<%@LANGUAGE="JAVASCRIPT" CODEPAGE="65001"%> Untitled Document

CURRICULUM VITAE

NAME:                                  B. MARK EVERS, M.D.                          

 

PRESENT POSITION:         Professor, Department of Surgery and

Department of Biochemistry & Molecular Biology

                                                Robertson-Poth Distinguished Chair in General Surgery 

                                                Director, Sealy Center for Cancer Cell Biology

                                                Director, UTMB Comprehensive Cancer Center

 

                                                The University of Texas Medical Branch

                                                Galveston, Texas  77555-0536

                                                Telephone:       409-772-5612

                                                FAX:               409-747-4819

 

BIOGRAPHICAL:

Born:                           18 October 1957 - Florence, Alabama

Address:                     2955 Dominique Drive; Galveston, Texas  77551

Marital Status:             Married, Karen Stroup Evers, R.Ph.

Children:                     Lauren Elise (10/89)

                                   Benjamin Mark (11/95)

 

EDUCATION:

 

Undergraduate:

1975-1979                  A.B., Microbiology, Summa Cum Laude,

                                    The University of Tennessee, Knoxville, Tennessee

 

Graduate:

1979-1983                   M.D., Summa Cum Laude, The University of Tennessee, Memphis, Tennessee

1989-1991                   Master of Medical Science, The University of Texas Medical Branch at Galveston, Texas

 

Postgraduate Training:

1983-1984                   Intern in Surgery, The University of Louisville, Louisville, Kentucky

1983-1984                   Resident, Administrative Chief Resident in General Surgery,

                                    The University of Louisville, Louisville, Kentucky

1988-1990                   Research Fellow (Gastrointestinal Physiology)

                                    The University of Texas Medical Branch at Galveston, Texas

PROFESSIONAL AND TEACHING EXPERIENCE:

 

2006-present               Director, UTMB Comprehensive Cancer Center

2003-present               Director, Sealy Center for Cancer Cell Biology

2001-2004                  Director, Gastrointestinal Research Interdisciplinary Program (GRIP)

2000-present               Scientist, Sealy Center for Cancer Cell Biology

1999-present               Robertson-Poth Distinguished Chair in General Surgery

1997-present               Professor, Department of Surgery and Department of Biochemistry & Molecular Biology

1997-1999                  Chela and Jimmy Storm Distinguished Professor, Department of

                                    Surgery and Professor, Department of Biochemistry & Molecular Biology

1995-present               Director, Surgical Research Laboratory

1994-present               Graduate Faculty, Graduate School of Biomedical Sciences

1995-1997                  Chela and Jimmy Storm Associate Professor, Department of Surgery                                  

1994-1995                  Associate Professor, Department of Surgery

1994-1997                  Associate Professor, Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Texas

1991-1994                  Assistant Professor, Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston, Texas

1990-1994                   Assistant Professor, Department of Surgery

                                    The University of Texas Medical Branch at Galveston, Texas

1988-1990                   Instructor, Department of Surgery

                                    The University of Texas Medical Branch at Galveston, Texas

 

TEACHING RESPONSIBILITIES:

 

A.        Third-year medical students' lectures (2):  "Surgical Endocrinology"

B.        Teach residents (Staff General Surgery B and endoscopy services)

C.        Instruct laboratory fellows

D.        Teach cancer courses for graduate and MD/PhD students

ADMINISTRATIVE RESPONSIBILITIES:

 

1995-present                Director of the Surgical Research Laboratory

2001-2004                   Director of the Gastrointestinal Research Interdisciplinary Program (GRIP)

2002-2004                   Chief of Staff, Medical Staf

2003-present                Director, Sealy Center for Cancer Cell Biology

2006-present                Director, UTMB Comprehensive Cancer Center

 

 

COMMITTEE RESPONSIBILITIES:

 

A.        University

 

            1991-1994                  Medical School Admissions Committee

            1994-present               M.D./Ph.D. Program Advisory Committee

            1994-2000                  Animal Care and Use Committee

            1995-1998                  John Sealy Memorial Endowment Fund for Biomedical Research Advisory Committee

                                                 - Chairman, 1997-1998

            1996-1997                  Search Committee for Chairman of the Department of

                                               Pharmacology and Toxicology

            1996-1998                  Research Advisory Council

            1996-2006                  Steering Committee, Master of Medical Science Program 

            1996-present               Mavis Kelsey Excellence in Medicine Award Committee

            1997-2006                  Fellowship Committee

            1997-1998                  Liaison Committee on Medical Education Task Force,

                                                Steering Committee

            1998-2000                   Nominating Committee

            1998-2002                  Faculty Performance Evaluation Committee

            1998-2000                  UTMB Faculty Senate

            2000-present               UTMB Cancer Center Steering Committee

                                                  - Chairman

            2000-2003                  Research Advisory Committee

  - Vice-Chairman, 2000-2001

  - Chairman, 2001-2003

2003-2004                   Faculty of Medicine Executive Committee

                                      - Member-at-Large

2003-2004                   Medical, Service, Research and Development Plan (MSRDP)

                                      - Member, Board of Directors

2003-2004                   Search Committee for Chair of Human Biological Chemistry & Genetics

2004-2005                   UTMB Core Committee for the Advancement of Women Faculty and Administrators

2005-present                Research Space Task Force Committee

2005-present                Research Ad hoc Task Force Committee

2008-present                Search Committee for Chair of the Department of Pharmacology and Toxicology

            2008-present                Optical Imaging Coordinating Board

 

B.        Hospital

 

            1993-1994                   Faculty Consultants to Business Affairs

            1993-1995                   Emergency Room Advisory Committee

            1994                            Nominating Committee for Hospital Chief of Staff

            1999-2000                   Secretary-Treasurer, Medical Staff

            2000-2002                   Chief of Staff (elect), Medical Staff

            2000-2002                   Credentials Committee

                                                 - Chairman

            2002-2004                   Chief of Staff, Medical Staff

            2002-2004                   Medical Staff Executive Committee

                                                 - Chair, Professional Affairs Committee

            2004-2006                   Accreditation and Bylaws Committee, Medical Staff

                                                 - Chair

            2004-2006                   Nominating Committee, Medical Staff

                                                 - Chair

C.        Department

 

            1991-1993                   Quality Assurance Committee

            1993-1994                   Search Committee for Chief of Plastic Surgery

            1992-1995                   Student Education Committee, Department of Surgery

            1992-present                Residency Evaluation Committee

            1997-present                Departmental APT Committee

 

D.        Task Forces/Consulting

 

            2004-2005                   BioHouston Oncology Task Force

 

 

MEMBERSHIP IN SCIENTIFIC SOCIETIES:

 

            Alpha Omega Alpha*

             - Secretary, UTMB Texas Chapter, 1992-2007

             - Councillor, UTMB Texas Chapter, 2007-present

            American Association for Advancement of Science

            American Association for Cancer Research

            American Board of Surgery*

             - Associate Examiner, 2/1996, 2/1998, 2/2002 and 2/2003

             - Examination Consultant for American Board of Surgery In-Training/Surgical Basic

