terms offered:
I
Year offered:
Annually
Hours per week:
Lecture 2, Conference 2
Course coordinator: Moslen, Staff
4
Credits
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PATH
6503 - FUNDAMENTALS
OF PATHOLOGY
The
purpose of this course is to examine the fundamental principles underlying
disease processes. The subject matter includes the basic mechanisms of cell
injury and death, immunity and inflammation, thrombosis, and neoplasia.
Pathologic mechanisms at the molecular and cellular levels are presented for the
general processes of infection, immune-mediated disease, thromboembolic disease
and atherosclerosis. The roles of genetic and environmental factors and
nutrition in disease are also discussed. The course is intended to provide the
foundation both for investigative work in the mechanisms of disease and also for
clear and effective interaction between the scientist and the clinician.
Material is presented in lectures and discussions, supplemented by assigned
readings from texts, reviews and research articles.
Grading is accomplished by midterm (25%) and final (25%) examinations,
weekly assignments (25%), and an acceptable research proposal (25%). The
research proposal should stem from some aspect of the course material and/or
research rotations and should be suitable for use as an actual plan or grant
proposal for the student’s subsequent research.
Prerequisites: CELL 6501, CELL
6502, CELL 6302 and CPMB 6501 are recommended.
Term offered:
III
Year offered:
Annually
Hours per week: Lecture 3, Conference
2
Course coordinator: Campbell,
Staff
5 Credits
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PATH
62?? - EVOLUTION
OF INFECTIOUS DISEASE
This
course is designed as an
introduction to the evolutionary biology of infectious diseases. The objectives
are: 1) to appraise the current state of our understanding of the evolution of
infectious disease, 2) to examine ways in which we may improve this
understanding and 3) to assess the prospects for applying contemporary
evolutionary theory to practical problems. The calls will meet twice per week
for one hour. Instruction will be in the form of lecture/discussion to review
the basics of evolutionary biology and population genetics and will include a 30
minute student- led discussion on a specific topic offered by the instructor,
followed by 30 minutes of discussion. Student presentations will represent 20%
of the final grade and participation in discussions 30% of the final grade. In
addition to the presentations, two examinations, a mid-term (20% of grade) and
final exam (30% of grade) will be used to evaluate student performance.
Prerequisites: Consent of instructor
Term offered:
II
Year offered:
biannually
Course coordinator: Lanzaro
2
Credits
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PATX
6000 - SPECIAL
TOPICS
Study of special topics in
Experimental Pathology. Topics are selected and study programs arranged on an
individual basis with staff member.
Prerequisites: Consent of
Instructor
Term
offered:
I, II, III
Year offered:
Annually
Hours per week:
Conference or
discussion, 2
Course Coordinator:
Staff
0-3
Credits
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