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Research Interests:
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My research interests during the past 17 years have been in identifying
virulence factors from gram-negative pathogens (e.g., Salmonella, Aeromonas,
Vibrio, and Pseudomonas) and to demonstrate their role in causing human diseases
by developing isogenic mutants. We have delineated the mechanism of action of
some of the important virulence factors and are currently studying the
regulation of these genes. New genes up regulated only during infections have
been isolated and are being characterized. We are performing microarray analysis
that would help in further defining the mechanism of action of the selected
virulence factors. Some of the microbial toxins identified in the laboratory are
being tested as potential mucosal adjuvants. Our research interests are also in
examining bacterial-host interaction with specific emphasis on cell signaling
leading to various biological effects in the host. My laboratory has developed
attenuated strains of Salmonella, Aeromonas, and Vibrio that could be potential
new vaccine candidates and need further study. My new research initiatives
include developing a safe and efficacious DtaP vaccine using recombinant DNA
technology. Finally, my laboratory is trying to develop new therapeutic agents
to control inflammation in diseases such as IBD and atherosclerosis.
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