               Science Examination, 7/2002 – 1/2006

             - Director, 6/2007-present

            American College of Surgeons, Fellow*

 - Surgical Research and Education Committee, 1994-2000

 - Committee for the Forum on Fundamental Surgical Problems, 1998-present

            American Gastroenterologic Association*

             - Councillor, Growth Development and Aging Section, 2001-present

             - Research Awards Review Panel, 2006-present

            American Medical Association

            American Pancreatic Association*

            American Physiological Society*

            American Society for Biochemistry & Molecular Biology

            American Society for Clinical Investigation*

            American Surgical Association*

             - Program Committee, 2005-present

            Association for Academic Surgery*

             - Program Committee, 1992-1994

             - Councillor, 1995-1997

             - Executive Council, 1995-1997

             - Nominating Committee, 1997

            Endocrine Society*

            Galveston County Medical Society

            Gastroenterology Research Group

            Halsted Society*

            Hiram C. Polk, Jr. Surgical Society

             - President-elect, 1994-1996

             - President, 1996-1997

            North American Endocrine Society

            Phi Beta Kappa*

            Singleton Surgical Society*

             - Secretary-Treasurer, 1995-1997

             - President-elect, 1997-1998

 - President, 1998-1999

            Society for Surgery of the Alimentary Tract*

            Society of Surgical Oncology*

             - Training Committee, 1998-2004

            Society of University Surgeons*

             - Chairman, Committee on Publications, 1994-1996

             - Executive Council, 1994-present

             - Secretary-elect, 1996-1997

             - Secretary, 1997-2000

             - President-elect, 2000-2001

             - President, 2001-2002

            Society of University Surgeons Foundation

             - President, 2006-present

            Southern Surgical Association*

             - Shipley Award Committee, 2004-2006

            Surgical Biology Club I*

            Texas Medical Association

            Texas Surgical Society*

            (*elected membership)

 

EDITORIAL BOARDS:

 

            1994-1996; 1999-2005            Surgery

            1996-2004                               Journal of Surgical Research

            1997-2000                               Surgical Oncology (Assistant Editor)

            1998-2001                               International Journal of Surgical Investigation

            2000-present                           Advances in Surgery (Associate Editor)

            2001-2007                               Endocrine Reviews

            2002-2007                               Gastroenterology

            2002-present                           Journal of Gastrointestinal Surgery

            2003-present                           Journal of the American College of Surgeons

            2007-present                           American Journal of Surgery

 

LICENSURE AND CERTIFICATION INFORMATION:

 

            Medical License, Texas #H5547

 

            Certification, Diplomate of American Board of Surgery #33989 (1/89)

- recertification 1/98

            - recertification 6/07

 

HONORS/AWARDS:

 

            1978                Phi Beta Kappa

            1982                Alpha Omega Alpha

            1987                Pediatric Surgery Award, Best Senior Surgical Resident in Pediatric Surgery, Department of Surgery, The University of Louisville

            1988                John W. Price Award for Teaching Excellence, Department of Surgery, The University of Louisville

            1988                William L. Brohm Award, Outstanding Performance as a Surgery Resident, Department of Surgery, The University of Louisville

            1990                American Surgical Association, Foundation Fellowship Award

            1995                Chela and Jimmy Storm Distinguished Professorship in Surgical Research

            1995                Arthur M. Shipley Award for best paper presented by a new member, Southern Surgical Association

            1996                Outstanding Teacher of the Year Award, presented by the Surgical Housestaff, The University of Texas Medical Branch

            1998                E.B. Tovee Lecture, The University of Toronto, Toronto, Canada

            1998                Associate Editor, Sabiston Textbook of Surgery, 16th, 17th and 18th editions (CM Townsend, Jr – Editor-in-Chief)

            1999                Robertson-Poth Distinguished Chair in General Surgery

            2000                Surgical Faculty of the year, presented by the Student Surgical Society,

                                    The University of Texas Medical Branch 

            2000                Gross Family Memorial Lecture, Department of Surgery, The

                                    University of Louisville, Louisville, Kentucky

            2001                George H.A. Clowes, M.D. Visiting Professor in Surgical Research, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts

            2001                Outstanding Teacher of the Year Award, presented by the Surgical Housestaff, The University of Texas Medical Branch

            2002                NIH Merit Award (R37)

            2002                Elected member, American Society for Clinical Investigation

            2002                Outstanding Teacher of the Year Award, presented by the Surgical Housestaff, The University of Texas Medical Branch

            2003                Society of Academic and Research Society  (SARS) / British Journal of Surgery (BJS) Invited Lecture, The University of Leeds

            2003                Honorary Member, Society of Academic and Research Surgery (SARS), United Kingdom

            2003                Honorary Member, European Society for Surgical Research (ESSR)

            2004, 2005      Listed in the Best Doctors in America, 2004-2005; 2005-2006 and 2007-

2007                2008 editions

2004                Invitation Honoree, The American Cancer Society Galveston Island Unit 

2004, 2005      Texas Super Doctors

2006, 2007 

            2005                Recipient of Jacob Markowitz Award from the Academy of Surgical Research

            2007                Director, American Board of Surgery

 

 

GRANT SUPPORT

 

A.  Current Grant Support (PI or Director):

 

            8/92-5/12         National Institutes of Health (2R37 AG10885) "Surgical Studies of Ontogeny, Aging and the Gut,"
(total costs $1,862,500), Principal Investigator     

            3/96-2/10         National Institutes of Health (2R01 DK48498) "Surgical Studies of Functional Gene Expression,"
(total costs $1,774,250), Principal Investigator

            7/04-6/09         National Institutes of Health (R01 CA104748) “Surgical Studies of Signaling Pathways in GI Cancers”
(total costs $1,887,500) Principal Investigator 

9/05-8/10         National Institutes of Health (R01 AG025273) “Surgical Studies of Aging and the Gut”
(total costs $1,510,000) Principal Investigator

            4/05-3/10         National Institutes of Health Program Project Grant (P01 DK35608) C.M. Townsend, Jr. – PI
“Studies in Gastrointestinal Endocrinology”; Director of Project 1: “Effect of Aging on GI Hormones” (total costs $153,556)                             

            4/05-3/10         National Institutes of Health Program Project Grant (P01 DK35608) C.M. Townsend, Jr. – PI
“Studies in Gastrointestinal Endocrinology”; Director of Core E: “Molecular Biology Core” (total costs $87,004)

            7/98-6/08         National Institutes of Health (T32 DK07639) “Research Training in Gastrointestinal Endocrinology”
(total costs $813,546), Principal Investigator

            1/06-12/08      American Cancer Society (IRG-110376) “Institutional Research Grant”
(total costs $247,500), Principal Investigator           

           

            7/06-6/11        National Institutes of Health (T32 CA117834-01) EB Thompson - PI
                                    “Multidisciplinary Training in Cancer Research”, (total costs $1,164,459) Associate Program Director

 

B.  Current Grant Support (Co-Investigator with Effort):

            12/02-11/07    National Institutes of Health (R01 DK71470) “Surgical Studies on the Role of Gastrin-releasing peptide in neuroblastoma”
(total costs $1,125,000), Co-Investigator (DH Chung - Principal Investigator)         

            5/05-4/10         National Institutes of Health (R01 AG025908) “Inflammation-mediated Vascular Damage and Aging”
(total costs &750,000), Collaborator  (H Saito - Principal Investigator

