Faculty Investigator

Jianli Dong, M.D., Ph.D.

Associate Professor
Department of Pathology
email: jidong@utmb.edu

(1) RAS/BRAF/MEK/ERK and p16/CDK/RB signaling pathways in cancer biology. Study the roles and interactions of aberrant RAS/BRAF/MEK/ERK and p16/CDK/RB signaling pathways in cancer cells. (2) Molecular Diagnostics. Research and development of molecular diagnostic test in clinical application.

Selected Publications

Dong J, Asa SL, Drucker DJ. Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. Mol Endocrinol. 5:1633-1641, 1991.

Dong J, Strome R, Hung LH, Krause HM. A phosphorylation site in the Ftz homeodomain is required for activity. EMBO J. 17:2308-2318, 1998.

Drean BS, Nasiadka A, Dong J., Krause HM. Dynamic changes in the functions of odd-skipped during early Drosophila embryogenesis. Development 125:4851-4861, 1998.

Dong J,  Krause HM. Tissue-specific requirements for a phosphorylation site in the Fushi tarazu homeodomain. Dev Genes Evol 209:427-431, 1999.

Dong J, Gailani MR, Pomeroy SL, Reardon D, Bale AE. Identification of PATCHED mutations in medulloblastomas by direct sequencing. Hum Mutat 16:89-90, 2000.

Dong J, Katz DR, Eng CM, Kornreich R, Desnick RJ. Non-radioactive detection of the common Connexin 26 167delT and 35delG mutations and frequencies among Ashkenazi Jews. Mol Genet Metab 73:160-163, 2001.

Edelmann L, Dong J,  Desnick RJ, Kornreich R. Carrier screening for mucolipidosis type IV in the American Ashkenazi Jewish population. Am J Hum Genet 70:1023-1027, 2002.

Dong J, Edelman L, Bajwa AM, Kornreich R, Desnick RJ. Familial dysautonomia: detection of the IKAP^IVS20+6T®C and R696P mutations and frequencies among Ashkenazi Jews. Am J Med Genet 110:253-257, 2002.

Krasilnikov M, Ivanov VN, Dong J, Ronai Z.  ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications regarding sensitization of melanoma to apoptosis. Oncogene 22:4092-4101, 2003.

Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z, Aaronson SA. BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 63:3883-3885, 2003.

Manfredi JJ, Dong J, Liu WJ, Resnick-Silverman L, Qiao R, Chahinian P, Saric M, Gibbs AR, Phillips JI, Murray J, Axten CW, Nolan RP, Aaronson SA. Evidence against a role for SV40 in human mesothelioma. Cancer Res. 65:2602-260, 2005.

Rotolo S, Diotti R, Gordon RE, Qiao RF, Phelps RG, Dong, J. Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells. Int J Cancer 115:164-16, 2005.