UTMB Pepper OAIC Publication - Current Cycle

P30 AG024832 – Volpi (UTMB) 2010-current

Year 6 (2010-11)

• Al Snih, Soham; Graham, James E; Kuo, Yong-Fang; Goodwin, James S; Markides, Kyriakos S; Ottenbacher, Kenneth J Obesity and disability: relation among older adults living in Latin America and the Caribbean. American Journal of Epidemiology. 2010 Jun 15; 171 (12) :1282-8.
• Anderson, J.F., Siller, E. and Barral, J.M. The Sacsin Repeating Region (SRR): A Novel Hsp90-Related Supra-Domain Associated with Neurodegeneration. J. Mol. Biol. 400:655-674 (2010).
• Anderson, J.F., Siller, E. and Barral, J.M. Disorders of Protein Biogenesis and Stability. Protein Pept. Lett. 18:110 (2011).
• Baillargeon J, Kuo YF, Lin Y, Raji MA, Singh A, Goodwin JS. Effect of Mental Disorders on Diagnosis, Treatment, and Survival of Older Patients with Colon Cancer. J Am Geriatr Soc, in press.
• Beard, Holly A; Markides, Kyriakos S; Al Ghatrif, Majd; Kuo, Yong-Fang; Raji, Mukaila A. Trends in diabetes medication use and prevalence of geriatric syndromes in older Mexican Americans from 1993/1994 to 2004/2005. The Annals of Pharmacotherapy. 2010 Sep; 44 (9) :1376-83
• Bindewas S, Al Snin S, Grady J, Protas EJ, Graham J, Markides K, Ottenbacher K. Evidence of Reduced Health-Related Quality of Life in Older Mexican Americans with Arthritis. Ethnicity & Disease. Accepted for publication
• Dickinson, J.M., M.J. Drummond, C.S. Fry, D.K. Walker, D.M. Gundermann, K.L. Timmerman, E. Volpi, B.B. Rasmussen. mTORC1 activation is necessary for the stimulation of human skeletal muscle protein synthesis following ingestion of essential amino acids. Journal of Nutrition. [Under Review.
• Dreyer, H C; Fujita, S; Glynn, E L; Drummond, M J; Volpi, E; Rasmussen, B B Resistance exercise increases leg muscle protein synthesis and mTOR signalling independent of sex. Acta Physiologica (Oxford, England). 2010 May; 199 (1) :71-81
• Drummond, Micah J; Glynn, Erin L; Fry, Christopher S; Timmerman, Kyle L; Volpi, Elena; Rasmussen, Blake B. An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 2010 May; 298 (5) :E1011-8
• Drummond, M.J. Perspective: MicroRNAs and Exercise-Induced Skeletal Muscle Adaptations. Journal of Physiology, 588 (Pt. 20): 3849-3850, 2010.
• Drummond, M.J., J.J. McCarthy, E. Volpi, K.A. Esser, and B.B. Rasmussen. Aging and MicroRNA Expression in Human Skeletal Muscle: A Microarray and Bioinformatics Analysis. Physiological Genomics. [In Press], 2010.
• Drummond, M. J., R. K. Conlee, G. Mack, S. Sudweeks, G. Bruce Schaalje, A. C. Parcell. Myogenic regulatory factor response to resistance exercise volume in skeletal muscle. European Journal of Applied Physiology, 108: 771-778, 2010.
• Drummond, M.J., E.L. Glynn, C.S. Fry, K.L. Timmerman, J.M. Dickinson, D. Walker, D. Gundermann, E. Volpi, and B.B. Rasmussen. Amino acid transporter expression is increased in the skeletal muscle of young and older humans following resistance exercise. Journal of Applied Physiology. [Under Review]
• Durham, William J; Casperson, Shanon L; Dillon, Edgar L; Keske, Michelle A; Paddon-Jones, Douglas; Sanford, Arthur P; Hickner, Robert C; Grady, James J; Sheffield-Moore, Melinda. Age-related anabolic resistance after endurance-type exercise in healthy humans. The Faseb Journal: Official Publication of the Federation of American Societies For Experimental Biology. 2010 Oct; 24 (10):4117-27.
• Fisher SR, Goodwin JS, Kuo Y-F, Graham JE, Ottenbacher KJ, Ostir GV. Ambulatory activity of older adults hospitalized with acute medical illness. J Am Geriatr Soc. 2011;59:91-95.
• Fisher SR, Kuo YF, Graham JE, Ottenbacher KJ, Letter in Reply to "In-hospital Mobility and Length of stay". Arch Intern Med. 2011; in press.
• Fisher SR, Kuo YF, Graham JE, Ottenbacher KJ, Ostir GV. Early ambulation and length of stay in older adults hospitalized for acute illness. Arch Intern Med. 2010;170:1942-1943.
• Fisher SR, Goodwin JS, Kuo Y-F, Graham JE, Ottenbacher KJ, Ostir GV. Factors that differentiate level of ambulation in hospitalized older adults. . [Under Review]
• Fisher SR, Goodwin JS, Kuo Y-F, Graham JE, Ottenbacher KJ, Ostir GV. Ambulatory Activity and Falls among Hospitalized Older Adults. . [Under Review]
• Fletcher KE, Sharma G, Zhang DD, Kuo YF, Goodwin JS. The Decline of Inpatient Continuity of Care. J. Hospital Med, in press.
• Fry, Christopher S; Glynn, Erin L; Drummond, Micah J; Timmerman, Kyle L; Fujita, Satoshi; Abe, Takashi; Dhanani, Shaheen; Volpi, Elena; Rasmussen, Blake B. Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. Journal of Applied Physiology (Bethesda, Md. 1985). 2010 May; 108 (5) :1199-20.
• Fry, C.S., E.L. Glynn, M.J. Drummond, K.L. Timmerman, S. Fujita, T. Abe, Y. Sato, S. Dhanani, E. Volpi, and B.B. Rasmussen. Effects of resistance exercise with blood flow restriction on muscle protein synthesis and mTORC1 signaling in older men. Journal of Applied Physiology. 108: 1199-1209, 2010.
• Fry, C.S., M.J. Drummond, E.L. Glynn, J.M. Dickinson, D.M. Gundermann, K.L. Timmerman, S. Dhanani, E. Volpi, and B.B. Rasmussen. Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skeletal Muscle. [In Press], 2011.
• Glynn, Erin L; Fry, Christopher S; Drummond, Micah J; Dreyer, Hans C; Dhanani, Shaheen; Volpi, Elena; Rasmussen, Blake B Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2010 Aug; 299 (2):R533-40
• Glynn, E.L., C.S. Fry, M.J. Drummond, K.L. Timmerman, S. Dhanani, E. Volpi, and B.B. Rasmussen. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. Journal of Nutrition. 140: 1970-1976, 2010.
• Goodwin JS, Asrabadi A, Howrey B, Giordano S, Kuo YF. Multiple measurement of serum lipids in the elderly. Med Care 2011 Feb: 49(2):225-30.
• Graham JE, Fisher SR, Ottenbacher KJ, Ostir GV. Walking speed threshold for classifying walking independence in hospitalized older adults. J Phys Ther, 2010;Aug
• Howrey B, Kuo YF, Goodwin JS. Association of care by hospitalists on discharge destination and 30 day outcomes following acute ischemic stroke. Medical Care, in press.
• Kuo, Yong-Fang; Goodwin, James S. Effect of hospitalists on length of stay in the medicare population: variation according to hospital and patient characteristics. Journal of The American Geriatrics Society. 2010 Sep; 58 (9) :1649-57
• Kuo Y, Goodwin JS. Association of hospitalist care with medical utilization after discharge: evidence or cost shifting. Ann Intern Med, in press.
• Liu H, Chen SE, Jin B, Carson JA, Niu A, Durham W, Lai JY, Li YP. TIMP3: a physiological regulator of adult myogenesis. J Cell Sci. 2010 Sep 1;123(Pt 17):2914-21
• Phillips MD, Flynn MG, McFarlin BK, Stewart LK, Timmerman KL (2010). Resistance training at eight-repetition maximum reduces the inflammatory milieu in elderly women. Med Sci Sports Exerc: 42(2): 314-25.
• Sharma, Gulshan; Kuo, Yong-Fang; Freeman, Jean L; Zhang, Dong D; Outpatient follow-up visit and 30-day emergency department visit and readmission in patients hospitalized for chronic obstructive pulmonary disease. Archives of Internal Medicine. 2010 Oct 11; 170 (18) :1664-7.
• Siller, E., DeZwaan, D.C., Anderson, J.F., Freeman, B.C. and Barral, J.M. Slowing bacterial translation speed enhances eukaryotic protein folding efficiency. J. Mol. Biol. 396:1310-1308 (2010).
• Starr, Marlene E; Ueda, Junji; Takahashi, Hitoshi; Weiler, Hartmut; Esmon, Charles T; Evers, B Mark; Saito, Hiroshi Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. Blood. 2010 Jun 10; 115 (23) :4886-93
• Stieren, E.S., El Ayadi, A.; Xiao, Y. Landsverk, M.L. Oberhauser, A.F.; Barral, J.M. and Boehning, D. Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein. Hum. Mol. Genet. Revision under review.
• Szczesny, Bartosz; Tann, Anne W; Mitra, Sankar. Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mechanisms Of Ageing And Development. 2010 May; 131 (5) :330-7
• Timmerman KL, Dhanani S, Glynn EL, Fry CS, Drummond MJ, Rasmussen BB, Volpi E. A single bout of aerobic exercise restores the anabolic effect of mixed meal feeding in older adults. In Preparation for American Journal of Clinical Nutrition.
• Timmerman, Kyle L; Lee, Jessica L; Dreyer, Hans C; Dhanani, Shaheen; Glynn, Erin L; Fry, Christopher S; Drummond, Micah J; Sheffield-Moore, Melinda; Rasmussen, Blake B; Volpi, Elena. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. The Journal of Clinical Endocrinology And Metabolism. 2010 Aug; 95 (8) :3848-57
• Timmerman, K.L., J.L. Lee, S. Fujita, S. Dhanani, H.C. Dreyer, C.S. Fry, M.J. Drummond, M. Sheffield-Moore, B.B. Rasmussen, E. Volpi. Pharmacological vasodilation improves the anabolic response of muscle proteins to insulin in older adults. Diabetes. 59:2764-2771, 2010.
• Walker, D.K., J.M. Dickinson, K.L. Timmerman, M.J. Drummond, P.T. Reidy, C.S. Fry, D.M. Gundermann, B.B. Rasmussen. Cellular mechanisms regulating human muscle protein synthesis: effects of exercise, nutrition and aging. Exercise and Sport Sciences Reviews. [Under Review]
• Wilkinson GS, Baillergeon J, Freeman JL, Kuo YF, Goodwin JS. Atrial fibrillation and stroke associated with intravenous bisphosphonate therapy in cancer patients. J Clin Oncol 2010 Nov; 28(33):4873-6.