            12/05-11/10     National Institutes of Health (R01 CA109136-01) “Novel Mechanisms of Carcinoma Cell Migration”
(total costs $250,000), Co-investigator (KL O’Connor - Principal Investigator)

            9/07-6/12         National Institutes of Health (R01 DK071976) “GKLF/β-catenin crosstalk in the Intestine”
(total costs ($1,321, 250), Co-Investigator (C Liu -Principal Investigator)

            4/08-9/09         National Institutes of Health (R43 GM084552-01) “New Reagents for Synthesizing Nuclease-resistant siRNA”
($199,202), Project Director (Xianbin Yang - Principal Investigator)

 

C.  Pending Grant Support:

 

                                    National Institutes of Health (R01) “Novel Technique for Drug Delivery in Tumors” Co-Investigator (R Esenaliev - Principal Investigator)

                                    National Cancer Institute (P50) “UTMB SPORE in Gastrointestinal Cancer”, Principal Investigator

 

D.  Previous Grant Support:

 

            7/90-6/92         American Surgical Association Foundation Fellowship Award - 2-year funding ($35,000/year), Principal Investigator

            9/90-8/92         John Sealy Memorial Endowment Recruitment Award - 2-year funding ($15,000/year), Principal Investigator

            4/91-3/92         UTMB Small Grant Award - 1-year funding ($12,000), Principal Investigator

            1/92-12/97       Shriners Burns Institute (#8670) "Molecular Mechanisms of Early Gut Changes After Thermal Injury," Principal Investigator

            4/96-4/97         Biomeasure Corporation “Effects of PYY Analogs on Absorptive Properties in the Canine Intestine,”
(total $105,000), Principal Investigator

            7/98-6/99         National Institutes of Health Fellowship Award (F32 CA79187) to Dr. Richard Ehlers (Surgery Resident/Research Fellow)
“Surgical Studies of Signaling Mechanisms of GI Cancers,” (total costs - $31,492), (B.M. Evers – Mentor)

            6/01-6/04         Department of Defense (Research Grant, Idea Award) “Novel Drug Delivery Technique for Breast Cancer Therapy”
(total costs $447,000), Co-Investigator (RO Esenaliev – Principal Investigator)

            1/02-1/04         Texas Higher Education Coordinating Board, Advanced Technology Program “Development of Novel Systems for Drug Delivery in Tumors (total costs $230,000), Co-Investigator (RO Esenaliev – Principal Investigator)

            6/03-9/03         Research Supplement for Underrepresented Minority [PA-01-079], Ekong Uffort, 6/23/03 – 9/22/03, total costs $3,674)

            7/03-6/05        National Cancer Institutes (R21 CA10212-01) “Pancreatic Integrin Contribution to Perineural Invasion”)
(total costs $75,000/year) Co-investigator (KL O’Connor - Principal Investigator)

            9/03-8/04         Gastrointestinal Research Interdisciplinary Program - Program Project Grant (GRIP PPG) “Inflammatory Mechanisms of Pancreatitis”
(total costs $50,000), Principal Investigato

4/04-3/08         National Institutes of Health “Surgical Study of Intestinal Proliferative Signaling”
(total cost $184,500) Co-Investigator (H Sheng - Principal Investigator)

            7/04-6/05         Texas Gulf Coast Digestive Diseases Center (DDC) “Molecular Mechanisms Regulating Age-Associated Enhanced Proliferation in the
Colonic Epithelium” ($12,500 total cost $25,000); Principal Investigator

 

NATIONAL STUDY SECTIONS:

 

            NIH

 

            Regular Member

            6/02-6/06         Bioengineering, Technology and Surgical Sciences Study Section (formerly, Surgery and Bioengineering Study Section)

            6/07-present    Tumor and Microenvironment (TME) Study Section

 

            Ad hoc Member

            2/97-2/02         Surgery and Bioengineering Study Section

            7/96, 7/97        Special Emphasis Panel of the Surgery, Anesthesiology and Trauma Study Section

            8/01                 NIDDK Special Review Committee

            12/02               NIDDK Special Emphasis Panel

            7/03                 NIH NCI Southwest Oncology Group (SWOG) Review Panel

            10/03,             NIH DDK-C Committee

            03/05, 10/05,

            6/07

            8/04                 NIH/NIDDK Special Emphasis Panel “Training for a New Interdisciplinary Workforce”

            3/07                 NIH/NIDDK Special Review Committee DDK-C

            10/06, 6/07      NIH/CSR Molecular Oncogenesis Study Section

                                    2/08

            10/06, 2/07      NIH/CSR Tumor Microenvironment Study Section

            6/07, 10/07

            2/08

            6/07                 NIH/NCI ZCA1 Cellular and Tissue Biology P01 Cluster Review Panel

            2/08                 NIH/ZRG1 DIG-C GCMB Study Section (Teleconference)

            2/08                 NIH/ZDK1 GI Tract Program Projects (Teleconference)

                                   

            Veteran's Administration

            6/04-3/06         Ad hoc member, VA Gastroenterology MERIT Review

            3/06-present    Regular member, VA Gastroenterology MERIT Review

 

            NASA

            1/07                 Review Panelist, NASA/National Space Biomedical Research Institute (NSBRI) “Research and Technology Development to Support Crew Health and Performance in Space Exploration Missions”

 

RESEARCH TRAINEES (Surgical Housestaff and Graduate Students only):

 

            7/90-7/92        Dai H. Chung, M.D.; SSAT/Ross Laboratories Resident Research Award (1992); currently Associate Professor, Chief of Pediatric Surgery, University of Texas Medical Branch, Galveston, TX

            7/93-7/95        John A. Ehrenfried, M.D.; Singleton Surgical Society Resident Research Award (1994); Surgical Oncology Fellowship, MD Anderson Cancer Center; currently Private Practice, Kingsport, TN

            7/94-7/96       Hong J. Kim, M.D.; SSAT/Ross Laboratories Resident Research Award (1996); Singleton Surgical Society Resident Research Award (1996); Surgical Oncology Fellowship, Memorial Sloan-Kettering Cancer Center; currently Assistant Professor, Department of Surgery, University of North Carolina, Chapel Hill, NC

            7/96-7/98        David A. Litvak, M.D.; Surgical Oncology Fellowship, John Wayne Cancer Institute, Santa Monica, CA; currently Assistant Professor, Department of Surgery, Michigan State University, East Lansing, MI

            6/96-6/03         Richard Ethridge, MD, PhD; American Digestive Health Foundation/

                                    American Gastroenterological Association Student Research Award and Student Abstract Prize Runner-up; Alpha Omega Alpha Honor Medical Society National and the Texas Alpha Chapter Student Research Fellowship Recipient; James F. Hury, Jr. Academic Scholarship; Stjepcevich Scholarship Award; McLaughlin Award for Excellence; Joseph B. Kass Award for Research; Stephen C. Silverthorne Memorial Award; currently Resident in Surgery, University of Texas Medical Branch, Galveston, TX

