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Mark R. Hellmich, Ph.D.
Department of Surgery
My major research
interest is in the elucidation of signaling pathways regulated by heptahelical G-protein linked
peptide hormone receptors of gastrointestinal (GI) tract, specifically those pathways coupled
to the bombesin and CCK/gastrin family of receptors. Currently, my research activities
are focused on: 1) defining the role of these peptide hormones and their receptors in
regulating the interactions between epithelial and stromal cells during GI carcinogenesis, 2)
define the mechanism by which mitogen activated protein kinases regulate peptide
hormone-mediated release of intracellular Ca2+ from intracellular stores, and 3)
characterizing the effects of intron 4 retention on the function of a novel splice-variant of
the gastrin/CCK2 receptor expressed in esophageal, pancreatic and colorectal
Levine L, Lucci JA 3rd, Pazdrak B, Cheng JZ,
Guo YS, Townsend CM Jr, Hellmich MR. Bombesin stimulates nuclear factor kappa B
activation and expression of proangiogenic factors in prostate cancer cells. Cancer
Levine L, Licci JA 3rd, Townsend CM Jr, Hellmich MR. Expression of gastrin-releasing
peptide receptors in endometrial cancer. J Am Coll Surg.19:898-904, 2003.
Olszewska-Pazdrak B, Townsend CM Jr, Hellmich MR. Agonist-independent activation of Src
tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. J Biol Chem.
Olszewska-Pazdrak B, Ives KL, Park J, Townsend CM Jr, Hellmich MR. Epidermal growth
factor potentiates cholecystokinin/gastrin receptor-mediated Ca2+ release by activation of
mitogen-activated protein kinases. J Biol Chem. 279:1853-60, 2004.
Chao C, Ives KL, Goluszko E,
Kolokoltsov AA, Davey RA, Townsend CM Jr, Hellmich MR. Src regulates constitutive
internalization and rapid resensitization of a CCK2 receptor splice variant. J Biol
Chem, 280:33368-33373, 2005.
Chao C, Tallman ML, Ives KL, Townsend CM Jr, Hellmich MR.
Gastrointestinal hormone receptors in primary human colorectal carcinomas. J Surg Res,
Chao C, Goluszko E, Lee
Y-T, Kolokoltsov A A, Davey R A, Uchida T, Townsend Jr. C M, Hellmich MR. Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1α expression
and tumor growth. Oncogene, 26:1013-1019, 2007.
Hellmich MR and Evers BM. Regulation of Gastrointestinal Normal Cell Growth. In:
Physiology of the Gastrointestinal Tract 4th Ed. 2006, pp 435-458, Leonard R.
Johnson (ed). Elsevier Academic Press, Burlington, MA USA.
Chao C, Hellmich MR. CCK2 receptor splice variants
in human gastrointestinal cancers, In Alternative Splicing in Cancer. 2006, pp 21-44,
ISBN:81-7895-235-1, Julian P Venables (ed). Transworld Research Network, Kerala, India.