UTMB Pepper OAIC Publication - 2nd Cycle

P30 AG024832 - Goodwin (UTMB)

Year 1 (2005)

• Al Snih S., Fisher M.N., Raji M.A., Markides K.S., Ostir G.V., Goodwin J.S. Diabetes mellitus and incidence of lower body disability among older Mexican Americans. Journal of Gerontology: Medical Sciences, 2005. 60(9):1152-6.
• Al Snih S., Raji M.A., Markides K.S., Ottenbacher K.J., Goodwin J.S. Weight change and lower body disability in older Mexican Americans. Journal of the American Geriatrics Society, 2005; 53(10):1730-7.
• Al Snih S., Raji M.A., Peek M.K., Ottenbacher K.J. Pain, lower-extremity muscle strength, and physical function among older Mexican Americans. Archives of Physical Medical Rehabilitation, 2005; 86(7):1394-400.
• Dreyer H.C. and Volpi E. Role of protein and amino acids in the pathophysiology and treatment of sarcopenia. Journal of the American College of Nutrition, 2005; 24(2):140S-145S.
• Katsanos, C.S., Chinkes, D.L., Sheffield-Moore, M., Aarsland, A.A., Kobayashi, H. and Wolfe, R.R. Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations. Am. J. Physiol. Endocrinol. Metab., 2005; 289(6), E1064-E1070.
• Katsanos, C.S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A.A. and Wolfe, R.R. Aging is associated with diminished accretion of muscle proteins following the ingestion of a small bolus of essential amino acids. Am. J. Clin. Nutr., 2005; 82(5), 1065-1073.
• Ottenbacher K.J., Ostir G.V., Peek M.K., Snih S.A., Raji M.A., Markides K.S. Frailty in older Mexican Americans. Journal of the American Geriatrics Society, 2005; 53(9):1524-31.
• Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Aarsland, A., Wolfe, R.R. and Ferrando, A. A. The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation. J. Clin. Endocrinol. Metab., 2005; 90(3), 1453-1459.
• Paddon-Jones, D., Sheffield-Moore, M., Aarsland, A., Wolfe, R.R., Ferrando, A.A. Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion. Am. J. Physiol. Endocrinol. Metab., 2005; 288(4), E761-767.
• Paddon-Jones, D., Sheffield-Moore, M., Zhang X.J, Katsanos, C.S., Wolfe, R.R. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Experimental Gerontology, Nov. 22, 2005.
• Paddon-Jones, D. Inactivity and muscle loss: nutritional countermeasures. Recent Advances in Nutritional Sciences. Journal of Nutrition, 2005. Invited reviewer.
• Paddon-Jones, D., Sheffield-Moore M. Anabolic agents and muscle protein synthesis. European Journal of Sports Science, 2005. Invited Reviewer.
• Papaconstantinou J, DeFord JH, Gerstner A, Hsieh CC, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE. Hepatic gene and protein expression of primary components of the IGF-1 axis in long lived Snell dwarf Mice. Mech Ageing Dev. 2005; 126:692-704.
• Peek MK, Patel KV, Ottenbacher KJ. Expanding the disablement process model among older Mexican Americans. J Gerontol A Biol Sci Med Sci. 2005 Mar;60(3):334-9.
• Protas E.J., Williams A, Qureshy H, Caroline K, Lai E. Gait and step training to reduce falls in Parkinson's disease. Neurorehabilitation 2005; 20(3):183-190.
• Protas EJ: Cardiovascular and pulmonary changes with aging. In Frownfelter D, Dean E (Ed): Principles and Practice of Cardiopulmonary Physical Therapy. Chicago, IL: Mosby Yearbook Publishers, 4th edition, 2005.
• Raji M.A., Kuo Y.F., Al Snih S., Sharaf B.M., and Loera J.A. Ethnic differences in herbs and vitamins/minerals use in the elderly. Annals of Pharmacotherapy, 2005; 39: 10.1345.
• Raji M.A., Kuo Y.F., Snih S.A., Markides K.S., Peek M.K., Ottenbacher K.J. Cognitive status, muscle strength, and subsequent disability in older Mexican Americans. Journal of the American Geriatrics Society, 2005; 53(9):1462-8.
• Reyes-Ortiz C.A., Kuo Y.F., DiNuzzo A.R., Ray L.A., Raji M.A., and Markides K.S. Near vision impairment predicts incident cognitive impairment in older Mexican Americans. Journal of the American Geriatrics Society, 2005; 53:681-6.
• Sheffield-Moore M, Paddon-Jones D, Cree MG, Lackan DW, and Urban RJ. Effect of Androgens on Muscle, Bone and Hair in Men. In: Aging Men's Health, R.S. Tan, Thieme Medical Publishers, New York; 2005: 83-93.
• Sheffield-Moore, M., Paddon-Jones, D., Sanford, A. P., Rosenblatt, J. I., Matlock, A. G., Cree, M. G. and Wolfe R. R. Mixed muscle and hepatic-derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise. Am. J. Physiol. Endocrinol. Metab., 2005; 288(5), E922-929.
• Veldhuis, J.D., Roemmich, J.N., Richmond, E.J., Rogol, A.D., Lovejoy, J.C., Sheffield-Moore, M., Mauras, N. and Bowers, C.Y. Endocrine control of body composition in infancy, childhood, and puberty. Endocrine Reviews, 2005; 26(1), 114-146.
• Wang CY, Olson S, Protas EJ. Physical performance tests to evaluate mobility disability in community-dwelling elders. J Physical Activity & Aging. 2005; 13:184-197

