Issues in Selection of an Antidepressant

Table of Contents

1. Objectives
2. Indications
3. Antidepressant Classes
4. "Newer" Antidepressant Classes
5. Selective Serotonin Reuptake Inhibitors
6. Pharmacokinetics
   1. Protein Binding
   2. Significance of Protein Binding in Pregnancy
   3. Cytochrome P450 Effects
   4. Antidepressants with minimal CYP450 Interactions
   5. Half-Life
7. Extra Receptor Effects
8. SSRIs in Summary
9. "New" Miscellaneous Antidepressants
10. Dual Agents
11. Special Circumstances
12. A Final Note
13. Review Questions
14. Your Feedback

Pharmacokinetics

SSRIs differ from each other significantly in a variety of ways. The most clinically significant include:

• Protein Binding
• Cytochrome P450 interactions
• Half Life
• Extra Receptor Effects