Real-Time PCR Core Facility

Jinyi Shao, Sean B. Lee, Huiping Guo, B. Mark Evers and Hongmiao Sheng. Prostaglandin E2 Stimulates the Growth of Colon Cancer Cells via Induction of Amphiregulin. Cancer Research  63:5218-5223, 2003.

John A Copland, Bruce A Luxon, Laila Ajani, Tapati Maity, Erica Campagnaro, Huiping Guo, Shauna N LeGrand, Pheroze Tamboli and Christopher G Wood. Genomic profiling identifies alterations in TGF signaling through loss of TGF receptor expression in human renal cell carcinogenesis and progression. Oncogene 22:6109-6118, 2003.

Wangsheng Yu, Nicole R. Murray, Capella Weems, Lu Chen, Huiping Guo , Richard Ethridge, Jeffrey D. Ceci, B. Mark Evers, E. Aubrey Thompson, and Alan P.Fields. Role of Cyclooxygenase 2 in Protein Kinase C II-mediated Colon Carcinogenesis. J. Biol. Chem. 278:11167-11174, 2003.

Chen L. Finnerty C. Gustafson WC. Bush CR. Chi P. Guo H. Luxon B. Fields AP. Thompson EA. Genomic analysis of glucocorticoid-regulated promoters in murine T-lymphoma cells.  Recent Progress in Hormone Research 58:155-74, 2003.

Bhakat KK. Izumi T. Yang SH. Hazra TK. Mitra S. Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. [Journal Article] EMBO Journal. 22:6299-309, 2003.

Athar M. Li C. Tang X. Chi S. Zhang X. Kim AL. Tyring SK. Kopelovich L. Hebert J. Epstein EH Jr. Bickers DR. Xie J. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. [Journal Article] Cancer Research. 64(20):7545-52, 2004 Oct 15.

Sheng T. Li C. Zhang X. Chi S. He N. Chen K. McCormick F. Gatalica Z. Xie J. Activation of the hedgehog pathway in advanced prostate cancer. [Journal Article] Molecular Cancer. 3:29, 2004 Oct 13.

Kim S, Domon-Dell C, Kang J, Chung DH, Freund J-N and Evers BM.  Down-regulation of the tumor suppressor PTEN by the TNFa/NIK/NF-kB pathway is linked to a default IkB-a autoregulatory loop. J. Biol. Chem 279:4285-4291, 2004.

Clay Gustafson, Sutapa Ray, Lee Jamieson, E. Aubrey Thompson, Allan R. Brasier, and Alan P. Fields. Bcr-Abl Regulates Protein Kinase C (PKC). Transcription via an Elk1 Site in the PKC Promoter J. Biol. Chem., Vol. 279, Issue 10, 9400-9408, March 5, 2004.

K. Chad Lambert, Edward M. Curran , Barbara M. Judy, Gregg N. Milligan, Dennis B. Lubahn^,and D. Mark Estes.The Journal of Immunology, 2005, 175: 5716-5723.

He N. Li C. Zhang X. Sheng T. Chi S. Chen K. Wang Q. Vertrees R. Logrono R. Xie J. Regulation of lung cancer cell growth and invasiveness by beta-TRCP. [Journal Article] Molecular Carcinogenesis. 42(1):18-28, 2005 Jan.

Chen M. O'Connor KL. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. [Journal Article] Oncogene. 24(32):5125-30, 2005 Jul 28.

Patrick B. Li J. Jeyabal PV. Reddy PM. Yang Y. Sharma R. Sinha M. Luxon B. Zimniak P. Awasthi S. Awasthi YC. Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression. [Journal Article] Biochemical & Biophysical Research Communications. 334(2):425-32, 2005 Aug 26.

Xiaoli Ma , Kai Chen , Shuhong Huang, Xiaoli Zhang,  Patrick A. Adegboyega, B.Mark Evers, Hongwei Zhang and Jingwu Xie. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.  Carcinogenesis 2005 26(10):1698-1705; doi:10.1093/carcin/bgi130.

Bing Tian, David E. Nowak, Mohammad Jamaluddin, Shaofei Wang, and Allan R. Brasier. Identification of Direct Genomic Targets Downstream of the Nuclear Factor-кB Transcription Factor Mediating Tumor Necrosis Factor Signaling. J. Biol. Chem. 280:17435-17448, 2005.

Tian B. Nowak DE. Brasier AR. A TNF-induced gene expression program under oscillatory NF-kappaB control. [Journal Article] BMC Genomics. 6:137, 2005.

Gan HT. Chen JD. Roles of nitric oxide and prostaglandins in pathogenesis of delayed colonic transit after burn injury in rats. [Journal Article] American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 288(5):R1316-24, 2005 May.

Tseng CT. Tseng J. Perrone L. Worthy M. Popov V. Peters CJ. Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. [Journal Article] Journal of Virology. 79(15):9470-9, 2005 Aug.

Tseng CT. Perrone LA. Zhu H. Makino S. Peters CJ. Severe acute respiratory syndrome and the innate immune responses: modulation of effector cell function without productive infection. [Journal Article] Journal of Immunology. 174(12):7977-85, 2005 Jun 15.

Shi XZ. Sarna SK. Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cells. [Journal Article] American Journal of Physiology - Gastrointestinal & Liver Physiology. 289(2):G274-84, 2005 Aug.

Shi XZ. Pazdrak K. Saada N. Dai B. Palade P. Sarna SK. Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB. [Journal Article]Gastroenterology. 2005 Nov;129(5):1518-32.

Beswick EJ. Das S. Pinchuk IV. Adegboyega P. Suarez G. Yamaoka Y. Reyes VE. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. [Journal Article] Journal of Immunology. 175(1):171-6, 2005 Jul 1.