Year 2 (2006)

• Al Snih S., Ray L., Markides K.S. Prevalence of self-reported arthritis among elders from Latin America and the Caribbean and among Mexican Americans from the southwestern United States. J Aging Health. 2006 Apr;18(2):207-23.
• Al Snih S., Markides K.S., Ray L.A., Freeman J.L., Ostir G.V., Goodwin J.S. Predictors of healthcare utilization among older Mexican Americans. Ethn Dis. Summer 2006; 16(3):640-6.
• Soham Al Snih Kenneth J. Ottenbacher K.J., Markides K.S., Kuo, Y-F, Eschbach K, Goodwin JS. The Impact of Obesity on Disability versus Mortality in Older Americans. Arch. Internal Med. In press.
• Bacsi A., Woodberry M., Widger W., Papaconstantinou J., Mitra S, Peterson J.W., Boldogh I. Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion 2006; 6, 235-244.
• Børsheim E., Kobayashi H., Traber D.L., R.R. Wolfe. Compartmental distribution of amino acids during hemodialysis induced hypoaminoacidemia. Am J Physiol Endocrinol Metab 2006; 290: E643-E652.
• Børsheim E., Kien L.C. & Pearl W.M. Differential effects of dietary intake of palmitic acid and oleic acid on oxygen consumption during and after exercise. Metabolism 2006; 55(9): 1215-21.
• Børsheim E., Q-U.T. Bui Q-U.T., Wolfe R.R. Plasma amino acid concentrations during late rehabilitation in patients with traumatic brain injury. Arch Phys Med Rehabil. 2007; 88(2):234-8.
• Boylston W.H., DeFord J.H., Papaconstantinou J. Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. Age 2006; 28, 125-144.
• Dreyer H.C., Fujita S., Cadenas J.G., Volpi E., Rasmussen B.B. Resistance exercise increases AMPK activity and inhibits translation initiation and protein synthesis in human muscle. J Physiol. 2006; 576:613-24.
• Fujita S., Rasmmussen B.B., Cadenas J.G., Volpi E. The effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab 2006; 291:E745-E754.
• Fujita S and Volpi E. Amino Acids and Muscle Loss with Aging. American Society for Nutrition J. Nutr. 2006 Jan;136:277S-280S.
• Hsieh C-C., Papaconstantinou J. Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J. 2006; 20, 259-268.
• Paddon-Jones, D. Interplay of stress and physical inactivity on muscle loss: nutritional countermeasures. Recent Advances in Nutritional Sciences. J. Nutr. 2006 Aug; 136(8):2123-6.
• Rasmussen B.B., Fujita S, Wolfe R.R., Mittendorfer B., Roy M., Rowe V.L., Volpi E. Insulin resistance of muscle protein metabolism in aging. FASEB J 2006; 20:768-769.
• Sheffield-Moore M., Paddon Jones D., Casperson S., Gilkison C.R., Volpi E., Wolf S.L., Jiang J., Rosenblatt J., Urban R.J. Androgen therapy induces muscle protein anabolism in older women. J Clin Endocrinol Metab. 2006; 91:3844-3849.
• Sun D., Cree M.G. Zhang X-J, Børsheim E.,Wolfe R.R. Measurement of stable isotopic enrichment and concentration of long chain fatty acyl-carnitines in tissue by ion-pairing HPLC/MS. J Lipid Research 2006; 47(2):431-439.
• Wolfe RR. The underappreciated role of muscle in health and disease. Am J Clin Nutr. 2006 Sep;84(3):475-82.
• Wolfe RR. Optimal nutrition, exercise, and hormonal therapy promote muscle anabolism in the elderly. J Am Coll Surg. 2006 Jan;202(1):176-80.

Year 3 (2007)

• Al Snih S. Ottenbacher KS. Markides KS. Kuo YF. Eschbach K. Goodwin JS. The effect of obesity on disability vs. mortality in older Americans. Archives of Internal Medicine. 2007;167(8):774-780. PMID:17452539
• Børsheim E. Bui Q-UT. Wolfe RR. Plasma amino acid concentrations during late rehabilitation in patients with traumatic brain injury. Archives of Physical Medicine and Rehabilitation. 2007;88(2):234-8. PMID:17270522
• Choksi KB. Nuss JE. Boylston WH. Rabek JP. Papaconstantinou J. Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes. Free Radical Biology & Medicine. 2007;43:1423-38. PMID:17936188
• Choksi KB. Jackson Roberts L. DeFord JH. Rabek JP. Papaconstantinou J. Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice: A possible mechanism of resistance to oxidative stress and longevity. Biochemical and Biophysical Research Communications. 2007;364:761-4. PMID:17964285
• Cree MG. Newcomer BR. Read LK. Sheffield-Moore M. Paddon-Jones D. Chinkes D. Aarsland A. Wolfe RR. Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment. Mechanisms of Ageing and Development. 2007 Oct;128(10):558-65. PMID:17904198
• Dillon EL. Volpi E. Wolfe RR. Sinha S. Sanford AP. Arrastia CD. Urban RJ. Casperson SL. Paddon-Jones D. Sheffield-Moore M. Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy. Clinical Nutrition. 2007 Dec;26(6):736-43. PMID:17804123
• Eschbach K. Stimpson JP. Kuo YF. Goodwin JS. Mortality of foreign-born and U.S.-born Hispanic adults at younger ages: a re-examination of recent patterns. American Journal of Public Health. 2007;97(7):1297-304. PMID:17538049
• Fitts RH. Romatowski JG. Peters JR. Paddon-Jones D. Wolfe RR. Ferrando AA. The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation. American Journal of Physiology - Cell Physiology. 2007 Jul;293(1):C313-20. PMID:17569770
• Fujita S. Rasmussen BB. Bell JA. Cadenas JG. Volpi E. Muscle intracellular amino acid kinetics in women and men. American Journal of Physiology - Endocrinology & Metabolism. 2007;292:77-83. PMID:16896165
• Fujita S. Abe T. Drummond MJ. Cadenas JG. Dreyer HC. Sato Y. Volpi E. Rasmussen BB. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. Journal of Applied Physiology. 2007 Sept;103(3):903-10. PMID:17569779
• Fujita S. Dreyer HC. Drummond MJ. Glynn EL. Cadenas JG. Yoshizawa F. Volpi E. Rasmussen BB. Nutrient signalling in the regulation of human muscle protein synthesis. Journal of Physiology. 2007;582(Pt 2):813-23. PMID:17478528
• Fujita S. Rasmussen BB. Cadenas JG. Drummond MJ. Glynn EL. Sattler FR. Volpi E. 2007. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007 Jun;56(6):1615-22. PMID:17351147
• Goodwin JS. Nguyen T. Kuo YF. Ottenbacher K. Epidemiology of Medicare abuse: the power wheelchair epidemic. Journal of the American Geriatric Society. 2007; 55(2):221-6. PMID: 17302658
• Jensky. NE. JK Sims. JC Rice. HC Dreyer. ET Schroeder. The influence of eccentric exercise on mRNA gene expression of skeletal muscle regulators. European Journal of Applied Physiology. 2007 Nov;101(4):473-80. PMID:17661068
• Kaushik VP. Al Snih S. Raji MA. Markides KS. Goodwin JS. Factors associated with seven-year incidence of diabetes complications among older Mexican Americans. Gerontology. 2007;53:194-9. PMID: 17337900
• Killewich LA. Tuvdendorj D. Bahadorani J. Hunter GC. Wolfe RR. Amino acids stimulate leg muscle protein synthesis in peripheral arterial disease. Journal of Vascular Surgery. 2007 Mar;45(3):554-9. PMID:17321342
• Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA. 2007 Apr 25;297(16):1772-4. PMID: 17456818
• Nguyen-Oghalai TU. Ottenbacher KJ. Caban M. Granger CV. Grecula M. Goodwin JS. The impact of rheumatoid arthritis on rehabilitation outcomes after lower extremity arthroplasty. Journal of Clinical Rheumatology. 2007 Oct;13(5):247-50. PMID:17921790
• Norberg Å. Hahn RG. Li H. Olsson J. Prough DS. Børsheim E. Wolf S. Minton RK. Svensén CH. Population volume kinetics predicts retention of 0.9% saline infused in awake and isoflurane anesthetized volunteers. Anesthesiology. 2007;107(1):24-32. PMID:17585212
• Nuss JE. Choksi KB. DeFord JH. Papaconstantinou J. Increased Endogenous oxidation of resident endoplasmic reticulum proteins, protein disulfide isomerase and BiP results in decreased chaperone-related enzymatic activities in aged mouse livers. Biochemical and Biophysical Research Communications. 2007;365(2):355-61. PMID:17996725
• Ostir GV. Kuo YF. Berges IM. Markides KS. Ottenbacher KJ. Measures of lower body function and risk of mortality over 7 years of follow-up. American Journal of Epidemiology. 2007 Sep 1;166(5):599-605. PMID:17566063
• Ottenbacher KJ. Graham JE. The state-of-the-science: access to postacute care rehabilitation services. A review. Archives of Physical Medicine and Rehabilitation. 2007 Nov;88(11):1513-21 PMID: 17964898
• Papaconstantinou J. Biological theories of aging. In Encyclopedia of Health & Aging. Ed. Markides K. Sage Publications. Thousand Oaks. CA. 2007;74-7.
• Protas EJ. Raines ML. Tissier S. Comparison of spatiotemporal and energy cost of the use of 3 different walkers and unassisted walking in older adults. Archives of Physical Medicine and Rehabilitation. 2007 Jun;88(6):768-73. PMID:17532900
• Raji MA. Reyes-Ortiz CA. Kuo YF. Markides KS. Ottenbacher KJ. Depressive symptoms and cognitive change in older Mexican Americans. Journal of Geriatric Psychiatry and Neurology. 2007 Sep;20(3):145-52. PMID:17712098
• Stowe RP. Kozlova EV. Yetman DL. Walling DM. Goodwin JS. Glaser R. Chronic herpesvirus reactivation occurs in aging. Experimental Gerontology. 2007;42(6):563-70. PMID: 17337145
• Symons TB. Schutzler SE. Cocke TL. Chinkes DL. Wolfe RR. Paddon-Jones D. 2007. Aging does not impair the anabolic response to a protein-rich meal. American Journal of Clinical Nutrition. 86(2):451-6. PMID:17684218
• Uchakin PN. Stowe RP. Paddon-Jones D. Tobin BW. Ferrando AA. Wolfe RR. Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Aviation, Space, and Environmental Medicine. 2007 Jun;78(6):608-12. PMID :17571663

