The major research focus in our
laboratory is function and regulation of protein kinases and small GTPases and their roles in
cancers. We are also conducting study of the molecular mechanism of ovarian cell transformation
and tumorgenesis using a genetically defined ovarian cancer model and functional proteomics
Dai Chung, M.D.
Our ongoing projects include (1)
characterizing expression of GRP and GRP-R in various clinical stages of neuroblastomas, (2)
determining mechanisms involved in the regulation of GRP-R gene and protein expression, and (3)
identifying the role of phosphatidylinositol 3-kinase in GRP-induced proliferation of
Jianli Dong, M.D., Ph.D.
RAS/BRAF/MEK/ERK and p16/CDK/RB signaling pathways in
cancer biology and Molecular Diagnostics.
The long-term research interest in the laboratory is to
understand precisely how AhR signaling regulates cell proliferation and apoptosis, and by
inference, identify the molecular basis for dioxin-induced toxicity.
Our research program focuses on
understanding the molecular and cellular mechanisms linking membrane trafficking with
receptor-signaling. Our goal is to identify novel targets for drug development aimed at
treating human diseases involving aberrant receptor signaling in vivo.
Mark R. Emmett, Ph.D.
Current research specializes in identification of novel therapeutic targets and biomarkers in oncology (esp. neuro-oncology).
Miriam Falzon, Ph.D.
Mark R. Hellmich, Ph.D.
My major research interest is in the elucidation of
signaling pathways regulated by heptahelical
G-protein linked peptide hormone receptors of gastrointestinal tracts, specifically those
pathways coupled to the bombesin and gastrin family of receptors.
Stanley M. Lemon, M.D.
Hepatitis A and C, infectious diseases, molecular
virology, vaccine development.
Suimin Qiu, M.D., Ph.D.
Vicente Resto, M.D., Ph.D.
Tumors that spread from their original sites to lymph
nodes are often more aggressive and least responsive to therapy. Dr. Resto is investigating how
head and neck tumors metastasize to lymph nodes. He will focus on identifying glycoproteins on
the surface of tumor cells that interact with proteins on lymphocytes (cells found in the lymph
nodes), and then determine whether expression of these glycoproteins correlates with lymph node
metastasis and clinical outcomes in patients.
Sarita K. Sastry, Ph.D.
My lab studies the role of protein tyrosine phosphatase in
controlling cell migration. My long-term goal is to understand their function and regulation
during tumor cell invasion and tumor angiogenesis.
Maki Wakamiya, Ph.D.
Transgenic Mouse Core Facility Director.