Neural Bases for Drug Abuse and Addiction

T32 Training Program

Our Training Program has historically embodied a community of scientists who cross disciplinary lines to identify neurobiological targets and pathways involved in drug abuse and addiction. Mechanistic studies underlying the neural effects of abused psychoactive substances and their behavioral consequences are the mainstay of the training grant and some examples include:

  • Pharmacological mechanisms of action of alcohol (Elferink, Kaphalia, Wu), psychostimulants (Allen, Anastasio, Cunningham, Dineley, Green, Hommel, Lane, Moeller, Nanovskaya), opiates (Anastasio, Cunningham, Nanovskaya), and palatable high-fat food (Abate, Anastasio, Cunningham, Hommel, Pyles, Vargas)
  • Chemical, genomic, functional and anatomical studies of adhesion proteins, ion channels, G protein-coupled receptors, transporters, and transcription factors involved in neurotransmission (Allen, Anastasio, Cunningham, Dineley, Elferink, Green, Hommel, Rudenko, Laezza, Zhou)
  • Neurocircuitry engaged in reward, and phenotypes associated with substance use disorders and relapse (e.g., depression, impulsivity, cue reactivity) (Anastasio, Cunningham, Green, Hommel, Lane, Moeller)
  • Genetics, gene expression and epigenetics in substance use and related disorder (Anastasio, Green, Lane, Moeller, Pyles, Sowers, Wu)            


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