Year 4-5 (2008 - 2009) For Pepper Renewal

• Børsheim E. Bui QU. Tissier S. Kobayashi H. Ferrando AA. Wolfe RR. Effect of amino acid supplementation on muscle mass, strength and physical function in elderly. Clinical Nutrition. 2008 Apr;27(2):189-95. PMID:18294740
• Børsheim E. Bui QU. Tissier S. Cree MG. Rønsen O. Morio B. Ferrando AA. Kobayashi H. Newcomer BR. Wolfe RR. Amino acid supplementation decreases plasma and liver triacylglycerols in elderly. Nutrition. In press 2008 Nov 26. PMID:19041223
• Bergés IM. Kuo YF. Ostir GV. Granger CV. Graham JE. Ottenbacher KJ. Gender and ethnic differences in rehabilitation outcomes after hip-replacement surgery. American Journal of Physical Medicine and Rehabilitation. 2008 July 87(7):567-72. PMID:18574348
• 83. Choksi KB. Nuss JE. Papaconstantinou J. Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes. Free Radical Biology & Medicine. 2008 Sept;45:826-38. PMID:18598756
• Choksi BK. Papaconstantinou J. Age-related alterations in oxidatively damaged proteins of mouse heart mitochondriaol electron transport chain complexes. Free Radical Biology & Medicine. 2008 May;44(10):1795-805. PMID: 18331850
• DeFord JH. Choksi KB. Bailey CE. Nuss JE. Tjernlund D. Horton TE. Papaconstantinou J. High-Throughput Liquid-Liquid Fractionation of Multiple Protein Post-Translational modifications. Journal of Proteome Research. 2009;8(2):907-16.
• Dillon EL. Janghorbani M. Angel JA. Casperson SL. Grady JJ. Urban RJ. Volpi E. Sheffield-Moore M. A novel non-invasive breath test method for screening persons at risk for diabetes. Diabetes Care. 2008 Dec 15. dc08-1578v1-0; PMID 19074994
• Dillon EL, Sheffield-Moore M, Paddon-Jones D, Gilkison C, Sanford AP, Casperson SL, Jiang J, Chinkes DL, Urban RJ. Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and IGF-1 Expression in Older Women. J Clin Endocrinol Metab. 2009 Feb 10. [Epub ahead of print]. PMID: 19208731
• Dreyer HC. Drummond MJ. Pennings B. Fujita S. Glynn EL. Chinkes DL. Dhanani S. Volpi E. Rasmussen BB. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. American Journal of Physiology - Endocrinology & Metabolism. 2008 Feb;294(2):E392-400. PMID:18056791
• Dreyer HC. Drummond MJ. Glynn EL. Fujita S. Volpi E. Rasmussen BB. Resistance exercise increases human skeletal muscle AS160/TBC1D4 phosphorylation in association with enhanced leg glucose uptake during postexercise recovery. Journal of Applied Physiology. 2008;105:1967-74. PMID:18845784
• Dreyer HC. Glynn EL. Lujan HL. Fry CS. DiCarlo SE. Rasmussen BB. Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway. Journal of Applied Physiology. 2008 Jan 104(1):27-33. PMID:17885021
• Drummond MJ. Bell JA. Fujita S. Dreyer HC. Glynn EL. Volpi E. Rasmussen BB. 2008. Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle. Clinical Nutrition. 2008 June 27(3):447-56. PMID:18342407
• Drummond MJ. Dreyer HC. Pennings B. Fry CS. Dhanani S. Dillon EL. Sheffield-Moore M. Volpi E. Rasmussen BB. 2008. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. Journal of Applied Physiology. 2008 May 104(5):1452-61. PMID:18323467
• Drummond MJ. Fujita S. Takashi A. Dreyer HC. Volpi E. Rasmussen BB. Human muscle gene expression following resistance exercise and blood flow restriction. Medicine & Science in Sports & Exercise. 2008 April 40(4):691-8. PMID:18317375
• Drummond MJ. Rasmussen BB. Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Current Opinion in Clinical Nutrition and Metabolic Care. 2008 May 11(3):222-6. PMID:18403916
• Drummond MJ. Miyazaki M. Dreyer HC. Pennings B. Volpi E. Esser KA. Rasmussen BB. Expression of growth-related genes in young and old human muscle following an acute stimulation of protein synthesis. Journal of Applied Physiology. 2008 Sept 11. PMID:18787087
• Drummond MJ. McCarthy JJ. Fry CS. Esser KA. Rasmussen BB. Aging differentially affects human skeletal muscle microRNA expression at rest and following resistance exercise and essential amino acid ingestion. American Journal of Physiology - Endocrinology & Metabolism. 2008;295:E1333-40. PMID:18827171
• Drummond MJ. Glynn EL. Lujan HL. Dicarlo SE. Rasmussen BB. Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle. Muscle & Nerve. 2008 April 37(4):505-13. PMID:18236467
• Drummond. MJ. Dreyer HC. Fry CS. Glynn EL. Rasmussen BB. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. Journal of Applied Physiology. 2009 Jan 15. PMID:19150856
• Drummond MJ. Fry CS. Glynn EL. Dreyer HC. Dhanani S. Timmerman KL. Volpi E. Rasmussen BB. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. Journal of Physiology. Feb. 2. 2009. PMID:19188252
• Durham WJ, Dillon EL, Sheffield-Moore M. Inflammatory burden and amino acid metabolism in cancer cachexia. Curr Opin Clin Nutr Metab Care. 2009 Jan;12(1):72-7. PMID: 19057191
• Fujita S. Dreyer HC. Drummond MJ. Glynn EL. Volpi E. Rasmussen BB. Essential amino acid and carbohydrate ingestion prior to resistance exercise does not enhance post-exercise muscle protein synthesis. Journal of Applied Physiology. 2008 Jun 5. PMID:18535123
• Glynn EL. Lujan HL. Kramer VJ. Drummond MJ. DiCarlo SE. Rasmussen BB. A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. Applied Physiology, Nutrition, and Metabolism. 2008 Feb 33(1):93-101. PMID:18347658
• Graham JE. Chang PF. Bergés IM. Granger CV. Ottenbacher KJ. Race/ethnicity and outcomes following inpatient rehabilitation for hip fracture. Journal of Gerontology A: Medical Sciences. 2008 Aug 63(8):860-6. PMID: 18772475
• Graham JE. Ostir GV. Fisher SR. Ottenbacher KJ. Assessing walking speed in clinical research: a systematic review. The Journal of Evaluation in Clinical Practice. 2008 Aug 14(4):552-62. PMID:18462283
• Graham JE. Ostir GV. Kuo YF. Fisher SR. Ottenbacher KJ. Relationship between test methodology and mean velocity in timed walk tests: a review. Archives of Physical Medicine and Rehabilitation. 2008 May 89(5):865-72. PMID:18452733