            7/97-6/99       Richard Ehlers, M.D.; Jeanne B. Kempner Scholar Award (1998-1999); NIH grant F32-CA79187 "Surgical Studies of Signaling Mechanisms of GI Cancer" (7/98-6/99); Surgical Oncology Fellowship, MD Anderson Cancer Center, Houston, TX; currently General Surgeon/Surgical Oncology, Bay Area Cancer Surgery, Baytown, TX

            7/98-6/00       Ambrosio Hernandez, M.D.; Pediatric Surgery Fellowship, University of Michigan, Ann Arbor, MI; Clinical Assistant Professor, Driscoll Valley Physician Group, McAllen, TX

            7/99-6/03        Sunghoon Kim, M.D.; completed Surgical Residency at University of California-Davis; Pediatric Surgery Fellow, Washington University, St. Louis, MO; currently Associate, Pediatric Surgical Associates/Children’s Hospital, Oakland, CA

            7/00-6/02        Robert Thomas, M.D.; Jeanne B. Kempner Scholar Award (2000-2001); Singleton Surgical Society Basic Science Research Award (2001);  Pediatric Surgery Fellow; Wayne State University, Detroit, MI; currently Pediatric Surgeon,  San Antonio Pediatric Associates, San Antonio, TX

            7/01-6/03        Buckminster Farrow III, M.D.; Jeanne B. Kempner Scholar Award (2001-2003);   Singleton Surgical Society Basic Science Research Award (2002-2003); currently Assistant Professor, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX

            7/01-6/03        Michele Slogoff, M.D.; Jeanne B. Kempner Scholar Award (2002-2003); currently Assistant Professor, Department of Surgery, Loyola University, Chicago, IL

            7/01-10/02      Barbara Held, MD; Fellow, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX; currently OB-Gyn Private Physician, Med Center, Houston, TX

            7/02-6/04        Carlos Murillo, MD; Jeanne B. Kempner Scholar Award (2003-2004); Singleton Surgical Society Basic Science Research Award (2003); American College of Surgeons Forum on Fundamental Surgical Problems Research/Fellow Excellence in Research Award (2003); currently Resident Instructor, Texas Tech University Health Sciences Center School of Medicine, El Paso, TX

            2/03-4/07        Salil Bose, B.S., M.S.; University of Texas Medical Branch, Galveston, TX

            9/03-present    Leechuan Andy Chen, B.S.; currently MD/PhD Student, University of Texas Medical Branch, Galveston, TX

            7/04-6/07        Lindsey Jackson, M.D.; Jeanne B. Kempner Scholar Award (2004); American College of Surgeons Forum on Fundamental Surgical Problems Research/Fellow Excellence in Research Award (2005); Society of University Surgeons Excellence in Research Travel Award (2007); Master of Medicine in Science Degree; currently Resident in Surgery, University of Texas Medical Branch, Galveston, TX

            7/05-6/07        Shawn Larson, M.D.; Jeanne B. Kempner Scholar Award (2006); Master of Medicine in Science Degree; currently Resident in Surgery, University of South Florida, Tampa, FL

            7/06-present    Sara Johnson, MD; Jeanne B. Kempner Scholar Award (2007); Residents Research Forum and Society of Surgery of the Alimentary Tract (2007); currently Resident in Surgery, University of Medicine and Dentistry of New Jersey, Newark, NJ

            6/07-present     Scott Silva, B.S.; currently MD/PhD Student, University of Texas Medical Branch, Galveston, TX

            6/07-present     Kanika Bowen, MD; currently Resident in Surgery, University of Texas Medical Branch, Galveston, TX

            6/07-present     Hung Doan, B.A., B.S.; currently MD/PhD Student, University of Texas Medical Branch, Galveston, TX

 

PATENTS/INVENTIONS

 

U.S. Patent Application Serial No. 09/861,694 filed May 21, 2001.  Evers BM, Ethridge RT.  Use of Cyclooxygenase-2 Inhibitors.

 

U.S. Patent Application 0771CG.000050 filed March 22, 2004.  Evers BM, Rychahou P.  SiRNA Targeting a PI3K Signal Transduction Pathway and Method of Treating Inflammatory Disease Using SiRNA Thereof.

 

U.S. Patent Application. Evers BM, Wang QD, Zhou Y.  Herbal Products as Treatment for Inflammatory Bowel Disease.

 

U.S. Patent Application 265.00490160 filed May 2006.  Evers BM, Rychahou P.  Methods and Compositions for Treating Cancer. 

BIBLIOGRAPHY:

 

