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Naira Baregamian
Medical School: St.George’s University School of Medicine (SGUSOM), Grenada
Mentors: Chung DH; O’Connor KL
Research Topic:  Effects of oxidative stress and Insulin-like Growth Factor- 1 (IGF-1) on intestinal epithelial cell survival signaling during necrotizing enterocolitis
Current Position: Resident, The University of Texas Medical Branch

 

Awards
Jeanne B. Kempner Scholar Award (2006-2007)
Best Basic Science Project, 53rd Annual Singleton Surgical Society Meeting, UTMB (2006)
Best Post-Doctoral/Associate Project, Poster Presentation in Basic Science, 14th Annual Science Forum, Sealy Center for Molecular Science & Sealy Center for Cancer Cell Biology, UTMB (2006)

Publications:

1. Baregamian N, Song J, Jeschke M, Evers BM, Chung DH.  IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis.  Journal of Surgical Research 136:31-37, 2006.
   
2. Kang J, Ishola TA, Baregamian N, Mourot JM, Rychahou PG, Evers BM, Chung DH. Bombesin induces angiogenesis and neuroblastoma growth. Cancer Letters 253:273-281, 2007.
   
3. Baregamian N, Rychahou PG, Evers BM, Chung DH. Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Surgery 142:295-302, 2007.
4. Baregamian N, Mourot JM, Ballard AR, Evers BM, Chung DH.  PPAR-γ agonist protects against intestinal injury during necrotizing enterocolitis.  Biochemical and Biophysical Research Communications 379:423-427, 2009.

Abstracts:

1. Baregamian N, Jeschke M, Song J, Evers BM, Chung DH. Insulin-like growth factor-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis. Journal of Surgical Research 130:232-233, 2006.
   
2. Kang J, Ishola T, Baregamian N, Evers BM, Chung DH. Phosphatidylinositol 3-kinase regulates bombesin-induced angiogenesis and in vivo neuroblastoma growth. Journal of the American College of Surgeons 203:S51, 2006.
   
3. Baregamian N, Rychahou N, Evers BM, Chung DH. Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Journal of Surgical Research 137:171, 2007.
   
4. Baregamian N, Evers BM, Chung DH. Oxidative stress increases IGF-IR expression and PI3K/Akt activation in intestinal epithelial cells. Gastroenterology 132:A571, 2007.
   
5. Baregamian N, Song J, Evers BM, Chung DH.  Activation of mitochondrial apoptotic signaling during oxidative stress in intestinal epithelial cells.  Journal of the American College of Surgeons 205:S48, 2007.

National Presentations:

1. Insulin-like growth factor-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis. Academic Surgical Congress (Feb. 2006, San Diego, CA [Assn. for Academic Surgery & Society of University Surgeons) (oral).
   
2. Phosphatidylinositol 3-kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis. Academic Surgical Congress (SUS, AAS) (Feb. 2007, Phoenix, AZ) (oral).
   
3. Oxidative stress increases IGF-IR expression and PI3-K/Akt activation in intestinal epithelial cells. American Gastroenterological Assn. (May 2007, Washington DC) (poster).
   
4. Tumor necrosis factor-a induces intestinal mitochondrial dysfunction during necrotizing enterocolitis. American Pediatric Surgical Association (May 2007, Orlando, FL) (oral).
5. Baregamian N, Song J, Evers BM, Chung DH. Activation of mitochondrial apoptotic signaling during oxidative stress in intestinal epithelial cells.American College of Surgeons. (Oct. 2007, New Orleans, LA) (oral)

 

 

Shawn D. Larson, M.D.
Medical School: University of Sheffield, Sheffield, England
Mentors: Evers, BMi O’Connor KL
Research Topic: Intestinal cell differentiation  regulated by signaling mechanisms involving the PI3K/Akt/PTEN and NF-κB pathways
Current Position: Resident, James A. Haley Veterans Administration Hospital

 

Awards:
Jeanne B. Kempner Scholar Award (2003-2004)
Singleton Surgical Society Basic Science Research Award (2003)
American College of Surgeons Forum on Fundamental Surgical Problems Research/Fellow Excellence in Research Award (2003).

Publications:

1. Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, Evers BM. Increased incidence of well-differentiated thyroid cancer associated with Hashimoto’s thyroiditis
2. and the role of the PI3K/Akt pathway. Journal of the American College of Surgeons 204:764-773, 2007.
   
3. Larson SD, Jackson LN, Chen AL, Rychahou PG, Evers BM. Effectiveness of siRNA uptake in target tissues by various delivery methods. Surgery 142:262-269, 2007.
   
4. Larson SD, Li J, Chung DH, Evers BM. Molecular mechanisms contributing to glutamine-mediated intestinal cell survival. American Journal of Physiology: Gastrointestinal and Liver 293:G1262-G1271, 2007.
   
5. Larson SD, Nealon WH, Evers BM. Management of gallstone pancreatitis. Advances in Surgery, Volume 40. Elsevier Inc, Philadelphia, PA, pp. 265-284, 2006.
   
6. Larson SD, Evers BM.  Diseases of the peritoneum, retroperitoneum, mesentery and omentum. In:  Yamada T (ed).  Textbook of Gastroenterology (5th Edition) Blackwell Publishing (in press).
   
7. Larson SD, Evers BM.  Diseases of the peritoneum, retroperitoneum, mesentery and omentum. In:  Yamada T (ed).  Atlas of Gastroenterology (4th Edition) Blackwell Publishing (in press).
   
8. Jackson LJ, Larson SD, Silva SR, Rychahou PG, Chen LA, Qiu S, Rajaraman S, Evers BM.  PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.  American Journal of Physiology: Gastrointestinal and Liver Physiology 294:G1401-G1410, 2008.

Abstracts:

1. Larson SD, Li J, Chung DH, Evers BM.  Molecular mechanisms contributing to glutamine-mediated intestinal cell survival.  Gastroenterology 130:A909, 2006.
   
2. Jackson LN, Larson SD, Silva SR, Ueda J, Chen A, Evers BM.  PI3K/AKT activation is critical for hepatic regeneration after partial hepatectomy.  Journal of the American College of Surgeons 203:S11, 2006.
   
3. Larson SD, Chung DH, Evers BM.  Activation of ERK is critical for glutamine-mediated intestinal cell survival.  Journal of the American College of Surgeons 203:S15, 2006.
   
4. Jackson LN, Larson SD, Silva SR, Rychahou PG, Chen LA Evers BM. Targeted knockdown of PI3K components with small interfering RNA (siRNA) inhibits liver regeneration following partial hepatectomy. Journal of Surgical Research 137:153, 2007.
   
5. Larson SD, Jackson LN, Chen LA Rychahou PG, Evers BM. Effectiveness of siRNA uptake in target tissues by various delivery methods. Journal of Surgical Research 137:189, 2007.
   
6. Jackson LN, Chen LA, Li J, Rychahou PG, Larson SD, Boor PJ, Townsend Jr CM, Evers BM. Development and characterization of a novel in vivo model for carcinoid syndrome. Gastroenterology 132:A130, 2007.
   
7. Larson SD, Chung DH, Evers BM. Intestinal epithelial cell survival is mediated, in part, by the mTOR pathway in glutamine-deprived cells. Gastroenterology 132:A382, 2007.
   
8. Larson SD, Jackson LN, Chung DH, Evers BM. Glutamine deprivation activates the PI3K/Akt pathway in intestinal epithelial cells. Journal of the American College of Surgeons 205:S17, 2007.

