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Jianhang Jia, Ph.D.

Assistant Professor
Biochemistry & Molecular Biology
email:  jijia@utmb.edu

 

Graduate Students and Postdoc Positions are available,

please contact Dr. Jia.


The goal of our research is to understand the molecular mechanisms of the Hedgehog (Hh) signaling pathway, which governs the pattern formation, cell proliferation and differentiation. Malfunction of Hh signaling pathway induces different types of cancers in many tissues. The study in our laboratory focuses on the components that participate in the Hh signal transduction.

Hh pathway consists of two transmembrane proteins, Patched (Ptc) and Smoothened (Smo), and a zinc-finger transcription factor, Cubitus interruptus (Ci), that transduces Hh signal into the nuclei. Without Hh stimulation, Ptc inhibits Smo thus allowing Ci processing to generate its truncated form which enters the nuclei and blocks downstream genes. Upon Hh stimulation, the inhibition of Ptc on Smo is blocked and Smo transduces the Hh signal to downstream blocking Ci processing. Full-length Ci is translocated to the nuclear and turns on downstream genes. We are investigating the mechanism of Smo transducing Hh signal and how Hh gradient can be translated into different thresholds of downstream gene expression.
 

Jianhang Jia, Kazuhito Amanai, Gelin Wang, Jiong Tang, Bing Wang and Jin Jiang. Shaggy/GSK3 anatagonizes Hedgehog signaling by regulating Cubitus interrupus. Nature 2002, 416:548-552.

Jianhang Jia, Chao Tong, and Jin Jiang. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its carboxyl-terminal tail. Genes and Development 17:2709-2720, 2003.

Jianhang Jia, Wensheng Zhang, Bing Wang, Richard Trinko and Jin Jiang. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes and Development 17:2514-2519, 2003.

Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang. Hedgehog signaling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432:1045-1050, 2004.

Wensheng Zhang, Yun Zhao, Chao Tong, Gelin Wang, Bing Wang, Jianhang Jia, and Jin Jiang. Hedgehog-Regulated Costal2-Kinase Complexes Control phosphorylation and Proteolytic Processing of Cubitus Interruptus. Developmental Cell 8:267278, 2005.

Jianhang Jia, L. Zhang, Q. Zhang, Chao Tong, Bing Wang, F. Hou, Kazuhito Amanai, Jin Jiang. Phosphorylation by Double-Time/CKlepsilon and CKlalpha Targets Cubitus Interruptus for Slimb/beta-TRCP-Mediated Proteolytic Processing. Developmental Cell 9(6):819-30, 2005.

Jianhang Jia and Jin Jiang. Decoding the Hedgehog signal in animal development. Cell. Mol. Life Sci. 63: 12491265, 2006.

Yajuan Liu, Xuesong Cao, Jin Jiang, and Jianhang Jia. Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes and Development 21(15): 1949-1963, 2007.

Hongge Jia, Yajuan Liu, Wei Yan, and Jianhang Jia. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136, 307-316, 2009.
 

Contact Information:
Jianhang Jia, Ph.D.
email:  jijia@utmb.edu

Tel:

(409) 772-2741

(office)

 

(409) 747-1964

(lab)

Fax:

(409) 747-1938

 


Mailing address:

University of Texas Medical Branch
Medical Research Building 9.138B
301 University Blvd. Route 1048
Galveston, TX 77555-1048

 
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  Last Revised: January 16, 2008