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Members

  • Benjamin B. Gelman, M.D., Ph.D.

    BenjaminGelmanProfessor
    Director, Texas NeuroAIDS Research Center
    Investigator, Center for AIDS Research (CFAR), Baylor College of Medicine, Houston, Texas
    T32 Participating Faculty Member
    Department: Pathology, and Neuroscience & Cell Biology

    Email: bgelman@utmb.edu
    Phone: 409.772.5316

    Bio & Research

Biography

We are interested in how persistent inflammation in the brain influences neurocognitive function in people with HIV/AIDS.  Our current emphasis is on its effect on synaptic protein turnover and dopaminergic synaptic transmission.  We are a national resource for HIV/AIDS neuropathology and a founding center of the National NeuroAIDS Tissue Consortium.  We also participate in the CHARTER study, which is a multi-site cross-sectional and longitudinal study of dementia in HIV-infected people.

Research in the laboratory is focused on HIV-related neurodegeneration.  One project is elucidating how reducing HIV loads with highly active antiretroviral therapy influences painful peripheral neuropathy.  Another project is exploring how neuronal protein turnover through the ubiquitin-proteasome system is abnormal in people with HIV dementia.  Our basic approach is to perform neurochemical analysis of banked human brain specimens that we collected from people with HIV infection.  Dr. Gelman is the founder and Principal Investigator of the Texas NeuroAIDS Research Center with clinics in Galveston, Houston and Dallas.  The Center is one of four HIV brain repositories of the National NeuroAIDS Tissue Consortium (NNTC).  Subjects are followed prospectively and CNS and PNS specimens and data are banked at autopsy.  Neurological, neurocognitive and drug use documentation information is stored in a database for use by researchers.  Specimens and data are distributed to investigators around the world.

Education
  • B.A., 1971, Ohio University, Athens, Ohio
  • Ph.D., 1978, University of Cincinnati, Cincinnati, Ohio
  • M.D., 1983, University of Cincinnati, Cincinnati, Ohio