National Presentations:

1. Molecular mechanisms contributing to glutamine-mediated intestinal cell survival. Society for Surgery of the Alimentary Tract (May 2006, Los Angeles, CA) (poster).
2. Activation of ERK is critical for glutamine-mediated intestinal cell survival. American College of Surgeons (Surgical Forum) (Oct 2006, Chicago, IL) (oral).
3. Increased incidence of well-differentiated thyroid cancer and PI3K/Akt associated with Hashimoto’s thyroiditis. Southern Surgical Association (Dec 2006, Palm Beach, FL) (oral).
4. Effectiveness of siRNA uptake in target tissues by various delivery methods. Academic Surgical Congress (SUS, AAS) (Feb. 2007, Phoenix, AZ) (oral).
5. Intestinal epithelial cell survival is mediated, in part, by the mTOR pathway in glutamine-deprived cells. American Gastroenterological Assn. (May 2007, Washington DC) (poster).
6. Molecular mechanisms contributing to glutamine-induced intestinal cell survival. American Pediatric Surgical Association (May 2007, Orlando, FL) (poster).
7. Glutamine deprivation activates the PI3K/Akt pathway in intestinal epithelial cells. American College of Surgeons. (Oct. 2007, New Orleans, LA) (oral).
8. Glutamine-induced autophagy, molecular mechanisms and intestinal cell survival Academic Surgical Congress (SUS, AAS) (Feb. 2008, Huntington Beach, CA) (oral).

 

 

Lindsey N. Jackson
Medical School: University of Texas Southwestern Medical School, Dallas, TX     
Mentors: Chung DH, Elferink C
Research Topic:  PI3K in liver regeneration
Current Position: Resident, The University of Texas Medical Branch

 

Awards
Jeanne B. Kempner Scholar Award (2004-2005)
American College of Surgeons Forum on Fundamental Surgical Problems Research/Fellow Excellence in Research Award (2005)
Society of University Surgeons Residents Award (2007)

Publications:

1. Jackson LN, Evers BM. Chronic inflammation and pathogenesis of GI and pancreatic cancers. In: Angus G. Dalgleish, Burkhard Haefner (eds). Cancer Treatment and Research Series: The Link Between Inflammation and Cancer. Springer Science+Business Media, Inc New York, NY, 130:39-65, 2006.
   
2. Jackson LN, Evers BMM. Gastrointestinal Lymphomas. In: Shackelford’s Surgery of the Alimentary Tract, 6th Edition. Elsevier, Philadelphia, PA, pp. 1199-1212, 2007.
   
3. Jackson LN, Evers BM. Small bowel carcinoid tumors. In: JL Cameron (ed) Current Surgical Therapy, 9th Edition. Elsevier Mosby, Philadelphia, PA , pp. 151-160, 2008.
   
4. Murillo CA, Woodside KJ, Jackson LN, Evers BM. Neoplastic disorders of the gastrointestinal tract. In: Thomas Miller (Editor) Modern Surgical Care: Physiologic Foundations and Clinical Applications, 3rd Edition (2006). Marcel Dekker Inc, New York, NY, pp. 555-586.
   
5. Rychahou PG, Jackson LN, Silva SR, Rajaraman S, Evers BM. Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma. Annals of Surgery 243:833-842, 2006.
   
6. Rychahou PG, Jackson LN, Farrow BJ, Evers BM.  RNA interference: mechanisms of action and therapeutic consideration.  Surgery 140:719-725, 2006.
   
7. Jackson LN, Li Jing, Chen AL, Townsend CM Jr, Evers BM. Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells. Biochemical and Biophysical Research Communications 348:945-949, 2006.
   
8. Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, Evers BM. Increased incidence of well-differentiated thyroid cancer associated with Hashimoto’s thyroiditis and the role of the PI3K/Akt pathway. Journal of the American College of Surgeons 204:764-773, 2007.
   
9. Larson SD, Jackson LN, Chen AL, Rychahou PG, Evers BM.  Effectiveness of siRNA uptake in target tissues by various delivery methods.  Surgery 142:262-269, 2007.
   
10. Jackson LJ, Larson SD, Silva SR, Rychahou PG, Chen LA, Qiu S, Rajaraman S, Evers BM.  PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy.  American Journal of Physiology: Gastrointestinal and Liver Physiology 294:G1401-G1410, 2008.
11. Jackson LN, Wang QD, Zhou Y, Qiu S, Evers BM. Alternative medicine products as a novel treatment strategy for inflammatory bowel disease. The American Journal of Chinese Medicine 36:953-965, 2008.
12. Jackson LN, Chen LA, Larson SD, Silva SR, Rychahou PG, Boor PJ, Li J, DeFreitas G, Stafford WL, Townsend Jr. CM, Evers BM. Development and characterization of a novel in vivo model of carcinoid syndrome.  Clinical Cancer Research 15:2747-2755, 2009.
13. Liu H, Weiss HL, Rychahou PG, Jackson LJ, Evers BM, Gao T.  Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis.  Oncogene 28 994-1004 2009.
14. Chen LA, Li J, Silva SR, Jackson LN, Zhou Y, Watanabe H, Ives KL, Hellmich MR, Evers BM. PKD3 is the predominant protein kinase D isoforms in mouse exocrine pancreas and promotes hormone-induced amylase secretion. Journal of Biological Chemistry 284:2459-2471, 2009.
15. Doan HQ, Bowen KA, Jackson LN, Evers BM.  Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells.  Anticancer Research 29:2473-2478, 2009.
16. Jackson LN, Evers BM. Regulation of proliferation, apoptosis and cell cycle in gastrointestinal disorders. Curr Opin Pharmacol 2009 (in press).

Abstracts:

1. Jackson LN, Rychahou PG, Evers BM. Targeted RNA interference of PI3K pathway components confers survival benefit in a mouse model of inflammatory bowel disease. Journal of American College of Surgeons 201:S15, 2005.
   
2. Rychahou PG, Jackson LN, Chau KT, Evers BM. RNAI directed to the PI3K p85α subunit attenuates inflammatory changes associated with DSS-induced colitis. Journal of Surgical Research 130:199, 2006.
   
3. Jackson LN, Silva SR, Ueda J, Watanabe H, Evers BM. PI3K/Akt activation is critical for hepatic regeneration after partial hepatectomy. Journal of Surgical Research. 130:301, 2006.
   
4. Jackson LN, Rychahou PG, Silva SR, Evers BM. Differential effects of selective or complete PI3K inhibition in a murine inflammatory bowel disease model. Gastroenterology 130:A345, 2006.
   
5. Jackson LN, Li J, Chen AL, Townsend CM Jr, Evers BM. Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells. Gastroenterology 130:A535, 2006.
   
6. Jackson LN, Larson SD, Silva SR, Ueda J, Chen A, Evers BM. PI3K/AKT activation is critical for hepatic regeneration after partial hepatectomy. Journal of the American College of Surgeons 203:S11, 2006.
   
7. Jackson LN, Larson SD, Silva SR, Rychahou PG, Chen LA Evers BM. Targeted knockdown of PI3K components with small interfering RNA (siRNA) inhibits liver regeneration following partial hepatectomy. Journal of Surgical Research 137:153, 2007.
   
8. Larson SD, Jackson LN, Chen LA Rychahou PG, Evers BM. Effectiveness of siRNA uptake in target tissues by various delivery methods. Journal of Surgical Research 137:189, 2007.
   
9. Rychahou PG, Chen LA, Jackson LN, Evers BM. Targeting the class IA PI3K in human colorectal cancer. Proceedings of the American Association of Cancer Research 48:292, 2007.
   
10. Jackson LN, Chen LA, Li J, Rychahou PG, Larson SD, Boor PJ, Townsend Jr CM, Evers BM. Development and characterization of a novel in vivo model for carcinoid syndrome. Gastroenterology 132:A130, 2007.
    
11. Wang QD, Zhou Y, Jackson LN, Chow CW, Evers BM. Role of the NFAT transcription factor in intestinal cell differentiation. Gastroenterology 132:A691, 2007.
    
12. Larson SD, Jackson LN, Chung DH, Evers BM. Glutamine deprivation activates the PI3K/Akt pathway in intestinal epithelial cells. Journal of the American College of Surgeons 205:S17, 2007.
    
13. Chen LA, Li J, Silva SR, Jackson LN, Watanabe H, Ives K, Hellmich MR, Evers BM. PKD3 is the predominant PKD isoform expressed in the exocrine pancreas and regulates hormone-induced exocrine enzyme secretion. Gastroenterology 134:A127, 2008. .
    
