Principle Investigator: George Kramer, PhD

2008-2012 :

• 1R01HL092253-01
• National Institutes of Health
• "Decision-Assist and Closed-Loop Resuscitation of Burn-Injured
  
  
  Patients"
• The major goal of this project is the development of software
  
  
  and associated hardware systems to guide and perform fluid therapy
  
  
  in critically injured patients.

2005-2008 :

• N00014-06-1-0300
• Department of the Navy, Office of Naval Research
• "Resuscitation Systems for Treatment of Hemorrhagic Shock
  
  
  Incorporating Sensors, Pumps, Displays and Control Algorithms"
• The major goal of this project is the final development and clinical testing of
  
  
  autonomous Resuscitation Systems with a goal of optimizing trauma care,
  
  
  particularly when direct medical expertise is limited or unavailable.

2005-2008 :

• #8830
• Shriners of North America
• "Enteral Resuscitation of Burn Shock"
• The major goal of this project is to evaluate the use of enteral resuscitation
  
  
  (drinking, gastric infusion and colonic infusion) for treatment of burn shock
  
  
  as compared to IV resuscitation.

Principle Investigator: Michael P. Kinsky, MD

2006-2008 :

• 0665074Y
• American Heart Association Beginning grant in aid
• "Pharmacologic modulation of fluid therapy"
• The goals of this project is to provide mechanistic and clinically relevant
  
  
  insight into the cause of rapid fluid redistribution the amount as well as
  
  
  to demonstrate how beta-adrenergic agents can influence and duration of
  
  
  vascular volume expansion after a fluid bolus. This work will provide a better
  
  
  understanding of the microcirculatory control points of fluid distribution
  
  
  and their modulation through the beta-adrenergic receptor.

2006-2008 :

• CON14876
• Foundation for Anesthesia Education Research Mentored Research
  
  
  Training Grant
• "Pharmacologic modulation of fluid therapy"
• The goals of this project is to provide mechanistic and clinically relevant
  
  
  insight into the cause of rapid fluid redistribution as well as to demonstrate
  
  
  how cardiovascular pharmacologic agents can influence the amount and
  
  
  duration of vascular volume expansion after a fluid bolus. This work will
  
  
  provide a better understanding of the microcirculatory control points of fluid
  
  
  distribution and their modulation through the beta-adrenergic receptor and
  
  
  other receptors.

2008-2010 :          Pending

• 08-001
• Department of the Navy, ONR,
• "Decision-Assist and Closed-Loop Control of Fluid Therapy"
• The major goal of this project is to advance the spiral development of
  
  
  autonomous care system for fluid therapy into the clinical aim and validate
  
  
  the proof of concept that better decision tools can achieve target blood
  
  
  pressure and normovolemia while logistically reducing volume needs in
  
  
  humans undergoing hemorrhage.

Principle Investigator: Stephen L. Hoskins, PhD

2007-2008 :

• CON17752
• Vidacare Inc.
• "The Delivery of drugs and tracers via the Intraosseous route"
• The goal of this project is to determine the pharmacokinetics of vascular
  
  
  delivery of dye tracers via humeral head intraosseous (IO) route during
  
  
  normovolemia, hypovolemia, and cardiopulmonary resuscitation (CPR).