 |
Xiaodong Cheng, Ph.D.
Associate Professor
Department of Pharmacology and Toxicology
email:
xcheng@utmb.edu |
|
The study of signal transduction provides fundamental information regarding the regulation of
biological processes that support the function of life under normal and disease states. Our
laboratory is interested in elucidating the functional roles of exchange protein directly
activated by cAMP (Epac) and cAMP-dependent protein kinase (PKA) in the overall cAMP-mediated
intracellular signaling by determining the down-stream effectors of Epac and different PKA
isoforms, as well as their mechanisms of activation. In addition, we are investigating the
complex intracellular signaling pathways important for oncogenic transformation using
genetically-defined human cancer models and functional proteomics approaches.
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Yu, S.,
Fan, F., Mei, F., and Cheng, X. Investigating the mechanism of exchange protein directly
activated by cAMP activation by FT-IR and structural modeling. Biochemistry. 45:15318-15326,
2006.
Mei, F. Young, T. W., and Cheng, X.
RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian
surface epithelial cells. FASEB J., 20:497-499, 2006.
Ji, Z., Mei, F. C.,
Johnson, B. H., Thompson, E. B., and Cheng, X. PKA, not Epac, suppresses hedgehog activity and
regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells. J. Biol. Chem.282:37370-37377,
2007.
Brock, M., Fan, F., Mei,
F., Li, S., Gessner, C., Woods Jr., V. L., and Cheng, X. Conformational analysis of Epac
activation revealed using amide
hydrogen/deuterium exchange mass spectrometry (DXMS). J. Biol. Chem. 282:32256-32263,
2007.
Cheng, X.,
Young, T. W., and Mei, F. C. Proteomics analyses of ovarian cancer using genetically defined
human ovarian cancer models. Frontiers in Bioscience. 12:5166-5176, 2007.
Young, T. W., Rosen, D.
G., Mei, F., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene
101 Conveys poor Prognosis through Suppression of p21 Expression in Ovarian Cancer. Clinical
Cancer Research. 13:3848-3854, 2007.
Ji, Z., Mei, F. C., Xie. J. and
Cheng, X. Oncogenic KRAS supresses GLI1 degradation and activates hedgehog signaling pathway in
pancreatic cancer cells. J. Biol. Chem. 282:14048-14055, 2007.
Young, T.W., Mei, F.C., Rosen, D.G., Yang, G., Li, N., Liu, J., and Cheng, X.
Up-regulation of tumor susceptibility gene 101 protein in human epithelial ovarian cancer
revealed by functional proteomics. Molecular and Cellular Proteomics. 6:294-304, 2007.
Li, J., O’Conner, K. L.,
Cheng, X., Mei, F. C., Uchida, T., Townsend, C. M., and Evers, B. M. Cyclic AMP-stimulated
neurotensin secretion is mediated through Rap1 downstream of both Epac and PKA signaling
pathways. Molecular Endocrinology. 21:159-171, 2007.
Wayne, C. W., Fan, H. Y.,
Cheng, X., and Richards, J. S. FSH induces multiple signaling cascades: evidence that
activation RAS, SRC and the EGF receptor are critical for granulosa cell differentiation.
Molecular Endocrinology. 21:1940-1957, 2007.
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