14. Wang QD, Zhou Y, Jackson LN, Chow C, Wang XF, Evers BM. Activation of NFAT Increases PTEN expression in human intestinal cells. Gastroenterology Gastroenterology 134:A706, 2008.
15. Silva SR, Jackson LN, Rychahou PG, Townsend CM Jr, Evers BM.  Novel expression and activation of the vascular endothelial growth factor receptor-2 in human carcinoid cells.  Gastroenterology 136:A759, 2009.
16. Wang XF, Doan HQ, Wang QD, Jackson LN, Evers BM.  Suppression of neurotensin receptor type I expression and function by histone deacetylase inhibitors involves GSK-3β/ERK pathway inhibition.  Gastroenterology 136:A236, 2009.

National Presentations:

1. Targeted RNA interference of PI3K pathway components confers survival benefit in a mouse model of inflammatory bowel disease. American College of Surgeons (Surgical Forum) (Oct. 2005, San Francisco, CA) (oral).
   
2. Role of PIK3CA gene in colon adenocarcinoma progression. Southern Surgical Association (Dec. 2005, Hot Springs, VA) (oral).
   PI3K/Akt activation is critical for hepatic regeneration after partial hepatectomy. Academic Surgical Congress [Assn. for Academic Surgery & Society of University Surgeons] (Feb. 2006, San Diego, CA) (oral poster).
   
3. Differential effects of selective or complete PI3K inhibition in a murine inflammatory bowel disease model. American Gastroenterological Assn. (May 2006, Los Angeles, CA) (poster).
   
4. Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells. American Gastroenterological Assn (May 2006, Los Angeles, CA) (poster).
   
5. PI3K/Akt activation is critical for hepatic regeneration after partial hepatectomy. American College of Surgeons (Oct. 2006, Chicago, IL) (oral).
   
6. Targeted knockdown of PI3K components with small interfering RNA (siRNA) inhibits liver regeneration following partial hepatectomy. Academic Surgical Congress (SUS, AAS) (Feb. 2007, Phoenix, AZ) (oral).
   
7. Development and characterization of a novel in vivo model for carcinoid syndrome. American Gastroenterological Assn. (May 2007, Washington, DC) (oral).

 

 

Carlos Murillo, MD
Medical School: The University of Texas Medical Branch
Mentors: Evers B,  Chung DH, Helllmich MR
Research Topic: Signaling mechanisms involved in aging and inflammation
Current Position: Resident Instructor, Texas Tech Univ. Health Sciences Center School of Medicine, Surgery, El Paso, TX

 

Awards:
Jeanne B. Kempner Scholar Award (2004-2005)
American College of Surgeons Forum on Fundamental Surgical Problems Research/Fellow Excellence in Research Award (2005)
Society of University Surgeons Residents Award (2007)

Publications:

1. Farrow B, Rychahou P, Murillo C, O’Connor KL, Iwamura T, Evers BM. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134:197-205, 2003.
   
2. Murillo CA, Rychahou PG, Evers BM. Inhibition of α5 integrin decreases PI3K activation and cell adhesion of human colon cancers. Surgery 136:143-149, 2004.
   
3. Sugiyama Y, Farrow B, Murillo C, Li J, Watanabe H, Sugiyama K, Evers BM. Analysis of differential gene expression patterns in colon cancer stroma using microdissected tissues. Gastroenterology 128:480-486, 2005.
   
4. Rychahou PG, Murillo CA, Evers BM. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery 138:391-397, 2005.
   
5. Murillo CA, Woodside KJ, Jackson LN, Evers BM. Neoplastic disorders of the gastrointestinal tract. In: Thomas Miller (Editor) Modern Surgical Care: Physiologic Foundations and Clinical Applications, 3rd Edition (2006). Marcel Dekker Inc, New York, NY, pp. 555-586.

Abstracts:

1. Kim S, Murillo C, Wang QD, Domon-Dell C, Freund JN, Evers BM. The homeobox gene CDX-2 is up-regulated in HT-29 cells by PI3-kinase inhibition. Gastroenterology 118:A820, 2000.
   
2. Murillo C, Wang QD, Farrow B, Marquant W, Evers BM. Inhibition of phosphatidylinositol 3-kinase attenuates the severity of dextran sulfate sodium induced intestinal inflammation. Gastroenterology 124:A801, 2003.
   
3. Murillo C, Evers BM. Novel age-associated induction of components of the phosphatidylinositol-3 kinase (PI3K)/Akt signaling in the intestine. Journal of the American College of Surgeons 197:S7, 2003.
   
4. Rychahou PG, Murillo CA, Evers BM. Downregulation of the PI3K/Akt pathway leads to decreased invasion of the human colon cancer cells. Journal of the American College of Surgeons 199:S10, 2004.
   
5. Sugiyama Y, Farrow B, Murillo C, Evers BM.  Identification of genes differentially expressed in microdissected colon cancer cells and tumor stroma matched to paired normal tissue.  Proceedings of the American Association for Cancer Research 45:3706, 2004
   
6. Murillo CA, Rychahou PR, Evers BM. RNAi-mediated inhibition of cyclin D1 decreases colon cancer cell proliferation and MMP protein expression. Journal of the American College of Surgeons 199:S11, 2004.

National Presentations:

1. Modulation of Akt phosphorylation by changes in PTEN and PI3K levels in the aorta of aged mice. Joan L. & Julius H. Jacobson Research Initiatives in Vascular Disease Conference (Apr. 2003) (oral).
2. Inhibition of phosphatidylinositol 3-kinase attenuates the severity of dextran sulfate sodium induced intestinal inflammation. Society for Surgery of the Alimentary Tract (May 2003, Orlando, FL) (oral and poster).
   
3. Differential expression of integrins and matrix metalloproteinases in primary and recurrent carotid atherosclerosis. Western Vascular Society (Sept. 2003, Kohala Coast, Hawaii) (oral).
   
4. Phosphatidylinositol-3 kinase (PI3K)/Akt signaling in the intestine. American College of Surgeons (Surgical Forum) (Oct. 2003, Chicago, IL) (oral).
   
5. Inhibition of a5 integrin decreases PI3K activation and increases apoptosis of human colon cancers. Society of University Surgeons (Feb. 2004, St. Louis, MO) (oral).
   
6. Inhibition of phosphoinositol 3-kinase using anti-p85 siRNA attenuates dextran-sulfate-induced inflammatory bowel disease. American Gastroenterological Assn. (May 2004, New Orleans, LA) (oral).
   
7. RNAi-mediated inhibition of cyclin D1 decreases colon cancer cell proliferation and MMP protein expression. American College of Surgeons (Surgical Forum) (Oct. 2004, New Orleans, LA) (oral).

 

Michele Slogoff, M.D.
Medical School: The University of Texas Medical Branch
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: Neurotensin-mediated signaling pathways and physiologic role of neurotensin in the gut
Current Position: Assistant Professor, Department of Surgery, Loyola University, Chicago, IL

 

Awards:
Jeane B. Kempner Scholars Award (07/012002 - 06/30/2003)

Publications:

1. Slogoff MI, Li FZ, Cao Y, Guo Y, Hellmich MR, Townsend CM Jr, Ko TC. Bombesin potentiates transforming growth factor-β (TGF-β)-mediated cell death in intestinal epithelial cells. J Surg Res 107:293, 2002. (A)
2. Ethridge RT, Chung DH, Slogoff M, Ehlers RA, Hellmich MR, Rajaraman S, Saito H, Uchida T, Evers BM. Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 123:1311-1322, 2002.
3. Ethridge RT, Slogoff MI, Chung DH, Evers BM. COX-2 gene disruption results in the attenuation of NF-κ-B activity. Gastroenterology 124:A 501, 2003. (A) Slogoff MI, Ethridge RT, Walker SL, Evers BM. Alteration of cytokine expression and release associated with COX-2 inhibition in acute pancreatitis. Gastroenterology 124:A 804, 2003. (A)
4. Thomas RP, Slogoff M, Smith FW, Evers BM. Effect of aging on the adaptive and proliferative capacity of the small bowel. J Gastrointest Surg 7:88-95, 2003.
5. Slogoff M, Evers BM. Neurotensin. In: Henry HL, Norman AW, et al (eds). Encyclopedia of Hormones, vol. 3. Academic Press: San Diego, 2003, pp. 45-53.
6. Slogoff MI, Ethridge RT, Rajaraman S, Evers BM. COX-2 inhibition results in alterations in nuclear factor (NF)-κ-B activation but not cytokine production in acute pancreatitis. J Gastrointest Surg 8:511-519, 2004.

