<%@LANGUAGE="JAVASCRIPT" CODEPAGE="65001"%> Untitled Document

NEWS

Link found between turmeric curry spice, cancer prevention
SEPT. 20. 2006--Looking for a cancer cure? Try the spice rack. In the last few years, that tactic has proved productive for researchers investigating turmeric, a curry spice used for centuries in Indian traditional medicine. They’ve found that turmeric’s active ingredient, curcumin, works in the lab to fight skin, breast and other tumor cells. In fact, human clinical trials employing curcumin have already been launched. Now, working with cell cultures in a laboratory, UTMB scientists have discovered that curcumin blocks the activity of a gastrointestinal hormone implicated in the development of colorectal cancer, the country’s second leading cancer killer with nearly 60,000 deaths annually. “We found that in colon cancer cells, neurotensin increases not just the rate of growth but also other critical things, including cell migration and metastasis,” said UTMB surgery professor Dr. B. Mark Evers, senior author of the article and director of UTMB’s Sealy Center for Cancer Cell Biology. “The fact that all that can be turned off by this natural product, curcumin, was really remarkable.”  See complete article...

 

ARTICLES IN PRESS

  1. Ishola TA, Chung DH. Neuroblastoma. (Review) Journal of Surgical Oncology.
  2. Kang J, Rychahou PG, Ishola TA, Mourot JM, Evers BM, Chung DH.    N-myc is a novel regulator of PI3K–mediated VEGF expression in neuroblastoma. Oncogene (1/8/08).
  3. Wang Q, Zhou Y, Wang X, Evers BM. p27Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells. Cell Death & Differentiation (1/4/08).
  4. atanabe H, Saito H, Nishimura H, Ueda J, Evers BM. Activation of phosphatidylinositol-3-kinase regulates pancreatic duodenal homeobox-1 in duct cell during pancreatic regeneration. BBRC (3/3/08).

 

ACCEPTED ABSTRACTS

Advances in Neuroblastoma Research

  1. Kang J, Rychahou PG, Mourot JM, Evers BM, Chung DH. N-myc is a novel regulator of PI3K–mediated VEGF expression in neuroblastoma (poster).

AGA   

  1. Bowen KA, Zhou BP, Doan H, Evers BM. Upregulation of epithelial mesenchymal transition in colorectal cancer after PTEN knockdown (poster).
  2. Cai Q, Li,J, Gao T, Evers BM. The mTOR complex 2 regulates the proliferation of colon cancer cells. (oral).
  3. Cai Q, Li,J, Gao T, Xie J, Evers BM. PKCδ is a negative regulator of the Hedgehog pathway by inhibition of GLI protein transcriptional activity (poster).
  4. Chen LA, Li J, Silva SR, Jackson LN,  Watanabe H, Ives K, Hellmich MR, Evers BM. PKD3 is the predominant PKD isoform expressed in the exocrine pancreas and regulates hormone-induced exocrine enzyme secretion (oral).
  5. Li,J, Gao T, Townsend, Jr, CM, Evers BM. ERK1c, a novel spliced form of ERK1, positively regulates PGE2-stimulated NT secretion in the human endocrine cell line, BON (oral).
  6. Li,J, Townsend, Jr, CM, Evers BM. Kidins220 phosphorylation by PKD is required in the regulation of neurotensin secretion in the BON human endocrine cell line (oral).
  7. Li,J, Gao T, Townsend, Jr, CM, Evers BM. hVps34, the class III PI3K, is involved in cAMP-stimulated neurotensin secretion in the human endocrine cell line BON (poster of distinction).
  8. Silva SR, Chen AL, Doan, HQ, Townsend, Jr, CM, Evers BM. The carcinoid cell line BON secretes factors that increase proliferation of human colonic and cardiac fibroblasts (poster).
  9. Song J, Li J, Evers BM, Chung DH. Protein kinase D3 plays a pro-apoptotic role in oxidative stress-induced apoptosis in intestinal epithelial cells (poster).
  10. Rychahou PG, Kang K, Doan H, Chung DH, Evers BM. Concurrent mutation of PTEN and Akt2 overexpression in colorectal cancer increases micrometastasis establishment and growth (oral).
  11. Takahashi H, Saito H, Evers BM. Aging attenuates PI3K/Akt activation and proliferation of pancreatic acinar cells (oral).
  12. Tsushimi T, Saito H, Evers BM. Inhibition of PI3K suppresses inflammation-mediated colon cancer in mice (poster).
  13. Wang Q, Zhou Y, Wang, X, Evers BM. Specific regulation of nuclear p27Kip1 expression and cyclin-dependent kinase inhibitory activity by glycogen synthase kinase-3β in intestinal cell differentiation (oral).
  14. Zhou Y, Wang Q, Jackson LN,  Chow  C, Wang, X, Evers BM. Activation of NFAT Increases PTEN expression in human intestinal cells (poster).

International Shock Congress

  1. Starr ME, Evers BM, Saito H. Altered adipokine expression in old age increases sensitivity to systemic inflammation  (poster).
  2. Takahashi H, Starr ME,  Mrazek AA,  Weiler H Evers BM, Saito H. Age-associated decrease in anti-coagulation factors results in increased coagulation and mortality during sepsis  (poster).

NSR  

  1. Bowen KA, Zhou BP, Doan H, Evers BM. Upregulation of epithelial mesenchymal transition in colorectal cancer after PTEN knockdown (oral).
  2. Doan H, Rychahou PG, Heinze D, Evers BM. PI3-kinase pathway inhibition modulates chemotherapeutic response in colon cancer cells (poster).
  3. Johnson S, Evers BM. Novel expression patterns of PI3K-MTOR pathway proteins in colorectal cancers (poster).
  4. Silva SR, Chen AL, Doan, HQ, Townsend, Jr, CM, Evers BM. The carcinoid cell line BON secretes factors that increase proliferation of human colonic and cardiac fibroblasts (poster).

SSAT

  1. Johnson SM, Evers BM. Curcumin inhibits the mammalian target of rapamycin subunits rictor and raptor in colon cancer cells (poster of distinction).