• Katsanos CS. Chinkes DL. Paddon-Jones D. Zhang XJ. Aarsland A. Wolfe RR. Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutrition Research. 2008 Oct 28(10):651-8. PMID:19083472
• Ketchandji M. Kuo YF. Shahinian V. Goodwin JS. Cause of death in older men after the diagnosis of prostate cancer. Journal of the American Geriatric Society. 2009;57:24-30. PMID:19054189
• Kortebein P. Symons TB. Ferrando A. Paddon-Jones D. Ronsen O. Protas E. Conger S. Lombeida J. Wolfe R. Evans WJ. Functional impact of 10 days of bed rest in healthy older adults. Journal of Gerontology A: Medical Sciences. 2008 Oct 63(10):1076-81. PMID:18948558
• Kuo YF. Sharma G. Freeman JL. Goodwin JS. Growth of general internal medicine hospitalists caring for older patients at 5771 US hospitals. New England Journal of Medicine. 2008. in press.
• Lackan N. Goodwin JS. Ethnic differences in in-hospital place of death among older adults in California: effects of individual and contextual characteristics and medical resource supply. Medical Care. 2008. in press. PMID:19169113
• Nguyen-Oghalai TU. Wu H. McNearney TA. Granger CV. Ottenbacher KJ. Functional outcome after stroke in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis and Rheumatology. 2008 Jul 15;59(7):984-8. PMID:18576291
• Nguyen-Oghalai TU. Kuo YF. Zhang DD. Graham JE. Goodwin JS. Ottenbacher KJ. Discharge setting for patients with hip fracture: trends from 2001 to 2005. Journal of the American Geriatric Society. 2008 Jun;56(6):1063-8. PMID: 18422950
• Nuss JE. Choksi BK. Deford JH. Papaconstantinou J. 2008. Decreased enzyme activities of chaperones pdi and bip in aged mouse livers. Biochemical and Biophysical Research Communications. 2008 Jan;365(2):355-61. PMID:17996725
• Ostir GV. Berges IM. Ottenbacher ME. Clow A. Ottenbacher KJ. Associations between positive emotion and recovery of functional status following stroke. Psychosomatic Medicine. 2008 May;70(4):404-9. PMID:18434490
• Ostir GV. Berges I. Ottenbacher M. Graham JE. Ottenbacher KJ. Positive emotion following a stroke. Journal of Rehabilitation Medicine. 2008 Jun;40(6):477-81. PMID:18509564
• Ottenbacher KJ. Campbell J. Kuo YF. Deutsch A. Ostir GV. Granger CV. Racial and ethnic differences in post acute rehabilitation outcomes after stroke in the United States. Stroke. 2008 May;39(5):1514-9. PMID:18340094
• Paddon-Jones D. Short KR. Campbell WW. Volpi E. Wolfe RR. Role of dietary protein in the sarcopenia of aging. American Journal of Clinical Nutrition. 2008 May;87(5):S1562-6. PMID:18469288
• Paddon-Jones D. Westman E. Mattes RD. Wolfe RR. Astrup A. Westerterp-Plantenga M. 2008. Protein, weight management, and satiety. American Journal of Clinical Nutrition. 2008 May;87(5):S1558-61. PMID:18469287
• Paddon-Jones D. Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Current Opinion in Clinical Nutrition and Metabolic Care. 2009 Jan;12(1):86-90. PMID:19057193
• Papaconstantinou J. Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Molecular and Cellular Endocrinology. 2009 Feb 5;299(1):89-100. PMID:19103250
• Raji MA. Kuo YF. Freeman JL. Goodwin JS. Effect of a dementia diagnosis on survival of older patients after a diagnosis of breast, colon, or prostate cancer. Archives of Internal Medicine. 2008;168(18):2033-40. PMID:18852406
• Rasmussen BB. Richter EA. The balancing act between protein synthesis and breakdown: exercise as a model to understand the molecular mechanisms regulating muscle mass. Journal of Applied Physiology. ePub ahead of print Jan. 29. 2009. PMID:19179654
• Reyes-Ortiz CA. Velez LF. Camacho ME. Ottenbacher KJ. Markides KS. Health insurance and cervical cancer screening among older women in Latin American and Caribbean cities. International Journal of Epidemiology. 2008 Aug;37(4):870-8. PMID:18511488
• Riall TS. Nealon. WH. Goodwin JS. Townsend CM Jr. Freeman JL. Outcomes following pancreatic resection: Variability among high-volume providers. Surgery. 2008 Aug;144(2):133-40. PMID: 18656618
• Riall TS. Reddy DM. Nealon WH. Goodwin JS. The effect of age on short-term outcomes after pancreatic resection: a population-based study. Annals of Surgery. 2008 Sept;248(3):459-67. PMID:18791366
• Robinson-Bennett BL. DeFord JH. Wang H-Q. Diaz-Arrastic C. Levine L. Hannigan EV. Papaconstantinou J. Implications of tyrosine phosphoproteomics in cervical carcinogensis. Journal of Carcinogenesis 2008;7: 2. PMID:18637184
• Samper-Ternent R. Al Snih S. Raji MA. Markides KS. Ottenbacher KJ. Relationship between frailty and cognitive decline in older Mexican Americans. Journal of the American Geriatric Society. 2008 Oct;56(10):1845-52. PMID: 18811611
• Sharma G. Freeman JL. Zhang DD. Goodwin JS. Continuity of care and intensive care unit use at the end of life. Archives of Internal Medicine. 2009 Jan;169(1):81-6. PMID: 19139328
• Sharma G. Fletcher KE. Zhang DD. Kuo Y-F. Freeman JL. Goodwin JS. Continuity of outpatient and inpatient care for hospitalized older adults. JAMA, 2009, in press.
• Svensen CH. Rodhe PM. Olsson J. Børsheim E. Aarsland A. Hahn RG. Arteriovenous differences in plasma dilution and the distribution kinetics of lactated ringer's solution. Anesthesia & Analgesia. 2009 Jan;108(1):128-33. PMID:19095840
• Timmerman KL. Volpi E. 2008. Amino acid metabolism and regulatory effects in aging. Current Opinion in Clinical Nutrition and Metabolic Care. 2008 Jan;11(1):45-9. PMID:18090658
• Volpi E. Chinkes DL. Rasmussen BB. Sequential muscle biopsies during a six-hour tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. American Journal of Physiology - Endocrinology & Metabolism. 2008 Oct;295(4):E959-63. PMID:18713956
• Wang F. Uretsky BF. Freeman JL. Zhang DD. Giordano SH. Goodwin JS. Survival advantage in Medicare patients receiving drug-elating stents compared with bare metal stents: real or artifactual. Catheter and Cardiovascular Interventions. 2008 Apr;71(5):636-43