Presentations:

1. American College of Surgeons (Surgical Forum) (Oct. 2002, San Francisco, CA) – Induction of nuclear factor-kB activation in colon cancer cells by neurotensin. (oral)
2. Assn. for Academic Surgery (Nov. 2002, Boston, MA) – Bombesin potentiates transforming growth factor- β (TGF-β)-mediated cell death in intestinal epithelial cells. (oral)
3. Society for Surgery of the Alimentary Tract       (May 2003, Orlando, FL) – Alteration of cytokine expression and release associated with COX-2 inhibition in acute pancreatitis (poster).

Robert Thomas, M.D.
Medical School: The University of Texas Medical Branch
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: Alterations of gene expression and function in the GI tract with aging
Current Position:Assistant Professor of Surgery/Division of Pediatric Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX

Awards:
Singleton Surgical Society Resident Research Award (2001)

Publications:

1. Thomas RP, Evers BM. The molecular biology of gastrointestinal neoplasia. New Surgery 1:10-16, 2001.
2. Wang Q,Thomas R, Li N, Wang X, Evers BM. Gene array analysis of the expression profile associated with intestinal cell differentiation. Gastroenterology 120:A88, 2001. (A)
3. Thomas R, Evers BM. Effects of aging on gene expression patterns in the liver. Gastroenterology 120:A90, 2001. (A)
4. Thomas RP, Evers BM. Alteration of oxidant/antioxidant gene expression patterns in rat small bowel with age. Surg Forum 52:15-16, 2001.
5. Hashimoto K, Ethridge RT, Kim S, Thomas RP, Evers BM. 15-Deoxy-δ 12,14-prostaglandin J2 (15d-PGJ2) inhibits human pancreatic cancer cell invasion and release of matrix metalloproteinases. Surg Forum 52:217-218, 2001.
6. Thomas RP, Hunter GC. Protein kinase C modulates H2O2-induced caspase-3-like activity in rat aortic smooth muscle cells. Surg Forum 52:390-393, 2001.
7. Chung DH, Owens-Stovall S, Kim S, Ethridge RT, Hashimoto K, Thomas RP, Evers BM. Inhibition of NF-κB by peroxisome proliferator-activated receptor-gamma agonist in necrotizing enterocolitis. Surg Forum 52:499-501, 2001
8. Kim S, Hu W, Thomas RP, Evers BM, Chung DH. Interferon-gamma induces caspase-8 in neuroblastoma cells: death receptor mediated apoptosis is dependent on caspase-8 and concomitant prevention of NF κB activation. Proc Am Assoc Cancer Res 43:705, 2002. (A)
9. Kim S, Hu W, Thomas RP, Evers BM, Chung DH. Geldanamycin induces apoptosis in neuroblastomas by reducing Raf-1 and Akt. Proc Am Assoc Cancer Res 43:891, 2002. (A)
10. Thomas RP, Farrow BJ, Kim S, Wang Q, Wang X, Evers BM. Butyrate sensitizes human pancreatic cancer cell to TRAIL-mediated apoptosis through TRAIL-receptor upregulation. Proc Am Assoc Cancer Res 43:702, 2002. (A)
11. Wang Q, Wang X, Thomas RP, Walker SL, Hellmich MR, Evers BM. Phorbol ester-induced cIAP2 expression in human colon cancer cells is dependent on the novel protein kinase C-δ. Proc Am Assoc Cancer Res 43:530, 2002. (A)
12. Wang X-F, Wang Q, Thomas RP, Evers BM. PKC-mediated induction of TRAF1 in human colon cancer cells is dependent on K-ras activation. Proc Am Assoc Cancer Res 43:107, 2002. (A)
13. Wang Q-D, Wang X-F, Thomas RP, Walker SL, Evers BM. Inhibition of GSK-3β attenuates sodium butyrate-mediated differentiation and apoptosis in the HT29 colon cancer cells. Gastroenterology 122:A132, 2002. (A)
14. Wang X-F, Wang Q-D, Hu W-Q, Thomas RP, Evers BM. Phorbol 12-myristate 13-acetate upregulates expression of proapoptotic genes and increases the sensitivity of Panc-1 cells to TRAIL. Gastroenterology 122:A242, 2002. (A)
15. Thomas RP, Smith FW, Evers BM. Effect of aging on the adaptive and proliferative capacity of the small bowel. Gastroenterology 123 (suppl):20, 2002. (A)
16. Thomas RP, Kim S, Wang Q-D, Evers BM. Gene expression profile analysis of the phosphatidylinositol 3-kinase pathway in the developing small intestine. J Am Coll Surg 195 (suppl):S11, 2002. (A)
    
17. Kim S, Thomas RP, Kang J, Evers BM, Chung DH. PI3-kinase inhibition increases TRAIL-induced apoptosis in neuroblastoma. J Am Coll Surg 195 (suppl):S42, 2002. (A)
18. Hernandez A, Thomas R, Smith F, Sandberg J, Kim S, Chung DH, Evers BM. Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. Surgery 130:265-272, 2001.
19. Farrow B, Thomas RP, Wang XF, Evers BM. Activation of conventional PKC isoforms increases expression of the pro-apoptotic protein Bad and TRAIL receptors. Int J Gastrointest Cancer 32:63-72, 2002.
20. Thomas RP, Farrow BJ, Kim S, May MJ, Hellmich MR, Evers BM. Selective targeting of the nuclear factor-κB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. Surgery 132:127-134, 2002. 20. Hu M, Woodside KJ, Thomas RP, Meng T, Cooper CW, Sower LE, Hunter GC, Daller JA. Altered PTHrP expression during cold storage with thymoglobulin. Transplant Proc 34:1629-1631, 2002.
21. Thomas RP, Guigneaux M, Wood T, Evers BM. Age-associated changes in gene expression patterns in the liver. J Gastrointest Surg 6:445-454, 2002.
22. Murillo CA, Owens-Stovall SK, Kim S, Thomas RP, Chung DH. Delayed cardiac tamponade after blunt chest trauma in a child. J Trauma 52:573-575, 2002.
23. Thomas RP, Hellmich MR, Townsend CM, Jr., Evers BM. Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues. Endocr Rev 24:571-599, 2003.
24. Thomas RP, Rajaraman S, Evers BM. Effect of ileocolonic transposition on gut morphology, gene expression, and function. J Surg Res 109:31-36, 2003.
25. Thomas RP, Slogoff M, Smith FW, Evers BM. Effect of aging on the adaptive and proliferative capacity of the small bowel. J Gastrointest Surg 7:88-95, 2003.
26. Kim S, Kang J, Qiao J, Thomas RP, Evers BM, Chung DH. Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. J Pediatr Surg 39:516-521, 2004.
27. Evers BM, Thomas RP. Tropic effects of gut hormones in the gastrointestinal tract. Chapter 337. Handbook in Cell Signaling, Volume 3. In: RA Bradshaw, EA Dennis (eds). Academic Press: San Diego, CA, 2004, p 477-484.