A.  Peer-Reviewed Publications: 

  1. Malangoni MD, Evers BM, Peyton JC, Wellhausen SR. Reticuloendothelial clearance and splenic mononuclear cell populations after resection and autotransplantation. American Journal of Surgery 155:298-302, 1988
  2. Cryer HM, Miller FB, Evers BM, Ruben LR, Seligson DL. Pelvic fracture classification-correlation with hemorrhage. Journal of Trauma 28:973-980, 1988.
  3. Evers BM, Mullins RJ, Matthews TH, Broghamer WL, Polk HC Jr. Multiple adenocarcinomas of the colon and rectum: an analysis of incidences and current trends. Diseases of the Colon and Rectum 31:518-522, 1988.
  4. Evers BM, Cryer HM, Miller FB. Pelvic fracture hemorrhage: priorities in management. Archives of Surgery 124:422-424, 1989. 
  5. Evers BM, Gomez G, Townsend CM Jr., Rajaraman S, Thompson JC. Endogenous cholecystokinin regulates growth of human cholangiocarcinoma. Annals of Surgery 210:317-323, 1989.
  6. Evers BM, Izukura M, Townsend CM Jr., Thompson JC. Differential effects of gut hormones on pancreatic and intestinal growth during administration of an elemental diet. Annals of Surgery 211:630-638, 1990.
  7. Evers BM, Townsend CM Jr., Greeley GH Jr., Uchida T, Allen E, Thompson JC. Effect of total jejunoileal denervation on fat-stimulated release of cholecystokinin and peptide-YY. Surgery 108:248-253, 1990.
  8. Evers BM, Townsend CM Jr., Upp JR Jr., Allen E, Hurlbut SC, Kim SW, Rajaraman S, Singh P, Reubi JC, Thompson JC. Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology 101:303-311, 1991.
  9. Evers BM, Hurlbut SC, Tyring SK, Townsend CM Jr., Uchida T, Thompson JC. Novel therapy for the treatment of human carcinoid. Annals of Surgery 213:411-416, 1991.
  10. Evers BM, Beauchamp RD, Ishizuka J, Townsend CM Jr., Alam T, Papaconstantinou J, Thompson JC. Posttranscriptional regulation of neurotensin in the gut. Surgery 110:247-252, 1991.
  11. Evers BM, Ishizuka J, Townsend CM Jr., Rajaraman S, Thompson JC. Expression of neurotensin messenger RNA in a human carcinoid tumor. Annals of Surgery 214:448-455, 1991.
  12. Chung DH, Evers BM, Townsend CM Jr., Huang KF, Herndon DN, Thompson JC. Burn-induced transcriptional regulation of small intestinal ornithine decarboxylase. American Journal of Surgery 163:157-163, 1992.
  13. Evers BM, Izukura M, Townsend CM Jr., Uchida T, Thompson JC. Neurotensin prevents intestinal mucosal hypoplasia in rats fed an elemental diet. Digestive Diseases and Sciences 37:426-431, 1992.
  14. Izukura M, Evers BM, Townsend CM Jr., Parekh D, Yoshinaga K, Uchida T, Thompson JC. Neurotensin augments intestinal regeneration after small bowel resection in rats. Annals of Surgery 215:520-527, 1992.
  15. Yoshinaga K, Evers BM, Izukura M, Parekh D, Uchida T, Townsend CM Jr., Thompson JC. Neurotensin stimulates growth of colon cancer. Surgical Oncology 1:127-134, 1992.
  16. Evers BM, Izukura M, Chung DH, Parekh D, Yoshinaga K, Greeley GH Jr., Uchida T, Townsend CM Jr., Thompson JC. Neurotensin stimulates growth of colonic mucosa in young and aged rats. Gastroenterology 103:86-91, 1992.
  17. Ishizuka J, Beauchamp RD, Evers BM, Townsend CM Jr., Thompson JC. Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells. Biochemical and Biophysical Research Communications 185:577-581, 1992.
  18. Evers BM, Rady PL, Tyring SK, Sanchez R, Rajaraman S, Townsend CM Jr., Thompson JC. Amplification of the HER-2/neu protooncogene in human endocrine tumors. Surgery 112:211-218, 1992.
  19. Chung DH, Evers BM, Townsend CM Jr., Herndon DN, Ko TC, Uchida T, Thompson JC. Cytokine regulation of gut ornithine decarboxylase gene expression and enzyme activity. Surgery 112:364-369, 1992.
  20. Chung DH, Evers BM, Shimoda I, Townsend CM Jr., Rajaraman S, Thompson JC. Effect of neurotensin on gut mucosal growth in jejunal and ileal Thiry-Vella fistulas. Gastroenterology 103:1254-1259, 1992.
  21. Evers BM, Ishizuka J, Chung DH, Townsend CM Jr., Thompson JC. Neurotensin expression and release in human colon cancers. Annals of Surgery 216:423-431, 1992.
  22. Chung DH, Evers BM, Beauchamp RD, Upp JR Jr., Rajaraman S, Townsend CM Jr., Thompson JC. Bombesin stimulates growth of human gastrinoma. Surgery 112:1059-1065, 1992.
  23. Koo JY, Parekh D, Townsend CM Jr., Saydjari R, Evers BM, Farre A, Ishizuka J, Thompson JC. Amiloride inhibits the growth of human colon cancer cells in vitro. Surgical Oncology 1:385-389, 1992.
  24. Evers BM, Thompson EB, Townsend CM Jr., Lawrence JL, Johnson B, Srinivasan G, Thompson JC. Cortivazol increases glucocorticoid receptor expression and inhibits growth of hamster pancreatic cancer (H2T) in vivo. Pancreas 8:7-14, 1993.
  25. Chung DH, Evers BM, Townsend CM Jr., Huang KF, Herndon DN, Thompson JC. Role of polyamine biosynthesis during gut mucosal adaptation after burn injury. American Journal of Surgery 165:144-149, 1993.
  26. Evers BM, Rajaraman S, Chung DH, Townsend CM Jr., Wang X, Graves K, Thompson JC. Developmental expression of the neurotensin gene in the rat liver. Annals of Surgery 218:183-188, 1993.
  27. Evers BM, Rajaraman S, Chung DH, Townsend CM Jr., Wang X, Graves K, Thompson JC. Differential expression of the neurotensin gene in the developing rat and human gastrointestinal tract. American Journal of Physiology 265 (Gastrointest. Liver Physiol. 28):G482-G490, 1993.
  28. Yoshinaga K, Ishizuka J, Evers BM, Townsend CM Jr., Thompson JC. Age-related changes in polyamine biosynthesis after starvation and refeeding. Experimental Gerontology 28:565-572, 1993.
  29. Sumi S, Evers BM, Townsend CM Jr., Yoshinaga K, Uchida T, Murakami M, Sato K, Ishizuka J, Thompson JC. Comparative effects of neurotensin and neuromedin N on growth of human pancreatic cancer, MIA PaCa-2. Surgical Oncology 2:267-272, 1993.
  30. Shimoda I, Evers BM, Sato K, Ishizuka J, Rajaraman S, Chung DH, Uchida T, Tsuchiya T, Greeley GH Jr., Townsend CM Jr., Thompson JC. Age dependent increase of neurotensin expression in the ileum. American Journal of Physiology 266 (Gastrointest. Liver Physiol. 29):G706-G712, 1994.
  31. Evers BM, Rady PL, Sandoval K, Arany I, Tyring SK, Sanchez RL, Nealon WH, Townsend CM Jr., Thompson JC. Gastrinomas demonstrate amplification of the HER-2/neu protooncogene. Annals of Surgery 219:596-604, 1994.
  32. Evers BM, Bold RJ, Ehrenfried JA, Li J, Townsend CM Jr., Klimpel GR. Characterization of functional neurotensin receptors on human lymphocytes. Surgery 116:134-140, 1994.
  33. Evers BM, Izukura M, Rajaraman S, Parekh D, Thakore K, Yoshinaga K, Uchida T, Townsend CM Jr., Thompson JC. Effect of aging on neurotensin-stimulated growth of rat small intestine. American Journal of Physiology 267 (Gastrointest. Liver Physiol. 30):G180-G186, 1994.
  34. Arany I, Rady P, Evers BM, Tyring SK, Townsend CM Jr. Analysis of multiple molecular changes in human endocrine tumors. Surgical Oncology 3:153-160, 1994.
