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Chunming Liu, Ph.D.
Associate Professor
Biochemistry & Molecular Biology
email:  chliu@utmb.edu

Our long-term goal is to investigate the molecular mechanisms of human cancers, and to use our knowledge of  cell signaling to develop novel methods for cancer diagnosis and therapeutics. We are particularly interested in Wnt/β-catenin signaling, which plays pivotal roles in development and tumorigenesis. β-catenin and APC (adenomatous polyposis coli) mutations are frequently found in human cancers. Our previous work provided insights into how these mutations cause β-catenin accumulation that leads to cancer (PNAS 1999; Cell, 2002; JBC 2006). We are also interested in the crosstalk between Wnt signaling and other signaling pathways. We have identified KLF4 as a novel inhibitor of b-catenin (MCB 2006). KLF4 is a tumor suppressor and a key factor for stem cell re-programming. We found that KLF4 controls transcription by regulating chromatin-remodeling (JBC 2007).  We are collaborating with clinicians and pathologists to study Wnt/β-catenin signaling in human cancers, especially GI cancers. We are collaborating with chemical biologists to develop b-catenin inhibitors. As available evidence pointed to the involvement of Wnt signaling in stem cell self-renewal, we are going to use  Wnt signaling as a molecular probe to explore the mechanism of stem cells, and to study the role of stem cell in tumorigenesis.

 

 


Graduate Students and Postdoc Positions are available,

please contact Dr. Liu.
 

 

 

Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X.  Beta-Trcp couples beta-catenin phosphorylation degradation and regulates Xenopus axis formation.  Proc Natl Acad of Sci USA 96:6273-6278, 1999.

 

Tama, K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X.  LDL-receptor-related proteins in Wnt signal transduction. Nature 407:530-535, 2000.

 

Liu C, Li Y, Semenov M, Han C, Baeg G, Tan Y, Zhang Z, Lin X, He, X.  Control of β-catenin phosphorylaton/degradation by a dual-kinase mechanism.  Cell 108:837-847, 2002.

 

Wu G, Liu C, He X. Ozz: A New Name on the Long List of β-Catenin's Nemeses. Molecular Cell 13:451-453 (review), 2004.

 

Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X.  A mechanism for Wnt co-receptor activation. Molecular Cell 13:149-156, 2004.

 

Shao J, Jung C, Liu C and Sheng H. Prostaglandin E2 stimulates the beta-catenin/TCF-dependent transcription in colon cancer. J Biol Chem 280: 26565-26572, 2005.

 

Evans PM, Liu C. SiteFind: A software tool for introducing a restriction site as a marker for successful site-directed mutagenesis. BMC Molecular Biology 6:22, 2005.

 

Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, Rychahou PG, Yang VW, He X, Evers BM and Liu C. Novel crosstalk of Krüppel-like factor 4 and b-catenin regulates normal intestinal homeostasis and tumor repression. Molecular and Cellular Biology 26: 2055-2064, 2006.

 

Yang J, Zhang W, Evans PM, Chen X, He X and Liu C. APC differentially regulates b-catenin phosphorylation and ubiquitination in colon cancer cells. J Biol Chem 281:17751-17757, 2006.

 

Zhang B, Luo S, Dong XP, Zhang X, Liu C, Luo Z, Xiong WC and Mei L. Beta-catenin regulates AChR clustering in muscle cells through interaction with rapsyn. Journal of Neuroscience 27: 3968-3973, 2007.

 

Evans PM, Zhang W, Chen X, Yang J, Bhakat K and Liu C. Krüppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem 282: 33994-34002, 2007.

Link:  Wnt Page

Software - Molecular Biology Tools

 


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