Presentations:

1. Surgical Forum (7-12 October 2001, New Orleans, LA) - Alteration of oxidant/antioxidant gene expression patterns in rat small bowel with age (oral).
2. Society for the Surgery of the Alimentary Tract (May 2001, Atlanta, GA) - Effects of aging on gene expression patterns in the liver (oral).
3. Society of University Surgeons (February 2002, Honolulu, HI) - Selective targeting of the NF-κB pathway enhances TRAIL-mediated pancreatic cancer cell death. (oral and manuscript).
4. American Association for Cancer Research (April 2002, San Francisco, CA) - Butyrate sensitizes human pancreatic cancer cell to TRAIL-mediated apoptosis through TRAIL-receptor upregulation (poster).
5. Society for the Surgery of the Alimentary Tract (May 2002, San Francisco, CA) - Effect of aging on the adaptive and proliferative capacity of the small bowel (poster).

Sunghoon Kim, M.D.
Medical School: University of California at Davis
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: PI3K/PTEN signaling pathway and intestinal cell differentiation
Current Position:Chief of Pediatric Surgery, Children's Hospital & Research Center at Oakland, Oakland, CA

 

Awards: The Texas Gulf Coast Digestive Diseases Center Pilot/Feasibility Award (2001-2002)

Publications:

1. Kim S, Murillo C, Wang Q, Domon-Dell C, Freund J-N, Evers BM. The homeobox gene CDX-2 is upregulated in HT-29 cells by P13-kinase inhibition. Gastroenterology 118:A820, 2000. (A)
2. Ehlers RA, Kim S, Zhang Y, Ethridge RT, Murrilo C, Hellmich MR, Evans DB, Townsend CM, Jr, Evers BM. Gut peptide receptor expression in human pancreatic cancers. Ann Surg 231:838-848, 2000.
3. Kim S, Chung DH, Escalon J, Hsieh J, Hellmich MR, Evers BM. Expression and functional regulation of the gastrin-releasing peptide receptor in the neuroblastoma cell line IMR-32. Surg Forum 51:532-534, 2000.
4. Wang Q, Kim S, Wang X, Evers BM. Activation of NF-κB binding in HT-29 colon cancer cells by inhibition of phosphatidylinositol 3-kinase. Biochem Biophys Res Commun 273:853-858, 2000.
5. Wang Q, Wang X, Kim S, Evers BM. Induction of TRAIL expression in fetal intestinal cells associated with PI3-kinase inhibition and differentiation. Gastroenterology 120:A104, 2001. (A)
6. Kim S, Domon-Dell C, Wang Q, Chung DH, Freund J-N, Evers BM. The PI3K/glycogen synthase kinase 3 pathway regulates nuclear translocation of the Cdx-2 transcription factor in colon cancer cells. Gastroenterology 120:A500, 2001. (A)
7. Wang Q, Wang X, Hernandez A, Kim S, Evers BM. Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. Gastroenterology 120:1381-1392, 2001
8. Chung DH, Ethridge RT, Kim S, Owens-Stovall S, Hernandez A, Kelly DR, Evers BM. Molecular mechanisms contributing to necrotizing enterocolitis. Ann Surg 233:835-842, 2001.
9. Hashimoto K, Ethridge RT, Kim S, Thomas RP, Evers BM. 15-Deoxy-δ 12,14-prostaglandin J2 (15d-PGJ2) inhibits human pancreatic cancer cell invasion and release of matrix metalloproteinases. Surg Forum 52:217-218, 2001.
10. Chung DH, Owens-Stovall S, Kim S, Ethridge RT, Hashimoto K, Thomas RP, Evers BM. Inhibition of NF-κB by peroxisome proliferator-activated receptor-gamma agonist in necrotizing enterocolitis. Surg Forum 52:499-501, 2001.
11. Domon-Dell C, Wang Q, Kim S, Kedinger M, Evers BM, Freund JN. Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. Gut 50:525-529, 2002.
12. Kim S, Hu W, Thomas RP, Evers BM, Chung DH. Interferon-gamma induces caspase-8 in neuroblastoma cells: death receptor mediated apoptosis is dependent on caspase-8 and concomitant prevention of NF κ B activation. Proc Am Assoc Cancer Res 43:705, 2002. (A)
13. Kim S, Hu W, Thomas RP, Evers BM, Chung DH. Geldanamycin induces apoptosis in neuroblastomas by reducing Raf-1 and Akt. Proc Am Assoc Cancer Res 43:891, 2002. (A)
14. Thomas RP, Farrow BJ, Kim S, Wang Q, Wang X, Evers BM. Butyrate sensitizes human pancreatic cancer cell to TRAIL-mediated apoptosis through TRAIL-receptor upregulation. Proc Am Assoc Cancer Res 43:702, 2002. (A)
15. Kim S, Kang J, Kelly DR, Hellmich MR, Evers BM, Chung DH. Mitogenic actions of gastrin-releasing peptide in neuroblastomas. Regul Pept 108:22, 2002. (A)
16. Thomas RP, Kim S, Wang Q-D, Evers BM. Gene expression profile analysis of the phosphatidylinositol 3-kinase pathway in the developing small intestine. J Am Coll Surg 195 (suppl):S11, 2002. (A)
17. Kim S, Thomas RP, Kang J, Evers BM, Chung DH. PI3-kinase inhibition increases TRAIL-induced apoptosis in neuroblastoma. J Am Coll Surg 195 (suppl):S42, 2002. (A)
18. Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κ B-dependent pathway. Gastroenterology 123:1163-1178, 2002.
19. Thomas RP, Farrow BJ, Kim S, May MJ, Hellmich MR, Evers BM. Selective targeting of the nuclear factor-κB pathway enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated pancreatic cancer cell death. Surgery 132:127-134, 2002.
20. Kim S, Hu W, Kelly DR, Hellmich MR, Evers BM, Chung DH. Gastrin-releasing peptide is a growth factor for human neuroblastomas. Ann Surg 235:621-630, 2002.
21. Murillo CA, Owens-Stovall SK, Kim S, Thomas RP, Chung DH. Delayed cardiac tamponade after blunt chest trauma in a child. J Trauma 52:573-575, 2002.
22. Kim S, Kang J, Qiao J, Kamal A, Burrows FJ, Evers BM, Chung DH. Heat shock protein 90 inhibitors reduce neuroblastoma growth in vivo. Proc Am Assoc Cancer Res 44:178, 2003. (A)
23. Qiao J, Kim S, Kang J, Evers BM, Chung DH. Negative regulation of transforming growth factor-β/SMAD by phosphatidylinositol 3-kinase pathway in neuroblastomas. J Am Coll Surg 197(suppl):S50, 2003. (A)
24. Kim S. Molecular biology of aging. Arch Surg 138:1051-1054, 2003.
25. Kim S, Kang J, Hu W, Evers BM, Chung DH. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. Int J Cancer 103:352-359, 2003.
26. Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM. Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-κB (NF-κB)-inducing kinase/NF-κB pathway is linked to a default IκB-alpha autoregulatory loop. J Biol Chem 279:4285-4291, 2004.
27. Qiao J, Cree J, Kang J, Kim S, Evers BM, Chung DH. Ets transcriptional regulation of gastrin-releasing peptide receptor in neuroblastomas. Surgery 136:489-494, 2004.
28. Kim S, Kang J, Qiao J, Thomas RP, Evers BM, Chung DH. Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. J Pediatr Surg 39:516-521, 2004.
29. Kim S, Kang J, Evers BM, Chung DH. Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter. J Pediatr Surg 39:509-515, 2004.

