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Research Interests:
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My research interests involve studies of virus-epithelial cell interactions
as they relate to mucosal inflammation. In the past few years I have been
investigating how respiratory syncytial virus (RSV) and rotavirus regulates CXC
and CC chemokine expression in airway and intestinal epithelial cells,
respectively. These studies have used approaches to describe cis and trans
control mechanisms in transcriptional regulation of these highly inducible
genes. I am currently studying several inducible intracellular signaling
pathways activated by RSV in airway epithelial cells with particular emphasis on
the Mitogen Activated Protein Kinase cascade. I am also investigating the role
of reactive oxygen species in RSV induced lung inflammation both in vitro and in
vivo, in a mouse model of RSV infection, in collaboration with Dr. Garofalo in
the Child Health Research Center. Using a genomic approach, I am investigating
the profile of rotavirus-induced gene expression in intestinal epithelial cells.
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