Several faculty are engaged in research to discover new small molecules and peptides to shut down or enhance mechanism-based target pathways in addictions. We also have an ongoing search for a new faculty member to develop addiction vaccines in collaboration with the UTMB Sealy Center for Vaccine Development. The three foundation centers offer complementary, non-overlapping mentoring opportunities in the pathway from target discovery to medications development (Figure: 1).
- New target and drug discovery for novel therapeutics
for addiction (Allen, Anastasio, Cunningham, Dineley, Gilbertson, Hommel, Laezza, Lane, Moeller, Nanovskaya, Rudenko, Zhou)
- Protein complexes for new molecule discovery (Allen, Cunningham, Dineley, Gilbertson, Laezza, Rudenko, Zhou)
- Noel cellular models for analyses and screening new chemical entities (Allen, Anastasio, Elferink, Pyles, Wu)
- Novel allosteric modulators and inverse agonists for G-protein coupled receptors (Anastasio, Cunningham, Gilbertson, Zhou)
- Medications development for psychostimulant and opiate use disorder (Lane, Moeller, Nanovskaya)