Presentations:

1. American Gastroenterological Association (San Diego, CA, May 2000) - The homeobox gene Cdx-2 is up-regulated I HT-29 cells by P13-kinase inhibition (poster).
2. Surgical Forum (October 2000, Chicago, IL) - Expression and functional regulation of the gastrin-releasing peptide (GRP) receptor in the neuroblastoma cell line IMR-32 (oral).
3. Society of University Surgeons (February 2001, Chicago, IL) - Differential expression of the PTEN tumor suppressor gene in the colon and regulation by P13K/Akt pathway (oral).
4. American Association for Cancer Research (March 2001, New Orleans, LA) - Transcriptional regulation of human neurotensin receptor by P13-kinase in human neuroblastoma (poster).
5. Surgical Forum ( American College of Surgeons, October 7-12, 2001, New Orleans LA) Thomas RP, Evers, BM. Alteration of oxidant/antioxidant gene expression patterns in the small bowel with age. (oral).
6. American Gastroenterological Association (May 2001, Atlanta, GA) - The PI3/glycogen synthase kinase 3 pathway regulates nuclear translocation of the Cdx-2 transcription factor in colon cancer cells (poster).
7. American Association for Cancer Research (May 2002, San Francisco, CA) - Interferon-gamma induces caspase-8 in neuroblastoma cells: death receptor mediated apoptosis is dependent on caspase-8 and concomitant prevention of NF-κB activation (poster).

Ambrosio Hernandez, M.D.
Medical School: The University of Texas Medical Branch
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: Examining the role of TRAIL-mediated immune-escape in colorectal carcinoma
Current Position:Pediatric Surgeon, Driscoll Children’s Hospital, Driscoll Children’s Specialty Clinic McAllen, TX

Publications:

1. Hernandez A, Evers BM. Novel molecular mechanisms contributing to colon cancer survival. Surg Forum 50:336-338, 1999.
   
2. Hernandez A, Evers BM. Functional genomics. Clinical effect and the evolving role of the surgeon. Arch Surg 134:1209-1215, 1999.
   
3. Ehlers RA, Hernandez A, Bloemendal LS, Ethridge RT, Farrow B, Evers BM. Mitochondrial DNA damage and altered membrane potential in pancreatic acinar cells induced by reactive oxygen species. Surgery 126:148-155, 1999.
   
4. Hernandez A, Evers BM. Novel molecular mechanisms contributing to colon cancer survival. Surg Forum 50:336-338, 1999.
   
5. Hernandez A, Evers BM. Functional genomics. Clinical effect and the evolving role of the surgeon. Arch Surg 134:1209-1215, 1999.
   
6. Hernandez A, Schwartz SA, Wang Q, Evers BM. Sensitization of human colon cancer cells to Trail-mediated apoptosis. Gastroenterology 118:A1025, 2000 (A)
   
7. Hernandez A, Wang Q, Evers BM. Trail-mediated immune escape by colon cancers. Gastroenterology 118:A533, 2000. (A)
   
8. Wang Q, Kim M, Li N, Hernandez A, Evers BM. Inhibition of P13-K enhances apoptosis of human colon cancer cells treated with sodium butyrate. Gastroenterology 118:A527, 2000. (A)
   
9. Wang Q, Wang X, Hernandez A, Evers BM. Induction of Trail in HT29 colon cancer cells by P13-K inhibition. Gastroenterology 118:A542, 2000. (A)
   
10. Hernandez A, Smith F, Wang Q, Wang X, Evers BM. Assessment of differential gene expression patterns in human colon cancers. Ann Surg 232:576-585, 2000.
    
11. Hernandez A, Wang QD, Wang X, Gatalica Z, Evers BM. Intestinal cell differentiation is associated with increased TRAIL expression. Surg Forum 51:56-57, 2000.
    
12. Hernandez A, Thomas R, Smith F, Sandberg J, Kim S, Chung DH, Evers BM. Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. Surgery 130:265-272, 2001.

Presentations:

1. Surgical Forum (October 1999, San Francisco, CA) - Novel molecular mechanisms contributing to colon cancer survival (oral).
   
2. Society of University Surgeons Resident’s Program (February 2000, Toronto, Canada) - Trail-mediated immune escape by colon cancers (oral).
   
3. American Surgical Association ( Philadelphia, PA April 2000) - cDNA microarrays demonstrate differential gene expression patterns in colon cancers of varying metastatic potential (oral and manuscript).
   
4. American Gastroenterological Association (San Diego, CA, May 2000) - Trail-mediated immune escape by colon cancers (poster).
   
5. Society for Surgery of the Alimentary Tract (San Diego, CA, May 2000) - Sensitization of human colon cancer cells to TRAIL-mediated apoptosis (poster).
   
6. Surgical Forum (October 2000, Chicago, IL) - Intestinal cell differentiation is associated with increased TRAIL expression (oral).
   
7. Society of University Surgeons (February 2001, Chicago, IL) - Butyrate sensitizes human colon cancer cells to TRAIL-medicated apoptosis (oral).

 

David Litvak, M.D.
Medical School: University of Chicago, Pritzker School of Medicine
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: Effects of gut hormones on mucosal adaptation and growth
Current Position: Surgical Oncologist/ General Surgeon, Southern California Permanente Medical Group
Department of Surgery, Kaiser Permanente Medical Center, Anaheim, CA

Publications:

1. Litvak DA, Hellmich MR, Evers BM, Banker NA, Uchida T, Townsend CM Jr. Glucagon-like peptide 2: a potent intestinal growth factor. Gastroenterology 112:A1455 1997.
   
2. Litvak DA, Hellmich MR, Evers BM, Banker NA, Townsend CM Jr. Glucagon-like peptide 2 is a potent growth factor for small intestine and colon. J Gastrointest Surg 2:146-150, 1998.
   
3. Litvak DA, Papaconstantinou HT, Ko TC, Townsend CM Jr. A novel cytotoxic agent for human carcinoid tumors. Surgery 124:1071-1076, 1998.
4. Litvak DA, Iseki H, Evers BM, Greeley GH Jr, Hellmich MR, Iwase K, Balasubramaniam A, Townsend CM Jr. Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM 43004C. Dig Dis Sci 44:643-648, 1999.
   
5. Litvak DA, Papaconstantinou HT, Townsend CM Jr, Evers BM. Targeting molecular pathways as novel therapy for gastric cancer. Gastroenterology 116:A1330, 1999 (A).
   
6. Litvak DA, Hellmich MR, Iwase K, Evers BM, Martinez J, Amblard M, Townsend CM Jr. JMV1155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo. Anticancer Res 19:45-50, 1999.
   
7. Litvak DA. Angiogenesis and GI cancer. In: BM Evers (ed). Molecular Mechanisms in Gastrointestinal Cancer. R.G. Landes Company: Austin, 1999, pp. 95-109.
   
8. Litvak DA, Evers BM, Hellmich MR, Townsend CM Jr. Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin. J Gastrointest Surg 3:432-440, 1999.
   
9. Litvak DA, Papaconstantinou HT, Hwang KO, Kim M, Evers BM, Townsend CM Jr. Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways. Surgery 126:223-230, 1999.
   
10. Litvak DA, Papaconstantinou HT, Evers BM, Townsend CM Jr. Targeting molecular pathways with camptothecin as novel therapy for gastric cancer. J Gastrointest Surg 3:618-624, 1999.
    
11. Litvak DA, Papaconstantinou HT, Hwang KO, Kim M, Evers BM, Townsend CM Jr. Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways. Surgery 126:223-230, 1999.
    
12. Litvak DA, Papaconstantinou HT, Evers BM, Townsend CM Jr. Targeting molecular pathways with camptothecin as novel therapy for gastric cancer. J Gastrointest Surg 3:618-624, 1999.
    
13. Litvak DA, Hwang KO, Evers BM, Townsend CM Jr. Induction of apoptosis in human gastric cancer by sodium butyrate. Anticancer Res 20:779-784, 2000.
    
14. Shin CE, Falcone RA Jr, Kemp CJ, Erwin CR, Litvak DA, Evers BM, Warner BW. Intestinal adaptation and enterocyte apoptosis following small bowel resection is p53 independent. Am J Physiol 277:G717-G724, 1999.
    
15. Kim HJ, Evers BM, Litvak DA, Hellmich MR, Townsend CM Jr. Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA. Am J Physiol 279:C326-C334, 2000

Presentations:

1. Society for Surgery of the Alimentary Tract (11-14 May 1997, Washington, DC) - Glucagon-like peptide 2: a potent intestinal growth factor. (oral)
   
2. Surgical Forum (October 1997, Chicago, IL) - Neurotensin augments glucagon-like peptide-2-induced intestinal growth. (oral and manuscript).
   
