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Faculty Investigator

Dr. Cheng

Xiaodong Cheng, Ph.D.

Professor
Department of Pharmacology and Toxicology
email: xcheng@utmb.edu

The study of signal transduction provides fundamental information regarding the regulation of biological processes that support the function of life under normal and disease states. Our laboratory is interested in elucidating the functional roles of exchange protein directly activated by cAMP (Epac) and cAMP-dependent protein kinase (PKA) in the overall cAMP-mediated intracellular signaling by determining the down-stream effectors of Epac and different PKA isoforms, as well as their mechanisms of activation. In addition, we are investigating the complex intracellular signaling pathways important for oncogenic transformation using genetically-defined human cancer models and functional proteomics approaches.

Dr. Cheng's Lab

Selected Publications

Ji, Z., Mei, F. C., Johnson, B. H., Thompson, E. B., and Cheng, X. PKA, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells. J. Biol. Chem.282:37370-37377, 2007.

Brock, M., Fan, F., Mei, F., Li, S., Gessner, C., Woods Jr., V. L., and Cheng, X. Conformational analysis of Epac activation revealed using amide hydrogen/deuterium exchange mass spectrometry (DXMS). J. Biol. Chem. 282:32256-32263, 2007.

Cheng, X., Young, T. W., and Mei, F. C. Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models. Frontiers in Bioscience. 12:5166-5176, 2007.

Young, T. W., Rosen, D. G., Mei, F., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene 101 Conveys poor Prognosis through Suppression of p21 Expression in Ovarian Cancer. Clinical Cancer Research. 13:3848-3854, 2007.

Ji, Z., Mei, F. C., Xie. J. and Cheng, X. Oncogenic KRAS supresses GLI1 degradation and activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 282:14048-14055, 2007.

Young, T.W., Mei, F.C., Rosen, D.G., Yang, G., Li, N., Liu, J., and Cheng, X. Up-regulation of tumor susceptibility gene 101 protein in human epithelial ovarian cancer revealed by functional proteomics. Molecular and Cellular Proteomics. 6:294-304, 2007.

Li, J., O’Conner, K. L., Cheng, X., Mei, F. C., Uchida, T., Townsend, C. M., and Evers, B. M. Cyclic AMP-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and PKA signaling pathways. Molecular Endocrinology. 21:159-171, 2007.

Wayne, C. W., Fan, H. Y., Cheng, X., and Richards, J. S. FSH induces multiple signaling cascades: evidence that activation RAS, SRC and the EGF receptor are critical for granulosa cell differentiation. Molecular Endocrinology. 21:1940-1957, 2007.

Cheng, X. Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes. Science Signaling. 1:pe14, 2008.

 Ji, Z., Mei, F. C., Miller, A. L., Thompson, E. B., and Cheng, X. Protein kinase A (PKA) isoform RIIβ mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. J. Biol. Chem. 283:21920-21925, 2008.

 Cheng, X., Ji, Z., Tsalkova, T., and Mei, F. C. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochimica et Biophysica Sinica. 40:651-662, 2008.

 Ji, Z., Mei, F. C., Lory, P. L., Gilbertson, S. R., Chen, Y., and Cheng, X. Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer. Frontiers in Bioscience. 14:2904-2910, 2009.

 Tsalkova, T., Blumenthal D. R., Mei, F. C., and Cheng, X. Mechanism of Epac activation: Structural and functional analyses of Epac2 hinge mutants with Constitutive and reduced activities.  J. Biol. Chem. 284:23644-23651, 2009.

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