Abuse and addiction are rooted in neuroadaptations that lead to compulsive craving, drug-seeking and drug-taking, but drugs are delivered to the entire body, and their impact contributes significantly to the burden of health problems in our country (e.g., cardiovascular disease, stroke, cancer, HIV/AIDS and other infectious diseases) and several mentors are engaged in research directed at understanding such medical consequences.
- Neurodegenerative mechanisms associated with methamphetamine and viral exposure (Dineley, Paessler, Pyles, Vargas, Wu)
- Pharmacokinetics/pharmacodynamics of opiates and other psychotropics in pregnancy (Nanovskaya)
- Funtional imaging and blood biomarkers of addictions (Anastasio, Cunningham, Green, Lane, Moeller, Nanovskaya)
- Transplacental transfer and metabolism of steroids and psychotropics (Nanovskaya)
- Immunology of therapeutic vaccine efficacy in addictions (Paessler, Pyles)
- Neurodegeneration, alcohol and cocaine effects on neural stem cells (Kaphalia, Vargas, Sowers, Wu)