Bruns A. Watts, III, Ph.D.
Assistant Professor, Division of Nephrology
Bruns A. Watts, III, Ph.D.
Division of Nephrology
Department of Internal Medicine
University of Texas Medical Branch
301 University Blvd.
Galveston, TX 77555-0562
|Degree/Training Completed||Year||Name & Location|
|B.A.||1984||University of Dallas, Irving, TX|
|Ph.D.||1994||University of Texas Medical Branch
Department of Cellular Physiology & Molecular Biophysics, Galveston, TX
|Postdoctoral||2000||University of Texas Medical Branch
Department of Internal Medicine,
Division of Nephrology, Galveston, TX
Dr. Watts' research focuses on the regulation of renal electrolyte and acid-base transport. His major areas of interest are the cellular and molecular mechanisms that regulate apical and basolateral membrane Na+/H+ exchangers and the functional interaction between these two transporters. Current projects examine the regulation of renal tubule intracellular signaling pathways by immune and inflammatory responses. Ongoing collaborative studies investigate therapeutic agents that prevent sepsis-induced renal dysfunction and seek to identify the cellular mechanisms that are responsible for the protective effects. In addition, Dr. Watts is interested in the effects of neurotrophins on renal transport and the cellular mechanisms by which neurotrophins regulate renal function.
Good, D.W., T. George, and B.A. Watts, III. Basolateral membrane Na+/H+ exchange enhances HCO3- absorption in rat medullary thick ascending limb: Evidence for functional coupling between basolateral and apical membrane Na+/H+ exchangers. Proc. Natl. Acad. Sci. USA 92: 12525-12529,1995.
Watts, III, B.A., T. George, and D.W. Good. Nerve growth factor inhibits HCO3- absorption through inhibition of basolateral membrane Na+/H+ exchange. J. Biol. Chem. 274: 7841-7847, 1999.
Watts, III, B.A., T. George, and D.W. Good. The basolateral NHE1 Na+ /H+ exchanger regulates transepithelial HCO-3 absorption through actin cytoskeleton remodeling in renal thick ascending limb. J. Biol. Chem. 280: 11439-11447, 2005.
Good, D.W., T. George, and B.A. Watts, III. Nerve growth factor inhibits Na+/H+ exchange and HCO-3 absorption through parallel phosphatidylinositol 3-kinase-mTOR and ERK pathways in thick ascending limb. J Biol. Chem. 283: 26602-26611, 2008.
Good, D.W., T. George, and B.A. Watts, III. Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes. Am. J. Physiol. Renal Physiol. 297: F866-F874, 2009.
Good, D.W., T. George, and B.A. Watts, III. Toll-like receptor 2 mediates inhibition of HCO3- absorption by bacterial lipoprotein in medullary thick ascending limb. Am. J. Physiol. Renal Physiol. 299: F536-F544, 2010.