Year 5 (2009 - 2010) End of 2nd Cycle

• Bryant MS, Rintala D, Lai E, Protas EJ. An evaluation of self-administration of auditory cueing to improve gait in persons with Parkinson's disease. Clinical Rehabilitation. 23:1078-85, 2009.
• Bryant MS, Rintala D, Lai E, Raines ML, Protas EJ. Evaluation of a new device to prevent falls in Parkinson's disease. Disability and Rehabil: Assistive Tech. Jun 29:1-7, 2009
• Bryant MS, Rintala DH, Lai EC, Protas EJ. An investigation of two interventions for micrographia in individuals with Parkinson's disease. Clinical Rehabilitation. 2010, June 16 [Epub ahead of print]
• Bryant MS, Rintala DH, Lai EC, Protas EJ. A pilot study: An investigation of visual cue color on freezing of gait in persons with Parkinson's disease. Disabil and Rehabil: Assistive Tech 2010, June 14 [Epub ahead of print]
• English, Kirk L; Paddon-Jones, Douglas Protecting muscle mass and function in older adults during bed rest. Current Opinion In Clinical Nutrition And Metabolic Care. 2010 Jan; 13 (1) :34-9
• Fisher, Steve R; Ottenbacher, Kenneth J; Goodwin, James S; Ostir, Glenn V. Chair rise ability and length of stay in hospitalized older adults. Journal Of The American Geriatrics Society. 2009 Oct; 57 (10) :1938-40.
• Fisher, Steve; Ottenbacher, Kenneth J; Goodwin, James S; Graham, James E; Ostir, Glenn V. Short Physical Performance Battery in hospitalized older adults. Aging Clinical And Experimental Research. 2009 Dec; 21 (6) :445-52
• Fujita, S; Glynn, E L; Timmerman, K L; Rasmussen, B B; Volpi, E. Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia. 2009 Sep; 52 (9) :1889-98
• Hsieh, C-C.; Papaconstantinou, J. Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS). Aging. 2009 Sep; 1 (9) :784-802.
• Protas EJ, Tissier S. Strength and speed training for elders with mobility disability. J Aging & Phys Act. 17:257-271, 2009.
• Rabek, Jeffrey P; Hafer-Macko, Charlene E; Amaning, James K; Deford, James H; Dimayuga, Vincent L; Madsen, Mark A; Macko, Richard F; Papaconstantinou, John. A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human vastus lateralis. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences. 2009 Aug; 64 (8) :839-49
• Raji, Mukaila A; Tamborello, Lynsey P; Kuo, Yong-Fang; Ju, Hyunsu; Freeman, Jean L; Zhang, Dong D; Giordano, Sharon H; Goodwin, James S. Risk of subsequent dementia diagnoses does not vary by types of adjuvant chemotherapy in older women with breast cancer. Medical Oncology (Northwood, London, England). 2009 Dec; 26 (4) :452-9
• Sharma, Gulshan; Kuo, Yong-Fang; Freeman, Jean; Zhang, Dong D; Goodwin, James S. Comanagement of hospitalized surgical patients by medicine physicians in the United States. Archives Of Internal Medicine. 2010 Feb 22; 170 (4) :363-8
• Symons, T B; Sheffield-Moore, M; Chinkes, D L; Ferrando, A A; Paddon-Jones, D. Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity.
• Wang CY, Sheu CF, Protas EJ. Test-retest reliability and measurement errors of six mobility tests in the community-dwelling elderly. Asian J Gerontol Geriatr 4:113-118, 2009.

UTMB Pepper OAIC Publication - 1st Cycle

P30 AG024832 - Goodwin (UTMB)

Year 1 (1999-2000)

• Ferrando AA. Stuart CA. Sheffield-Moore M. Wolfe RR. Inactivity amplifies the catabolic response of skeletal muscle to cortisol. Journal of Clinical Endocrinology & Metabolism. 1999 Oct; 84(10):3515-21.
• Phillips SM, Tipton KD, Ferrando AA, and Wolfe, RR. Resistance training reduces the acute exercise-induced increase in muscle protein turnover Am J Physiol Endocrinol Metab 1999; 276 (1): E118-E124.
• Saito H, Patterson C, Hu Z-Y, Runge M, Tipnis U, Sinha M, and Papaconstantinou J. Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia, Am. J. Physiol. 2000; 279:H2241-H2248.
• Sheffield-Moore M. Androgens and the control of skeletal muscle protein synthesis. Ann Med, 2000; 32: 181-186.
• Sheffield-Moore M, Urban, RJ, Wolf, SE, Jiang J, Catlin DH, Herndon DN, Wolfe RR, Gore DC, Ferrando AA. Short-term oxandrolone administration stimulated net muscle protein synthesis in young men. J Clin Endocrinol & Metabolism, 1999; 84(8):2705-2711.
• Sheffield-Moore M, Wolfe RR, Gore DC, Wolf SE. Ferrer DM, Ferrando AA. Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis. American Journal of Physiology - Endocrinology & Metabolism. 2000 Feb; 278(2):E273-9.
• Volpi E. Mittendorfer B. Rasmussen BB. Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. Journal of Clinical Endocrinology & Metabolism. 2000 Dec; 85(12):4481-90.
• Volpi E. Rasmussen BB. Nutrition and muscle protein metabolism in the elderly. Diabetes, Nutrition & Metabolism - Clinical & Experimental. 2000 Apr; 13(2):99-107.
• Volpi E. Jeschke MG. Herndon DN. Wolfe RR. Measurement of skin protein breakdown in a rat model. American Journal of Physiology - Endocrinology & Metabolism. 2000 Oct; 279(4):E900-6.
• Volpi E. Mittendorfer B. Wolf SE. Wolfe RR. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. American Journal of Physiology. 1999 Sept; 277(3 Pt 1):E513-20.
• Wolfe R. Ferrando A. Sheffield-Moore M. Urban R. Testosterone and muscle protein metabolism. Mayo Clinic Proceedings. 2000 Jan; 75 Suppl:S55-9; discussion S59-60.

Year 2 (2001)

• Flurkey K, Papaconstantinou J, and Harrison DE. Life span extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production, Proc. Natl. Acad. Sci. USA 2001; 98:6736-6741.
• Mittendorfer B. Volpi E. Wolfe RR. Whole body and skeletal muscle glutamine metabolism in healthy subjects. American Journal of Physiology - Endocrinology & Metabolism. 2001 Feb; 280(2):E323-33.
• Tipton KD. Muscle protein metabolism in the elderly: influence of exercise and nutrition. Can J Appl Physiol. 2001 Dec;26(6):588-606. Review.
• Volpi E. Sheffield-Moore M. Rasmussen BB. Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 2001 Sept; 286(10):1206-12.
• Wolfe RR. Control of muscle protein breakdown: effects of activity and nutritional states. Int J Sport Nutr Exerc Metab. 2001 Dec;11 Suppl:S164-9. Review.
• Yiangou M, Scott SG, Rabek JP, An MR, Xiong W, and Papaconstantinou J. Effects of mercuric chloride on the regulation of expression of the acute phase response components α1-acid glycoprotein and C/EPB transcription factors. Biochim Biophys. Acta 2001; 1518:47-56.

