Sarita K. Sastry, Ph.D.
Biochemistry & Molecular Biology
Dr. Sastry received her Ph.D. in Biochemistry
from the University of Illinois at Urbana-Champaign and completed her postdoctoral training at
the University of North Carolina, Department of Cell and Developmental Biology, Lineberger
Cancer Center, Chapel Hill, NC, where where she studied the function of a protein tyrosine
phosphatase, PTP-PEST, in cytoskeletal regulation during cell motility. Aberrant cell
motility is a hallmark of tumor metastasis as well as a vital component of tumor angiogenesis.
Tyrosine kinase signaling is often upregulated in many cancers and contributes to enhanced
motility. Tyrosine phosphatases are the endogenous inhibitors of tyrosine kinases.
By studying the function, regulation, subcellular localization and intracellular substrates of
PTP-PEST and other tyrosine phosphatases during normal cell motility, we hope to gain insight
into approaches to block inappropriate motility.
Sastry SK, Horwitz AF. Integrin cytoplasmic
domains: mediators of cytoskeletal linkages and intra-and extracellular initiated transmembrane
signaling. Curr Opin Cell Biol. 5:819-831, 1993.
Sastry SK, Horwitz AF. Adhesion-growth factor
interactions during differentiation: an integrated biological response. Dev Biol
Lakonishok M, Thomas DA, Muschler JL, Horwitz AF. Integrin alpha subunit ratios,
cytoplasmic domains, and growth factor synergy regulate muscle proliferation and
differentiation. J Cell Biol 133:169-184, 1996.
Truong TQ, Sastry SK,
Lakonishok M, Horwitz AF. Integrin modulation of mitogenic pathways involved in muscle
differentiation. In Signaling Through Cell Adhesion Molecules, 1999. Ed. J.L.
Guan. CRC Press, Boca Raton, FL.
Lakonishok M, Wu S, Truong T, Huttenlocher A, Turner CE, Horwitz AF. Quantitative changes
in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J Cell Biol
Sastry SK, Burridge K. Focal adhesions: a
nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res. 261:25-36,
Cox EA, Sastry
SK, Huttenlocher A. Integrin-mediated adhesion
regulates cell polarity and membrane protrusion through the rho family of GTPases. Mol
Biol Cell 12:265-277, 2001.
Sastry SK, Lyons PD, Schaller MD, Burridge K.
PTP-PEST controls cell motility through regulation of Rac1. J Cell Sci 115:4305-4316, 2002.
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