  35. Farre A, Ishizuka J, Gomez G, Evers BM, Saydjari R, Koo JY, Townsend CM Jr., Thompson JC. Bombesin inhibits growth of pancreatic ductal adenocarcinoma (H2T) in nude mice. Pancreas 9:652-656, 1994.
  36. Chu KU, Higashide S, Evers BM, Rajaraman S, Ishizuka J, Townsend CM Jr., Thompson JC. Bombesin improves survival from methotrexate-induced enterocolitis. Annals of Surgery 220:570-577, 1994.
  37. Ehrenfried JA, Zhou Z, Thompson JC, Evers BM. Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma. Annals of Surgery 220:484-491, 1994.
  38. Carraway RE, Mitra SP, Evers BM, Townsend CM Jr. BON cells display the intestinal pattern of neurotensin/neuromedin N precursor processing. Regulatory Peptides 53:17-29, 1994. 
  39. Evers BM, Ehrenfried JA, Wang X, Townsend CM Jr., Thompson JC. Temporal-specific and spatial-specific patterns of neurotensin gene expression in the small bowel. American Journal of Physiology 267 (Gastrointest. Liver Physiol. 30):G875-G882, 1994.
  40. Zhang T, Townsend CM Jr., Udupi V, Yanaihara N, Rajaraman S, Beauchamp RD, Ishizuka J, Evers BM, Gomez G, Thompson JC, Greeley GH Jr. Phorbol ester-induced alteration in the pattern of secretion and storage of chromogranin A and neurotensin in a human pancreatic carcinoid cell line. Endocrinology 136:2252-2261, 1995.
  41. Chu KU, Higashide S, Evers BM, Ishizuka J, Townsend CM Jr., Thompson JC. Bombesin stimulates mucosal growth in jejunal and ileal thiry-vella fistulas. Annals of Surgery 221:602-611, 1995.
  42. Evers BM, Zhou Z, Celano P, Li J. The neurotensin gene is a downstream target for ras activation. The Journal of Clinical Investigation 95:2822-2830, 1995.
  43. Evers BM, Wang X, Zhou Z, Townsend CM Jr., McNeil GP, Dobner PR. Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line. Molecular and Cellular Biology 15:3870-3881, 1995.
  44. Ehrenfried JA, Townsend CM Jr., Thompson JC, Evers BM. Increases in nup475 and c-jun are early molecular events that precede the adaptive hyperplastic response after small bowel resection. Annals of Surgery 222:51-56, 1995.
  45. Chu KU, Evers BM, Ishizuka J, Townsend CM Jr., Thompson JC. Role of bombesin on gut mucosal growth. Annals of Surgery 222:94-100, 1995.
  46. Ehrenfried JA, Chen J, Li J, Evers BM. Glutamine-mediated regulation of heat shock protein expression in intestinal cells. Surgery 118:352-357, 1995.
  47. Ehrenfried JA, Herron BE, Townsend CM Jr., Evers BM. Heat shock proteins are differentially expressed in human gastrointestinal cancers. Surgical Oncology 4:197-203, 1995.
  48. Evers BM, Wang X. Kinetics of neurotensin gene expression in the developing gut. Surgery 119:186-190, 1996. 
  49. Ehrenfried JA, Evers BM, Chu KU, Townsend CM Jr., Thompson JC. Caloric restriction increases the expression of heat shock protein in the gut. Annals of Surgery 223:592-599, 1996. 
  50. Evers BM, Zhou Z, Dohlen V, Rajaraman S, Thompson JC, Townsend CM Jr. Fetal and neoplastic expression of the neurotensin gene in the human colon. Annals of Surgery 223:464-471, 1996. 
  51. Chu KU, Evers BM, Ishizuka J, Beauchamp RD, Greeley GH Jr, Townsend CM Jr., Thompson JC. Short-term caloric restriction augments age-related decreases in gastrin content and release. Mechanisms of Ageing and Development 87:25-33, 1996. 
  52. Kim HJ, Evers BM, Guo Y, Banker NA, Hellmich MR, Townsend CM Jr. Bombesin-mediated AP-1 activation in a human gastric cancer (SIIA). Surgery 120:130-137, 1996. 
  53. Evers BM, Ko TC, Li J, Thompson EA. Cell cycle protein suppression and p21 induction in differentiating Caco2 cells. American Journal of Physiology 271 (Gastrointest. Liver Physiol. 34):G722-G727, 1996. 
  54. Iwase K, Evers BM, Hellmich MR, Kim HJ, Higashide S, Gully D, Townsend CM Jr. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth. Surgical Oncology 5:245-252, 1996. 
  55. Kim HJ, Evers BM, Banker NA, Hellmich MR, Townsend CM Jr. A functional in vitro model to examine signaling mechanisms in gastrin-mediated human cell growth. Journal of Gastrointestinal Surgery 1:69-77, 1997. 
  56. Iwase K, Evers BM, Hellmich MR, Kim HJ, Higashide S, Gully D, Thompson JC, Townsend CM Jr. Inhibition of neurotensin-induced pancreatic cancer growth by a nonpeptide neurotensin receptor antagonist, SR48692. Cancer 79:1787-1793, 1997.
  57. Banker NA, Hellmich MR, Kim HJ, Townsend CM Jr., Evers BM. SRC-mediated activation of the human neurotensin/neuromedin N promoter. Surgery 122:180-186, 1997.
  58. Iwase K, Evers BM, Hellmich MR, Guo Y-S, Higashide S, Kim HJ, Townsend CM Jr. Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 113:782-790, 1997.
  59. Ehrenfried JA, Ko TC, Thompson EA, Evers BM. Cell cycle-mediated regulation of hepatic regeneration. Surgery 122:927-935, 1997.
  60. Wang S, Wolf SE, Evers BM Differential activation of the STAT signaling pathway in the liver after burn injury. American Journal of Physiology 273 (Gastrointest. Liver Physiol. 36):G1153-G1159, 1997.
  61. Wang S, Evers BM. Cytokine-mediated differential induction of hepatic AP-1 genes. Surgery 123:191-198, 1998.
  62. Litvak DA, Hellmich MR, Evers BM, Banker NA, Townsend CM Jr. Glucagon-like peptide 2 is a potent growth factor for small intestine and colon. Journal of Gastrointestinal Surgery 2:146-150, 1998.
  63. Dong Z, Wang X, Zhao Q, Townsend CM Jr., Evers BM. DNA methylation contributes to expression of the human neurotensin/neuromedin N gene. American Journal of Physiology 274 (Gastrointest. Liver Physiol. 37):G535-G543, 1998.
  64. Wang X-M, Thomas RP, Evers BM. Effect of gut transposition on the expression of the endocrine gene neurotensin. Journal of Gastrointestinal Surgery 2:230-237, 1998.
  65. Wang X-M, Wang X, Li J, Evers BM. Effects of 5-azacytidine and butyrate on differentiation and apoptosis of hepatic cancer cell lines. Annals of Surgery 227:922-931, 1998.
  66. Litvak DA, Evers BM, Hwang KO, Hellmich MR, Ko TC, Townsend CM Jr. Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1. Surgery 124:161-170, 1998.
  67. Ehlers RA II, Bonnor RM, Wang X, Hellmich MR, Evers BM. Signal transduction mechanisms in neurotensin-mediated cellular regulation. Surgery 124:239-247, 1998.
  68. Kim HJ, Evers BM, Banker NA, Greeley GH Jr., Hellmich MR, Thompson JC, Townsend CM Jr. Novel expression and regulation of the gastrin gene in the human ovarian cancer cell line, SW626. Digestive Diseases and Sciences 43:1465-1473, 1998.
  69. Wang S, Tyring SK, Townsend CM Jr., Evers BM. Interferon-mediated activation of the STAT signaling pathway in a human carcinoid tumor. Annals of Surgical Oncology 5:642-649, 1998.
  70. Ding QM, Ko TC, Evers BM. Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4. American Journal of Physiology 275 (Cell Physiol. 44):C1193-C1200, 1998.
  71. Ethridge RT, Hellmich MR, DuBois RN, Evers BM. Inhibition of heat shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2 (COX-2) Gastroenterology 115:1454-1463, 1998.
