Jianhang Jia, Ph.D.
Biochemistry & Molecular Biology
Graduate Students and Postdoc Positions are
contact Dr. Jia.
The goal of our research is to understand the
molecular mechanisms of the Hedgehog (Hh) signaling pathway, which governs the pattern
formation, cell proliferation and differentiation. Malfunction of Hh signaling pathway induces
different types of cancers in many tissues. The study in our laboratory focuses on the
components that participate in the Hh signal transduction.
consists of two transmembrane proteins, Patched (Ptc) and Smoothened (Smo), and
a zinc-finger transcription
factor, Cubitus interruptus (Ci), that transduces Hh signal into the nuclei.
Without Hh stimulation, Ptc inhibits Smo thus allowing Ci processing to generate its truncated
form which enters the nuclei and blocks downstream genes. Upon Hh stimulation, the inhibition
of Ptc on Smo is blocked and Smo transduces the Hh signal to downstream blocking Ci processing.
Full-length Ci is translocated to the nuclear and turns on downstream genes. We are
investigating the mechanism of Smo transducing Hh signal and how Hh gradient can be translated
into different thresholds of downstream gene expression.
Kazuhito Amanai, Gelin Wang, Jiong Tang, Bing Wang and Jin Jiang. Shaggy/GSK3 anatagonizes
Hedgehog signaling by regulating Cubitus interrupus. Nature 2002, 416:548-552.
Chao Tong, and Jin Jiang. Smoothened transduces Hedgehog signal by physically interacting with
Costal2/Fused complex through its carboxyl-terminal tail. Genes and Development 17:2709-2720,
Wensheng Zhang, Bing Wang, Richard Trinko and Jin Jiang. The Drosophila Ste20 family
kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting
apoptosis. Genes and Development 17:2514-2519, 2003.
Chao Tong, Bing Wang, Liping Luo
and Jin Jiang. Hedgehog signaling activity of Smoothened
requires phosphorylation by protein kinase A and casein kinase I. Nature 432:1045-1050,
Wensheng Zhang, Yun Zhao, Chao Tong, Gelin Wang, Bing Wang, Jianhang Jia, and Jin Jiang.
Hedgehog-Regulated Costal2-Kinase Complexes Control phosphorylation and Proteolytic Processing
of Cubitus Interruptus. Developmental Cell 8:267–278, 2005.
Jianhang Jia, L. Zhang,
Q. Zhang, Chao Tong, Bing Wang, F. Hou, Kazuhito Amanai, Jin Jiang. Phosphorylation by
Double-Time/CKlepsilon and CKlalpha Targets Cubitus Interruptus for Slimb/beta-TRCP-Mediated
Proteolytic Processing. Developmental Cell 9(6):819-30, 2005.
and Jin Jiang. Decoding the Hedgehog signal in animal development.
Cell. Mol. Life Sci. 63: 1249–1265, 2006.
Yajuan Liu, Xuesong Cao, Jin Jiang, and Jianhang Jia.
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and
cell-surface accumulation. Genes and Development 21(15): 1949-1963, 2007.
Hongge Jia, Yajuan Liu, Wei Yan, and Jianhang Jia. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136, 307-316, 2009.
Jianhang Jia, Ph.D.
University of Texas Medical Branch
Medical Research Building 9.138B
301 University Blvd. Route 1048
Galveston, TX 77555-1048
| Mission | Investigators
| Transgenic Mouse Facility |
PCR Core Facility |
Human Tumor Bank | Career
Funding Opportunities |
Cancer Cell Biology
Track | SCCCB Pre-doctoral Fellowship
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