Year 3 (2002)

• Al Snih S, Markides KS, Ray L, Ostir GV, Goodwin JS. Handgrip strength and mortality in older Mexican Americans. J Am Geriatr Soc. 2002 Jul;50(7):1250-6.
• Brill KT, Weltman AL, Gentili A, Patrie JT, Fryburg DA, Hanks JB, Urban RJ, Veldhuis JD. Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. JCEM 2002; 87:5649-5657.
• Du XL, Osborne C, Goodwin JS.Population-based assessment of hospitalizations for toxicity from chemotherapy in older women with breast cancer. J Clin Oncol. 2002 Dec 15;20(24):4636-42.
• Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison C, Jiang J, Marcell T, Achacosa A, Lieberman SA, Tipton KD, Wolfe RR, Urban RJ. Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. American Journal of Physiology Endocrinology and Metabolism 2002; 282, E601-E607.
• Ferrando AA, Paddon-Jones D, Wolfe RR. Alterations in protein metabolism during space flight and inactivity. Nutrition. 18(10):837-41, 2002.
• Flurkey K, Papaconstantinou J, and Harrison DE. The Snell Dwarf Mutation Pit 1dw Can Increase Life Span in Mice. Mech Age. Dev. 2002; 123(2-3):121-30.
• Gardner AW. Killewich LA. Association between physical activity and endogenous fibrinolysis in peripheral arterial disease: a cross-sectional study. Angiology 2002; 53(4):367-74.
• Goodwin JS, Freeman JL, Mahnken JD, Freeman DH, Nattinger AB. Geographic variations in breast cancer survival among older women: implications for quality of breast cancer care. J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):M401-6.
• Gore DC, Chinkes DL, Hart DW, Wolf SE, Herndon DN, Sanford AP. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Critical Care Medicine 2002; 30(11):2438-42.
• Greer AL, Goodwin JS, Freeman JL, Wu ZH. Bringing the patient back in. Guidelines, practice variations, and the social context of medical practice. Int J Technol Assess Health Care. 2002 Fall;18(4):747-61.
• Hsieh C-C, and Papaconstantinou J. The Effect of Aging on p38 Signaling Pathway Activity in the Mouse Liver and in Response to ROS Generated by 3-Nitropropionic Acid, Mech Age Dev 2002; 123:1423-1435.
• Hsieh C-C, DeFord, JH, Flurkey K, Harrison DE, and Papaconstantinou J. Effects of the Pit1q Mutation on the Insulin Signaling Pathway: Implications on the Longevity of the Long-lived Snell dwarf mouse. Mech Age Dev 2002; 123:1245-1255.
• Hsieh C-C, DeFord JH, Flurkey K, Harrison DE and Papaconstantinou J. Implications of the Insulin Signaling Pathway in Snell dwarf Mouse Longevity: A Similarity with C. elegans Longevity Paradigm, Mech Age Dev 2002; 123:1229-1244.
• Ostir GV, Goodwin JS, Markides KS, Ottenbacher KJ, Balfour J, Guralnik JM. Differential effects of premorbid physical and emotional health on recovery from acute events. J Am Geriatr Soc. 2002 Apr;50(4):713-8.
• Ottenbacher KJ, Branch LG, Ray L, Gonzales VA, Peek MK, Hinman MR. The reliability of upper- and lower-extremity strength testing in a community survey of older adults. Arch Phys Med Rehabil. 2002 Oct;83(10):1423-7.
• Randolph WM, Goodwin JS, Mahnken JD, Freeman JL. Regular mammography use is associated with elimination of age-related disparities in size and stage of breast cancer at diagnosis. Ann Intern Med. 2002 Nov 19;137(10):783-90. Summary for patients in: Ann Intern Med. 2002 Nov
• Rasmussen BB, Wolfe RR, Volpi E. Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. J Nutr Health Aging. 2002; 6(6):358-62.
• Rasmussen BB. Holmback UC. Volpi E. Morio-Liondore B. Paddon-Jones D. Wolfe RR. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J of Clinical Investigation. 2002; 110(11):1687-93.
• Tipton KD, Børsheim E, Wolf SE, Sanford AP and Wolfe RR. Acute response of net muscle protein balance reflects 24h balance following exercise and amino acid ingestion. Am. J. Physiol. (Endocrinol. Metab.) 2002; 284:E76-89.
• Zhang XJ. Chinkes DL. Wolfe RR. Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection. American Journal of Physiology - Endocrinology & Metabolism. 2002; 283(4):E753-64.

Year 4 (2003)

• Al Snih S, Markides K.S., Ray L.A., Ostir G.V., Goodwin J.S. Predictors of recovery in activities of daily living among older Mexican Americans. Aging Clinical and Experimental Research, 2003; 15, 315-320.
• Bohe J, Low A, Wolfe RR, Rennie MJ. Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. J Physiol. 2003 Oct 1;552(Pt 1):315-24. Epub 2003 Aug 8.
• Børsheim E, Cree M, Tipton KD, Elliott TA, Aarsland A, Wolfe RR. Effect of carbohydrate intake on net muscle protein balance during recovery from resistance exercise. J Appl Physiol Oct 31; 2003. [Epub ahead of print]
• Copland JA, Davies PJ, Shipley GL, Wood CG, Urban RJ. The use of DNA microarrays to assess clinical samples. The transition from bedside to bench to bedside. Recent Progress in Hormone Research 58: 25-53, 2003.
• Cunha I, Henson H, Wankadia S, Protas EJ. Reliability of measures of gait performance and oxygen consumption with stroke survivors. J RR & D 2003, 40:19-26.
• Du X, Osborne C, Key C, Goodwin JS. Discrepancy between consensus recommendations and actual community use of chemotherapy in women with breast cancer. Annals Internal Med, 2003; 138:90-97.
• Ferrando AA, Sheffield-Moore M, Paddon-Jones D, Wolfe RR, Urban RJ. Differential anabolic effects of testosterone and amino acid feeding in older men. J of Clin Endocrinol & Metabolism. 2003; 88(1):358-62.
• Gerstner A, DeFord JH and Papaconstantinou J. Comparison of two PCR-based methods and automated DNA sequencing for prop-1 genotyping in Ames dwarf mice, Mut Res. 2003; 528:37-44.
• Goodwin JS, Freeman J, Satish S, Anderson E, Nattinger A. Effect of nurse case management on the treatment of older women with breast cancer. J.Am.Geriat.Soc. 2003; 51:1252-1259.
• Higgins JJ, Jankovic J, Lombardi RQ, Pucilowska J, Tan EK, Ashizawa T, and Ruszczyk MU. Haplotype analysis of the ETM2 locus in familial essential tremor. Neurogenetics 2003;4:185-189.
• Hsieh C-C, and Papaconstantinou J. Age-associated changes in SAPK/JNK signaling in response to the generation of ROS by 3-Nitropropionic acid. Mechanisms of Ageing Development, 2003; 124:733-746.
• Kobayashi H, Borsheim E, Traber DL, Badalamenti J, Anthony TG, Kimball SR, Jefferson LS, Wolfe RR. Reduced amino acid availability inhibits muscle protein synthesis by a mechanism involving initiation factor eIF2B. Am J Physiol 2003 Mar; 284:E488-E498.
• Kuo Y.F., Raji M.A., Markides K.S., Ray L.A., Espino D.V., and Goodwin J.S. Inconsistent use of diabetes medications, diabetic complications, and mortality in older Mexican Americans over a 7 year period: Data from the Hispanic-EPESE. Diabetes Care, 2003; 26:3054-3060.
• Lin X, and Ashizawa T. SCA10 and ATTCT repeat expansion: clinical features and molecular aspects. Nucleotide and Protein Expansions and Human Disease: Cytogen Genome Res 2003;100:184-188.
• Miller SL, Tipton KD, Chinkes DL, Wolf SE, and Wolfe RR. Independent and combined effects of amino acids and glucose on muscle protein following exercise. Med. Sci. Sports Exerc. 2003; 35:449-455.
• Murphy MA, Olson SL, Protas EJ, Overby AR. Screening for falls in community-dwelling elderly. J of Physical Activity & Aging 2003; 11:64-78.
• Ostir GV, Eschbach K, Markides KS, Goodwin JS. Neighborhood composition and depressive symptoms among older Mexican Americans. J Epidemiol Community Health. 2003 Dec;57(12):987-92.
• Ostir GV, Raji MJ, Ottenbacher KJ, Markides KS, Goodwin JS. Cognitive function and incidence of stroke in older Mexican Americans. Journal of Gerontology: Medical Sciences 2003; 58A(6): 531-535.
• Ottenbacher KJ, Smith P, Illig S, Linn RT, Ostir GV, Gonzales VA, Granger CV. Disparity in health services and outcomes for persons with hip fracture and lower extremity joint replacement. Medical Care 2003; 41:232-241.
• Ottenbacher KJ, Smith P, Illig S, Peek MK, Fielder RC, Granger CV. Hospital readmission of persons with hip fracture following medical rehabilitation. Archives of Gerontology and Geriatrics 2003; 36:15-22.
• Paddon-Jones D, Sheffield-Moore M, Creson D, Wolf SE, Sanford AP, Wolfe RR, and Ferrando AA. Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. American Journal of Physiology Endocrinology and Metabolism 2003; 284: E946-E953.
• Paddon-Jones D, Sheffield-Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR.
• Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E321-8. Epub 2003 Oct 28.
• Peek MK, Markides KS. Blood pressure concordance in older married Mexican-American couples. J Am Geriatr Soc. 2003 Nov;51(11):1655-9.
• Peek M Kristen, Ottenbacher Kenneth J, Markides Kyriakos S, & Ostir Glenn V. Examining the disablement process in older Mexican Americans. Social Science and Medicine 2003; 57: 413-425.
• Rabek JP, Boylston III WH, and Papaconstantinou J. Carbonylation of endoplasmic chaperone proteins in aged mouse liver. Biochem Biophys Res Com 2003; 305:566-572.
• Raji M.A., and Goodwin J.S. Perception of causes and treatments of common diseases in black, non-Hispanic white, and Hispanic Americans aged 75 years and older. Physicians & Patients, 2003; 1(4):20–22.
• Raji M.A., Ostir G.V., Markides K.S., Espino D.V., and Goodwin J.S. Potentially Inappropriate Medication Use by Elderly Mexican Americans. Annals of Pharmacotherapy, 2003; 37:1197–1202.
• Rosa AL, Jankovic J. & Ashizawa T. Screening for mutations in the MECP2 (Rett Syndrome) gene in Gilles de la Tourette Syndrome. Arch. Neurol. 2003; 60(4):502-503.
• Sheffield-Moore M, and Urban RJ. Androgens and the Aging Male. In Textbook of Men's Health, B. Lunenfeld and L. Gooren, Parthenon Publishing, New York, NY, pages 241-255, 2002.
• Szeczesny B, Hazra TK, Papaconstantinou J, Mitra S, Boldogh I. Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases, Proc Natl Acad Sci USA 2003; 100:10670-75.
• Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids stimulate muscle protein anabolism in healthy older adults regardless of the presence of non-essential amino acids. Am J Clin Nutr Aug 2003; 78:250-258.
• Walker RH, Rasmussen A, Rudnicki D, Holems SE, Alonso E, Matsuura T, Ashizawa T, Davidoff-Feldman B, Margolis, R.L. Huntington Disease-like 2 can present as chorea-acanthocytosis. Neurology 2003; 61:1002-1004.
• Wolf SE, Thomas SJ, Dasu MR, Ferrando AA, Chinkes DL, Wolfe RR, Herndon DN. Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned. Annals of Surgery, 2003; 237: 801-811.