3. Association of Academic Surgeons (November 1997, Dallas TX) - Identification of a potent reabsorptive PYY analog (oral and manuscript).
   
4. Society of University Surgeons (February 1998, Milwaukee, WI) - Gut differentiation is associated with apoptosis and early induction of p21WAF1/Cip1 (oral and manuscript).
   
5. Society of Surgical Oncology (March 1998, San Diego, CA) - JMV1155: a novel inhibitor of progastrin-mediated growth of a human colon cancer (poster).
   
6. American Association of Endocrine Surgeons (April, 1998, Orlando, FL) - A novel cytotoxic agent for human carcinoid. (oral and manuscript).
   
7. Society for Surgery of the Alimentary Tract (May 1998, New Orleans, LA) - The enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin (oral).
   
8. Association of Academic Surgeons (November 1998, Seattle, WA) - Sodium butyrate induces apoptosis and p21WAF1/Cip1 in the gastric cancer SIIA (oral).
   
9. Society of University Surgeons (February 1999, New Orleans, LA) - Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways (oral).
   
10. Society for Surgery of the Alimentary Tract (May 1999 Orlando, FL) - Targeting molecular pathways as novel therapy for gastric cancer (oral)

H.J. Kim, M.D.
Medical School: University of Virginia School of Medicine
Mentors: Townsend, CM, Jr, Evers, BM
Research Topic: Cellular mechanisms involved in gastrin- and bombesin-mediated growth of human cancer cells
Current Position: Assistant Professor, Department of Surgery, University of North Carolina, Chapel Hill, NC

 

Awards:
Society for Surgery of the Alimentary Tract Ross Laboratories Resident Research Award (1996)
Singleton Surgical Society Resident Research Award (1996)

Publications:

1. Kim HJ, Evers BM, Guo Y, Banker NA, Hellmich MR, Townsend CM Jr. Bombesin-mediated AP 1 activation in a human gastric cancer (SIIA). Surgery 120:130-137, 1996
2. Iwase K, Evers BM, Hellmich MR, Kim HJ, Higashide S, Gully D, Thompson JC, Townsend CM Jr. Inhibition of neurotensin-induced pancreatic carcinoma growth by a nonpeptide neurotensin receptor antagonist, SR48692. Cancer 79:1787-1793, 1997.
3. Kim HJ, Evers BM, Banker NA, Hellmich MR, Townsend CM Jr. A functional in vitro model to examine signaling mechanisms in gastrin-mediated human cell growth. J Gastrointestinal Surg 1:69-77, 1997.
4. Iwase K, Evers BM, Hellmich MR, Kim HJ, Higashide S, Gully D, Townsend CM Jr. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth. Surg Oncol 5:245-251, 1996.
5. Iwase K, Evers BM, Hellmich MR, Kim HJ, Higashide S, Gully D, Townsend CM Jr. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth. Surg Oncol 5:245-251, 1996.
6. Banker NA, Evers BM, Kim HJ, Hellmich MR, Townsend CM Jr. c-Src kinase activity is elevated in human gastric cancer. Surg Forum 48:828-830, 1997.
7. Bold RJ, Kim HJ, Ishizuka J, Townsend CM Jr, Thompson JC. A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide. Cancer Invest 16:12-17, 1998.
8. Kim HJ, Evers BM, Banker NA, Greeley GH Jr, Hellmich MR, Thompson JC, Townsend CM Jr. Novel expression and regulation of gastrin gene in human ovarian cancer cell line, SW626. Dig Dis Sci 43:1465-1473, 1998.
9. Kim HJ, Evers BM, Litvak DA, Hellmich MR, Townsend CM Jr. Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA. Am J Physiol 279:C326-C334, 2000.

Presentations:
1. Association for Academic Surgery (8-11 Nov 1995, Dearborn, MI) - Novel expression of gut peptides and receptors in ovarian cancer. (oral)
2. Society of University Surgeons (8-10 Feb 1996, Washington, DC) - Cellular mechanisms in bombesin-mediated regulation of AP-1 gene expression. (oral)
3. Society for Surgery of the Alimentary Tract (19-22 May 1996, San Francisco, CA) - Signal transduction mechanisms in gastrin regulation of human cell growth. (oral and poster)

Rick J. Bold, M.D.
Medical School: Stanford University School of Medicine
Mentors: Townsend, CM Jr
Research Topic: GI hormones, receptors and cancer
Current Position: Assistant Professor, Surgical Oncology, University of California, Davis, CA

Publications:

1. Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. Secretin potentiates cholecystokinin-stimulated amylase release from pancreatic acinar cells by a pertussis toxin-sensitive mechanism. Surg Forum 44:167-170, 1993.
2. Hirai M, Ishizuka J, Hirai A, Bold RJ, Townsend CM Jr, Thompson JC. Bombesin stimulates intracellular Ca2+ mobilization but not proliferation on human colon cancer cells. Life Sci 53:1859-1865, 1993.
3. Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. Biomolecular advances in gastrointestinal hormones. Arch Surg 128:1268-1273, 1993.
4. Ishizuka J, Townsend CM Jr, Bold RJ, Martinez J, Rodriguez M, Thompson JC. Effects of gastrin on 3’,5’-cyclic adenosine monophosphate, intracellular calcium, and phosphatidylinositol hydrolysis in human colon cancer cells. Cancer Res 54:2129-2135, 1994.
5. Ishizuka J, Bold RJ, Townsend CM Jr, Thompson JC. In vitro relationship between magnesium and insulin secretion. Magnes Res 7:17-22, 1994.
6. Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem Biophys Res Commun 202:1222-1226, 1994.
7. Bold RJ, Warren RE, Ishizuka J, Cho-Chung YS, Townsend CM Jr, Thompson JC. Experimental gene therapy of human colon cancer. Surgery 116:189-196, 1994.
8. Bold RJ, Alpard S, Ishizuka J, Townsend CM Jr, Thompson JC. Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content. Regul Pept 53:61-70, 1994.
9. Yao CZ, Ishizuka J, Bold RJ, Townsend CM Jr, Thompson JC. Cytocidal effect of high energy shock wave on tumour cells enhanced with larger dose and multiple exposures. Surg Oncol 3:229-235, 1994.
10. Bold RJ, Evers BM, Sperling HE, Gomez G, Ishizuka J, Townsend CM Jr, Thompson JC. Gastrointestinal hormone receptors and pancreatic cancer. Intl J Pancreatol 16:240-241, 1994.
11. Bold RJ, Lowry PS, Ishizuka J, Battey JF, Townsend CM Jr, Thompson JC. Bombesin stimulates the in vitro growth of a human gastric cancer cell line. J Cell Physiol 161:519-525, 1994.
12. Gomez G, Padilla LA, Bold RJ, Chen RR, Greeley GH Jr, Townsend CM Jr, Thompson JC. Cholecystokinin (CCK) and secretin stimulate implantation and growth of a human gastric adenocarcinoma. Surg Forum 45:130-132, 1994.
13. Bold RJ, Evers BM, Ishizuka J, Townsend CM Jr, Thompson JC. Functional responses of the endocrine cell line (BON) transfected with the human bombesin receptor. Surg Forum 45:158-160, 1994.
14. Ishizuka J, Bold RJ, Townsend CM Jr,Thompson JC. Role of calcium in the regulation of ornithine decarboxylase enzyme activity in mouse colon cancer cells. Cancer Invest 13:181-187, 1995.
15. Yao CZ, Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. Growth of mouse hepatocytes is stimulated by gastrin. J Cell Physiol 163:532-537, 1995.
16. Bold RJ, Ishizuka J, Rajaraman S, Perez-Polo JR, Townsend CM Jr, Thompson JC. Nerve growth factor as a mitogen for a pancreatic carcinoid cell line. J Neurochem 64:2622-2628, 1995.
17. Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. Secretin potentiates cholecystokinin-stimulated amylase release by AR4 2J cells via a stimulation of phospholipase C. J Cell Physiol 165:172-176, 1995.
18. Bold RJ, Ishizuka J, Townsend CM Jr, Thompson JC. All-trans-retinoic acid inhibits growth of a human pancreatic cancer cell line. Pancreas 12:189-195, 1996.
19. Yao CZ, Ishizuka J, Bold RJ, Sperling HE, Townsend CM Jr, Thompson JC. Human monoclonal antibody against colon cancer. Cancer Invest 14:211-217, 1996.
20. Hirai A, Bold RJ, Ishizuka J, Hirai M, Townsend CM Jr, Thompson JC. Hyperphosphorylation of retinoblastoma protein and stimulation of growth by okadaic acid in human pancreatic cancer. Dig Dis Sci 41:1975-1980, 1996.
21. Hirai A, Bold RJ, Ishizuka J, Hirai M, Townsend CM Jr, Thompson JC. Hyperphosphorylation of retinoblastoma protein and stimulation of growth by okadaic acid in human pancreatic cancer. Dig Dis Sci 41:1975-1980, 1996.
22. Bold RJ, Ishizuka J, Townsend CM Jr. Progress toward hormonal therapy of gastrointestinal cancer. Ann Surg 223:4-11, 1996.
23. Bold RJ, Kim HJ, Ishizuka J, Townsend CM Jr, Thompson JC. A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide. Cancer Invest 16:12-17, 1998.
24. Bold RJ, Ishizuka J, Yao CZ, Townsend CM Jr, Thompson JC. Bombesin stimulates in vitro growth of human breast cancer independent of estrogen receptors status. Anticancer Res 18:4051-4056, 1998.
25. Bold RJ, Evers BM, Sperling HE, Gomez G, Ishizuka J, Townsend CM Jr, Thompson JC. Gastrointestinal hormone receptors and pancreatic cancer. Intl J Pancreatol 16:240-241, 1994.
26. Yao CZ, Ishizuka J, Bold RJ, Sperling HE, Townsend CM Jr, Thompson JC. Human monoclonal antibody against colon cancer. Cancer Invest 14:211-217, 1996.

