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Faculty Investigator

Dr. Sastry

Sarita K. Sastry, Ph.D.

Assistant Professor
Biochemistry & Molecular Biology
email: sasastry@utmb.edu

Dr. Sastry received her Ph.D. in Biochemistry from the University of Illinois at Urbana-Champaign and completed her postdoctoral training at the University of North Carolina, Department of Cell and Developmental Biology, Lineberger Cancer Center, Chapel Hill, NC, where where she studied the function of a protein tyrosine phosphatase, PTP-PEST, in cytoskeletal regulation during cell motility.  Aberrant cell motility is a hallmark of tumor metastasis as well as a vital component of tumor angiogenesis.  Tyrosine kinase signaling is often upregulated in many cancers and contributes to enhanced motility.  Tyrosine phosphatases are the endogenous inhibitors of tyrosine kinases.  By studying the function, regulation, subcellular localization and intracellular substrates of PTP-PEST and other tyrosine phosphatases during normal cell motility, we hope to gain insight into approaches to block inappropriate motility.

Selected Publications

Sastry SK, Horwitz AF.  Integrin cytoplasmic domains: mediators of cytoskeletal linkages and intra-and extracellular initiated transmembrane signaling. Curr Opin Cell Biol. 5:819-831, 1993.

Sastry SK, Horwitz AF.  Adhesion-growth factor interactions during differentiation: an integrated biological response.  Dev Biol 180:455-467, 1996.

Sastry SK, Lakonishok M, Thomas DA, Muschler JL, Horwitz AF.  Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation. J Cell Biol 133:169-184, 1996.

Truong TQ, Sastry SK, Lakonishok M, Horwitz AF.  Integrin modulation of mitogenic pathways involved in muscle differentiation.  In Signaling Through Cell Adhesion Molecules, 1999. Ed. J.L. Guan. CRC Press, Boca Raton, FL.

Sastry SK, Lakonishok M, Wu S, Truong T, Huttenlocher A, Turner CE, Horwitz AF.  Quantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal. J Cell Biol 144:1295-1309, 1999.

Sastry SK, Burridge K.  Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.  Exp Cell Res. 261:25-36, 2000.

Cox EA, Sastry SK, Huttenlocher A.  Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the rho family of GTPases.  Mol Biol Cell 12:265-277, 2001.

Sastry SK, Lyons PD, Schaller MD, Burridge K.  PTP-PEST controls cell motility through regulation of Rac1. J Cell Sci 115:4305-4316, 2002.

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