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Research Interests:
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Dr. Leary’s multidisciplinary and collaborative research involves
high-technology, quantitative single-cell, approaches to a number of basic
biological applications in the fields including infectious diseases and
developmental immunobiology. He has more than 27 years’ experience in flow
cytometry/cell sorting with more than 65 published flow, image/confocal
microscopy articles, 150 published flow/image abstracts, and 5 issued patents,
with three pending. His technological development work includes high-speed flow
cytometry and cell sorting, rare-event analysis methods, and new data
mining techniques. His longer-term application areas have included minimal
residual disease monitoring, immune cell development, virus-host interactions,
and single-cell molecular characterizations of rare cells. New areas include
development of new high-throughput screening methods for library screening and
recombinant vaccine development, single-cell DNA sequencing and gene expression
microarray analysis for HIV virus-host cell interactions, and development of
nanoparticle/biosensor/gene-drug delivery systems for hepatitis anti-viral
therapy.
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