  72. Ding QM, Dong Z, Evers BM. Enterocyte-like differentiation of the Caco-2 intestinal cell line is associated with increases in AP-1 protein binding. Life Sciences 64:175-182, 1998.
  73. Wang S, Evers BM. Caco-2 cell differentiation is associated with a decrease in STAT protein levels and binding. Journal of Gastrointestinal Surgery 3 :200-207, 1999.
  74. Wang XM, Evers BM. Characterization of early developmental pattern of expression of the neurotensin/neuromedin gene in the foregut and midgut. Digestive Diseases and Sciences 44:33-40, 1999.
  75. Litvak DA, Iseki H, Evers BM, Greeley GH Jr, Hellmich MR, Iwase K, Balasubramaniam A, Townsend CM Jr. Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C. Digestive Diseases and Sciences 44:643-648, 1999.
  76. Litvak, DA, Evers BM, Hellmich MR, Townsend CM Jr. The enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin. Journal of Gastrointestinal Surgery 3:432-440, 1999.
  77. Litvak DA, Hellmich MR, Iwase K, Evers BM, Martinez J, Amblard M, Townsend CM Jr. JMV1155: A novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo. Anticancer Research 19:45-50, 1999.
  78. Ehlers RA, Hernandez A, Bloemendal SL, Ethridge RT, Farrow B, Evers BM. Mitochondrial DNA damage and altered membrane potential (DY) in pancreatic acinar cells induced by reactive oxygen species. Surgery 126:148-155, 1999.
  79.  Litvak DA, Papaconstantinou HT, Kim M, Evers BM, Townsend CM Jr. Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways. Surgery 126:223-230, 1999.
  80. Shin CE, Falcone RA Jr, Kemp CJ, Erwin CR, Litvak DA, Evers BM, Warner BW. Intestinal adaptation and enterocyte apoptosis following small bowel resection is p53 independent. American Journal of Physiology 277 (Gastrointest Liver Physiol.):G717-G724, 1999.
  81. Wang XM, Li J, Evers BM. Inhibition of proliferation, invasion and adhesion of liver cancer cells by 5-azacytidine and butyrate. Anticancer Research 19:2901-2906, 1999.
  82. Litvak DA, Papaconstantinou HT, Evers BM, Townsend CM Jr. Targeting molecular pathways with camptothecin as novel therapy for gastric cancer. Journal of Gastrointestinal Surgery 3:618-624, 1999.
  83. Ding QM, Wang QD, Dong Z, Evers BM. Characterization and regulation of E2F activity during intestinal cell differentiation. American Journal of Physiology (Cell Physiol.) 278:110-117, 2000.
  84. Wang QD, Ding QM, Dong Z, Ehlers RA, Evers BM. Downregulation of mitogen-activated protein kinases in human colon cancer. Anticancer Research 20:75-83, 2000.
  85. Ehlers RA, Kim S, Zhang Y, Ethridge RT, Murrilo C, Hellmich MR, Evans DB, Townsend CM Jr., Evers BM. Gut peptide receptor expression in human pancreatic cancers. Annals of Surgery 231:838-848, 2000.
  86. Litvak DA, Hwang KO, Evers BM, Townsend CM Jr. Induction of apoptosis in human gastric cancer by sodium butyrate. Anticancer Research 20:779-784, 2000.
  87. Kim HJ, Evers BM, Litvak DA, Hellmich MR, Townsend CM Jr. Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA. American Journal of Physiology (Cell Physiol.) 279:C326-C334, 2000.
  88. Ethridge RT, Ehlers RA, Hellmich MR, Rajaraman S, Evers BM. Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1. Pancreas 21:248-256, 2000.
  89. Ehlers RA, Zhang Y, Hellmich MR, Evers BM. Neurotensin-mediated activation of MAPK pathways and AP-1 binding in the human pancreatic cancer cell line, MIA PaCa-2. Biochemical and Biophysical Research Communications 269:704-708, 2000.
  90. Hernandez A, Smith F, Wang QD, Wang XF, Evers BM. Assessment of differential gene expression patterns in human colon cancers. Annals of Surgery 232:576-585, 2000.
  91. Wang QD, Kim S, Wang XF, Evers BM. Activation of NF-kB in HT-29 colon cancer cells by inhibition of phosphatidylinositol 3-kinase. Biochemical and Biophysical Research Communications 273:853-858, 2000.
  92. Dong Z, Wang XF, Ding QM, Evers BM. Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers. American Journal of Physiology (Gastrointest. Liver Physiol.) 279:­G1139-G1147, 2000.
  93. Hellmich MR, Rui XL, Hellmich HL, Fleming RYD, Evers BM, Townsend, CM Jr. Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. Journal of Biological Chemistry 275:32122-32128, 2000.
  94. Wang QD, Ji YS, Wang XF, Evers BM. Isolation and molecular characterization of the 5’-upstream region of the human trail gene. Biochemical and Biophysical Research Communications 276:466-471, 2000.
  95. Hernandez A, Wang QD, Schwartz SA, Evers BM. Sensitization of human colon cancer cells to trail-mediated apoptosis. Journal of Gastrointestinal Surgery 5:56-65, 2001.
  96. Wang QD, Wang XF, Hernandez A, Kim S, Evers BM. Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. Gastroenterology 120:1381-1392, 2001.
  97. Chung DH, Ethridge RT, Kim S, Hernandez A, Kelly DR, Evers BM. Molecular mechanisms contributing to necrotizing enterocolitis. Annals of Surgery 233:835-842, 2001.
  98. Hernandez A, Thomas R, Kim S, Smith F, Chung DH, Evers BM. Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. Surgery 130:265-272, 2001.
  99. Ding QM, Wang QD, Evers BM. Alterations of MAPK activities associated with intestinal cell differentiation. Biochemical and Biophysical Research Communications 284:282-288, 2001. 
  100. Domon-Dell C, Wang QD, Kim S, Kedinger M, Evers BM, Freund J-N. Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. Gut 50:525-529, 2002.
  101. Thomas RP, Guigneaux M, Wood T, Evers BM. Age-associated changes in gene expression patterns in the liver. Journal of Gastrointestinal Surgery 6:445-454, 2002.
  102. Kim S, Hu W, Kelly DR, Hellmich MR, Evers BM, Chung DH. Gastrin releasing peptide is a growth factor for human neuroblastomas. Annals of Surgery 235:621-630, 2002.
  103. Thomas RP, Farrow BJ, Kim S, May MJ, Hellmich MR, Evers BM. Selective targeting of the nuclear factor-kB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. Surgery 132:127-134, 2002.
  104. Wang QD, Li N, Wang XF, Kim MM, Evers BM. Augmentation of sodium butyrate-induced apoptosis by PI3-kinase inhibition in the KM20 human colon cancer cell line. Clinical Cancer Research 8:1940-1947, 2002.
  105. Ethridge RT, Hashimoto K, Chung DH, Ehlers RA, Rajaraman S, Evers BM. Selective inhibition of NF-kB attenuates the severity of caerulein-induced acute pancreatitis. Journal of the American College of Surgeons 195:497-505, 2002.
  106. Ethridge RT, Chung DH, Slogoff M, Ehlers RA, Hellmich MR, Rajaraman S, Saito H, Uchida T, Evers BM. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 123:1311-1322, 2002.
  107. Kim S, Domon-Dell C, Wang QD, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM. PTEN and TNF-a regulation of the Cdx-2 homeobox gene through a PI3K, PKB/Akt and NF-kB dependent pathway. Gastroenterology 123:1163-1178, 2002.
  108. Li J, Hellmich MR, Greeley GH Jr, Townsend CM Jr, Evers BM. Phorbol ester-mediated neurotensin secretion is dependent on the PKCa and d isoforms. American Journal of Physiology (Gastrointest Liver Physiol) 283:G1197-G1206, 2002.