Jamaluddin M. Choudhary S. Wang S. Casola A. Huda R. Garofalo RP. Ray S. Brasier AR. Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. [Journal Article] Journal of Virology. 79(24):15302-13, 2005 Dec.

Wataru Kamitani, Krishna Narayanan, Cheng Huang, Kumari Lokugamage, Tetsuro Ikegami, Naoto Ito, Hideyuki Kubo, and Shinji Makino. Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation  PNAS 2006 103: 12885-12890.

Das S. Suarez G. Beswick EJ. Sierra JC. Graham DY. Reyes VE. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. [Journal Article] Journal of Immunology. 176(5):3000-9, 2006 Mar 1.

Ma X. Sheng T. Zhang Y. Zhang X. He J. Huang S. Chen K. Sultz J. Adegboyega PA. Zhang H. Xie J. Hedgehog signaling is activated in subsets of esophageal cancers. [Journal Article] International Journal of Cancer. 118(1):139-48, 2006 Jan 1 .

Shuhong Huang, Yuehong Bian, Ling Yang, Guorui Xie, Kefei Zhang, Wendell Tang, Arwen A. Stelter, Qian Wang, Hongwei Zhang and Jingwu Xie. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006 27(7):1334-1340; doi:10.1093/carcin/bgi378.

Khoa A. Nguyen, PhD, Yanna Cao, MD, Justin R. Chen, Courtney M. Townsend, Jr, MD, and Tien C. Ko, MD. Dietary Fiber Enhances a Tumor Suppressor Signaling Pathway in the Gut. Ann Surg. 2006 May; 243(5): 619–627.

Yanna Cao, Lu Chen, Weili Zhang, Yan Liu, Harry T. Papaconstantinou, Craig R. Bush, Courtney M. Townsend, Jr., E. Aubrey Thompson, and Tien C. Ko. Identification of kapoptotic genes mediating transforming growth factor (TGF)-beta/Smad3-induced cell death in intestal epithelial cells using a genomic approach. Am J Physiol Gastrointest Liver Physiol (August 10, 2006).

Mitchell KA. Lockhart CA. Huang G. Elferink CJ. Sustained aryl hydrocarbon receptor activity attenuates liver regeneration. [Journal Article] Molecular Pharmacology. 70(1):163-70, 2006 Jul.

Xiaoli Shen, Miriam Falzon. PTH-related protein upregulates integrin Alpha6Beta4 expression and activates Akt in breast cancer cells. Experimental Cell Research.

Shen X, Evers BM, Falzon M. Increased cell survival, migration, invasion and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines.  Regulatory Peptides 141:61-72, 2007.

Zihong Chen, Yann Benureau, Rene Rijnbrand, Jianzhong Yi, Ting Wang, Lucile Warter, Robert E. Lanford, Steven A. Weinman, Stanley M. Lemon, Annette Martin, and Kui Li.  GB Virus B Disrupts RIG-I Signaling by NS3/4A-Mediated Cleavage of the Adaptor Protein MAVS Journal of Virology, January 2007, p. 964-976, Vol. 81, No. 2.

Zhenyu Ji, Fang C. Mei, Jingwu Xie, and Xiaodong Cheng. Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells. J. Biol. Chem., Vol. 282, Issue 19, 14048-14055, May 11, 2007.

Travis W. Young, Fang C. Mei, Daniel G. Rosen, Gong Yang, Nan Li, Jinsong Liu and Xiaodong Cheng. Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses. Molecular & Cellular Proteomics 6:294-304, 2007.

Zihong Chen, Rene Rijnbrand, Rohit K. Jangra, Santhana G. Devaraj, Lin Qu, Yinghong Ma, Stanley M. Lemon, Kui Li. Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus. Virology. 2007 May 23.

Beswick, E.J., I. V. Pinchuk, S. Das, and V.E. Reyes.  B7-H1 expression on gastric epithelial cells induces development of T regulatory cells during Helicobacter pylori infection. J. Immunology. 178:43-52, 2007.

Kang J, Ishola TA, Baregamian N, Mourot JM, Rychahou PG, Evers BM, Chung DH. Bombesin induces angiogenesis and neuroblastoma growth.  Cancer Letters (Epub ahead of print), 2007.

Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus. Virology, Volume 366, Issue 2, 30 September 2007, Pages 277-292.

Zihong Chen, Rene Rijnbrand, Rohit K. Jangra, Santhana G. Devaraj, Lin Qu, Yinghong Ma, Stanley M. Lemon and Kui Li. MECHANISMS OF SIGNAL TRANSDUCTION:
Santhana G. Devaraj, Nan Wang, Zhongbin Chen, Zihong Chen, Monica Tseng, Naina Barretto, Rongtuan Lin, Clarence J. Peters, Chien-Te K. Tseng, Susan C. Baker, and Kui Li. Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus.  J. Biol. Chem., Nov 2007; 282: 32208 - 32221; doi:10.1074/jbc.M704870200.

Cancer Lett. 2007 Oct 25; [Epub ahead of print]PTHrP increases xenograft growth and promotes integrin alpha6beta4 expression and Akt activation in colon cancer.Shen X, Rychahou PG, Evers BM, Falzon M.

Steroids. 2007 Dec;72(14):930-8. Epub 2007 Aug 15. PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3).Shen X, Mula RV, Li J, Weigel NL, Falzon M.

Jing Li, L. Andy Chen, Courtney M. Townsend ., Jr, and B. Mark Evers. PKD1, PKD2 and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line.  J. Biol. Chem., Nov 2007; doi:10.1074/jbc.M707513200.