Year 5 (2004)

• Al Snih S., Markides K.S., Ottenbacher K.J., and Raji M.A. Handgrip strength and incident ADL disability in elderly Mexican Americans over seven years. Aging Clinical & Experimental Research, 2004; 16: 481-486.
• Boylston W.H., Gerstner A., DeFord J.H., Madsen M.A., Flurkey K., Harrison D.E., and Papaconstantinou, J. Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1 dw/dwj) mice. Aging Cell, 2004; 3:283-296.
• Choksi K.B., Boylston III W.H., Rabek J.P., Widger W.R., and Papaconstantinou J. Oxidatively damaged proteins of heart mitochondrial electron transport complexes, Biochim. Biophys. Acta, 2004; 1688:95-101.
• Cree MG, Newcomer BR, Katsanos CS, Sheffield-Moore M, Chinkes D, Aarsland A, Urban R, Wolfe RR. Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab. 2004 Aug;89(8):3864-71.
• Eschbach K, Ostir GV, Patel KV, Markides KS, Goodwin JS. Neighborhood context and mortality among older Mexican Americans: is there a barrio advantage? Am J Public Health. 2004 Oct;94(10):1807-12.
• Fisher M.N., Al Snih S., Ostir G.V., Goodwin J.S. 2004. Positive affect and disability among older Mexican American with arthritis. Arthritis Care Res 2004;51:34-39.
• Garg N., Vyatkina G., Bhatia V., Gerstner A., and Papaconstantinou J. Impaired mitochondria respiratory chain and bioenergetics during chagasic cardiomyopathy development. Biochim. Biophys Acta, 2004; 1638:106-120.
• Garg N., Gerstner A., Bhatia, V., DeFord J.H., and Papaconstantinou J. Gene expression analysis in mitochondria from chagasic mice: Altered in specific metabolic pathways. Biochemical J, 2004; 381:743–752.
• Goodwin JS, Zhang DD, Ostir GV. Effect of depression on diagnosis, treatment, and survival of older women with breast cancer. J Am Geriatr Soc. 2004 Jan;52(1):106-11.
• Heyn P., Abreu B.C. and Ottenbacher, K.J. The effects of exercise on the elderly with cognitive impairment and dementia: A Meta-analysis. Archives of Physical Med and Rehab,2004; 85, 1694–1704.
• Highstead RG, Tipton KD, Creson DL, Wolfe RR, Ferrando AA. Incidence of associated events during the performance of invasive procedures in healthy human volunteers. J Appl Physiol. 2005 Apr;98(4):1202-6. Epub 2004 Nov 24.
• Hsieh C-C., and Papaconstantinou J. Akt/PKB Signaling, Translational Initiation and Longevity in Snell dwarf Mouse Livers. Mech Ageing Dev, 2004; 125:785-798. (Invited Submittal for Special Issue dedicated to the memory of Dr. Arun Roy)
• Kuo Y.F., Raji M.A., Peek M.K., and Goodwin J.S. Health-related social disengagement in elderly diabetic patients: Association with subsequent disability and survival. Diabetes Care, 2004; 27:1630–7.
• Madsen M.A., Hsieh C-C, Boylston W.H., Flurkey K., Harrison, D.E., and Papaconstantinou J. Altered Oxidative Stress Response of the Long Lived Snell Dwarf Mouse. Biochem Biophys Res Comm. 2004; 318:998-1005.
• Ostir G.V., Ottenbacher K.J., and Markides K.S. Onset of frailty in older adults and the protective role of positive affect. Psychology of Aging, 2004; 19(3), 402–408.
• Ottenbacher K.J., Ostir G.V., Peek M.K., and Markides, K.S. Diabetes mellitus as a risk factor for stroke in Mexican American Older Adults. Journal of Gerontology: Medical Sciences, 2004; 59A:6, 640–645.
• Ottenbacher K.J., Linn R., Smith P., Illig S., Mancuso M., and Granger, C.V. Comparison of logistic regression and neural network analysis applied to predicting living setting after hip fracture. Annals of Epidemiology, 2004;14(8), 551–559.
• Ottenbacher K.J., Smith P.M., Illig S.B., Linn R.T., Ostir G.V., and Granger, C.V. Trends in length of stay, living setting, functional outcome and mortality following medical rehabilitation. Journal of the American Medical Association, 2004; 292:1687–1695.
• Papaconstantinou, John. 2004. Mechanisms of Stress Response Signaling and Recovery in the Liver of Young versus Aged Mice: The p38 MAPK and SOCS Families of Regulatory Proteins. IN Handbook of Cell Signaling, Volume 3. Eds: Elsevier Science USA, San Diego, CA, pp 515-529.
• Papaconstantinou J. L.S. Stone: Lens Regeneration – Contributions to the Establishment of an In Vivo Model of Transdifferentiation. J of Exp. Zoology, 2004; 301A:787-792. (Invited article to celebrate 100th Anniversary of J. Experimental Zoology).
• Peek M.K., Ray L., Patel, K., Stoebner-May D., and Ottenbacher K. Reliability and validity of the SF-36 among older Mexican Americans. The Gerontologist, 2004; 44:3, 418–425.
• Reyes-Ortiz C.A., Al Snih S., Loera J., Ray L.A., and Markides K.S. Risk factors for falling in older Mexican Americans. Ethnicity & Disease, 2004; 14:417–422.
• M. Sheffield-Moore, C. W. Yeckel, E. Volpi, S. E. Wolf, B. Morio, D. L. Chinkes, D. Paddon-Jones, and R. R. Wolfe. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise Am J Physiol Endocrinol Metab 2004; 287: E513-E522.
• Sheffield-Moore M, Urban RJ. An overview of the endocrinology of skeletal muscle. Trends Endocrinol Metab. 2004 Apr;15(3):110-5. Review.