Presentations:

1. Society for Surgery of the Alimentary Tract (17-19 May 1993, Boston, MA) - Retinoic acid inhibits growth of a human pancreatic carcinoid. (poster)
2. American Association for Cancer Research (19-22 May 1993, Orlando, FL) - Retina conditioned media induces a morphologic alteration in a human pancreatic carcinoid cell line in vitro. (poster)
3. Surgical Forum (10-15 Oct 1993, San Francisco, CA) - Secretin potentiates cholecystokinin-stimulated amylase release from pancreatic acinar cells by a pertussis toxin-sensitive mechanism. (oral)
4. American Pancreatic Association (4-5 Nov 1993, Chicago, IL) - Nerve growth factor is a mitogen for a human pancreatic carcinoid cell line. (oral)
5. Society of University Surgeons (9-12 Feb 1994, Jackson, MI) - Experimental gene therapy of human colon cancer. (oral)
6. American Association for Cancer Research (10-13 Apr 1994, San Francisco, CA) - Gastrin stimulates growth of a human colon cancer cell line via a receptor other than CCK-A and CCK-B type. (poster)
7. American Gastroenterological Association (15-18 May 1994, New Orleans, LA) - Receptor-specific growth regulatory mechanisms of bombesin (BBS) in human stomach cancer. (poster)
8. Surgical Forum (9-14 Oct 1994, Chicago, IL) - Functional responses of the endocrine cell line (BON) transfected with the human bombesin receptor. (oral)

Kyo Chu, M.D.
Medical School: The University of Texas Medical Branch
Mentors: Townsend, CM Jr, Thompson, JC
Research Topic: Age-related changes and effects of diet restriction on GI tract proliferation
Current Position: Assistant Professor, Department of Surgery, University of Virginia, Charlottesville, VA

 

Awards:
UTMB Jeane B. Kempner Scholar Award (1994)

Publications:

1. Chu KU, Tsuchiya T, Ishizuka J, Sato K, Uchida T, Townsend CM Jr, Thompson JC. Effects of ileo-jejunal transposition on intestinal mucosa and pancreas. Surg Forum 44:139-141, 1993.
2. Chu KU, Higashide S, Evers BM, Rajaraman S, Ishizuka J, Townsend CM Jr, Thompson JC. Bombesin improves survival from methotrexate-induced enterocolitis. Ann Surg 220:570-577, 1994.
3. Chu KU, Ishizuka J, Townsend CM Jr, Thompson JC. Growth effect of bombesin on normal and neoplastic GI tissue. Surg Forum 45:190-192, 1994.
4. Chu KU, Tsuchiya T, Ishizuka J, Uchida T, Townsend CM Jr, Thompson JC. Trophic response of gut and pancreas after ileojejunal transposition. Ann Surg 221:249-256, 1995.
5. Chu KU, Higashide S, Evers BM, Ishizuka J, Townsend CM Jr, Thompson JC. Bombesin stimulates mucosal growth in jejunal and ileal Thiry-Vella fistulas. Ann Surg 221:602-611, 1995.
6. Chu KU, Evers BM, Ishizuka J, Townsend CM Jr, Thompson JC. Role of bombesin on gut mucosal growth. Ann Surg 222:94-100, 1995.
7. Chu KU, Evers BM, Ishizuka J, Beauchamp RD, Greeley GH Jr, Townsend CM Jr, Thompson JC. Short-term caloric restriction augments age-related decreases in gastrin content and release. Mech Ageing Dev 87:25-33, 1996.
8. Ehrenfried JA, Evers BM, Chu KU, Townsend CM Jr, Thompson JC. Caloric restriction increases the expression of heat shock protein in the gut. Ann Surg 223:592-599, 1996.
9. Chu KU, Ishizuka J, Battey JF, Uchida T, Beauchamp RD, Townsend CM Jr, Thompson JC. Mechanisms of bombesin on the growth of gastrinoma (PT) in vivo. Dig Dis Sci 41:2180-2186, 1996.
10. Higashide S, Chu KU, Gomez G, Greeley GH Jr, Thompson JC, Townsend CM Jr. Caloric restriction causes secretagogue specific changes of gastric acid secretion in rats. Regul Pept 68:205-210, 1997.

Presentations:

1. Surgical Forum (10-15 Oct 1993, San Francisco, CA) - Effect of ileojejunal transposition on intestinal mucosa and pancreas. (oral)
2. American Pancreatic Association (4-5 Nov 1993, Chicago, IL) - Effects of bombesin analog on pancreatic growth of Balb/c nude mice. (poster)
3. Society of University Surgeons (9-12 Feb 1994, Jackson, MS) - Bombesin improves survival from methotrexate-induced enterocolitis. (oral, Residents' Conference)
4. American Surgical Association (7-9 Apr 1994, San Francisco, CA) - Bombesin improves survival in lethal enterocolitis. (oral)
5. American Association for Cancer Research (10-13 Apr 1994, San Francisco, CA) - Effects of bombesin analogs on the growth of human colon cancer. (poster)
6. American Gastroenterological Association (15-18 May 1994. New Orleans. LA) - Effect of caloric restriction on rat pancreas. (poster)
7. Gastrointestinal Hormone 10th Intl Symposium (27-31 Aug 1994, Santa Barbara. CA) - Effect of caloric restriction on gastrin synthesis and gene expression. (poster)
8. Surgical Forum (9-14 Oct 1994, Chicago, IL) - Growth effect of bombesin on normal and neoplastic GI tissue. (oral)
9. American Pancreatic Association (3-4 Nov 1994, Chicago, IL) - Mechanisms of bombesin on the growth of human gastrinoma in vivo. (oral)
10. Southern Surgical (4-7 Dec 1994, Palm Beach, FL) - Hormone regulation of gut mucosal growth. (oral)