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PESC Pilot Project - Year 4

Tristi Muir, MD,  PhDTristi Muir, MD
Associate Professor, Department of OB-Gyn Gynecology
Mentor: Melinda Sheffield-Moore, PhD

Role of Connective Tissue Degradation in the Development of Pelvic Floor Dysfunction in the Elderly: Identifying Targets and Medical Management

Pelvic floor dysfunction (PFD), disproportionately affecting older women, involves loss of pelvic floor support and urinary and fecal incontinence. Medical options are limited and up to 11% of women will require surgery, with increasing risk due to surgery with advancing age. The cause of PFD is multi-factorial and complex, and although risk factors are known, precise mechanisms are yet to be elucidated.

Our primary aim in the current proposal is to determine important tissue differences, including muscle and connective tissue changes, between postmenopausal women and reproductive age women with PFD to help develop targeted treatments. In addition, we propose to develop noninvasive methods to evaluate future treatments for PFD. These goals will be complementary to provide preliminary data for submission for NIH funding for preclinical or clinical (FDA approved drugs) studies of potential medical treatments for PFD.



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