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The goal of the
Pilot/Exploratory Core (P/EC) is to facilitate development of
innovative and methodologically rigorous research designed to
enhance our understanding of the etiology and mechanisms related
to the sarcopenia of aging.
Specific
Aims:
1) Solicit and select the most meritorious research proposals
for P/EC funding;
2) Provide P/EC investigators with access to resources from
other OAIC cores and institutional research facilities/centers;
3) Identify potential opportunities for co-sponsorship of P/EC
studies;
4) Monitor the progress of P/EC studies;
5) Provide assistance and mentorship to develop P/EC studies
into independently funded grant applications; and
6) Ensure the safety and protection of human subjects enrolled
in P/EC studies. |
Elisabet
Borsheim Ph.D.,
Department of
Surgery
“Transcapillary insulin transport in
aging”
Henry Epstein, M.D.,
Department of
Neuroscience and Cell Biology
“Chaperone modulation of motor activity in aging”
Melinda Sheffield-Moore, Ph.D.,
Department
of Internal Medicine
“Cyclic testosterone and bone turnover in older
men”
Bartosz Szczesny, Ph.D.,
Sealy Center for Molecular Science
“Age-dependent change in activity of DNA base excision repair
proteins and its impact on the functions of mitochondria in
skeletal muscle” |
Satoshi Fujita,
Ph.D.,
Department of Internal Medicine
“Muscle mTOR signaling and the regulation of
translation initiation in sarcopenia”
Wolfgang Maret, Ph.D.,
Department of
Preventive Medicine and Community Health
“Zinc and muscle wasting (sarcopenia"
Elizabeth Protas, Ph.D. –
Department of
Physical Therapy
“Activity and outcomes in hospitalized elders”
Hiroshi Saito, Ph.D.,
Department of Surgery
“IL-15 and
adipocytokines in sarcopenia” |
Hans Dreyer,
Ph.D.
Department of Physical Therapy
“Muscle mTOR signaling and the regulation of
translation initiation in sarcopenia” – Year 2
Hiroshi Saito, Ph.D.,
Department of Surgery
“IL-15 and adipocytokines in sarcopenia” - Year 2
Melinda
Sheffield- Moore, Ph.D.,
Department of
Internal Medicine, Endocrinology
“Suppression
of Atrophy Signaling in Skeletal Muscle Following Testosterone
Therapy”
Douglas Paddon-Jones, Ph.D.,
Department of
Physical Therapy
“Restoration of cell signaling and muscle protein
synthesis in the Elderly”
Glenn Ostir, Ph.D.,
Department of Internal Medicine-Geriatrics
“Ongoing
Functional Status in Hospitalized Older Adults” |
Blake Rasmussen, PhD,
Professor, Department of Physical Therapy, was appointed and
approved as Leader of the P/E C
Pilot studies supported
by the P/E Core 2008-09:
José Manuel
Barral,
MD, PhD
Neuroscience & Cell Biology
Chaperone Function in
Age-Related
Sarcopenia
Micah Drummond,
Ph.D.
Physical Therapy
Muscle
microRNA
expression in aging: Effects of exercise and essential amino
acids
Barbara
Doucet,
Ph.D.
Occupational Therapy
Electrical Stimulation and
Nutritional Support in Hospitalized Elders
Alan
Brasier,
MD
Internal Medicine
Serum
biomarkers in inactivity-induced
sarcopenia
Hans Dreyer,
PhD
Physical Therapy
Muscle Metabolism &
Function during Rehabilitation and Amino Acid Supplementation
Janna
McGaugh, PhD
Physical Therapy
Effects of
nutrition and intensive rehabilitation on recovery after hip
fracture |