  109. Wang QD, Wang X, Hernandez A, Hellmich MR, Gatalica Z, Evers BM. Regulation of TRAIL expression by the PI3-kinase/Akt/GSK-3 pathway in human colon cancer cells. Journal of Biological Chemistry 277:36602-36610, 2002.
  110. Modur V, Nagarajan R, Evers BM, Milbrandt J. FOXO proteins regulate TRAIL expression: implications for PTEN mutation in prostate cancer. Journal of Biological Chemistry 277:47928-47937, 2002.
  111. Hashimoto K, Ethridge RT, Evers BM. Peroxisome proliferator-activated receptor g ligand inhibits cell growth and invasion of human pancreatic cancer cells. International Journal of Gastrointestinal Cancer 32:7-22, 2002.
  112. Farrow BJ, Thomas RP, Wang XF, Evers BM. Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein BAD and TRAIL receptors. International Journal of Gastrointestinal Cancer 32:63-72, 2002.
  113. Thomas RP, Slogoff M, Smith FW, Evers BM. Effect of aging on the adaptive and proliferative capacity of the small bowel. Journal of Gastrointestinal Surgery 7:88-95, 2003.
  114. Kim S, Kang J, Hu W, Evers BM, Chung DH. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. International Journal of Cancer 103:352-359, 2003.
  115. Thomas RP, Rajaraman S, Evers BM. Effect of ileocolonic transposition on gut morphology, gene expression and function. Journal of Surgical Research 109:31-36, 2003.
  116. Farrow B, Evers BM. Activation of PPARg increases PTEN expression in pancreatic cancer cells. Biochemical and Biophysical Research Communications 301:50-53, 2003.
  117. Yu W, Murray NR, Weems C, Chen L, Guo H, Ethridge R, Evers BM, Thompson EA, Fields AP. Role of cyclooxygenase 2 in protein kinase C bII-mediated colon carcinogenesis. Journal of Biological Chemistry 278:11167-11174, 2003.
  118. Hashimoto K, Ethridge RT, Saito H, Rajaraman S, Evers BM. The PPARg ligand, 15d-PGJ2, attenuates the severity of caerulein-induced acute pancreatitis. Pancreas 27:58-66, 2003.
  119. Farrow B, RychahouP, Murillo C, O’Connor KL, Iwamura T, Evers BM. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134:197-205, 2003.
  120. Farrow B, O’Connor KL, Evers BM. Selective activation of PPARg inhibits pancreatic cancer invasion and decreases tPA and b7 integrin expression. Surgery 134:206-212, 2003.
  121. Shao J, Evers BM, Sheng H. Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. Cancer Research 63:5218-5223, 2003.
  122. Sheng H, Shao J, Townsend Jr CM, Evers BM. Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells. Gut 52:1472-1478, 2003.
  123. Farrow B, Rychahou P, O’Connor KL, Evers BM. Butyrate inhibits pancreatic cancer invasion. Journal of Gastrointestinal Surgery 7:864-870, 2003.
  124. Saito H, Sherwood ER, Varma TK, Evers BM. Effects of ageing on mortality, hypothermia and cytokine induction in mice with endotoxemia or sepsis. Mechanisms of Ageing and Development 124:1047-1058, 2003.
  125. Wang QD, Wang XF, Evers BM. Induction of cIAP-2 in human colon cancer cells through PKCδ/NF-κB. Journal of Biological Chemistry 278:51091-51099, 2003.
  126. Shao J, Evers BM, Sheng H. Roles of phosphatidylinositol 3’-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-ras-mediated transformation of intestinal epithelial cells. Cancer Research 64:229-235, 2004.
  127. Shao J, Evers BM, Sheng H. PGE2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. Journal of Biological Chemistry 279:14287-14293, 2004.
  128. Hashimoto K, Farrow BJ, Evers BM. Activation and role of MAP kinases in peroxisome proliferator-activated receptor γ ligand-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. Pancreas 28:153-159, 2004.
  129. Wang XF, Wang QD, Hu W,Evers BM. Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB dependent pathway. Oncogene 23:1885-1895, 2004.
  130. Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM. Down-regulation of the tumor suppressor PTEN by the TNFα/NFK/NF-κB pathway is linked to a default IκB-α autoregulatory loop. Journal of Biological Chemistry 279:4285-4291, 2004.
  131. Kim S, Kang J, Qiao J, Thomas RP, Evers BM, Chung DH. Phosphatidylinositol 3-kinase inhibition downregulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. Journal of Pediatric Surgery 39:516-521, 2004.
  132. Kim S, Kang J, Evers BM, Chung DH. Interferon-g induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter. Journal of Pediatric Surgery 39:509-515, 2004.
  133. Slogoff MI, Ethridge RT, Rajaraman S, Evers BM. COX-2 inhibition results in alterations in NF-κB activation but not cytokine production in acute pancreatitis. Journal of Gastrointestinal Surgery 8:511-519, 2004.
  134. Farrow B, Sugiyama Y, Chen A, Uffort E, Nealon WH, Evers BM. Inflammatory mechanisms contributing to pancreatic cancer development. Annals of Surgery 239:763-771, 2004.
  135. Li J, O’Connor KL, Hellmich MR, Greeley GH Jr, Townsend CM Jr, Evers BM. The role of protein kinase D in neurotensin secretion mediated by protein kinase C-α/-δ and Rho/Rho Kinase. Journal of Biological Chemistry 279:28466-28474, 2004.
  136. Murillo CA, Rychahou PG, Evers BM. Inhibition of α5 integrin decreases PI3K activation and cell adhesion of human colon cancers. Surgery 136:143-149, 2004.
  137. Qiao J, Cree J, Kang J, Kim S, Evers BM, Chung DH. Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastoma. Surgery 136:489-494, 2004.
  138. Li N, Wang QD, Li J, Wang XF, Hellmich MR, Rajaraman S, Greeley GH Jr, Townsend CM Jr, Evers BM. Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON. American Journal of Physiology: Gastrointestinal Liver Physiology 288:G213-220, 2005.
  139. Sugiyama Y, Farrow B, Murillo C, Li J, Watanabe H, Sugiyama K, Evers BM. Analysis of differential gene expression patterns in colon cancer stroma using microdissected tissues. Gastroenterology 128:480-486, 2005.
  140. Ueda J, Saito H, Watanabe H, Evers BM. Novel and quantitative DNA dot-blotting method for assessment of proliferation. American Journal of Physiology: Gastrointestinal Liver Physiology 288:G842-847, 2005.
  141. Li J, O’Connor KL, Greeley GH, Blackshear PJ, Townsend CM Jr, EEvers BM. Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-δ downstream of the Rho/ROK pathway. Journal of Biological Chemistry 280:8351-8357, 2005.
  142. Larina IV, Evers BM, Ashitkov TV, Bartels C, Larin KV, Esenaliev RO. Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation. Technology in Cancer Research and Treatment 4:217-226, 2005.
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  145. Watanabe H, Saito H, Uchida T, Evers BM. Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology 128:1391-1404, 2005.
  146. Chen AL, Soman KV, Rychahou PR, Luxon BA, Evers BM. Proteomic analysis of colonic myofibroblasts and effect on colon cancer cell proliferation. Surgery 138:382-390, 2005.
  147. Rychahou PG, Murillo CA, Evers BM. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery 138:391-397, 2005.
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